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| 1 | Plant fertility defects induced by the enhanced expression of microRNA167显示文摘植物荷尔蒙植物生长素在调整植物生长和开发起一个关键作用。最近的进展在植物生长素反应小径的理解被做了,首先由在 Arabidopsis 的植物生长素反应异种的描述。另外, microRNAs (miRNAs ) 被显示了是为正常植物开发和生理学重要的基因的批评管理者。然而,很少对在 miRNAs 并且在正常开发期间的神经质的发信号之间的可能的相互作用被知道。这里,我们显示出那 Arabidopsis microRNA, miR167,有一个互补序列到 AUXIN 反应 FACTOR6 (ARF6 ) 和 ARF8 mRNAs 的部分,能为 ARF8,然而并非为 ARF6 引起抄本降级。我们报导 35S::MIR167b 的 phenotypic 描述转基因的线,和表演转基因的线有的那严重 35S::MIR167b arf6 arf8 的类似于那些的显型加倍异种。转基因的显型建议 miR167 可以镇压在翻译的水平的 ARF6。我们证明转基因的植物在花的机关的所有四锭盘是有缺点的。在转基因的花,细丝是反常地短的,花药不能适当地释放花粉,并且花粉谷物没发芽。我们的结果提供在表明网络支持的基因表示和植物生长素的调停 miRNA 的规章的小径之间的一个重要连接种繁殖开发。 | Peng Ru Lin Xu Hong Ma Hai Huang | 2006 | Cell Research2006，16，5： | 35 |
| 2 | Grape Seed Proanthocyanidin Extract Alleviates Arsenic-induced Oxidative Reproductive Toxicity in Male Mice显示文摘Objective To determine the ability of grape seed proanthocyanidin extract(GSPE) in alleviating arsenic-induced reproductive toxicity. Methods Sixty male Kunming mice received the following treatments by gavage: normal saline solution(control); arsenic trioxide(ATO; 4 mg/kg); GSPE(400 mg/kg); ATO+GSPE(100 mg/kg); ATO+GSPE(200 mg/kg) and ATO+GSPE(400 mg/kg). Thereafter, the mice were sacrificed and weighed, and the testis was examined for pathological changes. Nuclear factor(erythroid-derived 2)-like 2(Nrf2), heme oxygenase 1(HO1), glutathione S-transferase(GST), NAD(P)H dehydrogenase, and quinone 1(NQO1) expression in the testis was detected by real-time PCR. Superoxide dismutase(SOD), glutathione(GSH), total antioxidative capability(T-AOC), malondialdehyde(MDA), 8-hydroxydeoxyguanosine(8-OHd G), and reproductive indexes were analyzed. Results ATO-treated mice showed a significantly decreased sperm count and testis somatic index and activity levels of SOD, GSH, and T-AOC than control group. Compared to the ATO-treated group, ATO +GSPE group showed recovery of the measured parameters. Mice treated with ATO+high-dose GSPE showed the highest level of m RNA expression of Nrf2, HO, NQO1, and GST. Conclusion GSPE alleviates oxidative stress damage in mouse testis by activating Nrf2 signaling, thus counteracting arsenic-induced reproductive toxicity. | LI Shu Gang DING Yu Song NIU Qiang XU Shang Zhi PANG Li Juan MA Ru Lin JING Ming Xia FENG Gang Ling LIU Jia Ming GUO Shu Xia | 2015 | Biomedical and Environmental Sciences2015，28，4： | 14 |
| 3 | Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China显示文摘Objective To study the optimal waist circumference(WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome(MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China. | HOU Xin Guo WANG Chuan MA Ze Qiang YANG Wei Fang WANG Ji Xiang LI Cheng Qiao WANG Yu Lian LIU Shu Min Hu Xiu Ping ZHANG Xiu Ping JIANG Mei WANG Wei Qing NING Guang ZHENG Hui Zhen MA Ai Xia SUN Yu SONG Jun LIN Peng LIANG Kai LIU Fu Qiang LI Wen Juan XIAO Juan GONG Lei WANG Mei Jian LIU Ji Dong YAN Fei YANG Jun Peng WANG Ling Shu TIAN Meng ZHAO Ru Xing JIANG Ling CHEN Li | 2014 | Biomedical and Environmental Sciences2014，27，5： | 3 |
| 4 | The Bidirectional Effects of Arsenic on miRNA-21: A Systematic Review and Meta-analysis显示文摘Objective Arsenic is a metalloid environmental carcinogen involved in the occurrence and development of many cancers. miRNA-21 plays a crucial role in arsenic-induced carcinogenesis. We aimed to elucidate the mechanism by which miRNA-21 influences arsenic-induced cancer. Methods We used meta-analysis of published studies to determine how arsenic induces cancerous cells through miRNA-21. Results Low-dose arsenic exposure(≤ 5 μmol/L) can increase miRNA-21 and phosphorylated signal transducter and activator of transcription 3(pSTAT3) expression, and decrease programmed cell death protein 4(PDCD4) and protein sprouty homolog 1(Spry1) expression. High-dose arsenic exposure(> 5 μmol/L), can increase miRNA-21 expression, and decrease Spry1 and E-cadherin expression. Short-term arsenic exposure(≤ 24 h) can increase miRNA-21 and pS TAT3 expression, and decrease PDCD4 expression. Moreover, long-term arsenic exposure(> 24 h) can increase the miRNA-21, STAT3, and pSTAT3 expression, and decrease PDCD4 expression. We found that activation of miRNA-21 and pSTAT3 were most pronounced following long-term arsenic exposure at low doses, and the effects on PDCD4 expression were most pronounced following short-term arsenic exposure at low doses. miRNA-21 inhibitors increased the expression of tumor suppressor genes PDCD4, PTEN, and Spry1 and miRNA-21-mimics suppressed the expression of these tumor suppressor genes. Conclusion Arsenic can cause cancer by activating miRNA-21 and inhibiting the expression of PDCD4, PTEN, and Spry1. | LIU Jia Qing NIU Qing HU Yun Hua LI Yu WANG Hai Xia XU Shang Zhi DING Yu Song LI Shu Gang MA Ru Lin | 2018 | Biomedical and Environmental Sciences2018，31，9： | 2 |
| 5 | Antinociceptive effect of matrine on vincristine-induced neuropathic pain model in mice显示文摘 | Dun Linglu Li Yuxiang Xu Yaqiong Zhou Ru Ma Lin Jin Shaoju Du Juan Sun Tao Yu Jianqiang | 2014 | Neurological Sciences2014，，： | 1 |
| 6 | Investigation on steric effect in the coordination of S, N and O donor heterocycle to organotin( Ⅳ): syntheses and crystal structures of triorganotin (Ⅳ) derivatives with 5 - phenyl - 1,3,4 - oxadiazole - 2 - thiol 显示文摘 | Ma Chun - lin Tian Guang - ru Zang Ru - fen | 2005 | Polyhedron2005，24，17： | 1 |
| 7 | Neuroprotective effects of oxysophocarpine on neonatal rat primary cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion显示文摘 | Qing-Luan Zhu Yu-Xiang Li Ru Zhou Ning-Tian Ma Ren-Yuan Chang Teng-Fei Wang Yi Zhang Xiao-Ping Chen Yin-Ju Hao Shao-Ju Jin Lin Ma Juan Du Tao Sun Jian-Qiang Yu | 2014 | Pharmaceutical Biology2014，，8： | 1 |
| 8 | Antinociceptive effects of oxymatrine from Sophora flavescens , through regulation of NR2B-containing NMDA receptor-ERK/CREB signaling in a mice model of neuropathic pain显示文摘 | Wang Haiyan Li Yuxiang Dun Linglu Xu Yaqiong Jin Shaojv Du Juan Ma Lin Li Juan Zhou Ru He Xiaoliang Sun Tao Yu Jianqiang | 2013 | Phytomedicine2013，，： | 1 |
| 9 | The Improved Lipid Accumulation Product is an Accurate Index for Predicting Metabolic Syndrome in the Xinjiang Population显示文摘The metabolic syndrome(MetS),which comprises of a variety of metabolic disorders,including obesity,hyperglycemia,hypertension,dyslipidemia,hyperviscosity,hyper uric acid,fatty liver,and hyperinsulinemia[1],has impacted all nations and races,becoming a significant challenge for public health institutions worldwide.MetS is associated with cardiovascular disease。 | DING Yu Song LI Yang ZHANG Xiang Hui MA Ru Lin GUO Heng MA Long LIU Tao YAO Ping | 2021 | Biomedical and Environmental Sciences2021，34，6： | 1 |
| 10 | Three fabricated pigments (Han Purple, indigo and emerald green )in ancient Chinese artifacts studied by Raman microscopy, energy - dispersive X - ray spectrometry and polarized light microscopy 显示文摘 | CHENG Xiao- lin XIA Yin MA Yan- ru | 2007 | J Raman Speetr2007，38，： | 1 |
| 11 | 基于个体化机器学习的原发性免疫性血小板减少症危重出血预测模型:一项全国前瞻性队列研究显示文摘原发性免疫性血小板减少症(ITP)中少见但至关重要的危重出血事件,给患者的预后、生活质量和治疗决策带来严重影响。尽管有一些研究探讨了ITP中与危重出血相关的风险因素,但目前尚缺乏大样本数据、大规模多中心研究结果以及针对ITP患者致命出血事件的预测模型。本研究首次采用国际血栓与止血学会新提出的ITP致命出血标准,利用大样本数据开发了首个基于机器学习的在线应用,用于预测ITP患者的致命出血.研究中,我们使用中国各地大型多中心数据进行开发,并对全国39家医疗中心进行为期一年的外部测试,得到了较好的训练、验证和测试数据集预测能力该基于新算法的便捷网络工具能够快速识别ITP患者的出血风险,辅助临床决策,有望未来降低不良事件的发生。 | Zhuo-Yu An Ye-Jun Wu Yu Hou Heng Mei Wei-Xia Nong Wen-Qian Li Hu Zhou Ru Feng Jian-Ping Shen Jun Peng Hai Zhou Yi Liu Yong-Ping Song Lin-Hua Yang Mei-Yun Fang Jian-Yong Li Yun-Feng Cheng Peng Liu Ya-Jing Xu Zhao Wang Yi Luo Zhen Cai Hui Liu Jing-Wen Wang Juan Li Xi Zhang Zi-Min Sun Xiao-Yu Zhu Xin Wang Rong Fu Liang Huang Shao-Yuan Wang Tong-Hua Yang Li-Ping Su Liang-Ming Ma Xie-Qun Chen Dai-Hong Liu Hong-Xia Yao Jia Feng Hong-Yu Zhang Ming Jiang Ze-Ping Zhou Wen-Sheng Wang Xu-Liang Shen Yangjin Baima Yue-Ying Li Qian-Fei Wang Qiu-Sha Huang Hai-Xia Fu Xiao-Lu Zhu Yun He Qian Jiang Hao Jiang Jin Lu Xiang-Yu Zhao Ying-Jun Chang Tao Wu Yao-Zhu Pan Lin Qiu Da Gao A-Rong Jin Wei Li Su-Jun Gao Lei Zhang Ming Hou Xiao-Jun Huang Xiao-Hui Zhang on behalf of the National Cooperative ITP Working Group | 2023 | Science Bulletin2023，68，18： | 0 |
| 12 | Biomimetic Au nanodot synthesis using Escherichia coli secretion and interaction with α-ketoglutaric acid显示文摘Dear Editor,Gold nanostructures have distinctive physicochemical properties,such as quantum size effects,surface plasmon resonance(SPR),high catalytic activity,and self-assembly,so they are one of the most widely studied materials.Over the past few years,researchers have increasingly focused on a diverse range of biomedical applications of gold nanoparticles(AuNPs)for photothermal and targeted drug delivery treatment for cancer and as biodiagnostic probes(Rao and Cheetham,2001).However,conventional AuNP chemosynthesis involves hazardous chemicals and has a high cost.In addition,a lack of excellent monodispersion,water dispersibility,and biocompatibility limit applications in biology and medicine(Kumar et al.,2008).Therefore,a green chemistry strategy for fabricating eco-friendly,nontoxic,cost-effective AuNPs with good biocompatibility and functionality is required. | Xiaoxiao Xie Xiaoli Yang Yi Chang Xiangli Ru Xiaoming Ma Lin Yang | 2021 | Science China(Life Sciences)2021，64，3： | 0 |
| 13 | High Risk of Malnutrition in Uyghur Patients with Cancer in China显示文摘Background Patients with advanced cancer often present with malnutrition.Globally,minority populations frequently suffer from higher rates of malnutrition than the majority group.It was unknown whether the nutritional status of cancer patients is different between ethicality groups(i.e.Uyghur and Han)in China.Methods A total of 251 Uyghur cancer patients were enrolled from the Xinjiang Kashgar First People's Hospital in the INSCOC Program.The Han patients were 1∶1 matched to Uyghur patients by age,gender and type of cancer from 72 hospitals around China in INSCOC Program.The nutritional risk and nutritional status were assessed using the Nutrition Risk Screening 2002(NRS 2002)and Patient-Generated Subjective Global Assessment(PG-SGA),respectively.Then,the functional status of cancer patients was determined based on the Karnofsky Performance Status(KPS).Results The incidence of an abnormal NRS-2002(≥3),PG-SGA(≥4),and KPS(≤70)was significantly different(86.1%vs 59.0%,70.5%vs 27.5%,and 18.7%vs 4.0%,respectively P<0.05).The abnormal rate of laboratory indicators in Uyghur cancer patients was significantly higher than that in Han cancer patients,including total protein,albumin,serum total bilirubin,direct bilirubin,HDL-C,white blood cell,lymphocyte,red blood cell,and platelet(all P<0.05).The abnormal rates of TSF,HGS and CC were significantly higher than that of Han nationality patients(17.5%vs 9.7%,39.6%vs 19.6%,29.1%vs 15.2%,P<0.001).The nutritional support rate of Uyghur patients was lower than that of Han patients(0%vs 16.3%).After adjusting for potential risk factors,malnutrition was associated with gender(female,OR=0.35,95%CI=0.13-0.92,P=0.034),age(>60 years,OR=5.32,95%CI=1.46-19.41,P=0.011),cancer type(gastroesophageal tumor,OR=33.62,95%CI=3.42-330.67,P=0.003),and treatment methods(received radical tumor resection,OR=5.78,95%CI=1.45-23.08,P=0.008;received radiotherapy or chemotherapy:OR=7.69,95%CI=2.27-26.04,P<0.001).Conclusions The nutritional status of Uyghur cancer patients is worse than that of Han patients and the Uyghur patients with poor nutritional status lack the necessary nutritional support. | Xiao Ru Jiang Chun Hua Song Hong Xia Xu Jiu Wei Cui Yuan Lin Jun Qiang Chen Qing Chuan Zhao Zeng Qing Guo Kun Hua Wang Ying He Su Yi Li Hu Ma Han Ping Shi Jing Wu 无 | 2021 | Journal of Nutritional Oncology2021，6，4： | 0 |
| 14 | Comparison of Efficacy and Safety between First- and Second-Generation Drug-Eluting Stents in Patients with Acute Coronary Syndrome显示文摘 | Yuan-Liang Ma Xiao-Fang Tang Yi Yao Na Xu Ying Song Ping Jiang Jing-Jing Xu Huan-Huan Wang Lin Jiang Ru Liu Xue-Yan Zhao Jue Chen Zhan Gao Shu-Bin Qiao Yue-Jin Yang Run-Lin Gao Bo Xu Jin-Qing Yuan | 2018 | Chinese Medical Journal2018，，12： | 0 |
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