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| 1 | 人急性B淋巴细胞白血病-NOD/SCID/IL2rγnull新生小鼠异种移植模型的建立显示文摘本研究旨在应用NOD/SCID/IL2rγnull新生小鼠建立人急性B淋巴细胞白血病(B-ALL)的异种移植模型。NOD/SCID/IL2rγnull新生期(出生48 h之内)小鼠经亚致死剂量(100 cGy)137Cs全身照射后,由面静脉输注FACSAria流式细胞仪分选纯化的B-ALL患者骨髓CD3-CD4-CD8-CD34+CD19+细胞,于移植后8-12周用流式细胞术检测受鼠外周血、骨髓和脾脏中人源细胞的植入水平及其免疫表型,并通过HE染色评价人源B-ALL细胞在受鼠各组织器官中的迁移浸润能力。结果表明,在接受B-ALL患者CD34+CD19+细胞移植的受鼠外周血、骨髓和脾脏细胞中,不仅检测到了不同程度的人源B-ALL(huCD45+CD19+)细胞的植入〔(83.36±10.05)%,(93.88±5.05)%,(88.31±5.01)%〕,而且植入细胞具有与B-ALL患者相似的细胞形态和免疫表型特征。此外,人源B-ALL细胞广泛迁移浸润到受鼠的肝脏、肺脏、肾脏和脑等组织器官中。结论:NOD/SCID/IL2rγnull新生小鼠模型能够支持B-ALL患者CD34+CD19+细胞的高水平植入,是对人B-ALL进行体内功能性研究的新型异种移植模型。 | 孔圆 刘艳荣 刘开彦 黄晓军 Fumihiko Ishikawa Mine Harada | 2012 | 中国实验血液学杂志2012，20，3： | 4 |
| 2 | Optimum Treatment Strategy for Superficial Esophageal Cancer: Endoscopic Mucosal Resection versus Radical Esophagectomy显示文摘 | Hiromasa Fujita Susumu Sueyoshi Hideaki Yamana Koji Shinozaki Uhi Toh Yuichi Tanaka Takashi Mine Masahiro Kubota Kazuo Shirouzu Atsushi Toyonaga Hiroshi Harada Sigeki Ban Masahide Watanabe Yukihiko Toda Emi Tabuchi Naofumi Hayabuchi Hiroki Inutsuka | 2001 | World Journal of Surgery2001，，4： | 2 |
| 3 | Autologous peripheral blood stem cell transplantation with granulocyte colony-stimulating factor combined conditioning regimen as a postremission therapy for acute myelogenous leukemia in first complete remission显示文摘 | Tetsuya Eto Ken Takase Toshihiro Miyamoto Yuju Ohno Tomohiko Kamimura Koji Nagafuji Yasushi Takamatsu Takanori Teshima Hisashi Gondo Shuichi Taniguchi Koichi Akashi Mine Harada | 2013 | International Journal of Hematology2013，，2： | 2 |
| 4 | Characterization of non-small-cell lung cancer cell lines established before and after chemotherapy显示文摘 | Haruyuki Kawai Katsuyuki Kiura Masahiro Tabata Tadashi Yoshino Ichiro Takata Akio Hiraki Kenichi Chikamori Hiroshi Ueoka Mitsune Tanimoto Mine Harada | 2002 | Lung Cancer2002，，3： | 2 |
| 5 | Complementary roles of pro-gastrin-releasing peptide (ProGRP) and neuron specific enolase (NSE) in diagnosis and prognosis of small-cell lung cancer (SCLC)显示文摘 | Takuo Shibayama Hiroshi Ueoka Kenji Nishii Katsuyuki Kiura Masahiro Tabata Kazuyo Miyatake Takuji Kitajima Mine Harada | 2001 | Lung Cancer2001，，： | 1 |
| 6 | In vitro sequence-dependent interaction between nedaplatin and paclitaxel in human cancer cell lines显示文摘 | Risa Tanaka Yasushi Takii Yoshihiro Shibata Hiroshi Ariyama Baoli Qin Eishi Baba Hitoshi Kusaba Kenji Mitsugi Mine Harada Shuji Nakano | 2005 | Cancer Chemotherapy and Pharmacology2005，，3： | 1 |
| 7 | Peptide vaccination for patients with melanoma and other types of cancer based on preexisting peptide-specific cytotoxic T-lymphocyte precursors in the periphery显示文摘 | Tanaka S Harada M Mine T | 2003 | J Immunother2003，26，4： | 1 |
| 8 | Successful Treatment of Primary Cardiac Lymphoma by Rituximab-CHOP and High-Dose Chemotherapy with Autologous Peripheral Blood Stem Cell Transplantation显示文摘 | Atsushi Nonami Katsuto Takenaka Kenjiro Kamezaki Toshihiro Miyamoto Naoki Harada Koji Nagafuji Takanori Teshima Mine Harada | 2007 | International Journal of Hematology2007，，3： | 1 |
| 9 | Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells显示文摘 | Baoli Qin Hiroshi Ariyama Eishi Baba Risa Tanaka Hitoshi Kusaba Mine Harada Shuji Nakano | 2006 | Cancer Chemotherapy and Pharmacology2006，，5： | 1 |
| 10 | Chronic graft-versus-host disease following varicella-zoster virus infection in allogeneic stem cell transplant recipients显示文摘 | Noriaki Kawano Hisashi Gondo Tomohiko Kamimura Kenichi Aoki Tadafumi Iino Fumihiko Ishikawa Toshihiro Miyamoto Koji Nagafuji Kazuya Shimoda Shin Hayashi Teruhisa Otsuka Yukumasa Kazuyama Mine Harada | 2003 | International Journal of Hematology2003，，4： | 1 |
| 11 | Characterization of non-small-cell lung cancer cell lines established before and after chemotherapy显示文摘 | Haruyuki Kawai Katsuyuki Kiura Masahiro Tabata Tadashi Yoshino Ichiro Takata Akio Hiraki Kenichi Chikamori Hiroshi Ueoka Mitsune Tanimoto Mine Harada | 2002 | Lung Cancer2002，，3： | 1 |
| 12 | Optimum Treatment Strategy for Superficial Esophageal Cancer: Endoscopic Mucosal Resection versus Radical Esophagectomy显示文摘 | Hiromasa Fujita Susumu Sueyoshi Hideaki Yamana Koji Shinozaki Uhi Toh Yuichi Tanaka Takashi Mine Masahiro Kubota Kazuo Shirouzu Atsushi Toyonaga Hiroshi Harada Sigeki Ban Masahide Watanabe Yukihiko Toda Emi Tabuchi Naofumi Hayabuchi Hiroki Inutsuka | 2001 | World Journal of Surgery2001，，4： | 1 |
| 13 | Long-term outcome of esophagectomy for primary malignant melanoma of the esophagus : a single-institute retrospective analysis 显示文摘 | Harada K Mine S Yamada K | 2015 | Dis Esophagus2015，28，2： | 1 |
| 14 | Studying Human Leukemic Stem Cells in Mice显示文摘Transplantation of human leukemic cells into severe combined immunodeficiency(SCID)mice has been attempted to study leukemogenesis and to develop therapeuticmodalities.Previous models,however,were limited in efficient initiation orlong-term engraftment of leukemic cells following the transplantation of primaryhuman leukemic cells.The insufficient engraftment of primary leukemic cells couldbe caused by the residual innate immunity in CB-17/SCID or NOD/SCID mice.We | Mine Harada | 2007 | 中国实用内科杂志2007，27，S1： | 0 |
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