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| 1 | Comparing the Diagnostic Criteria of MAFLD and NAFLD in the Chinese Population:A Population-based Prospective Cohort Study显示文摘Background and Aims:Metabolic dysfunction-associ-ated fatty liver disease(MAFLD)is a new concept,pro-posed in 2020;however,its applicability in Asia populations has yet to be evaluated.Therefore,we aimed to compare the difference in epidemiological and clinical characteris-tics between MAFLD and non-alcoholic fatty liver disease(NAFLD)among Asian populations.Methods:Based on the Jinchang cohort,30,633 participants were collected.The prevalence and incidence of MAFLD and NAFLD were used to analyze the epidemic characteristics and its overlapping effects.In addition,the corresponding clinical character-istics of the two diagnostic criteria populations were com-pared.Results:The prevalence rates of MAFLD and NAFLD were 21.03%and 18.83%,respectively.After an average 2.28-year follow-up,the incidence densities of MAFLD and NAFLD were 41.58 per 1,000 person-years and 37.69 per 1,000 person-years,respectively.With the increase of baseline age,body mass index(BMI),and waist circumfer-ence(WC)levels,the prevalence and incidence of MAFLD and NAFLD were on the rise(all ptrend<0.05).Among the total patients diagnosed at baseline or follow-up,most pa-tients had both MAFLD and NAFLD,accounting for 78.84%and 82.88%,respectively.Compared with NAFLD,MAFLD patients had greater proportions of males and metabolic diseases(diabetes,dyslipidemia),and had higher BMI,WC,liver enzymes,blood glucose,and lipid levels in the base-line diagnosis patients(p<0.05).Additionally,lean MAFLD patients had higher metabolic disorders than lean NAFLD patients(p<0.05).Conclusions:Compared with NAFLD,the newly proposed definition of MAFLD is more practical and accurate,and it can help identify more fatty liver pa-tients with high-risk diseases. | Cheng Yu Minzhen Wang Shan Zheng Miao Xia Hongyan Yang Desheng Zhang Chun Yin Ning Cheng Yana Bai | 2022 | Journal of Clinical and Translational Hepatology2022，10，1： | 7 |
| 2 | Study on corrosion resistance of rust-preventive oil under shipment and storage conditions显示文摘In recent decades,the demand for cold-rolled steel sheets has remarkably increased. To prevent the sheets from rusting before the manufacturing process,a layer of rust-preventive oil has to be coated on the sheets. In this study,the shipment and storage environments were simulated through a salt spray test and a damp-heat experiment,respectively,and the packaging status of the sheets was imitated by a laminated sheet test. The protection effect of oil on the steel sheet was investigated under the different environmental conditions and oil weights by using electrochemical approaches,scanning electron microscopy( SEM),and X-ray diffraction( XRD) techniques. It was found that chloride ions had more severe effects on the corrosion resistance of the oils than hydrothermal conditions did. This was shown in the sheets with oil weights of 0. 4,0. 9,and 1. 2 g·m^(-2),which were too severely corroded after a four-hour salt spraying test to meet the demands of subsequent processing. However,the sheets showed satisfactory corrosion resistance after a three-week damp-heat experiment with a temperature of 49 ℃ and 95% RH. In addition,it was disclosed that the penetration of the chloride ions determined the protection mechanism of the oil,i. e.,the corrosion resistance was initially enhanced by the increase in the oil content. As long as the chloride ion reached the interface between the oil film and the sheet,the oil distribution became the predominant factor in the protection of the sheet. The corrosion mechanism of the steel sheet was dependent on the stacking style of the sample. When exposed to air,the corrosion product of the sample was rust red with a composition of Fe_2O_3,whereas the black product that is mainly composed of Fe_3O_4 was found on the edge of the laminated sheets,which resulted from the oxygen concentration cell. | FANG Baiyou LU Lin DING Minzhen LI Xiaogang | 2015 | Baosteel Technical Research2015，9，1： | 4 |
| 3 | E. coli and bacteriophage MS2 disinfection by UV, ozone and the combined UV and ozone processes显示文摘低剂量的臭氧与的联合紫外(紫外) 照耀应该是一种选择把利益给消毒和还原剂缺点紫外并且臭氧消毒。然而,少些对消毒表演被知道紫外并且臭氧(UV/ozone ) coexposure 和顺序的 UV-followed-by-ozone (紫外臭氧) 并且 ozone-followed-by-UV (臭氧 -- 紫外) 暴露。在这研究, E 的 inactivation。coli 和抗菌素 MS2 由紫外,臭氧, UV/ozone coexposure,并且顺序紫外臭氧并且臭氧 -- 紫外暴露被调查并且比较。E 上的 0.50.9 木头杀死的 Synergistic 效果。包括率和效率的增加, coli inactivation 在象 0.05 mg 潩 ? 慷 ? 捡畴污祬椠据敲獡摥愠瑦牥挠汨牯湩瑡潩一样低的臭氧集中在 UV/ozone coexposure 以后被观察吗? | Jingyun FANG Huiling LIU Chii SHANG Minzhen ZENG Mengling NI Wei LIU | 2014 | Frontiers of Environmental Science & Engineering2014，8，4： | 3 |
| 4 | Serum hepatic enzyme manifestations in patients with severe acute respiratory syndrome:Retrospective analysis显示文摘AIM: To evaluate the hepatic function in patients with severe acute respiratory syndrome (SARS) and possible causes of hepatic disorder in these patients. METHODS: One hundred and eighty-two patients with SARS were employed in a retrospective study that investigated hepatic dysfunction. Liver alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactic dehydrogenase (LDH) were analyzed in these patients. Patients with different hospital treatments were further investigated. RESULTS: Of the 182 patients, 128(70.3%) had abnormal ALT activity, 57(31.3%) had abnormal AST activity and 87(47.8%) had abnormal LDH activity. The peak of elevated hepatic enzyme activities occurred between the sixth day and the tenth day after the first day of reported fever. Of the 182 patients, 160(87.9%) had been treated with antibiotics, 137(75.2%) with Ribavirin, and 115(63.2%) with methylpredisolone. There was no statistically significant correlation between the duration of Ribavirin treatement and hepatic dysfunction. CONCLUSION: Abnormal liver functions were common in patients with SARS and could be associated with virus replication in the liver. | Hui-JuanCui Xiao-LinTong PingLi Ying-XuHao Xiao-GuangChen Ai-GuoLi Zhi-YuanZhang JunDuan MinZhen BinZhang Chuan-JinHua Yue-WenGong | 2004 | World Journal of Gastroenterology2004，10，11： | 2 |
| 5 | Short-Term effects of gaseous pollutants and particulate matter on daily hospi- tal admissions for Cardio- Cerebrovascular disease in Lanzhou: Evidence from a heavily polluted city in China 显示文摘 | Shan Zheng Minzhen Wang Shigong Wang | 2013 | International Journal of Environmental Research and Public Health2013，10，2： | 1 |
| 6 | Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes显示文摘 | Shweta Rane Minzhen He Danish Sayed Himanshu Vashistha Ashwani Malhotra Junichi Sadoshima Dorothy E. Vatner Stephen F. Vatner Maha Abdellatif | 2009 | Circulation Research2009，，7： | 1 |
| 7 | Preparation and properties chitasan poly (N-isopropylacrylamide) semiIPN hydrogels显示文摘 | Wang Minzhen Qian Junchao Fang Yu | 2000 | Journal of Polymer Science Part A: Polymer Chemistry2000，38，3： | 1 |
| 8 | Systematic screening reveals synergistic interactions that overcome MAPK inhibitor resistance in cancer cells显示文摘Objective:Effective adjuvant therapeutic strategies are urgently needed to overcome MAPK inhibitor(MAPKi)resistance,which is one of the most common forms of resistance that has emerged in many types of cancers.Here,we aimed to systematically identify the genetic interactions underlying MAPKi resistance,and to further investigate the mechanisms that produce the genetic interactions that generate synergistic MAPKi resistance.Methods:We conducted a comprehensive pair-wise sgRNA-based high-throughput screening assay to identify synergistic interactions that sensitized cancer cells to MAPKi,and validated 3 genetic combinations through competitive growth,cell viability,and spheroid formation assays.We next conducted Kaplan-Meier survival analysis based on The Cancer Genome Atlas database and conducted immunohistochemistry to determine the clinical relevance of these synergistic combinations.We also investigated the MAPKi resistance mechanisms of these validated synergistic combinations by using co-immunoprecipitation,Western blot,qRTPCR,and immunofluorescence assays.Results:We constructed a systematic interaction network of MAPKi resistance and identified 3 novel synergistic combinations that effectively targeted MAPKi resistance(ITGB3+IGF1R,ITGB3+JNK,and HDGF+LGR5).We next analyzed their clinical relevance and the mechanisms by which they sensitized cancer cells to MAPKi exposure.Specifically,we discovered a novel protein complex,HDGF-LGR5,that adaptively responded to MAPKi to enhance cancer cell stemness,which was up-or downregulated by the inhibitors of ITGB3+JNK or ITGB3+IGF1R.Conclusions:Pair-wise sgRNA library screening provided systematic insights into elucidating MAPKi resistance in cancer cells.ITGB3-+IGF1R-targeting drugs(cilengitide+linsitinib)could be used as an effective therapy for suppressing the adaptive formation of the HDGF-LGR5 protein complex,which enhanced cancer stemness during MAPKi stress. | Yu Yu Minzhen Tao Libin Xu Lei Cao Baoyu Le Na An Jilin Dong Yajie Xu Baoxing Yang Wei Li Bing Liu Qiong Wu Yinying Lu Zhen Xie Xiaohua Lian | 2022 | Cancer Biology & Medicine2022，19，2： | 1 |
| 9 | An antago- nism between the AKT and beta-adrenergic signa- ling pathways mediated through their reciprocal effects on miRNA-199a-5p显示文摘 | Shweta R Minzhen H Danish S | 2010 | Cell Signal2010，22，7： | 1 |
| 10 | Tumor immunotherapy by converting tumor cells to MHC class II–positive, Ii protein–negative phenotype显示文摘 | Xueqing Lu Nikoletta L. Kallinteris Jizhi Li Shuzhen Wu Yu Li Zhong Jiang Gilda G. Hillman Joseph V. Gulfo Robert E. Humphreys Minzhen Xu | 2003 | Cancer Immunology Immunotherapy2003，，10： | 1 |
| 11 | Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism显示文摘Vascular etiology is the second most prevalent cause of cognitive impairment globally.Endothelin-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of stroke.However,the way in which changes in astrocytic endothelin-1 lead to poststroke cognitive deficits following transient middle cerebral artery occlusion is not well understood.Here,using mice in which astrocytic endothelin-1 was overexpressed,we found that the selective overexpression of endothelin-1 by astrocytic cells led to ischemic stroke-related dementia(1 hour of ischemia;7 days,28 days,or 3 months of reperfusion).We also revealed that astrocytic endothelin-1 overexpression contributed to the role of neural stem cell proliferation but impaired neurogenesis in the dentate gyrus of the hippocampus after middle cerebral artery occlusion.Comprehensive proteome profiles and western blot analysis confirmed that levels of glial fibrillary acidic protein and peroxiredoxin 6,which were differentially expressed in the brain,were significantly increased in mice with astrocytic endothelin-1 overexpression in comparison with wild-type mice 28 days after ischemic stroke.Moreover,the levels of the enriched differentially expressed proteins were closely related to lipid metabolism,as indicated by Kyoto Encyclopedia of Genes and Genomes pathway analysis.Liquid chromatography-mass spectrometry nontargeted metabolite profiling of brain tissues showed that astrocytic endothelin-1 overexpression altered lipid metabolism products such as glycerol phosphatidylcholine,sphingomyelin,and phosphatidic acid.Overall,this study demonstrates that astrocytic endothelin-1 overexpression can impair hippocampal neurogenesis and that it is correlated with lipid metabolism in poststroke cognitive dysfunction. | Jie Li Wen Jiang Yuefang Cai Zhenqiu Ning Yingying Zhou Chengyi Wang Sookja Ki Chung Yan Huang Jingbo Sun Minzhen Deng Lihua Zhou Xiao Cheng | 2024 | Neural Regeneration Research2024，19，3： | 1 |
| 12 | Cancer immunotherapy by antisense suppression of Ii protein in MHC-class-II-positive tumor cells显示文摘 | Gang Qiu John Goodchild Robert E. Humphreys Minzhen Xu | 1999 | Cancer Immunology Immunotherapy1999，，9： | 1 |
| 13 | Invariant chain expression in colon neoplasms显示文摘 | Zhong Jiang Minzhen Xu Louis Savas Paula LeClair B. F. Banner | 1999 | Virchows Archiv1999，，1： | 1 |
| 14 | On Latest Developments in China's Human Rights Cause显示文摘China’s human rights cause has undergone a new phase of development under the reform and opening-up policy that became off icial in the late 1970s. The changes include a shift from protection of human rights by law to Constitutional | LONG CHENG & TAN MINZHEN | 2011 | The Journal of Human Rights2011，10，2： | 0 |
| 15 | Effects of Polypyrrole / Graphene Oxide Composites with Different Reaction Times on Electrochemical Performance显示文摘Graphene oxide(GO)was prepared using the modified Hummers method and used as a template for polypyrrole.Polypyrrole was polymerized in situ on the surface of GO to finally obtain the polypyrrole/graphene oxide composite material.The effects of different reaction times on the electrochemical performance of polypyrrole/graphene oxide in the second step were studied.It was obtained that the composite material had optimal properties when the reaction time was 24 h. | Minzhen Feng Wei Lu Ranran Zhen Ya Wang Yun Zhou | 2020 | Non-Metallic Material Science2020，2，1： | 0 |
| 16 | Efficacy of electroacupuncture on myocardial protection and postoperative rehabilitation in patients undergoing cardiac surgery with cardiopulmonary bypass:a systematic review and Meta-analysis显示文摘OBJECTIVE:To evaluate the efficacy of electroacupuncture(EA)intervention on myocardial protection and postoperative rehabilitation in patients undergoing cardiac surgery with cardiopulmonary bypass(CPB).METHODS:Eight databases,including Pub Med,Embase,the Cochrane Library,Web of Science,Chinese Bio Medical Literature Database,China National Knowledge Infrastructure Database,Wanfang Data,China Science and Technology Journal Database,and two clinical trial registries,were searched.All randomized controlled trials(RCTs)related to EA intervention in cardiac surgery with CPB were collected.Based on the inclusion and exclusion criteria,two researchers independently screened articles and extracted data.After the quality evaluation,RevMan 5.3 software was used for analysis.RESULTS:Fourteen RCTs involving 836 patients were included.Compared with the control treatment,EA significantly increased the incidence of cardiac automatic rebeat after aortic unclamping[relative risk(RR)=1.15,95%confidence interval(CI)(1.01,1.31),P<0.05;moderate].Twenty-four hours after aortic unclamping,EA significantly increased the superoxide dismutase[standardized mean difference(SMD)=0.96,95%CI(0.32,1.61),P<0.05;low],and interleukin(IL)-2[SMD=1.33,95%CI(0.19,2.47),P<0.05;very low]expression levels and decreased the malondialdehyde[SMD=-1.62,95%CI(-2.15,-1.09),P<0.05;moderate],tumour necrosis factor-α[SMD=-1.28,95%CI(-2.37,-0.19),P<0.05;moderate],and cardiac troponin I[SMD=-1.09,95%CI(-1.85,-0.32),P<0.05;low]expression levels as well as the inotrope scores[SMD=-0.77,95%CI(-1.22,-0.31),P<0.05;high].There was no difference in IL-6 and IL-10 expression levels.The amount of intraoperative sedative[SMD=-0.31,95%CI(-0.54,-0.09),P<0.05;moderate]and opioid analgesic[SMD=-0.96,95%CI(-1.53,-0.38),P<0.05;low]medication was significantly lower in the EA group than in the control group.Moreover,the postoperative tracheal intubation time[SMD=-0.92,95%CI(-1.40,-0.45),P<0.05;low]and intensive care unit stay[SMD=-1.71,95%CI(-3.06,-0.36),P<0.05;low]were significantly shorter in the EA group than in the control group.There were no differences in the time to get out of bed for the first time,total days of antibiotic use after surgery,or postoperative hospital stay.No adverse reactions related to EA were reported in any of the included studies.CONCLUSIONS:In cardiac surgery with CPB,EA may be a safe and effective strategy to reduce myocardial ischaemia-reperfusion injury and speed up the recovery of patients after surgery.These findings must be interpreted with caution,as most of the evidence was of low or moderate quality.More RCTs with larger sample sizes and higher quality are needed to provide more convincing evidence. | QIN Xiaoyu WANG Chunai XUE Jianjun ZHANG Jie LU Xiaoting DING Shengshuang GE Long WANG Minzhen | 2024 | Journal of Traditional Chinese Medicine2024，44，1： | 0 |
| 17 | Determination of Double Beta Decay Half-Life of 136Xe with the PandaX-4T Natural Xenon Detector显示文摘Precise measurement of two-neutrino double beta decay(DBD)half-life is an important step for the searches of Majorana neutrinos with neutrinoless double beta decay.We report the measurement of DBD half-life of 136xe using the Pandax-4T dual-phase Time Projection Chamber(TPC)with 3.7-tonne natural xenon and the first 94.9-day physics data release. | Lin Si Zhaokan Cheng Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Jinrong He Di Huang Yanlin Huang Zhou Huang Ruquan Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu Xiaoying Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yujun Mao Yue Meng Nasir Shaheed Xiaofeng Shang Xuyang Ning Ningchun Qi Zhicheng Qian Xiangxiang Ren Changsong Shang Guofang Shen Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Zhe Yuan Dan Zhang Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou | 2023 | Research2023，，2： | 0 |
| 18 | Construction of a CRISPR-based paired-sgRNA library for chromosomal deletion of long non-coding RNAs显示文摘Background:Derived from an adaptive bacterial immune system,the clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated 9(Cas9)system has shown great potential in high-throughput functional genomic screening,especially for protein-coding genes.However,it is still challenging to apply the similar strategy to study non-coding genomic elements such as long non-coding RNAs(lncRNAs)or clusters of microRNAs,because short insertions or deletions may not be sufficient to generate loss-of-function phenotypes.Methods:Here,we presented a systematic strategy for designing a CRISPR-based paired-sgRNA library for highthroughput screening in non-coding regions.Due to the abundance of lncRNAs and their diverse regulatory roles in vivo,we repurposed microarray datasets to select 600 highly expressed lncRNAs in non-small-cell lung cancer and designed two schemes for lncRNA deletion with^20 paired-sgRNAs for each lncRNA.Through Golden-Gate assembly,we generated a pooled CRISPR-based library with a total of 12,878 sgRNA pairs.Results:Over 80%of paired-sgRNAs were recovered from final pooled library with a relarively even distribution.Cleavage efficiency of sgRNA pairs was validated through experiments of transient transfection and viral infection.Moreover,randomly selected paired-sgRNAs showed that efficient deletion of genomic DNA could be achieved with a deletion size within the range of 500 to 3000 bp.Conclusions:In summary,we have demonstrated a strategy to design and construct a pooled paired-sgRNA library to generate genomic deletion in the lncRNA regions,validated their deletion efficiency and explored the relationship of deletion efficiency with respect to deletion size.This method would be also suitable for investigation of other uncharacterized non-coding genomic regions in mammalian cells in an efficient and cost-efTective manner. | Minzhen Tao Qiaochu Mu Yurui Zhang Zhen Xie | 2020 | Quantitative Biology2020，8，1： | 0 |
| 19 | The first chromosome-level Fallopia multiflora genome assembly provides insights into stilbene biosynthesis显示文摘Fallopia multiflora(Thunb.)Harald,a vine belonging to the Polygonaceae family,is used in traditional medicine.The stilbenes contained in it have significant pharmacological activities in anti-oxidation and anti-aging.This study describes the assembly of the F.multiflora genome and presents its chromosome-level genome sequence containing 1.46 gigabases of data(with a contig N50 of 1.97 megabases),1.44 gigabases of which was assigned to 11 pseudochromosomes.Comparative genomics confirmed that F.multiflora shared a whole-genome duplication event with Tartary buckwheat and then underwent different transposon evolution after separation.Combining genomics,transcriptomics,and metabolomics data to map a network of associated genes and metabolites,we identified two FmRS genes responsible for the catalysis of one molecule of p-coumaroyl-CoA and three molecules of malonyl-CoA to resveratrol in F.multiflora.These findings not only serve as the basis for revealing the stilbene biosynthetic pathway but will also contribute to the development of tools for increasing the production of bioactive stilbenes through molecular breeding in plants or metabolic engineering in microbes.Moreover,the reference genome of F.multiflora is a useful addition to the genomes of the Polygonaceae family. | Yujiao Zhao Zhengyang Yang Zhongren Zhang Minzhen Yin Shanshan Chu Zhenzhen Tong Yuejian Qin Liangping Zha Qingying Fang Yuan Yuan Luqi Huang Huasheng Peng | 2023 | Horticulture Research2023，10，5： | 0 |
| 20 | Hybrid model enabling highly efficient follicular segmentation in thyroid cytopathological whole slide image显示文摘Background The prevalence of thyroid cancer is growing rapidly.Early and precise diagnosis is critical in thy-roid cancer caring.An automatic thyroid cancer diagnostic tool can be valuable to achieve early detection and diagnostic consistency.Only the follicular areas in the sample contain useful information to the thyroid cancer diagnosis based on fine needle aspiration(FNA).This study aimed to develop a highly efficient accurate method for follicular cell areas segmentation(FCAS)of thyroid cytopathological whole slide images(WSIs).Methods A total of 96 cell samples from July 2017 to July 2018 were collected in one hospital in Beijing,China.Forty-three WSIs were selected and manually labeled,including 17 cases of papillary thyroid carci-noma sample and 26 cases of benign sample.Six thousand and nine hundred cropped typical image patches(available on http://gffzz188fe103f8f1460as6ubnk9wpv96f6x0v.ffgz.tsg.suse.edu.cn/bupt-ai-cz/Hybrid-Model-Enabling-Highly-Efficient-Follicular-Segmentation)of 1024×1024 pixels from 13 large WSIs were used for patch-level model training and testing and all of the 13 large WSIs were papillary thyroid carcinoma samples.Thirty testing WSIs with an average size 36,217×29,400(from 10,240×10,240 to 81,920×61,440)were used to test the effectiveness of the hybrid model.Based on the traditional semantic segmentation model deeplabv3,we constructed a hybrid segmentation architecture by adding a classification branch into the segmentation scheme to improve efficiency.Accuracy was used to measure the performance of the classification model;pixel accuracy(pAcc),mean accuracy(mAcc),mean intersection over union(mIoU),and frequency weighted intersection over union(fwIoU)were used to measure the performance of the segmentation model,respectively.Results Using this method,up to 93%WSI segmentation time was reduced by skipping the colloidal areas and the blank background areas.The average processing time of 30 WSI was 49.49 s.On the patch dataset,this hybrid model might reach pAcc=98.65%,mAcc=85.60%,mIoU=79.61%,and fwIoU=97.54%.On the WSI dataset,this model might reach pAcc=99.30%,mAcc=68.94%,mIoU=58.21%,and fwIoU=99.50%.Conclusion The proposed hybrid method might significantly improve previous solutions and achieve the superior performance of efficiency and accuracy. | Chuang Zhu Siyan Tao Huang Chen Minzhen Li Ying Wang Jun Liu Mulan Jin | 2021 | Intelligent Medicine2021，1，2： | 0 |
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