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| 1 | Up-Regulation of Trem2 Inhibits Hippocampal Neuronal Apoptosis and Alleviates Oxidative Stress in Epilepsy via the PI3K/Akt Pathway in Mice显示文摘Epilepsy is a chronic and severe neurological disorder that has negative effects on the autonomous activities of patients. Functionally, Trem2(triggering receptor expressed on myeloid cells-2) is an immunoglobulin receptor that affects neurological and psychiatric genetic diseases. Based on this rationale, we aimed to assess the potential role of Trem2 integration with the PI3 K/Akt pathway in epilepsy. We used microarray-based gene expression profiling to identify epilepsy-related differentially-expressed genes. In a mouse hippocampal neuron model of epilepsy, neurons were treated with lowMg^2+ extracellular fluid, and the protein and mRNA expression of Trem2 were determined. Using a gain-offunction approach with Trem2, neuronal apoptosis and its related factors were assessed by flow cytometry, RT-qPCR,and Western blot analysis. In a pilocarpine-induced epileptic mouse model, the malondialdehyde(MDA) and8-hydroxy-20-deoxyguanosine(8-OHdG) content and superoxide dismutase(SOD) and glutathione-peroxidase(GSH-Px) activity in the hippocampus were determined,and the protein expression of Trem2 was measured. In addition, the regulatory effect of Trem2 on the PI3 K/Akt pathway was analyzed by inhibiting this pathway in both the cell and mouse models of epilepsy. Trem2 was found to occupy a core position and was correlated with epilepsy.Trem2 was decreased in the hippocampus of epileptic miceand epileptic hippocampal neurons. Of crucial importance,overexpression of Trem2 activated the PI3 K/Akt pathway to inhibit neuronal apoptosis. Moreover, activation of the PI3 K/Akt pathway through over-expression of Trem2 alleviated oxidative stress, as shown by the increased expression of SOD and GSH-Px and the decreased expression of MDA and 8-OHdG. The current study defines the potential role of Trem2 in inhibiting the development of epilepsy, indicating that Trem2 up-regulation alleviates hippocampal neuronal injury and oxidative stress, and inhibits neuronal apoptosis in epilepsy by activating the PI3 K/Akt pathway. | Ai-Hua Liu Min Chu Yu-Ping Wang | 2019 | Neuroscience Bulletin2019，35，3： | 25 |
| 2 | A novel gene delivery system targeting cells expressing VEGF receptors显示文摘Two ligand oligopeptides GV1 and GV2 were designed according to the putative binding region of VEGF to its receptors. GV1, GV2 and endosome releasing oligopeptide HA20 were conjugated with poly-L-lysine or protamine and the resulting conjugates could interact with DNA in a noncovalent bond to form a complex. Using pSV2-β-galactosidase as a reporter gene, it has been demonstrated that exogenous gene was transferred into bovine aortic arch-derived endothelial cells (ABAE) andhuman malignant melanoma cell lines (A375) in vitro. In vivo experiments, exogenous gene was transferred into tumor vascular endothelial cells and tumor cells of subcutaneously transplanted human colon cancer LOVO, human malignant melanoma A375 and human hepatoma graft in nude mice. This system could also target gene to intrahepatically transplanted human hepatoma injected via portal vein in nude mice. These results are correlated with theGene delivery system targeting VEGF receptors relevant receptors (flt-1, flk-1/KDR) expression on the targeted cells and tissues. | LI JUN MIN JUN SONG HAN YI HUANG PEI KUN TIAN SHU MIN QU MIN YAO HUI QIU JIANG DA FANG WAN JING CHU LUO CHENG XIAO GU JIAN REN GU( National Labomtory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032,China)(National Laboratory of | 1999 | Cell Research1999，9，1： | 22 |
| 3 | Degradation of chlorpyrifos alone and in combination with chlorothalonil and their effects on soil microbial populations显示文摘在实践,杀虫剂通常为庄稼保护同时或一个接一个被使用,并且这类杀虫剂申请经常在土壤环境导致杀虫剂残余的联合污染。实验室研究被进行在土壤上在 chlorpyrifos 降级和它的效果上调查 chlorothalonil 的影响细菌,真菌,并且放射菌类人口。在这里的试验性的条件下面, chlorpyrifos 的一半生活独自,并且在有 chlorothalonil 的联合,在推荐并且两倍剂量,被测量分别地是 3.24, 2.77,和 2.63 d。Chlorpyrifos 降级没被它的联合显著地与 chlorothalonil 改变。然而,土壤微生物上的 chlorpyrifos 的禁止的效果被它的联合与 chlorothalonil 增加,并且增加与增加的 chlorothalonil 的层次有关。在控制,细菌的人口,真菌,和放射菌类比作那些分别地,被 chlorpyrifos 被 44.1% , 61.1% ,和 72.8% 显著地独自在处理(DAT ) 以后在第一天减少。与 chlorothalonil 的增加,抑制在推荐剂量被增加到 55.2% , 79.3% ,和 85.8% ,并且 86.0% , 94.1% ,和 90.8% 在双剂量在一 DAT,分别地。结果建议联合效果应该被考虑估计杀虫剂应用的实际影响。 | CHU Xiaoqiang FANG Hua PAN Xuedong WANG Xiao SHAN Min FENG Bo YU Yunlong | 2008 | Journal of Environmental Sciences2008，20，4： | 16 |
| 4 | Effect of various crop rotations on rice yield and nitrogen use efficiency in paddy–upland systems in southeastern China显示文摘To evaluate the effects of various rotation systems on rice grain yield and N use efficiency, a paddy–upland cropping experiment(2013–2016) was conducted in southeastern China. The experiment was designed using six different rice––winter crop rotations: rice–fallow(RF),rice–wheat(RW), rice–potato with rice straw mulch(RP), rice–green manure(Chinese milk vetch; RC–G), rice–oilseed rape(RO), and rice–green manure crop(oilseed rape with fresh straw incorporated into soil at flowering; RO–G) and three N rates, N0(0 kg N ha-1), N1(142.5 kg N ha-1), and N2(202.5 kg N ha-1). Average rice yields in the RF(5.93 t ha-1) rotation were significantly lower than those in the rotations with winter crops(7.20–7.48 t ha-1)under the N0 treatment, suggesting that incorporation of straw might be more effective for increasing soil N than winter fallow. The rice yield differences among the rotations varied by year with the N input. In general, the grain yields in the RP and RO–G rotations –were respectively 11.6–28.5% and 14.80–37.19% higher than those in the RF in plots with N applied. Increasing the N rate may have tended to minimize the average yield gap between the RF and the other rotations; the yield gaps were 18.55%, 4.14%, and 0.23% in N0, N1, and N2, respectively. However, the N recovery efficiency in the RF was significantly lower than that in other rotations, except for 2015 under both N1 and N2 rates, a finding that implies a large amount of chemical N loss. No significant differences in nitrogen agronomic efficiency(NAE) and physiological efficiency(NPE) were found between the rotations with legume(RC–G) and non–legume(RO and RW) winter crops, a result that may be due partly to straw incorporation. For this reason, we concluded that the return of straw could reduce differences in N use efficiency between rotations with and without legume crops. The degree of synchrony between the crop N demand and the N supply was evaluated by comparison of nitrogen balance degree(NBD) values. The NBD values in the RP and RW were significantly lower than those in the other rotations under both N1 and N2 rates. Thus,in view of the higher grain yield in the RP compared to the RW under the N1 rate, the RP rotation might be a promising practice with comparable grain yield and greater N use efficiency under reduced N input relative to the other rotations. The primary yield components of the RF and RP were identified as number of panicles m-2 and numbers of kernels panicle-1, respectively. The NAE and NPE were positively correlated with harvest index, possibly providing a useful indicator for evaluating N use efficiency. | Song Chen Shaowen Liu Xi Zheng Min Yin Guang Chu Chunmei Xu Jinxiang Yan Liping Chen Danying Wang Xiufu Zhang | 2018 | The Crop Journal2018，6，6： | 13 |
| 5 | Influence of CYP3A5 genetic polymorphism on cyclosporine A metabo-lism and elimination in Chinese renal transplant recipients显示文摘瞄准:调查 CYP3A5 *3 多型性是否将影响 cyclosporine A (CsA ) 在中国肾的 transplant 病人的新陈代谢。方法:CYP3A5 *3 遗传型用聚合酶链反应和特定的等位基因(PCR-ASA ) 的扩大在中国肾的 transplant 接受者被决定。CsA 和代谢物的集中被荧光极化免疫分析和调整剂量的马槽集中独立测量,新陈代谢的比率(先生) 价值是计算的。结果:与剂量调整的马槽集中在与两个相比的野等位基因搬运人是显著地更高的同型结合(*3*3 ) 并且异质接合的变体(*1*3 ) 。然而,没有有效差量被作出对有利的裁决调整剂量的代谢物集中。为 3 个遗传型组的先生价值如下:为 CYP3A5 *3 /*3 (n=14 ) 的 0.92+/-0.62,为 CYP3A5 *1 /*3 (n=15 ) 的 0.99+/-0.51,和为 CYP3A5 *1 /*1 (n=9 ) 的 1.45+/-0.62 分别地。帖子 hoc 比较证明仅仅 MR 在 CYP3A5 *3 /*3 组和 CYP3A5 *1 /*1 组之间珍视是显著地不同的。结论:CYP3A5 *3 多型性在 cyclosporine 新陈代谢上施加了小效果。先生可以是为治疗学的药监视的更精确的指示物,就它父母药和代谢物的身体暴露的综合信息而言。 | Xiao-man CHU Hai-ping HAO Guang-ji WANG Lian-qing GUO Pei-qing MIN | 2006 | Acta Pharmacologica Sinica2006，27，11： | 12 |
| 6 | Human organoids in basic research and clinical applications显示文摘Organoids are three-dimensional(3D)miniature structures cultured in vitro produced from either human pluripotent stem cells(hPSCs)or adult stem cells(AdSCs)derived from healthy individuals or patients that recapitulate the cellular heterogeneity,structure,and functions of human organs.The advent of human 3D organoid systems is now possible to allow remarkably detailed observation of stem cell morphogens,maintenance and differentiation resemble primary tissues,enhancing the potential to study both human physiology and developmental stage.As they are similar to their original organs and carry human genetic information,organoids derived from patient hold great promise for biomedical research and preclinical drug testing and is currently used for personalized,regenerative medicine,gene repair and transplantation therapy.In recent decades,researchers have succeeded in generating various types of organoids mimicking in vivo organs.Herein,we provide an update on current in vitro differentiation technologies of brain,retinal,kidney,liver,lung,gastrointestinal,cardiac,vascularized and multi-lineage organoids,discuss the differences between PSC-and AdSC-derived organoids,summarize the potential applications of stem cell-derived organoids systems in the laboratory and clinic,and outline the current challenges for the application of organoids,which would deepen the understanding of mechanisms of human development and enhance further utility of organoids in basic research and clinical studies. | Xiao-Yan Tang Shanshan Wu Da Wang Chu Chu Yuan Hong Mengdan Tao Hao Hu Min Xu Xing Guo Yan Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 10 |
| 7 | Idiopathic ventricular fibrillation with fragmented QRS complex and J wave in resting electrocardiogram显示文摘ObjectiveTo 在放松从 21 大小写的考察数据在我们的医院里使遭到的 electrocardiogram.MethodsWe 与碎裂的 QRS 建筑群( f-QRS )和 J 波浪描述自发的室的纤维性颤动( IVF )的临床的特征由于 IVF 在心脏的拘捕以后被复活并且在放松心电图估计了 f-QRS 和 J 波浪的流行( ECG )。所有盒子题目基于 electrocardiographic 形态学在三个组之中被分类:组我, f-QRS 和 J 波浪被观察(n = 6 ) ,组 II,仅仅 J 波浪被观察(n = 9 ) ,组 III,两 f-QRS 也不 J 波浪被观察(n = 6 ) 。人口特征,中略的历史或突然的心脏的拘捕,室的纤维性颤动( VF )的发生,和 VF 的情形在索引事件的三 groups.ResultsThe 发生之中被评估(中略,在可植入的 cardioverter 使用高压脉冲来消减心脏( ICD )或心律调整器记录的熬过的心脏的拘捕和 VF 事件)是 13.4 ± ;在组的 5.6 每年我, 10.8 ±在组 II 的 3.9 每年,和 9.8 ±在组 III 的 4.2 每年。在在三个组,之中的发生有重要差别最经常的索引事件在组被观察我。为发生的危险比率是 3.2 (95%CI, 1.1-7.9;P = 0.01 ) 。索引事件的历史和情形在这些组之中是不同的。在组我,所有索引事件在清早发生在睡觉期间。在组 II,四个题目在奋发的物理活动或焦虑状态期间承受了 VF,二在在清早的睡觉期间,三在里面平常的活动。在组 III ,一个题目在清早在睡觉期间承受了 VF ,处于焦虑状态的,四在平常的 activity.ConclusionsThis ,学习建议有在休息 ECG 的 f-QRS 和 J 波浪的联合外观的 IVF 病人承受 VF 的增加的风险, IVF 病人的这亚群有一个唯一的临床的特征。 | Jing Wang Min Tang Ke-Xiu Mao Jian-Min Chu Wei Hua Yu-He Jia Ying-Jie Zhao Wei Wei Xu-Hua Chen Jie-Lin Pu Shu Zhang | 2012 | Journal of Geriatric Cardiology2012，9，2： | 10 |
| 8 | DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways显示文摘Background:Gastric cancer(GC)is one of the most common malignancies worldwide,particularly in China.DNA damage-inducible transcript 4(DDIT4)is a mammalian target of rapamycin inhibitor and is induced by various cellular stresses;however,its critical role in GC remains poorly understood.The present study aimed to investigate the poten-tial relationship and the underlying mechanism between DDIT4 and GC development.Methods:We used western blotting,real-time polymerase chain reaction,and immunohistochemical or immunoflu-orescence to determine DDIT4 expression in GC cells and tissues.High-content screening,cell counting kit-8 assays,colony formation,and in vivo tumorigenesis assays were performed to evaluate cell proliferation.Flow cytometry was used to investigate cell apoptosis and cell cycle distribution.Results:DDIT4 was upregulated in GC cells and tissue.Furthermore,downregulating DDIT4 in GC cells inhibited proliferation both in vitro and in vivo and increased 5-fluorouracil-induced apoptosis and cell cycle arrest.In contrast,ectopic expression of DDIT4 in normal gastric epithelial cells promoted proliferation and attenuated chemosensitivity.Further analysis indicated that the mitogen-activated protein kinase and p53 signaling pathways were involved in the suppression of proliferation,and increased chemosensitivity upon DDIT4 downregulation.Conclusion:DDIT4 promotes GC proliferation and tumorigenesis,providing new insights into the role of DDIT4 in the tumorigenesis of human GC. | Feng Du Lina Sun Yi Chu Tingyu Li Chao Lei Xin Wang Mingzuo Jiang Yali Min Yuanyuan Lu Xiaodi Zhao Yongzhan Nie Daiming Fan | 2018 | Cancer Communications2018，38，1： | 10 |
| 9 | Novel SNP of EPAS1 gene associated with higher hemoglobin concentration revealed the hypoxia adaptation of yak(Bos grunniens)显示文摘Endothelial PAS domain protein 1 gene(EPAS1) is a key transcription factor that activates the expression of oxygen-regulated genes. In this study, in order to better understand the effects of EPAS1 gene on hematologic parameters in yak, we firstly quantified the tissue expression patterns for EPAS1 m RNA of yak, identified polymorphism in this gene and evaluated its association with hematologic parameters. Expression of EPAS1 m RNA was detected in all eight tissues(heart, liver, lung, spleen, pancreas, kidney, muscles and ovary). The expressions of EPAS1 in lung and pancreas were extremely higher than other tissues examined. Three novel single nucleotide polymorphisms(SNPs)(g.83052 C>T, g.83065 G>A and g.83067 C>A) within the EPAS1 were identified and genotyped in Pali(PL), Gannan(GN) and Tianzhu White(TZW) yak breeds. Significant higher frequencies of the AA and GA genotypes and A allele of the g.83065 G>A were observed in the PL and GN breeds than that in the TZW breed(P<0.01). Association analysis of the PL breed indicated that the g.83065 G>A polymorphism was significantly associated with hemoglobin(HGB) concentration in yaks(P<0.05). Individuals with genotype AA had significantly higher HGB concentration(P<0.05) than those with genotype GA and GG. All these results will help our further understanding of biological functional of yak EPAS1 gene in responding to hypoxia and also indicate EPAS1 might contribute to the hypoxia adaptation of the yak. | WU Xiao-yun DING Xue-zhi CHU Min GUO Xian BAO Peng-jia LIANG Chun-nian YAN Ping | 2015 | Journal of Integrative Agriculture2015，14，4： | 8 |
| 10 | PGE patterns of ores of Dajing Cu-polymetallic deposit in Linxi County, Inner Mongolia:Indicator to source of metallogenic elements显示文摘By comparing PGE patterns of sulfide ores with that of basic-ultrabasic dikes occurring in the Dajing Cu-polymetallic deposit, we discover that there are similar positive slopes between the basic-ultrabasic dikes and the black ores composed mainly of sphalerite and galena, reflecting affinity of their source. The PGE patterns of the yellow ores composed basically of chalcopyrite, arsenopyrite and pyrite are actually different. One is close to the pattern of the mantle 1herzolite, and others resemble the pattern of the basic rocks. However, the concentrations of Ru are higher in the yellow ores, reflecting that sulfur attains or approaches saturation in their parent magma. The PGE characteristics of ores and dikes show that the magmas derived from the deep of crust and the metallogenic elements were supplied mainly by growth material of the crust. In addition, the mantle-derived magma also offered some elements. | CHU Xuelei, SUN Min & ZHOU MeifuInstitute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China Key Laboratory of Mineral Resources, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100101, China Department | 2002 | Chinese Science Bulletin2002，47，13： | 8 |
| 11 | Breaking the barriers: advances in acoustic functional materials显示文摘Acoustics is a classical field of study that has witnessed tremendous developments over the past 25 years.Driven by the novel acoustic effects underpinned by phononic crystals with periodic modulation of elastic building blocks in wavelength scale and acoustic metamaterials with localized resonant units in subwavelength scale, researchers in diverse disciplines of physics, mathematics, and engineering have pushed the boundary of possibilities beyond those long held as unbreakable limits. More recently, structure designs guided by the physics of graphene and topological electronic states of matter have further broadened the whole field of acoustic metamaterials by phenomena that reproduce the quantum effects classically. Use of active energy-gain components, directed by the parity–time reversal symmetry principle,has led to some previously unexpected wave characteristics. It is the intention of this review to trace historically these exciting developments, substantiated by brief accounts of the salient milestones. The latter can include, but are not limited to, zero/negative refraction, subwavelength imaging, sound cloaking, total sound absorption, metasurface and phase engineering, Dirac physics and topology-inspired acoustic engineering, non-Hermitian parity–time synthetic active metamaterials, and one-way propagation of sound waves. These developments may underpin the next generation of acoustic materials and devices, and offer new methods for sound manipulation, leading to exciting applications in noise reduction, imaging, sensing and navigation, as well as communications. | Hao Ge Min Yang Chu Ma Ming-Hui Lu Yan-Feng Chen Nicholas Fang Ping Sheng | 2018 | National Science Review2018，5，2： | 7 |
| 12 | Simultaneous quantification of ginsenoside Rg1 and its metabolites by HPLC–MS/MS:Rg1 excretion in rat bile, urine and feces显示文摘Ginsenoside Rg1(Rg1), the major effective component of ginseng, has been shown to have multiple bioactivities, but low oral bioavailability. The aim of this study was to develop a simple, sensitive and rapid high performance liquid chromatography–tandem mass spectrometry(LC–MS/MS) method, which could be used to validate and quantify the concentrations of Rg1 and its metabolites in Sprague-Dawley rat bile,urine, and feces after oral administration(25 mg/kg). Calibration curves offered satisfactory linearity(r40.995)within the determined ranges. Both intra-day and inter-day variances were less than 15%, and the accuracy was within 80–120%. The excretion recoveries of Rg1, ginsenoside Rh1(Rh1), and protopanaxatriol(Ppt) in bile,urine, and feces combined were all greater than 70%. The fecal excretion recoveries of Rg1, Rh1, and Ppt were40.11%, 22.19%, and 22.88%, respectively, whereas 6.88% of Rg1 and 0.09% of Rh1 were excreted in bile.Urinary excretion accounted for only 0.04% of Rg1. In conclusion, the observed excretion profiles for Rg1 and its metabolites after oral administration are helpful for understanding the poor oral bioavailability of Rg1 and will aid further investigations of Rg1 as a pharmacologically active component. | Chiyu He Ru Feng Yupeng Sun Shifeng Chu Ji Chen Chao Ma Jie Fu Zhenxiong Zhao Min Huang Jiawen Shou Xiaoyang Li Yuzhu Wang Jinfeng Hu Yan Wang Juntian Zhang | 2016 | Acta Pharmaceutica Sinica B2016，6，6： | 6 |
| 13 | Percutaneous extraction of leads from coronary sinus vein and branch by modified techniques显示文摘 | CHU Xian-ming LI Xue-bin ZHANG Ping, WANG Long LI Ding LI Bing AN Yi LENG Min DUAN Jiang-bo GUO Ji-hong | 2012 | Chinese Medical Journal2012，，20： | 6 |
| 14 | Effect of chlorpyrifos on soil microbial populations and enzyme activities显示文摘 | SHAN Min FANG Hua WANG Xiao FENG Bo CHU Xiao-qiang YU Yun-long | 2006 | Journal of Environmental Sciences2006，18，1： | 6 |
| 15 | Catalytic combustion of methane over nano ZrO_2-supported copper-based catalysts显示文摘nano 为甲烷燃烧的支持 ZrO2 的基于铜的催化剂借助于 N2 吸附, TEM, XRD, H2-TPR 技术和甲烷氧化的测试被调查。二种 ZrO2 被用作支持,(ZrO2-1 ) 从商业 ZrO2 被获得,其它(ZrO2-2 ) 从锆硝酸盐的热解被发出。CuO/ZrO2-2 催化剂比 CuO/ZrO2-1 更活跃,这被发现。N2 吸附, H2-TPR 和 XRD 大小比 CuO/ZrO2-1 的为 CuO/ZrO2-2 显示出那更大的表面积,更好的减小性质,四角形的 ZrO2 的存在和活跃部件的更高的分散。这些因素能是为它为甲烷燃烧的更高的活动的统治原因。 | Fen Fen Qua Wei Chu Li Min Shi Mu Hua Chen Jin Yan Hu | 2007 | Chinese Chemical Letters2007，18，8： | 6 |
| 16 | Effects of high-volume hemofiltration on alveolar- arterial oxygen exchange in patients with refractory septic shock显示文摘 | Hong-sheng Ren Shi-xue Gao Chun-ting Wang Yu-fcng Chu Jin-jiao Jiang Ji-chcng Zhang Mci Mcng Guo-qian Qi Min Ding | 2011 | World Journal of Emergency Medicine2011，2，2： | 5 |
| 17 | A text-to-speech system with high intelligibility and naturalness for Chinese显示文摘A Chinese text-to-speech system, which is based on the time domain PitchSynchronous-Overlap-Add (PSOLA) method, with a Chinese syllable dictionary and a prosodicrule dictionaIy, can produce very clear and natural Chinese speech. Research work on naturalness of synthetic Chinese show that, when synthesizing Chinese, pitch, energy, syllable duration and coarticulation between syllables are main factors which affect the naturalness. Among them pitch and duration play the most important roles. The time domain PSOLA scheme provides a method to modify the pitch and duration of a speech segment in time domain, and this makes it possible to adjust the prosody of speech in word level and sentence level, when synthesizing Chinese using waveform concatenation technique. Acoustics analysis of news broadcast speech provides theoretical basis for building up prosodic rules in this system. In this paper the flowchart of the new Chinese text-to-speech system, the research result of acoustics analysis of news broadcast speech, prosodic rules of the new system, and the evaluation results of speech quality of the new system are given. | CHU Min and LU Shinan(Institute of Acoustics, Academia Sinica, Beijing 100080) | 1996 | Chinese Journal of Acoustics1996，15，1： | 5 |
| 18 | Quasi-phase-matching-division multiplexing holography in a three-dimensional nonlinear photonic crystal显示文摘Nonlinear holography has recently emerged as a novel tool to reconstruct the encoded information at a new wavelength,which has important applications in optical display and optical encryption.However,this scheme still struggles with low conversion efficiency and ineffective multiplexing.In this work,we demonstrate a quasi-phasematching(QPM)-division multiplexing holography in a three-dimensional(3D)nonlinear photonic crystal(NPC).3D NPC works as a nonlinear hologram,in which multiple images are distributed into different Ewald spheres in reciprocal space.The reciprocal vectors locating in a given Ewald sphere are capable of fulfilling the complete QPM conditions for the high-efficiency reconstruction of the target image at the second-harmonic(SH)wave.One can easily switch the reconstructed SH images by changing the QPM condition.The multiplexing capacity is scalable with the period number of 3D NPC.Our work provides a promising strategy to achieve highly efficient nonlinear multiplexing holography for high-security and high-density storage of optical information. | Pengcheng Chen Chaowei Wang Dunzhao Wei Yanlei Hu Xiaoyi Xu Jiawen Li Dong Wu Jianan Ma Shengyun Ji Leran Zhang Liqun Xu Tianxin Wang Chuan Xu Jiaru Chu Shining Zhu Min Xiao Yong Zhang | 2021 | Light(Science & Applications)2021，10，8： | 5 |
| 19 | Proliposomes for oral delivery of dehydrosilymarin: preparation and evaluation in vitro and in vivo显示文摘目的: 改进 dehydrosilymarin 的口头的 bioavailability 的大豆 phospholipids,胆固醇, isopropyl 十四酸盐和钠 cholate 创作了与一个多相的驱散的系统提出 proliposomes,草药的药 silymarin 的一种氧化形式。 | Chang CHU Shan-shan TONG Ying XU Li WANG Min FU Yan-ru GE Jiang-nan YU Xi-ming XU | 2011 | Acta Pharmacologica Sinica2011，32，7： | 5 |
| 20 | Effect of bevacizumab on the expression of fibrosis-related inflammatory mediators in ARPE-19 cells显示文摘AIM:To investigate the effect of anti-vascular epithelial growth factor(VEGF)agents on the expression of fibrosisrelated inflammatory mediators under normoxic and hypoxic conditions,and to further clarify the mechanism underlying fibrosis after anti-VEGF therapy. METHODS:Human retinal pigment epithelial(RPE)cells were incubated under normoxic and hypoxic conditions.For hypoxia treatment,CoCl_2 at 200μmol/L was added to the media. ARPE-19 cells were treated as following:1)control group:no treatment; 2)bevacizumab group:bevacizumab at 0.25 mg/mL was added to the media; 3)hypoxia group:CoCl_2 at 200 μmol/L was added to the media; 4)hypoxia+bevacizumab group:CoCl_2 at 200 μmol/L and bevacizumab at 0.25 mg/mL were added to the media.The expression of interleukin(IL)-1β,IL-6,IL-8 and tumor necrosis factor(TNF)-α were evaluated using real-time polymerase chain reaction(RT-PCR)and enzyme-linked immunosorbent assay(ELISA)at 6,12,24 and 48 h. RESULTS:Both m RNA and protein levels of IL-1β,IL-6 and IL-8 were statistically significantly higher in the bevacizumab group than in the control group at each time point,and TNF-α gene and protein expression was only significantly higher only at 24 and 48h(P<0.05). Under hypoxic conditions,bevacizumab significantly increased the expression of IL-1β,IL-6,IL-8 and TNF-α at 6,12,24 and 48h(P<0.05). IL-1β,IL-8 and TNF-α peaked at 24 h and IL-6 peaked at 12 h after the bevacizumab treatment under both normoxic and hypoxic conditions. CONCLUSION:Treatment of ARPE-19 cells with bevacizumab can significantly increase the expression of fibrosis-related inflammatory mediators under bothnormoxic and hypoxic conditions. Inflammatory factors might be involved in the process of fibrosis after antiVEGF therapy,and the up-regulation of inflammatory factors induced by anti-VEGF drugs might promote the fibrosis process. | San-Jun Chu Zhao-Hua Zhang Min Wang Hai-Feng Xu | 2017 | International Journal of Ophthalmology(English edition)2017，10，3： | 4 |
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