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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 3 | Exome sequencing confirms molecular diagnoses in 38 Chinese families with hereditary spherocytosis显示文摘Hereditary spherocytosis(HS), the most common cause of congenital hemolytic anemia, is caused by deficiency of the erythrocyte membrane proteins. Five causative genes(ANK1, SPTB, SPTA1, SLC4 A1, and EPB42) have been identified. To date,molecular genetic studies have been performed in different populations, including the American, European, Brazilian, Japanese and Korean populations, whereas only a few studies have been described in the Chinese population. Here, by reanalysis of the exome data, we revealed causative mutations and established a definitive diagnosis of HS in all 38 Chinese families. We found 34 novel mutations and four reported mutations in three known HS-causing genes—17 in ANK1, 17 in SPTB and four in SLC4 A1,suggesting that ANK1 and SPTB are the major genes in Chinese patients with HS. All of the ANK1 or SPTB mutations, scattered throughout the entire genes, are non-recurrent; and most of them are null mutations, which might cause HS via a haploinsufficiency mechanism. De novo mutations in ANK1 or SPTB often occur with an unexpected high frequency(87.5% and64.2%, respectively). Our study updates our knowledge about the genetic profile of HS in Chinese and shows that family-based,especially parent-offspring trio, sequencing analysis can help to increase the diagnostic power and improve diagnostic efficiency. | Rongrong Wang Shuanghao Yang Ming Xu Jia Huang Hongyan Liu Weiyue Gu Xue Zhang | 2018 | Science China(Life Sciences)2018，61，8： | 22 |
| 4 | Incidence and psychological-behavioral characteristics of refractory functional dyspepsia:A large, multi-center, prospective investigation from China显示文摘AIM:To explore the incidence and psychological and behavioral characteristics of refractory functional dyspepsia(RFD)in China.METHODS:The subjects of this study were 1341 new outpatients with functional dyspepsia(FD)who were diagnosed according to the RomeⅢcriteria at four hospitals in Guangdong Province between June and September 2012,and 100 healthy volunteers.All subjects completed questionnaires and scales administered.RESULTS:Three-hundred and twenty-seven of the 1341patients with FD had RFD(24.4%).Patients with RFD had a longer disease duration and a more severe form of the disease than patients with non-refractory FD(NRFD).The prevalence of depression and anxiety symptoms was higher in patients with RFD than in patients with NRFD.The prevalence of unhealthy eating behaviors,lack of physical activity,and sleeping disorders was higher in patients with RFD than in patients with NRFD.Patients with RFD sought medical advice on more occasions and spent more money on treatment than patients with NRFD.Finally,patients with RFD had poorer quality of life than patients with NRFD.CONCLUSION:RFD is not rare in clinical practice and should get attention by patients and doctors because of its long duration,severe symptoms,and associations with abnormal psychology and poor quality of life. | Shu-Man Jiang Lin Jia Xiao-Gai Lei Ming Xu Sheng-Bing Wang Jing Liu Min Song Wei-Dong Li | 2015 | World Journal of Gastroenterology2015，21，6： | 20 |
| 5 | Use of the Metabolomics Approach to Characterize Chinese Medicinal Material Huangqi显示文摘基因、新陈代谢的采指纹的罐头的集成提供一条新途径区分类似的繁体中文医药(TCM ) 材料。二豆科的植物, Mojia Huangqi 和 Menggu Huangqi,是在形态学,化学成分,和 genomic DNA 顺序的重要医药植物和份额伟人类似。Mojia Huangqi 和 Menggu Huangqi 的分类为超过 50years 被辩论了, TCM 材料的辨别直接影响药理学和临床的效果。AFLP 基于新陈代谢的采指纹的基因采指纹和 GCTOF/MS-based 被用来成功地区别二种。AFLP 的结果支持了 Menggu Huangqi 是 Mojia Huangqi 的变体的意见。新陈代谢的采指纹证明生长地点比遗传型在代谢物作文和数量上有更大的影响(栽培对野) 在 Menggu Huangqi。一些可溶的糖,丰满的酸,脯氨酸,和 polyamine 的差别反映了植物改编到不同生长环境。用 multivariate 和 univariate,统计分析,三个 AFLP 标记和八代谢物作为候选人 DNA 和新陈代谢的标记被识别区分二植物材料。在 AFLP 标记和代谢物之间的关联网络揭示了一个复杂关联网络,它显示了特殊新陈代谢的小径和 Huangqi 的规定网络。 | Li-Xin Duan Tian-Lu Chen Ming Li Min Chen Ye-Qing Zhou Guang-Hong Cui Ai-Hua Zhao Wei Jia Lu-Qi Huang Xiaoquan Qi | 2012 | Molecular Plant2012，5，2： | 19 |
| 6 | Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE-/- mice by downregulating the HMGB1-RAGE axis显示文摘 | Ming LIU Ying Yu Hong JIANG Lei ZHANG Pei-pei ZHANG PengYU Jian-guo JIA Rui-zhen CHEN Yun-zeng ZOU Jun-bo GE | 2013 | Acta Pharmacologica Sinica2013，34，6： | 18 |
| 7 | Expression of phosphatidylinositol-3 kinase and effects of inhibitor Wortmannin on expression of tumor necrosis factor-α in severe acute pancreatitis associated with acute lung injury显示文摘BACKGROUND: Acute lung injury(ALI) is a common and serious complication of severe acute pancreatitis(SAP). The study aimed to investigate the protective effect and mechanism of phosphatidylinositol-3 kinase(PI3K) inhibitor Wortmannin in SAP associated with ALI.METHODS: Ninety rats were randomly divided into three groups: sham operation(SO) group(n=30), SAP group(n=30), and SAP+Wortmannin(SAP+W) group(n=30). SAP model was induced by retrograde injection of 4% sodium taurocholate into the biliopancreatic duct of rats. The rate of lung water content, myeloperoxidase(MPO), matrix metalloproteinase 9(MMP-9), protein kinase B(PKB), abdphosphorylation of protein kinase B(P-PKB) activity in the lung tissue were evaluated.RESULTS: In the SAP group, the p-PKB expression in the lung tissue began to rise at 3 hours after modeling, and peaked at 12 hours(P<0.05); the rate of lung water content, MPO and TNF-α activity were also gradually increased, and the degree of lung lesion gradually increased(P<0.05). In the SAP+Wortmannin group, the p-PKB expression in the lung tissue began to rise at 3 hours after modeling, and peaked at 12 hours; it was higher than that in the SO group(P<0.05), but significantly lower than that in the SAP group(P<0.05). The rest indicators in the SAP+Wortmannin group were also significantly decreased as compared with the SAP group(P<0.05).CONCLUSIONS: The expression of phosphatidylinositol-3 kinase/protein kinase B was elevated in severe pancreatitis rats with lung injury. This suggested that PI3 K signal transduction pathway is involved in the control and release of proinfl ammatory cytokines TNF-α, which may play an important role in the pathogenesis of severe acute pancreatitis associated with lung injury. This finding indicated that Wortmannin can block the PI3 K signal transduction pathway, and inhibit the release of infl ammatory factor TNF-α. | Ming Wei Yan-jie Gong Ling Tu Jia Li Ying-hong Liang Yi-hua Zhang | 2015 | World Journal of Emergency Medicine2015，6，4： | 18 |
| 8 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 9 | Fine mapping and marker-assisted selection (MAS) of a low glutelin content gene in rice显示文摘Rice with low glutelin content is suitable as functional food for patients affected with diabetes and kidney failure. The fine mapping of the gene(s) responsible for low glutelin content will provide information regarding the distribution of glutelin related genes in rice genome and will generate markers for the selection of low glutelin rice varieties. Following an SDS-PAGE screen of rice germplasm from Taihu Valley of China, Japonica selection W3660 is identified to be a novel mutant characterized with low glutelin content. For fine mapping the mutant gene for low glutelin content, F2 and F3 populations were derived from a cross between W3660 and Jingrennuo. SDS-PAGE analysis of the total endosperm protein showed that the low glutelin content trait was controlled by a single dominant nuclear gene. Genetic mapping, using SSRs, located this gene to chromosome 2, in the region between SSR2-001/SSR2-004 and RM1358. The dis- tances of the two markers to the target gene were 1.1 cM and 3.8 cM respectively. By semi-quantitative RT-PCR analysis, the transcripts of GluB4/GluB5 genes located within the region do not change. However, GluB5 gene located proximal to SSR2-001/SSR2-004 was specifically reduced. SSR profiles of seven Japonica varieties were compared with that of W3660 for loci in the relevant genetic region. The markers SSR2-004 and RM1358 were used for marker- assisted selection. The selection efficiencies of SSR2-004 and RM1358 were 96.8% and 92.7% respectively. This provides a standard starting point for the breeding of low glutelin content rice varieties in China. | Yi Hua WANG Shi Jia LIU Su Lan JI Wen Wei ZHANG Chun Ming WANG Ling JIANG Jian Min WAN | 2005 | Cell Research2005，15，8： | 16 |
| 10 | Non-invasive ventilation improves hemorheology status in hypoxemic patients with acute myocardial infarction after PCI显示文摘血氧不足有时在经皮的冠的干预(一种总线标准) 以后与尖锐心肌的梗塞(AMI ) 在病人发生在紧急情况房间里,甚至在那些与常规高流动的氧吸入的管理。现在的学习是在与 AMI 和 hypoxemia.MethodsThis 在病人改进血氧内容和 hemorheology 评估非侵略的通风(NIV ) 的有效性的 of 未来的学习与 AMI 注册了 50 个连续合格病人(72.3 ??? 折?? | Xi-Fu WANG Ming YE Dong YAN Hui-Min ZHANG Ping JIA Xue-Jun REN Yu-Jie ZENG | 2017 | Journal of Geriatric Cardiology2017，14，4： | 15 |
| 11 | Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes:A Population-based Prospective Cohort Study of Inner Mongolians in China显示文摘This prospective study was designed to examine the combined influence of insulin resistance(IR)and inflammatory biomarker levels on type 2 diabetes mellitus(T2DM)among 1,903Inner Mongolians.During follow-up,205(10.77%)participants developed T2DM,and the incidence | QIU Qiao Yan ZHANG Bei Lei ZHANG Ming Zhi WU Jia Hui ZHOU Jing Wen LIANG Zhu ZHANG Yong Hong ZHANG Shao Yan | 2018 | Biomedical and Environmental Sciences2018，31，4： | 15 |
| 12 | Effects of the novel 6 % hydroxyethyl starch 130/0.4 on renal function of recipients in living-related kidney transplantation显示文摘背景为使用的最佳的胶体不在肾移植期间是清楚的。经历生活相关的肾移植(LRKT ) 的病人被用来比较 6% hydroxyethyl 淀粉 130/0.4 (HES 130/0.4 ) 和 4% succinylated 胶的保护的效果,作为施主肾获得,局部缺血时间和外科的条件是可比较的。击卷变化(SVV ) 被用来监视 intravascular 体积避免肾的 allograft hypoperfusion.Methods 经历 LRKT 的八十个病人被划分成二个组:组 H 收到了 6% HES 130/0.4,组 G 收到了 4% succinylated 胶。所有施主和接受者在外科期间收到了相关胶体的 15-25 ml/kg。动脉的血压(ABP ) ,心率(HR ) ,中央静脉的压力(CVP ) , SVV 和心脏的索引(CI ) , electrocardiography (ECG ) 和 SpO2 连续地被监视。SVV 在 100-130 mmHg 在 6%-13% 和吝啬的动脉的压力之间被保留。静脉的血和尿的样品被获得 30 在 unclamping 以后并且在手术后的天(邮政部门) 的早上纪录 1-4 测量浆液和尿 2-microglobulin,尿 1-microglobulin, microalbumin 和 N 乙酰 -- D-glucosaminidase。血脲氮(甜面包) 和肌酸是坚定的操作前(到) ,在外科(t1 ) 以后并且在豆荚上的 3 个小时 1 (t2 ) , 2 (t3 ) , 4 (t4 ) , 7 (t5 ) 并且 10 (t6 ) 。尿输出在 t1, t2, t5, t6.Results 年龄,身体重量,身体表面区域(BSA ) ,操作时间,尿输出和灌输的胶体卷被记录在这些组之间是可比较的, hemodynamics 在外科期间是稳定的。在在相对 baseline.BUN 的两个组的外科在 t1, t2 和 t4 与组 G 相比在组 H 显著地减少了以后,甜面包,浆液肌酸,浆液 2-microglobulin 和尿 2-microglobulin 显著地减少了。尿 microalbumin 在与组 G 相比的邮政部门 4 上在组 H 显著地减少了。尿 1-microglobulin 不两个都在二 groups.Conclusion 之间是显著地不同的胶体能安全地为 LRKT 被使用,但是 HES130/0.4 与肾的功能的更快速的恢复被联系。 | WU Yan WU An-shi WANG Jun TIAN Ming JIA Xin-yuan RUI Yan YUE Yun | 2010 | Chinese Medical Journal2010，，21： | 14 |
| 13 | Grape Seed Proanthocyanidin Extract Alleviates Arsenic-induced Oxidative Reproductive Toxicity in Male Mice显示文摘Objective To determine the ability of grape seed proanthocyanidin extract(GSPE) in alleviating arsenic-induced reproductive toxicity. Methods Sixty male Kunming mice received the following treatments by gavage: normal saline solution(control); arsenic trioxide(ATO; 4 mg/kg); GSPE(400 mg/kg); ATO+GSPE(100 mg/kg); ATO+GSPE(200 mg/kg) and ATO+GSPE(400 mg/kg). Thereafter, the mice were sacrificed and weighed, and the testis was examined for pathological changes. Nuclear factor(erythroid-derived 2)-like 2(Nrf2), heme oxygenase 1(HO1), glutathione S-transferase(GST), NAD(P)H dehydrogenase, and quinone 1(NQO1) expression in the testis was detected by real-time PCR. Superoxide dismutase(SOD), glutathione(GSH), total antioxidative capability(T-AOC), malondialdehyde(MDA), 8-hydroxydeoxyguanosine(8-OHd G), and reproductive indexes were analyzed. Results ATO-treated mice showed a significantly decreased sperm count and testis somatic index and activity levels of SOD, GSH, and T-AOC than control group. Compared to the ATO-treated group, ATO +GSPE group showed recovery of the measured parameters. Mice treated with ATO+high-dose GSPE showed the highest level of m RNA expression of Nrf2, HO, NQO1, and GST. Conclusion GSPE alleviates oxidative stress damage in mouse testis by activating Nrf2 signaling, thus counteracting arsenic-induced reproductive toxicity. | LI Shu Gang DING Yu Song NIU Qiang XU Shang Zhi PANG Li Juan MA Ru Lin JING Ming Xia FENG Gang Ling LIU Jia Ming GUO Shu Xia | 2015 | Biomedical and Environmental Sciences2015，28，4： | 14 |
| 14 | Results of hip resurfacing for developmental dysplasia of the hip of Crowe type Ⅰ and Ⅱ显示文摘背景最近,整修关节造形术的 metal-on-metal 总数臀部的新一代是众所周知的因为保存近似大腿骨的骨头股票,用大大腿骨的头最小化手术后的脱臼的风险,并且期望低为更长的修复术幸存 metal-on-metal 穿连接。它也在在近似腿节装载的 biomechanical 有优点。对臀部(DDH ) 的发展发育异常第二等的骨关节炎是为全部的新潮的关节造形术的最普通的原因。大多数病人年轻、积极,除疼痛的地势以外要求臀部的运动的改进范围,甚至期望恢复能力在联合关节造形术以后跑并且跳,这样被给予一种活跃生活方式。当前的学习的目的是评估为温和 DDH 盒子整修关节造形术的早结果(Crowe 类型并且) 在 2005 年 9 月和 2007 年 5 月之间的 .Methods,有对 DDH 第二等的骨关节炎的诊断的 21 个连续病人(26 个臀部) 经历了整修关节造形术的 metal-on-metal。平均年龄在外科的时候是 46.5 年(范围, 37-59 年) 。六个病人(28.6%) 是男性的,(71.4%) 十五是女性。临床、 X 光线照相术的结果被观察。后续在 6 个星期被执行, 3, 6, 9 个月然后 yearly.Results 所有病人为 18 个月(9-29 月) 的一个平均数被跟随。在后续经期期间没有复杂并发症感染或大腿骨的颈骨折例如新潮的关节的脱臼,发生了。临床的结果与哈里斯臀部分数评价与外科手术前的级别相比显著地改善了。吝啬的手术后的哈里斯臀部分数外科手术前地是 90.7,与 35.5 相比。X 光线照相术的分析证明所有 prostheses 没有 radiolucencies 被修理。有相等的手足的病人,长度外科手术前地有的所有手术后地等于长度。有 0.8 ~ 1.2 厘米的外科手术前的手足长度差异的九个病人,所有手术后地重获相等的手足长度。另外,疼痛将近完全被减轻,运动的范围显著地被改进,没有限制关于整修关节造形术的 metal-on-metal 的新一代可以是的早 exercise.Conclusions 在操作以后被需要为 Crowe 的 DDH 的一种合理选择打字并且。 | XU Wei-dong LI Jia ZHOU Zhen-hua WU Yue-song LI Ming | 2008 | Chinese Medical Journal2008，，15： | 13 |
| 15 | Vagus Nerve Stimulation for Pediatric and Adult Patients with Pharmaco-resistant Epilepsy显示文摘 | Fan-Gang Meng Fu-Min Jia Xiao-Hui Ren Yan Ge Kai-Liang Wang Yan-Shan Ma Ming Ge Kai Zhang Wen-Han HU Xin Zhang Wei Hu Jian-Guo Zhang | 2015 | Chinese Medical Journal2015，，19： | 13 |
| 16 | Energy Efficient Power Allocation for Relay-Aided D2D Communications in 5G Networks显示文摘As one of the key technologies for the fifth generation(5G) wireless networks,device-to-device(D2D) communications allow user equipment(UE) in close proximity to communicate with each other directly.Forwarded by a relay,the relay-aided D2D(RA-D2D) communications can not only be applied to communications in much longer distance but also achieve a high quality of service(Qo S) .In this paper,we first propose a two-layer system model allowing RA-D2 D links to underlay traditional cellular uplinks.Then we maximize the energy efficiency of the RA-D2 D link while satisfying the minimum data-rate of the cellular link.The optimal transmit power at both D2 D transmitter and D2 D relay sides is obtained by transforming the nonlinear fractional programming into a nonlinear parameter programming.Simulation results show that our proposed power allocation method is more energy efficient than the existing works,and the proposed RA-D2 D scheme outperformed direct D2 D scheme when the distance between two D2 D users is longer. | Ru Wang Jia Liu Guopeng Zhang Shuanghong Huang Ming Yuan | 2017 | China Communications2017，14，6： | 13 |
| 17 | Spatial variability of soil water content and related factors across the Hexi Corridor of China显示文摘Soil water content(SWC) is a key factor limiting ecosystem sustainability in arid and semi-arid areas of the Hexi Corridor of China, which is characterized by an ecological environment that is vulnerable to climate change. However, there is a knowledge gap regarding the large-scale spatial distribution of SWC in this region. The specific objectives of this study were to determine the spatial distribution patterns of SWC across the Hexi Corridor and identify the factors responsible for spatial variation of SWC at a regional scale. This study collected and analyzed SWC in the 0–100 cm soil profile from 109 field sampling sites(farmland, grassland and forestland) across the Hexi Corridor in 2017. We selected 17 factors, including land use, topography(latitude, longitude, elevation, slope gradient, and slope aspect), soil properties(soil clay content, soil silt content, soil bulk density, saturated hydraulic conductivity, field capacity, and soil organic carbon content), climate factors(mean annual precipitation, potential evaporation, and aridity index), plant characteristic(vegetation coverage) and planting pattern(irrigation or rain-fed), as possible environmental variables to analyze their effects on SWC. The results showed that SWC was 0.083(±0.067) g/g in the 0–100 cm soil profile and decreased in the order of farmland, grassland and forestland. The SWC in the upper soil layers(0–20, 20–40 and 40–60 cm) had obvious difference when the mean annual precipitation differed by 200 mm. The SWC decreased from southeast to northwest following the same pattern as precipitation, and had a moderate to strong spatial dependence in a large effective range(75–378 km). The SWC showed a similar distribution and had no significant difference between soil layers in the 0–100 cm soil profile. The principal component analysis showed that the mean annual precipitation, geographical position(longitude and latitude) and soil properties(soil bulk density and soil clay content) were the main factors dominating the variance of environmental variables. A stepwise linear regression equation showed that plant characteristic(vegetation coverage) and soil properties(soil organic carbon content, field capacity and soil clay content) were the optimal factors to predict the variation of SWC. Soil clay content could be better to explain the SWC variation in the deeper soil layers compared with the other factors. | LI Xiangdong SHAO Ming'an ZHAO Chunlei JIA Xiaoxu | 2019 | Journal of Arid Land2019，11，1： | 12 |
| 18 | Antagonistic Potential against Pathogenic Microorganisms and Hydrogen Peroxide Production of Indigenous Lactobacilli Isolated from Vagina of Chinese Pregnant Women显示文摘Objective To investigate the indigenous lactobacilli from the vagina of pregnant women and to screen the isolates with antagonistic potential against pathogenic microorganisms.Methods The strains were isolated from pregnant women's vagina and identified using the API50CH system.The ability of the isolates to produce hydrogen peroxide was analyzed semi-quantitatively using the TMB-HRP-MRS agar.The antagonistic effects of the isolates on pathogenic microorganisms were determined with a double layer agar plate.Results One hundred and three lactobacilli strains were isolated from 60 samples of vaginal secretion from healthy pregnant women.Among them,78 strains could produce hydrogen peroxide,in which 68%,80%,80%,and 88% had antagonistic effects against Candida albicans CMCC98001,Staphylococcus aureus CMCC26003,Escherichia coli CMCC44113,and Pseudomonas aeruginosa CMCC10110,respectively.Conclusion The recovery of hydrogen peroxide-producing lactobacilli decreases with the increasing pregnant age and time.The most commonly isolated species from vagina of Chinese pregnant women are Lactobacillus acidophilus and Lactobacillus crispatus.Most of L.acidophilus and L.crispatus produce a high H2O2 level. | HENG-YI XU WAN-HONG TIAN CUI-XIANG WAN LI-JUN JIA LAN-YIN WANG JING YUAN CHUN-MEI LIU MING ZENG HUA WEI | 2008 | Biomedical and Environmental Sciences2008，21，5： | 12 |
| 19 | Large-field high-resolution two-photon digital scanned light-sheet microscopy显示文摘 | Weijian Zong Jia Zhao Xuanyang Chen Yuan Lin Huixia Ren Yunfeng Zhang Ming Fan Zhuan Zhou Heping Cheng Yujie Sun Liangyi Chen | 2015 | Cell Research2015，25，2： | 12 |
| 20 | LEAFY HEAD2,which encodes a putative RNA-binding protein,regulates shoot development of rice显示文摘在植物的开发期间,更高的植物连续地在常规空间、时间的模式形成新叶子。有反常的叶的异种发展模式不仅提供大卓见进理解植物建筑学的规章的机制,而且充实方法到它庄稼产量能被改进的修正。这里,我们报导了米饭 leafy-head2 (lhd2 ) 的描述展览弄短的异种阶段的 plastochron,侏儒症,减少的 tiller 数字,和失败转移从对繁殖生长植物。而减少的 tiller 数字是 tiller 芽长出的抑制的后果,解剖、组织学的学习表明在 lhd2 的叶子的快速的出现从叶 primordia 的快速的开始被结果。分子、基因的分析证明 LHD2 与 67% 类似编码通常认为的 RNA 有约束力的蛋白质到玉米 TE1。染色体规模表示侧面在之间的比较野类型并且 lhd2 植物建议 LHD2 可以通过 KNOX 和荷尔蒙相关的基因调整米饭射击开发。LHD2 变化和 LHD2 的保存表示模式引起的类似的显型在在草控制时间的叶开始显示了保存机制。 | Guo Sheng Xiong Xing Ming Hu Yong Qing Jiao Yan Chun Yu Cheng Cai Chu Jia Yang Li Qian Qian Yong Hong Wang | 2006 | Cell Research2006，16，3： | 11 |
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