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| 1 | Prevalence and evolution of drug resistance HIV-1 variants in Henan, China显示文摘To understand the prevalence and evolution of drug resistant HIV strains in Henan China after the implementation of free antiretroviral therapy for AIDS patients. 45 drug nave AIDS patients, 118 AIDS patients who received three months antiretroviral therapy and 124 AIDS patients who received six months antiretroviral treatment were recruited in the southern part of Henan province. Information on general condition, antiretroviral medicines, adherence and clinical syndromes were collected by face to face interview. Meanwhile, 14ml EDTA anticoagulant blood was drawn. CD4/CD8 T cell count, viral load and genotypic drug resistance were tested. The rates of clinical improvement were 55.1% and 50.8% respectively three months and six months after antiretroviral therapy. The mean CD4 cell count after antiretroviral therapy was significantly higher than in drug nave patients. The prevalence rate of drug resistant HIV strains were 13. 9%, 45.4% and 62.7% in drug nave patients, three month treatment patients and six month treatment patients, respectively. The number of resistance mutation codons and the frequency of mutations increased significantly with continued antiretroviral therapy. The mutation sites were primarily at the 103, 106 and 215 codons in the three-month treatment group and they increased to 15 codon mutations in the six-month treatment group. From this result, the evolution of drug resistant strains was inferred to begin with the high level NNRTI resistant strain, and then develop low level resistant strains to NRTIs. The HIV strains with high level resistance to NVP and low level resistance to AZT and DDI were highly prevalent because of the AZT+DDI+NVP combination therapy. These HIV strains were also cross resistant to DLV, EFV, DDC and D4T. Poor adherence to therapy was believed to be the main reason for the emergence and prevalence of drug resistant HIV strains. The prevalence of drug resistant HIV strains was increased with the continu- ation of antiretroviral therapy in the southern part of Henan province. Measures, that could promote high level adherence, provide new drugs and change ART regimens in failing patients, should be implemented as soon as possible. | Jing Yun LI Han Ping LI Lin LI Hong LI Zhe WANG Kun YANG Zuo Yi BAO Dao Min ZHUANG Si Yang LIU Yong Jian LIU Hui XING Yi Ming SHAO | 2005 | Cell Research2005，15，11： | 34 |
| 2 | Numerical Calculation and Experimental Research on Residual Stresses in Precipitation-hardening Layer of NAK80 Steel for Shot Peening显示文摘Shot peening can improve fatigue strength of materials by creating compressive residual stress field in their surface layers,and offers a protection against crack initiation and propagation,corrosion,etc.And fatigue fracture and stress corrosion cracking of NAK80 steel parts are improved effectively.Currently there lacks in-depth research in which the beneficial effect of the residual stress may be offset by the surface damage associated with shot peening,especially in terms of the research on the effective control of shot peening intensity.In order to obtain the surface residual stress field of NAK80 steel after shot peening,the samples are shot peened by pneumatic shot peening machine with different rules.The residual stress in the precipitation-hardening layer of NAK80 steel is measured before and after a shot peening treatment by X-ray diffraction method.In order to obtain true residual stress field,integral compensation method is used to correct results.By setting up analytical model of the residual stress in the process of shot peening,the surface residual stress is calculated after shot peening,and mentioning the reason of errors occurred between calculated and experimental residual stresses,which is mainly caused by the measurement error of the shoot arc height.At the same time,micro hardness,microstructure and roughness in the precipitation-hardening layer of NAK80 steel before and after shot peening were measured and surveyed in order to obtain the relation between shot peening strength and surface quality in the precipitation-hardening layer.The results show that the surface quality of NAK80 steel is significantly improved by shot peening process.The over peening effect is produced when the shot peening intensity is too high,it is disadvantageous to improve sample's surface integrity,and leading to reduce the fatigue life.When arc high value of optimal shot peening is 0.40 mm,the surface quality is the best,and the depth of residual stress in the precipitation-hardening layer reaches to about 450 μm.Numerical calculation is very useful to define the process parameters when a specific residual stress profile is intended,either to quantify the benefits on a specific property like fatigue life or to help on modeling a forming process like shot peen forming.In particular,the proposed parameter optimization in the progress of shot peening and effective control of the surface texture provide new rules for the quantitative evaluations of shot peening surface modification of NAK80 steel. | MIAO Hong ZUO Dunwen WANG Min ZHANG Ruihong WANG Hongfeng | 2011 | Chinese Journal of Mechanical Engineering2011，24，3： | 17 |
| 3 | Cloning and characterization of a potato StAN11 gene involved in anthocyanin biosynthesis regulation显示文摘Anthocyanins are a class of products of plant secondary metabolism and are responsible for tubers color in potato.The biosynthesis of anthocyanins is a complex Researchbiological process,in which multiple genes are involved including structural genes and regulatory genes.In this study,StAN11,a WD40-repeat gene,was cloned from potato cultivar Chieftain(Solanum tuberosum L.).StAN11(HQ599506)contained no intron and its open reading frame(ORF)was 1,029 bp long,encoding a putative protein of 342 amino acids.In order to verify its role in anthocyanin biosynthesis,StAN11 was inserted behind the CaMV-35S promoter of pCMBIA1304 and the recombination vector was introduced into the potato cultivar Désirée plants by Agrobacterium-mediated transformation.The color of transgenic tuber skin was significantly deepened,compared to the wild-type control,which was highly consistent with the accumulation of anthocyanin and expression of StAN11 in transgenic lines tuber skin.Further analysis on the expression of Flavonone-3-hydroxylase(F3H),Dihydroflavonol reductase(DFR),Anthocyanidin synthase(ANS),and Flavonoid 3-O-glucosyl transferase(3GT)in transgenic plants revealed that only DFR was upregulated.This result suggested that StAN11 regulated anthocyanin biosynthesis in potato by controlling DFR expression and accumulation of anthocyanin could be increased through overexpression of StAN11 in the tubers with the genetic background of anthocyanin biosynthesis. | Wang Li Bing Wang Man Wang Min Chen Jing-Ming Yin Ghullam Murtaza Kaleri Rui-Jie Zhang Tie-Niu Zuo Xiong You Qing Yang | 2014 | Journal of Integrative Plant Biology2014，56，4： | 13 |
| 4 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 5 | Al-Si-P master alloy and its modification and refinement performance on Al-Si alloys显示文摘An Al-Si-P master alloy has been developed by an in-situ reaction and the electron probe microanalyzer (EPMA) results show that there are many pre-formed AlP particles contained in the master alloy. Silicon introduced into the system plays an important role in remarkably improving the distribution and content of AlP particles due to their similar crystal structure and lattice parameters. ZL109 alloys have shown fast modification response to the addition of 0.5% Al-15Si-3.5P master alloy at 720°C, with a mass of primary Si precipitating in size of about 15 μm. Also, coarse primary Si grains in Al-30Si alloy can be refined dramatically from 150 μm to 37 μm after the addition of 2.0% Al-15Si-3.5P master alloy at 850°C. The P recovery of the Al-15Si-3.5P master alloy is much higher than that of a Cu-8.5P master alloy due to the pre-formed AlP particles. | ZUO Min LIU Xiangfa DAI Hongshang LIU Xiangjun | 2009 | Rare Metals2009，28，4： | 11 |
| 6 | Effect of Gd addition on microstructure and corrosion behaviors of Mg-Zn-Y alloy显示文摘The Mg_(97-x)Zn_(1)Y_(2)Gd_(x) alloys were prepared by as-casting method.Corrosion performance of alloys was evaluated by using potentiodynamic polarization,hydrogen evolution rate and mass loss measurements in 3%sodium chloride solution at room temperature.The results shown that the atomic rate of the long period stacking ordered(LPSO)with the composition of Mg_(12)Zn_(1)Y_(1).The microstructure of LPSO phases was lamellar structure.When the atomic fraction of Zn is 1%and the atomic ratio of Zn/RE(Y,Gd)is 2:5,the volume fraction of LPSO phase can reach the extreme value.The corrosion resistance of Mg–Zn–Y alloy improves with the increase of the volume fraction of LSPO phase.The Mg_(96.5)Zn_(1)Y_(2)Gd_(0.5)(MG0.5)alloy had better corrosion resistance than those of other alloys.It meant that 0.5 at.%gadolinium(Gd)was a suitable addition to Mg_(97)Zn_(2)Y alloy about corrosion resistance. | Jinyang Zhang Min Xu Xinying Teng Min Zuo | 2016 | Journal of Magnesium and Alloys2016，4，4： | 11 |
| 7 | Expert consensus on the glycemic management of critically ill patients显示文摘Introduction The incidence of hyperglycemia is 40-60%in critically ill patients and is up to 60-80%in those who have undergone car-diac surgery.[1]The results of an epidemiological study in the United States showed that 28.6%of diabetic patients and 9.3%of non-diabetic patients had elevated mean daily glucose on the day of ICU admission.[2]In critically ill patients,elevated blood glucose is primarily the result of stress,and stress-induced hy-perglycemia is an independent risk factor associated with prog-nosis,regardless of a previous diagnosis of diabetes.Nutritional therapy has become an integral treatment option for patients in the ICU,[3,4]though nearly 30%of patients with enteral nu-trition and 44-50%with parenteral nutrition(PN)experience elevated glucose.[5,6]Intensive insulin therapy(IIT)is an impor-tant treatment for controlling hyperglycemia in critically ill pa-tients,but it also carries a corresponding risk of hypoglycemia. | Zhixiong Wu Jiao Liu Dong Zhang Kai Kang Xiangrong Zuo Qianghong Xu Aijun Pan Wei Fang Fen Liu You Shang Haiyan Yin Juntao Hu Jinglun Liu Jiangquan Fu Wei Zhang Yuan Zong Min Shao Feng Zhao Mei Meng Yanfei Mao Yingchuan Li Dechang Chen | 2022 | Journal of Intensive Medicine2022，2，3： | 9 |
| 8 | Comparative studies on epithelial lesions at gastric cardia and pyloric antrum in subjects from a high incidence area for esophageal cancer in Henan,China显示文摘ComparativestudiesonepitheliallesionsatgastriccardiaandpyloricantruminsubjectsfromahighincidenceareaforesophagealcancerinHena... | GAO ShanShan1, ZHOU Qi1, LI YongXin1, BAI YongMin1, ZHENG ZuoYu1, ZOU JianXiang1, LIU Gang1, FAN ZongMin1, QI YiJun1, ZHAO Xin1 and WANG LiDong1,2Keywords esophageal neoplasms stomach neoplasms gastric ca | 1998 | World Journal of Gastroenterology1998，4，4： | 8 |
| 9 | Induction of cytotoxic T lymphocyte respones in vivo after immunotherapy with dendritic cells in patients with nasopharyngeal carcinoma显示文摘The aim of the present study was to determine the efficacy of immunotherapy with dendritic cells to elicit EBV-specific CTL-immunity in advanced cases of EBV-positive patients with nasopharyngeal carcinoma (NPC) and to determine the safety and toxicity of this preparation. Nine cases of histologically confirmed patients with NPC undergoing treatment with radiological therapy were enrolled in this study. Dendritic cells, generated in vitro from blood monocytes of patients were cultured and matured with cytokines and then infected with recombinant adenovirus vaccine containing EBV-latent membrane protein-2 (Ad-LMP2). On 9 days' cultivation of cells, the matured DCs were harvested, irradiated with Co and then injected intradermally to patients with NPC. The injections were performed 3 times totally. After immunization, the CTL responses were assayed by means of cytotoxicity and epitope-specific IFN-γproduction. The results of this trial showed that all patients could tolerate this kind of treatment without any side effect, during which marked increase of LMP2-specific CTL-responses could be demonstrated in 5 patients of this group. And the level of IgA/VCA antibody decreased in 8 of 9 patients, thus accounting for a better prognosis for these patients. All patients will be followed up for another one year. At least, the present work shows that intradermal vaccination with autologous DCs infected with recombinant Ad-LMP2 adenovirus is a safe procedure in NPC patients, in which this procedure can enhance the LMP2-specific CTL responses in patients. These data are encouraging to develop more effective vaccine strategies for the treatment of nasopharyngeal carcinoma. | JIAN MIN ZUO LING ZHOU ZHI JIAN CHEN DE RUI LI QI WANG JIONG YU CHEN ZHAN WANG SI-IU QING WE YI ZENG | 2006 | Journal of Microbiology and Immunology2006，4，1： | 7 |
| 10 | Floral traits and pollination system of Zygophyllum xanthoxylum in the managed and wild populations in an arid region of Northwest China显示文摘Zygophyllum xanthoxylum, which belongs to Sarcozygium of Zygophyllaceae, is one of the ecologically important species in Northwest China. In order to understand the pollination system of Z. xanthoxylum, we investigated the following characteristics of this species in the Urat Desert-grassland Research Station in western Inner Mongolia of China: flowering dynamics, pollen viability, pollen limitation, floral visitors and breeding system. The results showed that the flowering period and flowering peak were different between the wild and managed populations, being longer in the managed population. Z. xanthoxylum was pollen-limited, and pollen limitation was more intense in the wild population than in the managed population. Chalicodoma deserticola(Hymenoptera) was found to be the most frequent pollinator in the wild population, while Anthophora fulvitarsis(Hymenoptera) was the most frequent and effective visitor in the managed population. Out-crossing was dominant in the breeding system and self-pollination just played an assistant role to assure the reproduction of Z. xanthoxylum. | CHEN Min ZHAO Xueyong ZUO Xiao'an LIAN Jie ZHU Yangchun | 2015 | Journal of Arid Land2015，7，4： | 7 |
| 11 | Prehistoric agriculture development in the Yunnan-Guizhou Plateau, southwest China: Archaeobotanical evidence显示文摘The origin, development and expansion of prehistoric agriculture in East Asia have been widely investigated over the past two decades using archaeobotanical analysis from excavated Neolithic and Bronze Age sites. Research on prehistoric agriculture has predominantly focused in the valleys of the Yellow River and the Yangtze River. Agricultural development during the Neolithic and Bronze Age periods in the Yunnan-Guizhou Plateau of southwest China, an important passageway for human migration into Southeast Asia, still remains unclear. In this paper, based on macrofossil and microfossil analysis and radiocarbon dating at the Shilinggang site, we investigate plant subsistence strategies in the Nujiang River valley during the Bronze Age period. Combined with previous archaeobotanical studies in the Yunnan-Guizhou Plateau, we explore agricultural development processes in this area during the Neolithic and Bronze Age. Our results indicate that rice and foxtail millet were cultivated in Shilinggang around 2500 cal a BP. Three phases of prehistoric agricultural development in the Yunnan-Guizhou Plateau can be identified: rice cultivation from 4800–3900 cal a BP, mixed rice and millet crop(foxtail millet and broomcorn millet) cultivation from 3900–3400 cal a BP, and mixed rice, millet crop and wheat cultivation from 3400–2300 cal a BP. The development of agriculture in the Yunnan-Guizhou Plateau during the Neolithic and Bronze Age periods was primarily promoted by prehistoric agriculture expansion across Eurasia, agricultural expansion which was also affected by the topographic and hydrological characteristics of the area. | LI HaiMing ZUO XinXin KANG LiHong REN LeLe LIU FengWen LIU HongGao ZHANG NaiMeng MIN Rui LIU Xu DONG GuangHui | 2016 | Science China Earth Sciences2016，59，8： | 6 |
| 12 | Data Analysis of Chang'E-1 Gamma-Ray Spectrometer and Global Distribution of U,K,and Th Elemental Abundances显示文摘Gamma 光线分光计(GRS ) 是 Chang'E-1 (CE-1 ) 上的主要收费载重之一月亮的探查,主要试图在月亮的表面上检测元素的丰富和分布。在 03:58 在 2007 年 11 月 28 日,它执行了月亮的 gamma 光线的第一观察。2008 年 10 月 24 日,有效 gamma 光线系列的 2105 h 被 CE-1 GRS 获得了,它盖住月亮的整个表面。这份报纸主要描述处理由使用导出元素的丰富的过程和 CE-1 GRS 时间系列改正了系列的方法的数据:首先,到进为印射的象素的箱数据;然后,执行累积系列的背景扣除并且获得元素的一个山峰区域;并且最后,当模特儿使用元素的丰富倒置生产元素的丰富。在这些上基于比 EPR 在 5s 处理方法, U 的全球丰富地图, K,和 Th。在在 near-EPR 海底山下面的岩浆结晶化压力和融化的条件之间的关联暗示来源吗? | ZOU Yongliao ZHANG Liyan LIU Jianzhong MU Lingli REN Xin ZHANG Guangliang CHANG Jin YAN Jun ZHANG Nan ZHANG Hongbo LU Chang LIU Jianjun ZUO Wei SU Yan WEN Weibin BIAN Wei WANG Min XU Chun LI Chunlai OUYANG Ziyuan | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 6 |
| 13 | Numerical Analysis of Nd:YAG Pulsed Laser Polishing CVD Self-standing Diamond Film显示文摘Chemical vapor deposited(CVD) diamond film has broad application foreground in high-tech fields.But polycrystalline CVD self-standing diamond thick film has rough surface and non-uniform thickness that adversely affect its extensive applications.Laser polishing is a useful method to smooth self-standing diamond film.At present,attentions have been focused on experimental research on laser polishing,but the revealing of theoretical model and the forecast of polishing process are vacant.The paper presents a finite element model to simulate and analyze the mechanism of laser polishing diamond based on laser thermal conduction theory.The experimental investigation is also carried out on Nd:YAG pulsed laser smoothing diamond thick film.The simulation results have good accordance with the results of experimental results.The temperature and thermal stress fields are investigated at different incidence angles and parameters of Nd:YAG pulsed laser.The pyramidal-like roughness of diamond thick film leads to the non-homogeneous temperature fields.The temperature at the peak of diamond film is much higher than that in the valley,which leads to the smoothing of diamond thick film.The effect of laser parameters on the surface roughness and thickness of graphite transition layer is also carried out.The results show that high power density laser makes the diamond surface rapid heating,evaporation and sublimation after its graphitization.It is also found that the good polish quality of diamond thick film can be obtained by a combination of large incident angle,moderate laser pulsed energy,large repetition rate and moderate laser pulse width.The results obtained here provide the theoretical basis for laser polishing diamond film with high efficiency and high quality. | XU Feng HU Haifeng ZUO Dunwen XU Chun QING Zhenghua WANG Min | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 6 |
| 14 | Responses of estuarine salinity and transport processes to sea level rise in the Zhujiang(Pearl River) Estuary显示文摘Understanding the changes of hydrodynamics in estuaries with respect to magnitude of sea level rise is important to understand the changes of transport process. Based on prediction of sea level rise over the 21st century, the Zhujiang(Pearl River) Estuary was chosen as a prototype to study the responses of the estuary to potential sea level rise. The numerical model results show that the average salt content, saltwater intrusion distance, and stratification will increase as the sea level rises. The changes of these parameters have obvious seasonal variations. The salt content in the Lingdingyang shows more increase in April and October(the transition periods). The saltwater intrusion distance has larger increase during the low-flow periods than during the highflow periods in the Lingdingyang. The result is just the opposite in Modaomen. The stratification and its increase are larger during the low-flow periods than during the high-flow periods in Lingdingyang. The response results of transport processes to sea level rise demonstrate that:(1) The time of vertical transport has pronounced increase.The increased tidal range and currents would reinforce the vertical mixing, but the increased stratification would weaken the vertical exchange. The impact of stratification changes overwhelms the impact of tidal changes. It would be more difficult for the surface water to reach the bottom.(2) The lengthways estuarine circulation would be strengthened. Both the offshore surface residual current and inshore bottom residual current will be enhanced.The whole meridional resident flow along the transect of the Lingdingyang would be weakened. These phenomena are caused by the decrease of water surface slope(WWS) and the change of static pressure with the increase of water depth under sea level rise. | CHEN Yuxiang ZUO Juncheng ZOU Huazhi ZHANG Min ZHANG Kairong | 2016 | Acta Oceanologica Sinica2016，35，5： | 6 |
| 15 | CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development显示文摘学习必要基因的早功能是在发展生物学的一个重要、挑战性的问题。这里,我们为很快在二房间的阶段胚胎的一个分裂球导致 CRISPR-Cas9-mediated 变化建立了一个方法,称为的 2 房间 embryo-CRISPR-Cas9 注射(2CC ) ,学习在里面必需品的 vivo 功能(或未知) 在创始人的基因妄想的鼠标。由注射指向兴趣的基因进的 Cre mRNA 和 CRISPR-Cas9 荧光灯记者老鼠, 2CC 方法能在不同发展阶段跟踪野类型、变异的房间,为变异的房间的 phenotypic 分析的出现内部控制。用这个方法,我们在在发展中的鼠标调整有刺激性、禁止的 synaptic 传播识别了必要基因 Tet3 的新奇函数服的外皮。由产生妄想的变异的老鼠, 2CC 方法允许在多重纸巾和房间的基因功能的快速的屏蔽录入妄想的老鼠创始人,显著地扩展基因工具的当前的一套设备。 | Wang, Lingbo Li, Min-Yin Qu, Chao Miao, Wan-Ying Yin, Qi Liao, Jiaoyang Cao, Hua-Teng Huang, Min Wang, Kai Zuo, Erwei Peng, Guangdun Zhang, Shu-Xin Chen, Guodong Li, Qing Tang, Ke Yu, Qian Li, Zhoujie Wong, Catherine C. L. Xu, Guoliang Jing, Naihe Yu, Xiang Li, Jinsong | 2017 | Cell Research2017，27，6： | 5 |
| 16 | Role of intestinal flora imbalance in pathogenesis of pouchitis显示文摘Objective: To discuss the role of intestinal flora imbalance in the pathogenesis of pouchitis. Methods: The puochitis rat model was established and the faeces sample and the mucous membrane sample were collected regularly, in which the bacterial nucleic acids were extracted for quantitative analysis of the intestinal flora in the samples through using the real-time quantitative PCR technique and high energy sequencing technology. Results: The disorder phenomenon of the intestinal flora appeared at the 7th day of the experiment, and the pouchitis was presented at the 21 th day of the experiment. At the 31 th day of the experiment, compared to control group and non-pouchitis group, the quantity of Bifidobacterium and the Lactobacillusof the pouchitis model rats in the mucous membrane sample and the faeces sample were significantly decreased(P<0.05), and the Bacteroidetes, Faecalibacterium prausnitzii and 桛 Clostridium leptum subgroup in the mucous membrane of pouchitis were significantly decreased(P<0.05). The Clostridium coccoides group was the main flora in the mucous membrane of pouchitis, the bacterial diversity of non-puochitis group and control group was significantly higher than that of the puochitis group(P<0.05). Conclusions: The intestinal flora imbalance is one of the factors that cause the incidence of the pouhitis; this study provides a clue of the pathogenesis and treatment direction of the intestinal inflammatory disease. | Xiao-Bo Feng Jun Jiang Min Li Gang Wang Jin-Wei You Jian Zuo | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，8： | 5 |
| 17 | Refinement of primary Si in Cu-50Si alloys with novel Al-Zr-P master alloy显示文摘In this article, a novel Al-6Zr-2P master alloy with ZrP particles was successfully synthesized, and the refining performance of this novel master alloy for the primary Si in Cu-50Si alloys was also investigated. By means of the fracture plane observation, it is found that the ZrP phase would precipitate first in the solidification process, and then, the ZrAl 3 phase grows around them. Furthermore, it is observed that the refining effect can be remarkably improved by changing the addition sequence of the raw materials. After the melting of commercial Cu, the 2.0 wt% Al-6Zr-2P master alloy and crystalline Si were added in sequence, and the mean size of the primary Si in Cu-50Si alloy can be significantly refined from 255.7 to 75.3 lm. Meanwhile, the refining mechanism was discussed in detail. | Min Zuo Zhong-Shi Zhang Xin-Ying Teng Hao-Ran Geng | 2013 | Rare Metals2013，32，3： | 5 |
| 18 | A New Farnesyl Diphosphate Synthase Gene from Taxus media Rehder:Cloning,Characterization and Functional Complementation显示文摘Farnesyl diphosphate synthase (FPS;EC 2.5.1.10 ) 催化是为许多 terpenoids 的分支点中介的生产 of15 碳 farnesyl diphos-phate。Thisreaction 被认为是在 terpenoid 生合成的限制率的步。这里,我们第一次报导克隆从裸子植物植物种编码 farnesyl diphosphate synthase 的新全身的 cDNA, Taxus 媒介 Rehder,指定了为 TmFPSI。TmFPS1 的全身的 cDNA (GenBank 就职数字:AY461811 ) 有开的读装裱的 1 056-bp 的 1 464 bp 与 40.3 kDa 和理论 pl of5.07 的计算分子量正在编码 a351 氨基的酸多肽。生物信息的分析表明 TmFPSI 包含了所有五保存领域 ofprenyltransferases,并且显示出相同到植物起源的另外的 FPS。种系发生的分析证明 farnesyl diphosphate synthases 能被划分成二个组:真核细胞的起源的原核生物的起源和其它之一。TmFPSI 与植物起源的 FPS 被组织。当模特儿的 Homology-basedstructural 证明 TmFPSI 有 FPS 的典型空间结构,谁的很突出的结构的特征是 13 核心的安排他在催化反应在发生的一个大中央洞附近的 lices。我们的生物信息的分析强烈建议那 TmFPSIis 功能的基因。南部的污点分析表明 TmFPSI 在 T 属于一个小 FPS 基因家庭。媒介。北污点分析显示 TmFPSI 在所有测试纸巾被表示,包括 T 的针,茎和根。媒介。随后,在 FPS 缺乏的变异的酵母的功能的互补 withTmFPSI 证明 TmFPSI 确实编码了 farnesyl diphosphatesynthase,它救了酵母异种。这研究将在瞄准在分子的基因水平在 terpenoid 生合成流动控制理解 FPS 的详细角色的未来调查是有用的。 | Zhi-Hua Liao Min Chen Yi-Fu Gong Zhu-Gang Li Kai-Jing Zuo Peng Wang Feng Tan Xiao-Fen Sun Ke-Xuan Tang | 2006 | Journal of Integrative Plant Biology2006，48，6： | 4 |
| 19 | Distribution characteristics of heavy metals in surface sediments and core sediments of the Shenzhen Bay in Guangdong Province,China显示文摘The concentration of zinc,chromium,cadmium,nickel,lead and copper was measured on both surface sediments and core sediments in the Shenzhen Bay.The average contents of all metals have exceeded the background values in the coastal zone of Guangdong Province.Cadmium is a heavy pollution matter which indicates a strong pollution level according to the ecological risk coefficient method.The ecological risk index of the whole area is 299 which belongs to middle and strong level.The area with strong pollution level is the near shore area closing to the inside of Shenzhen Bay,Shakou area is in the middle level while the weak pollution level occurs in Shenzhenhe Estuary according to ecological risk index.The four sediment cores can be divided into two parts based on lead-210 dating,sediments size analysis and economic development period in surrounding areas since 1950 with strong human intervention.The sediment size,deposition rate and human activities have positive relationship with the contents of heavy metals which directly impact the pollution level of heavy metals in sediments in Shenzhen Bay. | ZUO Ping WANG Yaping MIN Fengyang CHENG Jun | 2009 | Acta Oceanologica Sinica2009，28，6： | 4 |
| 20 | MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in gastric cancer显示文摘AIM: To investigate the mechanism by which mi R-19 a is up-regulated in gastric cancer(GC), which plays an oncogenic role.METHODS: In the present study, we investigated the role of mi R-19 a in gastric tissues as well as two GC cell lines. In vivo, we detected the basal expression level of mi R-19 a using real-time reverse transcription-PCR(RTPCR), and the relevance between expression of mi R-19 a and clinicopathological information was analyzed.In vitro, mi R-19 a was ectopically expressed using overexpression and knock-down strategies.RESULTS: Overexpression of mi R-19 a was significantly associated with metastasis of GC and inferior overall prognosis. However, no significant correlation was f o u n d b e t w e e n m i R- 1 9 a e x p r e s s i o n a n d o t h e r characteristics such as age, gender, tobacco, alcohol or tumor size. Cell proliferation, migration and invasion assays showed that overexpression of mi R-19 a promoted the proliferation, migration and invasion, and that overexpression of mi R-19 a promoted the epithelialmesenchymal transition through activating the PI3K/AKT pathway. Blocking the PI3K/AKT pathway could cancel the effect of mi R-19 a.CONCLUSION: All together, our results suggest that mi R-19 a could be used as a promising therapeutic target in the treatment of GC. | Wei-Dong Lu Yun Zuo Zhen Xu Min Zhang | 2015 | World Journal of Gastroenterology2015，21，15： | 4 |
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