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| 1 | 评估大气细颗粒物暴露引起的全球疾病负担的一个综合风险函数显示文摘[背景]评估由于环境空气中细颗粒物(PM2.5)长期暴露引起的疾病负担,需要了解相对风险度(RR)函数的图形和幅度。然而,在世界上很多观察到高PM2.5环境浓度的地方,都缺乏足够的直接证据确定死亡RR函数的图形。[目的]建立可用于全球PM2.5暴露范围内成人死因的RR函数:缺血性心脏病(IHD)、脑血管疾病(脑卒中)、慢性阻塞性肺病(COPD)和肺癌(LC)。建立急性下呼吸道感染(ALRI)发病的RR函数,用于估算〈5岁的儿童中死亡率和健康生活损失年数。[方法]通过整合现有的来自于环境空气污染(AAP)、二手烟草烟雾、家用固体烹饪用燃料和主动吸烟(AS)等研究的RR信息,拟合综合暴露-反应(IER)模型。采用颗粒物质的吸入剂量,通过转化AS暴露来估计全年PM2.5的暴露当量。在估算全球环境PM2.5浓度的基础上,得出各国的人群归因分数(PAFs)。[结果]与以往负担评估中使用的其他7种模型相比,IER模型是一种优越的RR预测方法。在不同国家中,归因于AAP暴露的PAF百分数各不相同,分别为:IHD,2~41;脑卒中,1~43;COPD,〈1~21;LC,〈1~25;ALRI,〈1~38。[结论]我们建立了一种以细颗粒物为基础的RR模型,它通过整合来自不同类型的燃烧所产生颗粒物排放的RR信息,涵盖全球范围的暴露。当获得新的RR信息时,可以对这个模型进行更新。 | Richard T.Burnett C.Arden Pope III Majid Ezzati Casey Olives Stephen S.Lim Sumi Mehta Hwashin H.Shin Gitanjali Singh Bryan Hubbell Michael Brauer H.Ross Anderson Kirk R.Smith John R.Balmes Nigel G.Bruce Haidong Kan Francine Laden Annette Prüss-Ustün Michelle C.Turner Susan M.Gapstur W.Ryan Diver Aaron Cohen 何蓉 张伊人 金泰廙 | 2014 | 环境与职业医学2014，31，11： | 80 |
| 2 | C:N:P stoichiometry and nutrient limitation of the soil microbial biomass in a grazed grassland site under experimental P limitation or exces显示文摘Introduction:The availability of essential nutrients,such as nitrogen(N)and phosphorus(P),can feedback on soil carbon(C)and the soil microbial biomass.Natural cycles can be supplemented by agricultural fertiliser addition,and we determined whether the stoichiometry and nutrient limitation of the microbial biomass could be affected by an unbalanced nutrient supply.Methods:Samples were taken from a long-term trial(in effect since 1968)with annual applications of 0,15 and 30 kg P ha^(−1) with constant N and potassium.Soil and microbial biomass CNP contents were measured and nutrient limitation assessed by substrate-induced respiration.Linear regression and discriminant analyses were used to identify the variables explaining nutrient limitation.Results:Soil and biomass CNP increased with increasing P fertiliser,and there was a significant,positive,correlation between microbial biomass P and biomass C,apart from at the highest level of P fertilisation when the microbial biomass was over-saturated with P.The molar ratios of C:N:P in the microbial biomass remained constant(homeostatic)despite large changes in the soil nutrient ratios.Microbial growth was generally limited by C and N,except in soil with no added P when C and P were the main limiting nutrients.C,N and P,however,did not explain all the growth limitation on the soils with no added P.Conclusions:Increased soil C and N were probably due to increased net primary production.Our results confirm that C:N:P ratios within the microbial biomass were constrained(i.e.homeostatic)under near optimum soil conditions.Soils with no added P were characterised by strong microbial P limitation and soils under high P by over-saturation of microorganisms with P.Relative changes in biomass C:P can be indicative of nutrient limitation within a site. | Bryan S Griffiths Annette Spilles Michael Bonkowski | 2012 | Ecological Processes2012，1，1： | 23 |
| 3 | Bioactive polymeric materials and electrical stimulation strategies for musculoskeletal tissue repair and regeneration显示文摘Electrical stimulation(ES)is predominantly used as a physical therapy modality to promote tissue healing and functional recovery.Research efforts in both laboratory and clinical settings have shown the beneficial effects of this technique for the repair and regeneration of damaged tissues,which include muscle,bone,skin,nerve,tendons,and ligaments.The collective findings of these studies suggest ES enhances cell proliferation,extracellular matrix(ECM)production,secretion of several cytokines,and vasculature development leading to better tissue regeneration in multiple tissues.However,there is still a gap in the clinical relevance for ES to better repair tissue interfaces,as ES applied clinically is ineffective on deeper tissue.The use of a conducting material can transmit the stimulation applied from skin electrodes to the desired tissue and lead to an increased function on the repair of that tissue.Ionically conductive(IC)polymeric scaffolds in conjunction with ES may provide solutions to utilize this approach effectively.Injectable IC formulations and their scaffolds may provide solutions for applying ES into difficult to reach tissue types to enable tissue repair and regeneration.A better understanding of ES-mediated cell differentiation and associated molecular mechanisms including the immune response will allow standardization of procedures applicable for the next generation of regenerative medicine.ES,along with the use of IC scaffolds is more than sufficient for use as a treatment option for single tissue healing and may fulfill a role in interfacing multiple tissue types during the repair process. | Bryan Ferrigno Rosalie Bordett Nithyadevi Duraisamy Joshua Moskow Michael R.Arul Swetha Rudraiah Syam P.Nukavarapu Anthony T.Vella Sangamesh G.Kumbar | 2020 | Bioactive Materials2020，5，3： | 8 |
| 4 | Screening pre-bariatric surgery patients for esophageal disease with esophageal capsule endoscopy显示文摘AIM:To determine if esophageal capsule endoscopy(ECE)is an adequate diagnostic alternative to esophagogastroduodenoscopy(EGD)in pre-bariatric surgery patients.METHODS:We conducted a prospective pilot study to assess the diagnostic accuracy of ECE(PillCam ESO2,Given Imaging)vs conventional EGD in pre-bariatric surgery patients.Patients who were scheduled for bariatric surgery and referred for pre-operative EGD were prospectively enrolled.All patients underwent ECE followed by standard EGD.Two experienced gastroenterologists blinded to the patient’s history and the findings of the EGD reviewed the ECE and documented their findings.The gold standard was the findings on EGD.RESULTS:Ten patients with an average body mass index of 50 kg/m2were enrolled and completed the study.ECE identified 11 of 14(79%)positive esophageal/gastroesophageal junction(GEJ)findings and 14of 17(82%)combined esophageal and gastric findings identified on EGD.Fisher’s exact test was used to compare the findings and no significant difference was found between ECE and EGD(P=0.64 for esophageal/GEJ and P=0.66 for combined esophageal and gastric findings respectively).Of the positive esophageal/GEJ findings,ECE failed to identify the following:hiatal hernia in two patients,mild esophagitis in two patients,and mild Schatzki ring in two patients.ECE was able to identify the entire esophagus in 100%,gastric cardia in0%,gastric body in 100%,gastric antrum in 70%,pylorus in 60%,and duodenum in 0%.CONCLUSION:There were no significant differences in the likelihood of identifying a positive finding using ECE compared with EGD in preoperative evaluation of bariatric patients. | Ashish Shah Erica Boettcher Marianne Fahmy Thomas Savides Santiago Horgan Garth R Jacobsen Bryan J Sandler Michael Sedrak Denise Kalmaz | 2013 | World Journal of Gastroenterology2013，19，37： | 7 |
| 5 | Cholesterol Efflux and Atheroprotection: Advancing the Concept of Reverse Cholesterol Transport显示文摘 | Robert S. Rosenson H. Bryan Brewer W. Sean Davidson Zahi A. Fayad Valentin Fuster James Goldstein Marc Hellerstein Xian-Cheng Jiang Michael C. Phillips Daniel J. Rader Alan T. Remaley George H. Rothblat Alan R. Tall Laurent Yvan-Charvet | 2012 | Circulation2012，，15： | 4 |
| 6 | Surgery for Early-Stage Non-Small Cell Lung Cancer: A Systematic Review of the Video-Assisted Thoracoscopic Surgery Versus Thoracotomy Approaches to Lobectomy显示文摘 | Bryan A. Whitson Shawn S. Groth Susan J. Duval Scott J. Swanson Michael A. Maddaus | 2008 | The Annals of Thoracic Surgery2008，，6： | 3 |
| 7 | The Importance of Medial Support in Locked Plating of Proximal Humerus Fractures显示文摘 | Michael J Gardner Yoram Weil Joseph U Barker Bryan T Kelly David L Helfet Dean G Lorich | 2007 | Journal of Orthopaedic Trauma2007，，3： | 2 |
| 8 | Survival of patients with distal esophageal and gastric cardia tumors: A population-based analysis of gastroesophageal junction carcinomas显示文摘 | Bryan A. Whitson Shawn S. Groth Zhongze Li Robert A. Kratzke Michael A. Maddaus | 2010 | The Journal of Thoracic and Cardiovascular Surgery2010，，1： | 2 |
| 9 | Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis显示文摘BACKGROUND Rotator cuff pathology is a very common source of shoulder pain.Similarly,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar symptoms.Surgical management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of GHOA.AIM To evaluate if a relationship exists between outcomes of RCR in the setting of GHOA.METHODS This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between 2010-2017.Patients were stratified based on rotator cuff tear size and glenohumeral osteoarthritis severity.Cohorts were paired 1:1 with patients without glenohumeral osteoarthritis.Patients included had a minimum two year follow-up.Rate of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were collected.RESULTS A total of 142 patients were included.The number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without GHOA.Following rotator cuff repair,both groups showed favorable patientreported outcomes.CONCLUSION Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis. | Ian S Hong Allison J Rao Tyler L CarlLee Joshua D Meade Daniel J Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor James E Fleischli Bryan Michael Saltzman | 2022 | World Journal of Orthopedics2022，13，7： | 2 |
| 10 | 含有0.8%精氨酸、PVM/MA共聚物、焦磷酸盐和0.05%氟化钠的新型脱敏漱口水的作用方式的研究显示文摘目的:经提出并证实,采用Pro-Argin TM漱口水工艺制成的含有0.8%精氨酸、PVM/MA共聚物、焦磷酸盐和0.05%氟化钠的精氨酸漱口水的作用方式,可利用多种体外技术产生封闭作用。方法:采用定量和定性实验室技术研究这种新型精氨酸漱口水的作用方式。利用共焦激光扫描显微镜检查(CSLM)和原子力显微镜检查(AFM)研究牙本质表面的水合层。化学分析电子光谱学(ESCA)、二次离子质谱学(SIMS)和近红外光谱学(NIR)提供了关于这种漱口水的化学性质的信息。结果:使用精氨酸漱口水后,采用CLSM观察暴露牙本质小管上的水合层的形成。经荧光研究证实,水合层可渗透到牙本质小管内壁。经AFM研究证实,精氨酸漱口水对牙本质表面具有亲合力,这与其粘合性质相一致。NIR表明,使用漱口水数次后,精氨酸会沉积下来,而ESCA/SIMS检测到磷酸基团和有机酸基团的存在,表明PVM/MA共聚物和焦磷酸盐是连同精氨酸一起沉积下来的。结论:研究表明:富含精氨酸层连同来自于含有0.8%精氨酸、PVM/MA共聚物、焦磷酸盐和0.05%氟化钠的无酒精漱口水的共聚物和磷酸盐离子一起沉积下来后,可封闭牙本质表面。 | Sarita V.Melloa Evangelia Arvanitidoua Michael A.Stranicka Ramon Santanaa Yasemin Kutesb Bryan Hueyb | 2014 | 口腔护理用品工业2014，24，6： | 2 |
| 11 | Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory, Musculoskeletal, and Neuromotor Fitness in Apparently Healthy Adults: Guidance for Prescribing Exercise显示文摘 | Carol Ewing Garber Bryan Blissmer Michael R. Deschenes Barry A. Franklin Michael J. Lamonte I-Min Lee David C. Nieman David P. Swain | 2011 | Medicine & Science in Sports & Exercise2011，，7： | 2 |
| 12 | Atomic force microscopy correlates antimetastatic potentials of HepG2 cell line with its redox/energy status: effects of curcumin and Khaya senegalensis显示文摘OBJECTIVE: The fatality of cancer is mostly dependent on the possibility of occurrence of metastasis. Thus, if the development of metastasis can be prevented through novel therapeutic strategies targeted against this process, then the success of cancer treatment will drastically increase. In this study, therefore, we evaluated the antimetastatic potentials of an extract of Khaya senegalensis and curcumin on the metastatic liver cell line HepG2, and also assessed the anticancer property of the extract.METHODS: Cells were cultured and treated with graded concentrations of test substances for 24, 48, or 72 h with provisions made for negative controls. Treated cells were assessed as follows: nanotechnologically—atomic force microscopy(AFM) was used to determine cell stiffness; biochemically—cell cytotoxicity, glutathione level and adenosine triphosphate status, caspase activation and mitochondrial toxicity were considered; and microbiologically—a carrot disk assay was used to assess the anticancer property of the extract of K. senegalensis.RESULTS: Curcumin and K. senegalensis increased the cell stiffness by 2.6-and 4.0-fold respectively, indicating their antimetastatic effects. Corresponding changes in redox(glutathione level) and energy(adenosine triphosphate) status of the cells were also demonstrated. Further mechanistic studies indicated that curcumin was not mitotoxic in HepG2 cells unlike the K. senegalensis extract. In addition, the extract potently inhibited the Agrobacterium tumefaciens-induced genetic transformation based on carrot disk assay.CONCLUSION: Cell elasticity measurement data, using AFM, strongly suggested, for the first time, that both curcumin and the extract of K. senegalensis exhibited antimetastatic properties on HepG2 cells. | Jeremiah Olorunjuwon Olugbami Robert Damoiseaux Bryan France Michael A. Gbadegesin Adam Z. Stieg Shivani Sharma Oyeronke A. Odunola James K. Gimzewski | 2017 | Journal of Integrative Medicine2017，15，3： | 2 |
| 13 | Selection of Patients for Resection of Hepatic Colorectal Metastases: Expert Consensus Statement显示文摘 | Chusilp Charnsangavej MD Bryan Clary MD Yuman Fong MD Axel Grothey MD Timothy M. Pawlik MD MPH Michael A. Choti MD MBA | 2006 | Annals of Surgical Oncology2006，，10： | 2 |
| 14 | Optical information processing using dual state quantum dot lasers: complexity through simplicity显示文摘We review results on the optical injection of dual state InAs quantum dot-based semiconductor lasers.The two states in question are the so-called ground state and first excited state of the laser.This ability to lase from two different energy states is unique amongst semiconductor lasers and in combination with the high,intrinsic relaxation oscillation damping of the material and the novel,inherent cascade like carrier relaxation process,endows optically injected dual state quantum dot lasers with many unique dynamical properties.Particular attention is paid to fast state switching,antiphase excitability,novel information processing techniques and optothermally induced neuronal phenomena.We compare and contrast some of the physical properties of the system with other optically injected two state devices such as vertical cavity surface emitting lasers and ring lasers.Finally,we offer an outlook on the use of quantum dot material in photonic integrated circuits. | Bryan Kelleher Michael Dillane Evgeny A.Viktorov | 2021 | Light(Science & Applications)2021，10，12： | 2 |
| 15 | An Exploratory Study of Environmental Attitudes and the Willingness to Pay for Environmental Certi- fication in Mexico 显示文摘 | Bryan W H Michael V R Carlos E B M etal | 2014 | Business Research2014，67，5： | 1 |
| 16 | Anterior Cervical Plating Enhances Arthrodesis after Discectomy and Fusion with Cortical Allograft显示文摘 | Michael G. Kaiser Regis W. Haid Brian R. Subach Bryan Barnes Gerald E. Rodts | 2002 | Neurosurgery2002，，2： | 1 |
| 17 | Fibroblast Growth Factor 23, Bone Mineral Density, and Risk of Hip Fracture Among Older Adults: The Cardiovascular Health Study显示文摘 | Anna Jovanovich Petra Bù?ková Michel Chonchol John Robbins Howard A. Fink Ian H. de Boer Bryan Kestenbaum Ronit Katz Laura Carbone Jennifer Lee Gail A. Laughlin Kenneth J. Mukamal Linda F. Fried Michael G. Shlipak Joachim H. Ix | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，8： | 1 |
| 18 | A preliminary test of the interpersonal-psychological theory of suicidal behavior in a military sample 显示文摘 | Craig J Bryan Chad E Morrow Michael D Anestis | 2010 | Personality and Individual Differences2010，48，3： | 1 |
| 19 | Expression of Engrailed-2 (EN2) protein in bladder cancer and its potential utility as a urinary diagnostic biomarker显示文摘 | Richard Morgan Richard T. Bryan Saqib Javed Francesca Launchbury Maurice P. Zeegers K.K. Cheng Nicholas D. James D. Michael A. Wallace Carolyn D. Hurst Douglas G. Ward Margaret A. Knowles Hardev Pandha | 2013 | European Journal of Cancer2013，，9： | 1 |
| 20 | An Efficient Asymmetric Approach to Carbocyclic Nucleosides:Asymmetric Synthesis of 1592U89,a Potent Inhibitor of HIV Reverse Transcriptase显示文摘 | Michael T C Bryan W K | 1996 | J Org Chem1996，61，： | 1 |
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