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| 1 | Isolation and initial characterization of GW5, a major QTL associated with rice grain width and weight显示文摘谷物重量是庄稼谷物产量的一个主要决定因素并且被自然地发生的量的特点 loci (QTL ) 控制。我们更早识别了控制米饭谷物宽度和重量的主要 QTL, GW5,它在米饭染色体 5 上被印射到一个再结合热点。获得 GW5 怎么控制米饭谷物宽度的更好的理解,我们进行了这个地点的好印射并且揭开在米饭栽培变种 Asominori 与增加的谷物宽度联系的 1 212-bp 删除,与苗条谷物米饭 IR24 比较。另外, 46 米饭栽培变种的 genotyping 分析表明这删除高度与谷物宽度显型被相关,建议 GW5 删除可能在米饭驯服期间被选择了。GW5 编码对原子核局部性的 144 氨基酸的新奇原子蛋白质。而且,我们证明 GW5 身体上在酵母与 polyubiquitin 交往二混血儿的试金。一起,我们的结果建议 GW5 代表主要 QTL 内在的米饭宽度和重量,并且它多半在 ubiquitin-proteasome 小径行动在种子开发期间调整房间分割。这研究提供新奇卓见进控制米饭谷物开发的分子的机制并且建议 GW5 能为庄稼的产量很高的繁殖用作一个潜在的工具。 | Jianfeng Weng Suhai Gu Xiangyuan Wan He Gao Tao Guo Ning Su Cailin Lei Xin Zhang Zhijun Cheng Xiuping Guo Jiulin Wang Ling Jiang Huqu Zhai Jianmin Wan | 2008 | Cell Research2008，18，12： | 248 |
| 2 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 3 | Re-Os isotopes and PGE geochemistry of black shales and intercalated Ni-Mo polymetallic sulfide bed from the Lower Cambrian Niutitang Formation, South China显示文摘The Lower Cambrian Niutitang Formation consists of a thick black shale sequence with a regionally distributed conformable Ni Mo polymetallic sulfide horizon and a chert bed at its basal strata on theYangtze Platform, South China. In this paper, we discuss all available data on Re Os isotopes and Platinum Group Element (PGE) distribution pattern of the Ni Mo polymetallic sulfide ore and its host rocks (black shales, cherts, and phosphorites) from Guizhou and Hunan provinces. Our results show that the black shales and the Ni Mo sulfide ore have a high initial 187 Os/ 188 Os ratio of 0.78~0.86, indicating that the Early Cambrian ocean across the Yangtze Platform had a highly radiogenic Os value. This ratio is slightly lower than but still similar to present day seawater, possibly as a result of high continental weathering at that time. The Ni Mo sulfide ore yields a Re Os isochron of 537±10 Ma (MSWD=11.9), possibly representing the depositional age of the Niutitang Formation. The chondrite normalized PGE pattern, Pt anomaly (Pt/Pt *), Pt/Pd, Ir/Pd, Au/Ir and Re/Mo ratios of the Ni Mo sulfide ore and its host rocks from South China indicate a varying source contribution of the PGE and other metals for different rocks. It is suggested that the cherts and Ni Mo sulfide ore may have a significant proportion of PGE and probably other metals deriving from submarine hydrothermal fluids with a mantle signature. | JIANG Shaoyong*, YANG Jinghong, LING Hongfei, FENG Hongzhen, CHEN Yongquan and CHEN Jianhua(State Key Laboratory for Mineral Deposits Research, Department of Earth Sciences, Nanjing University, Nanjing 210093, China) | 2003 | Progress in Natural Science:Materials International2003，13，10： | 78 |
| 4 | Effect of electro-acupuncture on substance P, its receptor and corticotropin-releasing hormone in rats with irritable bowel syndrome显示文摘AIM: To investigate the effect and mechanism of electro-acupuncture (EA) at ST25 and ST37 on irritable bowel syndrome (IBS) of rats. METHODS: A total of 21 male Sprague-Dawley rats were randomly divided into normal group, model group and EA group. A rat model of IBS was established by constraining the limbs and distending the colorectum of rats. Rats in EA group received bilateral EA at ST25 and ST37 with a sparse and intense waveform at a frequency of 2/50 Hz for 15 min, once a day for 7 d as a course. Rats in normal and model groups were stimulated by distending colorectum (CR). An abdominal withdrawal reflex (AWR) scoring system was used to evaluate improvements in visceral hypersensitivity. Toluidine blue-improved method, immunohistochemistry and radioimmunoassay were used to observe mucosal mast cells (MC), changes of substance P (SP) and substance P receptor (SPR) in colon and change of corticotropin-releasing hormone (CRH) in hypothalamus.RESULTS: The threshold of visceral sense was signif icantly lower in model group than in normal group,and significantly higher in EA group than in model group. The number of mucosal MC was greater in model group than in normal group and significantly smaller in EA group than in model group. The CRH level in hypothalamus of rats was signif icantly higher in model group than in normal group, which was remarkably decreased after electro-acupuncture treatment. The SP and SPR expression in colon of rats in model group was decreased after electro-acupuncture treatment. CONCLUSION: EA at ST25 and ST37 can decrease the number of mucosal MC and down-regulate the expression of CRH in hypothalamus, and the expression of SP and SPR in colon of rats with IBS. | Xiao-Peng Ma Lin-Ying Tan Yun Yang Huan-Gan Wu Bin Jiang Hui-Rong Liu Ling Yang | 2009 | World Journal of Gastroenterology2009，15，41： | 49 |
| 5 | A Novel QTL qTGW3 Encodes the GSK3/ SHAGGY-Like Kinase OsGSK5/OsSK41 that Interacts with OsARF4 to Negatively Regulate Grain Size and Weight in Rice显示文摘谷物尺寸和形状在米饭是谷物重量和产量的重要决定因素。这里,我们报导一个新主要量的特点在米饭的地点(QTL ) , qTGW3,那种控制谷物尺寸和重量。这个地点, qTGW3,编码 OsSK41 (也作为 OsGSK5 知道) , GLYCOGEN SYNTHASE KINASE 3/SHAGGY-like 家庭的一个成员。带 OsSK41 的 loss-of-function 等位基因的瑞斯 near-isogenic 线增加了谷物长度和重量。我们证明那 OsSK41 交往与并且 phosphorylates 植物生长素反应因素 4 (OsARF4 ) 。有 OsARF4 的 OsSK41 的合作表示在米饭原物增加 OsARF4 的累积。OsARF4 的功能的损失导致更大的米饭谷物。定序 RNA 分析建议 OsARF4 和 OsSK41 镇压下游的基因的一个普通集合的表示, ? 包括一些植物生长素应答的基因,在米饭谷物开发期间。在 qTGW3 的 OsSK41 的 loss-of-function 形式代表没被指向的基因编辑或 QTL 节节上升广泛地在 OsSK41 功能的米饭 breeding.?Suppression 利用了的稀罕等位基因提高米饭谷物尺寸和重量。因此,我们的学习在米饭谷物开发揭示 OsSK41 的重要角色 ?? 并且在另外的谷物庄稼在米饭并且也许为谷物产量的基因改进提供新候选人基因。 | Zejun Hu Sun-Jie Lu Mei-Jing Wang Haohua He Le Sun Hongru Wang Xue-Huan Liu Ling Jiang Jing-Liang sun Xiaoyun Xin Wei Kong Chengcai Chu Hong-Wei Xue Jinshui Yang Xiaojin Luo Jian-Xiang Liu | 2018 | Molecular Plant2018，11，5： | 47 |
| 6 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 7 | Effect of intracoronary administration of anisodamine on slow reflow phenomenon following primary percutaneous coronary intervention in patients with acute myocardial infarction显示文摘许多基本、临床的研究证明了那 anisodamine 的背景能在减轻 microvascular 痉挛上生产重要效果,改进并且挖出冠的 microcirculation。它可能对为尖锐心肌的梗塞( AMI )跟随经皮的冠的干预(一种总线标准)的慢回流现象( SRP )的改进有益我们调查了的 .So 梗塞的 SRP 上的 anisodamine 的 intracoronary 管理的效果联系了在病人跟随主要一种总线标准,圣片断提高了的动脉( IRA )尖锐心肌的梗塞( STEAMI ) .Methods 有从 148 个 STEAMI 病人的一个总数的 SRP 的 21 个病人相信主要一种总线标准从9月被注册进这研究当 SRP 发生了时,硝化甘油(200 g ) 是“大丸药”第一注入了 IRA 排除 epicardial 动脉的痉挛并且识别 SRP 以及一个基线和克制代理人追随者一种总线标准。十分钟以后,当冠的 angiography (CAG ) 被拿在前并且在时, anisodamine 的 1000 g 在 200 g/s 与 SRP 被注入 IRA 第一,第 10 分别地在硝化甘油或 anisodamine 的管理以后纪录的第三 and。改正的 TIMI 框架计数(cTFC ) , TIMI 心肌的灌注等级(TMPG ) 和 IRA 的直径被吉布森的 TIMI 框架计数方法用量的计算机 angiography (QCA ) 计算并且分析在冠的流动和容器腔上评估 anisodamine 的影响的系统。同时, intracoronary 和全身的动脉和心电图(ECG )( 收缩、心脏舒张、吝啬的压力) 的侵略血液动力学的参数被测量并且监视。室的性能参数和不利反应的变化被评估并且在在 cTFCs 和 TMPG 的重要变化都没被发现在的 1 月 post-PCI.Results 跟随起来第一,第 10 作为与基线控制(P0.05 ) 相比在硝化甘油的 intracoronary 管理以后纪录的第三 and。cTFCs 被 58.3% , 56.2% ,和 54.6% 减少,分别地(P0.001 ) ,并且 TMPG 从 1.13 被增加 ??????????? 呃 ???????? 偓 ?? 吗? | FU Xiang-hua FAN Wei-ze GU Xin-shun WEI Yong-yun JIANG Yun-fa WU Wei-li LI Shi-qiang HAO Guo-zhen WEI Qing-min XUE Ling | 2007 | Chinese Medical Journal2007，，14： | 37 |
| 8 | Sr-Nd isotopic compositions of the Changjiang sediments: Implications for tracing sediment sources显示文摘The suspended particulate and fine-grained floodplain sediments were collected from the main stream and tributaries of the Changjiang River for Sr-Nd isotopic measurements. The εNd(0) values gradually decrease downstream from -10.8 on average in the upper reaches to -12.3 in the lower reaches, whereas the 87Sr/86Sr ratios increase correspondingly, averaging 0.721899 and 0.725826 respectively in the upper and middle-lower reaches. The compositional variations primarily reflect the complex con- trols of provenance rocks, chemical weathering, and sediment characters between different catchments, among which the abnormal Sr-Nd isotopic compositions of the Yalong, Fujiang, Tuojiang and Yuanjiang rivers indicate the sediment provenance contributions from the Emeishan Basalt in the upper reaches and the old metamorphic and siliceous rocks in the middle-lower reaches. The Sr-Nd isotopic ratios of the Changjiang sediments can better reflect the average composition of weathered continental crust compared to other major rivers in the world because of the unique source rock types in the Changjiang drainage basin. The recognition of the Sr-Nd isotopic systematics of the Changjiang sediments will contribute to our understanding of the Changjiang evolution history and continental weathering processes during the Cenozoic, and also to reconstructing the paleoenvironmental changes in East China and the marginal seas. | YANG ShouYe1?, JIANG ShaoYong2, LING HongFei2, XIA XiaoPing3, SUN Min3 & WANG DeJie4 1 State Key Laboratory of Marine Geology, Tongji University, Shanghai 200092, China 2 State Key Laboratory for Mineral Deposit Research, Nanjing University, Nanjing 210093, China 3 Departmen of Earth Sciences, The University of Hong Kong, Hong Kong SAR, China 4 Development Research Center, China Geological Survey, Beijing 100083, China | 2007 | Science China Earth Sciences2007，50，10： | 32 |
| 9 | Identification of a Stable Quantitative Trait Locus for Percentage Grains with White Chalkiness in Rice (Oryza sativa)显示文摘High chalkiness is a major problem in many rice-producing areas of the world, especially in hybrid rice (Oryza sativa L.) in China. We previously showed a major quantitative trait locus for the percentage of grains with white chalkiness (QTLqPGWC-8) in the interval G1149-R727 on chromosome 8 using a chromosome segment substitution line (CSSL). Here, we selected the line-CSSL50 harboring the QTLqPGWC-8 allele from the CSSLs derived from a cross between Asominori (as a recurrent parent) and IR24 (as a donor parent), which had higher percentage chalkiness, markedly different from that of Asominori. There were also significant differences in starch granules, appearance of amylose content (AAC) and milling qualities between Asominori and CSSL50, but not in grain size or thousand grain weight (TGW). The BC4F2 and BC4F3 populations from a cross between CSSL50 and Asominori were used for fine mapping of qPGWC-8. We narrowed down the location of this QTL to a 142 kb region between Indel markers 8G-7 and 8G-9. QTLqPGWC-8 accounted for 50.9% of the difference in PGWC between the parents. The markers tightly linked to qPGWC-8 should facilitate cloning of the gene underlying this QTL and will be of value for marker-assisted selection in breeding rice varieties with better grain quality. | Tao Guo Xiaolu Liu Xiangyuan Wan Jianfeng Weng Shijia Liu Xi Liu Mingjiang Chen Jingjing Li Ning Su Fuqing Wu Zhijun Cheng Xiuping Guo Cailin Lei Jiulin Wang Ling jiang Jianmin Wan | 2011 | Journal of Integrative Plant Biology2011，53，8： | 25 |
| 10 | Evaluating the Phylogenetic Position of Chinese Tree Shrew(Tupaia belangeri chinensis) Based on Complete Mitochondrial Genome:Implication for Using Tree Shrew as an Alternative Experimental Animal to Primates in Biomedical Research显示文摘Tree shrew(Tupaia belangeri) is currently placed in Order Scandentia and has a wide distribution in Southeast Asia and Southwest China.Due to its unique characteristics,such as small body size,high brain-to-body mass ratio,short reproductive cycle and life span,and low-cost of maintenance,tree shrew has been proposed to be an alternative experimental animal to primates in biomedical research.However,there are some debates regarding the exact phylogenetic affinity of tree shrew to primates.In this study,we determined the mtDNA entire genomes of three Chinese tree shrews(T.belangeri chinensis) and one Malayan flying lemur(Galeopterus variegatus).Combined with the published data for species in Euarchonta,we intended to discern the phylogenetic relationship among representative species of Dermoptera,Scandentia and Primates.The mtDNA genomes of Chinese tree shrews and Malayan flying lemur shared similar gene organization and structure with those of other mammals.Phylogenetic analysis based on 12 concatenated mitochondrial proteinencoding genes revealed a closer relationship between species of Scandentia and Glires,whereas species of Dermoptera were clustered with Primates.This pattern was consistent with previously reported phylogeny based on mtDNA data,but differed from the one reconstructed on the basis of nuclear genes.Our result suggested that the matrilineal affinity of tree shrew to primates may not be as close as we had thought.The ongoing project for sequencing the entire genome of Chinese tree shrew will provide more information to clarify this important issue. | Ling Xu Shi-Yi Chen Wen-Hui Nie Xue-Long Jiang Yong-Gang Yao | 2012 | Journal of Genetics and Genomics2012，39，3： | 25 |
| 11 | Effects of dietary Clostridium butyricum supplementation on growth performance,intestinal development,and immune response of weaned piglets challenged with lipopolysaccharide显示文摘Background: Weanling pigs, with immature immune system and physiological function, usually experience postweaning diarrhea. This study determined the effects of dietary Clostridium butyricum supplementation on growth performance, diarrhea, and immunity of weaned pigs challenged with lipopolysaccharide(LPS).Methods: In Experiment(Exp.) 1,144 weaned piglets were weaned at 21 d and randomly assigned to six groups,with six replicates per group and four pigs per replicate, receiving a control diet(CON) or diet supplemented with antibiotics(AB) or C. butyricum(CB)(0.1%, 0.2%, 0.4%, or 0.8%), respectively. All diets in Exp. 1 were a highly digestible basal diet, with 3,000 mg/kg zinc oxide supplied in the first 2 wk only. In Exp. 2, 180 piglets were weaned at 21 d and randomly assigned to five groups, with six replicates per group and six pigs per replicate, receiving CON, AB, or CB(0.2%, 0.4%, or 0.6%) diets. The digestibility of diets was lower than those in Exp. 1, and did not include zinc oxide. At 36 d of Exp. 2, 12 piglets were selected from each of the CON and 0.4% CB groups, six piglets were intraperitoneally injected with LPS(50 μg/kg body weight) and the other six piglets with normal saline;animals were killed at 4 h after injection to collect blood, intestine, and digesta samples for biochemical analysis.Results: In Exp. 1, CB and AB diets had no effect on growth performance of piglets. In Exp. 2, 0.4% CB decreased feed-gain ratio(P < 0.1), diarrhea score(P < 0.05), and increased duodenal, jejunal, and ileal villus height and jejunal villus height/crypt depth(P < 0.05). The 0.4% CB decreased the plasma tumor necrosis factor(TNF) α(P < 0.05) but increased ileal mucosa IL-10 and TLR2 mRNA expression(P < 0.05). Furthermore, 0.4% CB altered the microbial profile, with Bacillus and Ruminococcaceae UGG-003 at genus level and Lactobacillus casei and Parasutterella secunda at species level were higher than CON in colonic content(P < 0.05).Conclusions: Dietary C. butyricum supplementation had positive effects on growth of weaned piglets with less digestible diets. There was a tendency to reduce the feed-gain ratio, which could reduce feed costs in pig production. Moreover, C. butyricum decreased post-weaning diarrhea by improving the intestinal morphology,intestinal microflora profile, and immune function. | Ling Chen Shuang Li Jie Zheng Wentao Li Xuemei Jiang Xilun Zhao Jian Li Lianqiang Che Yan Lin Shengyu Xu Bin Feng Zhengfeng Fang De Wu | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 26 |
| 12 | Hf isotopic composition of zircons from the Huashan-Guposhan intrusive complex and their mafic enclaves in northeastern Guangxi:Implication for petrogenesis显示文摘High precision zircon U-Pb dating indicates that main intrusive bodies (Tong'an,Niumiao,Huashan,Lisong),and a mafic microgranular enclave in the Huashan-Guposhan complex were formed at 160-163 Ma.The εHf(t) values of zircons from the Huashan granite vary from -2.8 to +0.3 and those from the Lisong granite vary from -2.3 to +0.3,which are obviously different with those values (+2.6 to +7.4) of the mafic enclaves from the Lisong granite.These Hf isotopic data indicate that the mafic enclaves and host granites were crystallized from different sources of magmas,providing evidence for mafic-felsic magma mixing processes.The highest εHf(t) value of zircons from the mafic enclaves is up to +7.4,indicating that the mafic magma was originated from a relatively depleted mantle source.Studies on regional geology and the contemporaneous mafic and alkaline rocks in this area indicate that the mafic magma was not originated from reworking of basaltic juvenile crust,but from partial melting of the mantle.However,it remains to be resolved whether the mafic magma was derived from partial melting of the asthenosphere or the lithospheric mantle.The Huashan granite and the Lisong granite were formed from hybrid magma of mantle-derived and crust-derived magmas,and the mafic enclaves are considered as remains of mantle-derived magma during mixing processes.The εHf(t) values of zircons from the Niumiao diorite vary from -1.1 to +2.1,and those from the Tong'an quartz monzonite vary from -1.7 to +1.7.These values are lower than those from the mafic enclaves,suggesting that the diorite and monzonite were formed from different source-derived magmas with the mafic enclaves.The εHf(t) values for the Niumiao diorite and the Tong'an monzonite are only slightly higher than those for the Hushan granite and the Lisong granite.Abundant mafic enclaves also occur in the Niumiao diorite and in the Tong'an monzonite.Thus,we suggest that the Niumiao diorite and the Tong'an monzonite were probably also formed from the same hybrid magma as the granites but come through less degree of fractional crystallization and crustal contamination.The strong mantle-derived and crust-derived magma mixing caused by an intense crustal extension and thinning in the Mid-Late Jurassic may be the major mechanism for generating the diorites and granites in southeastern Hunan and northeastern Guangxi belt in South China. | ZHAO KuiDong JIANG ShaoYong ZHU JinChu LI Liang DAI BaoZhang JIANG YaoHui LING HongFei | 2010 | Chinese Science Bulletin2010，55，6： | 24 |
| 13 | SHRIMP U-Pb zircon dating for lamprophyre from Liaodong Peninsula: Constraints on the initial time of Mesozoic lithosphere thinning beneath eastern China显示文摘It is undebated fact that the lithospheric mantle beneath eastern China was considerably thinned during the Mesozoic time. However, it has no adequate evidence for the exact timing when the lithosphere thinning started. The Liaodong Peninsula is located in the eastern segment of the North China Craton and is one of the important domains to explore the event of lithosphere thinning. SHRIMP U-Pb zircon dating and geochemical study were carried out for the lamprophyre dike swarm that intruded into the magnesite ore-beds in the Dashiqiao Formation of Paleoproterozoic Liaohe Group at the Huaziyu magnesite ore district, Liaodong Peninsula. The results indicate that these lampro- phyre dikes were intruded in late Jurassic (155±4 Ma) and show some geochemical characteristics of potassic magmas. It is now accepted that the lithosphere thinning took place in the late Mesozoic, and the peak thinning stage occurred in early Cretaceous (130―120 Ma). Considering the potassic mafic magmatism marking the onset of the lithospheric thin- ning, we therefore suggest that the studied late Jurassic potassic lamprophyre dike swarm could imply that the late Jurassic is the time that lithosphere thinning started. | JIANG Yaohui JIANG Shaoyong ZHAO Kuidong NI Pei LING Hongfei LIU Dunyi | 2005 | Chinese Science Bulletin2005，50，22： | 22 |
| 14 | Cloud point extraction coupled with HPLC-UV for the determination of phthalate esters in environmental water samples显示文摘A method based on cloud point extraction was developed to determine phthalate esters including di-ethyl-phthalate (DEP), di-(2-ethylhexyl)-phthalate (DEHP) and di-cyclohexyl-phthalate (DCP) in environmental water samples using high-performance liquid chromatography separation and ultraviolet detection (HPLC-UV). The non-ionic surfactant Triton X-114 was chosen as extraction solvent. The parameters affecting extraction effciency, such as concentrations of Triton X-114 and Na2SO4, equilibration temperature, equilibration time and centrifugation time were evaluated and optimized. Under the optimum conditions, the method can achieve preconcentration factors of 35, 88, 111 and detection of limits of 2.0, 3.8, 1.0 ngml for DEP, DEHP and DCP in 10-ml water sample, respectively. The proposed method was successfully applied to the determination of trace amount of phathalate esters in effuent water of the wastewater treatment plant and the lixivium of plastic fragments. | WANG Ling JIANG Gui-bin CAI Ya-qi HE Bin WANG Ya-wei SHEN Da-zhong | 2007 | Journal of Environmental Sciences2007，19，7： | 23 |
| 15 | Dynamic Prediction Method of Production Logistics Bottleneck Based on Bottleneck Index显示文摘In modern manufacturing pattern,there are many uncertain factors in the modern manufacturing process,such as changes of product attribute,changes of manufacturing resources' state,and so on,which cause production logistics bottleneck frequently shift,and make decisions of production planning and control based on formed bottleneck deviated from practical production process.Considering these factors,present researches mainly apply afterwards control to optimize production process to passively adapt to bottleneck changes.If the direction of bottleneck shifting can be accurately forecasted,the transition from afterwards control of chasing bottleneck to beforehand control can be realized.Therefore,aiming at the phenomenon of production logistics bottleneck shifting under uncertain manufacturing circumstances,this paper starts off with dynamic property of capability and requirement and then builds the concepts of bottleneck degree and bottleneck index to describe dynamic bottleneck characteristic of production unit;taken production capability,production load and quality assurance capability into consideration,mathematical model of bottleneck index is established to measure bottleneck degree accurately,consequently,quantitative research on mechanism of production logistics shifting is achieved.Based on bottleneck index,the prediction model of production logistics bottleneck is founded to predict dynamic change of bottleneck accurately.Finally,an example of forecasting and monitoring the production logistics bottleneck in one manufacturing shop is given to testify the validation and practicability of the prediction method. | LIU Mingzhou TANG Juan GE Maogen JIANG Zengqiang HU Jing LING Lin | 2009 | Chinese Journal of Mechanical Engineering2009，22，5： | 22 |
| 16 | Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study显示文摘Background and purpose COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2).Apart from respiratory complications,acute cerebrovascular disease(CVD)has been observed in some patients with COVID-19.Therefore,we described the clinical characteristics,laboratory features,treatment and outcomes of CVD complicating SARS-CoV-2 infection.Materials and methods Demographic and clinical characteristics,laboratory findings,treatments and clinical outcomes were collected and analysed.Clinical characteristics and laboratory findings of patients with COVID-19 with or without new-onset CVD were compared.Results Of 219 patients with COVID-19,10(4.6%)developed acute ischaemic stroke and 1(0.5%)had intracerebral haemorrhage.COVID-19 with new onset of CVD were significantly older(75.7±10.8 years vs 52.1±15.3 years,p<0.001),more likely to present with severe COVID-19(81.8%vs 39.9%,p<0.01)and were more likely to have cardiovascular risk factors,including hypertension,diabetes and medical history of CVD(all p<0.05).In addition,they were more likely to have increased inflammatory response and hypercoagulable state as reflected in C reactive protein(51.1(1.3-127.9)vs 12.1(0.1-212.0)mg/L,p<0.05)and D-dimer(6.9(0.3-20.0)vs 0.5(0.1-20.0)mg/L,p<0.001).Of 10 patients with ischemic stroke;6 received antiplatelet treatment with aspirin or clopidogrel;and 3 of them died.The other four patients received anticoagulant treatment with enoxaparin and 2 of them died.As of 24 March 2020,six patients with CVD died(54.5%).Conclusion Acute CVD is not uncommon in COVID-19.Our findings suggest that older patients with risk factors are more likely to develop CVD.The development of CVD is an important negative prognostic factor which requires further study to identify optimal management strategy to combat the COVID-19 outbreak. | Yanan Li Man Li Mengdie Wang Yifan Zhou Jiang Chang Ying Xian David Wang Ling Mao Huijuan Jin Bo Hu | 2020 | Stroke & Vascular Neurology2020，5，3： | 22 |
| 17 | Isolation and characterization of dengue virus serotype 2 from the large dengue outbreak in Guangdong, China in 2014显示文摘Dengue has been well recognized as a global public health threat,but only sporadic epidemics and imported cases were reported in recent decades in China.Since July 2014,an unexpected large dengue outbreak has occurred in Guangdong province,China,resulting in more than 40000 patients including six deaths.To clarify and characterize the causative agent of this outbreak,the acute phase serum from a patient diagnosed with severe dengue was subjected to virus isolation and high-throughput sequencing(HTS).Traditional real-time RT-PCR and HTS with Ion Torrent PGM detected the presence of dengue virus serotype 2(DENV-2).A clinical DENV-2 isolate GZ05/2014 was obtained by culturing the patient serum in mosquito C6/36 cells.The complete genome of GZ05/2014 was determined and deposited in Gen Bank under the access number KP012546.Phylogenetic analysis based on the complete envelope gene showed that the newly DENV-2 isolate belonged to Cosmopolitan genotype and clustered closely with other Guangdong strains isolated in the past decade.No amino acid mutations that are obviously known to increase virulence or replication were identified throughout the genome of GZ05/2014.The high homology of Guangdong DENV-2 strains indicated the possibility of establishment of local DENV-2 circulation in Guangdong,China.These results help clarify the origin of this epidemic and predict the future status of dengue in China. | ZHAO Hui ZHAO Ling Zhai JIANG Tao LI Xiao Feng FAN Hang HONG Wen Xin ZHANG Yu ZHU Qin YE Qing TONG Yi Gang CAO Wu Chun ZHANG Fu Chun QIN Cheng Feng | 2014 | Science China(Life Sciences)2014，57，12： | 21 |
| 18 | Lithofacies and sedimentary characteristics of the Silurian Longmaxi Shale in the southeastern Sichuan Basin,China显示文摘The Silurian Longmaxi Shale (SLS) is the target for shale gas exploration and exploitation in the southeastern Sichuan Basin.Based on detailed description of cores and outcrops,analysis of Gamma Ray (GR) logs,thin sections and mineralogical data,the SLS can be subdivided into six lithofacies:(1) clayey shale,(2) siliceous calcareous shale,(3) siliceous dolomitic shale,(4) silty-clayey interlaminated shale,(5) muddy siltstone,and (6) graptolite shale.Three facies associations are recognized in the study area,i.e.,inner shelf,outer shelf,and bathyal plain (including turbidite) facies.Outer shelf and bathyal plain facies dominate the lower interval of the SLS,while inner shelf facies dominates the upper part of the SLS.The thickness of the black shale in the northern part of the study area is the greatest,where siliceous calcareous shale,siliceous dolomitic shale,and graptolite shale are predominant.These three kinds of shale are rich in total organic carbon (TOC) content and brittle minerals,which is favourable for the accumulation of shale gas and its future exploitation. | Jiang Zaixing Guo Ling Liang Chao | 2013 | Journal of Palaeogeography2013，2，3： | 21 |
| 19 | Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease显示文摘Diabetic kidney disease(DKD)is one of the microvascular complications of diabetes mellitus and a major cause of end-stage renal disease with limited treatment options.Wogonin is a flavonoid derived from the root of Scutellaria baicalensis Georgi,which has shown a potent renoprotective effect.But the mechanisms of action in DKD are not fully elucidated.In this study,we investigated the effects of wogonin on glomerular podocytes in DKD using mouse podocyte clone 5(MPC5)cells and diabetic mice model.MPC5 cells were treated with high glucose(30 mM).We showed that wogonin(4,8,16μM)dose-dependently alleviated high glucose(HG)-induced MPC5 cell damage,accompanied by increased expression of WT-1,nephrin,and podocin proteins,and decreased expression of TNF-α,MCP-1,IL-1βas well as phosphorylated p65.Furthermore,wogonin treatment significantly inhibited HG-induced apoptosis in MPC5 cells.Wogonin reversed HG-suppressed autophagy in MPC5 cells,evidenced by increased ATG7,LC3-II,and Beclin-1 protein,and decreased p62 protein.We demonstrated that wogonin directly bound to Bcl-2 in MPC5 cells.In HG-treated MPC5 cells,knockdown of Bcl-2 abolished the beneficial effects of wogonin,whereas overexpression of Bcl-2 mimicked the protective effects of wogonin.Interestingly,we found that the expression of Bcl-2 was significantly decreased in biopsy renal tissue of diabetic nephropathy patients.In vivo experiments were conducted in STZ-induced diabetic mice,which were administered wogonin(10,20,40 mg·kg^(−1)·d^(−1),i.g.)every other day for 12 weeks.We showed that wogonin administration significantly alleviated albuminuria,histopathological lesions,and p65 NF-κB-mediated renal inflammatory response.Wogonin administration dose-dependently inhibited podocyte apoptosis and promoted podocyte autophagy in STZ-induced diabetic mice.This study for the first time demonstrates a novel action of wogonin in mitigating glomerulopathy and podocytes injury by regulating Bcl-2-mediated crosstalk between autophagy and apoptosis.Wogonin may be a potential therapeutic drug against DKD. | Xue-qi Liu Ling Jiang Yuan-yuan Li Yue-bo Huang Xue-ru Hu Wei Zhu Xian Wang Yong-gui Wu Xiao-ming Meng Xiang-ming Qi | 2022 | Acta Pharmacologica Sinica2022，43，1： | 20 |
| 20 | Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer显示文摘渗入肿瘤的 Tregs 的起源,肿瘤免疫力的抑制的批评调停人,是不清楚的。这里,,我们证明在人的乳癌的渗入肿瘤的天真的 CD4 + T 房间和 Tregs 有重叠 TCR 全部剧目几乎别与传播 Tregs 重叠,建议 intratumoral Tregs 主要在 situ 而非从招募的 Tregs 从天真的 T 房间发展。而且,许多天真的 CD4 + T 房间和 Tregs 密切被相关,两个显示的穷人为乳癌病人的预后。天真的 CD4 + T 房间与许多生产 CCL18 巨噬细胞成比例遵守肿瘤片。而且,采纳地转移的人的天真的 CD4 + T 房间以一种 CCL18 依赖的方式渗入人的乳癌 orthotopic 异种皮移植。在在人性化的鼠标的人的乳癌异种皮移植,由将 PITPNM3 的表达式击倒堵住天真的 CD4 + T 房间的招募进肿瘤, CCL18 受体,显著地减少 intratumoral Tregs 并且禁止肿瘤前进。这些调查结果建议那个乳房渗入肿瘤的 Tregs 从在 situ 区分进 Tregs 的传播天真的 CD4 + T 房间的趋化性产生。由防碍 CCL18 的 PITPNM3 识别禁止天真的 CD4 + T 房间招募进肿瘤可以是为 anticancer 免疫疗法的吸引人的策略。 | Shicheng Su Jianyou Liao Jiang Liu Di Huang Chonghua He Fei Chen LinBing Yang Wei Wu Jianing Chen Ling Lin Yunjie Zeng Nengtai Ouyang Xiuying Cui Herui Yao Fengxi Su Jian-dong Huang Judy Lieberman Qiang Liu Erwei Song | 2017 | Cell Research2017，27，4： | 19 |
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