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| 1 | Clinical utility of Epstein-Barr virus DNA and other liquid biopsy markers in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor ubiquitously associated with the Epstein-Barr virus(EBV),which is highly prevalent in South China,Southeast Asia,and North Africa.Despite being a highly radio-sensitive and treatable cancer,a majority of NPC patients are diagnosed in their advanced stage,and locoregional and distant relapses following definitive treatment contribute largely to cancer-specific mortality among these patients.Given that EBV-driven NPC is the predominant variant seen in endemic regions,various EBV detection methods have been developed and are utilized in screening,prognostication,and post-treatment surveillance of NPC patients.While the Immunoglobulin A(IgA)serology assay is the most extensively studied EBV detection method,the detection of plasma EBV DNA released during replication or cellular apoptosis has shown superior outcomes in endemic population screening,prognostication,and detection of distant relapse.Furthermore,there is emerging evidence on the use of circulating tumor cells,microRNAs,DNA hypermethylation,and combination assays in various clinical scenarios.Herein,this paper provides a comprehensive overview of the relevant studies using various EBV detection techniques in the management of NPC.Specifically,the recent advances,clinical evidence,and challenges associated with the clinical application of EBV liquid biopsies in population screening,prognostication,and surveillance of NPC are presented. | Rong Tan Sean Kean Ann Phua Yoke Lim Soong Lynette Lin Ean Oon Kian Sing Chan Sasidharan Swarnalatha Lucky Jamie Mong Min Han Tan Chwee Ming Lim | 2020 | Cancer Communications2020,40,11: | 8 |
| 2 | Review of imaging and endovascular intervention of iliocaval venous compression syndrome显示文摘Iliocaval venous compression syndrome(ICS)is the extrinsic compression of the common iliac vein by the overlying iliac artery against the vertebra.Chronic compression can lead to venous stenosis and stasis,which manifests as chronic venous disease and treatment resistance.Therefore,early recognition of ICS and prompt treatment are essential.Clinical presentations of ICS can be ambiguous and diagnosis requires a high index of suspicion with the relevant imaging studies.The initial imaging test is typically a Duplex ultrasound for vessel assessment and pelvic ultrasound to exclude a compressive mass,which is followed by computed tomography(CT)or magnetic resonance(MR)venography.CT and MRI can identify the anatomical causes for venous compression.In patients with high clinical suspicion for ICS,negative findings on CT and MR venography would still warrant further investigations.Definitive diagnosis can be established using catheter-based venography complemented with intravascular ultrasonography but the nature of their invasiveness limits its utility as a routine imaging modality.In this review paper,we will discuss the evidence,utility and limitations of the existing imaging modalities and endovascular intervention used in the management of ICS. | Ming Ren Toh Tjun Yip Tang Han Hui Mervin Nathan Lim Nanda Venkatanarasimha Karthikeyan Damodharan | 2020 | World Journal of Radiology2020,12,3: | 4 |
| 3 | Static coarsening behaviour of lamellar microstructure in selective laser melted Ti–6Al–4V显示文摘Static coarsening mechanism of selective laser melted(SLMed) Ti–6Al–4V with a lamellar microstructure was established at temperatures from 700℃ to 950℃. Microstructure evolution revealed that high heat treatment temperature facilitated martensite decomposition and promoted lamellae growth. At each temperature, the growth rate decreased with increasing holding time. The static coarsening behaviour of SLMed Ti–6Al–4V can be interpreted by Lifshitz, Slyozov, and Wagner(LSW) theory. The coarsening coefficient were 0.33, 0.33–0.4, 0.4–0.5 for 700–800℃, 900℃ and 950℃, respectively. This indicated the coarsening mechanism was bulk diffusion at 700–800℃, and a combination of bulk diffusion and interface reaction at 900℃ and 950℃ conditions. | Sheng Cao Qiaodan Hu Aijun Huang Zhuoer Chen Ming Sun Jiahua Zhang Chenxi Fu Qingbo Jia Chao Voon Samuel Lim Rodney R.Boyer Yi Yang Xinhua Wu | 2019 | Journal of Materials Science & Technology2019,35,8: | 3 |
| 4 | Long-Range Balanced Electron- and Hole-Transport Lengths in Organic-Inorganic CH3NH3PbI3显示文摘 | Guichuan Xing Nripan Mathews Shuangyong Sun Swee Sien Lim Yeng Ming Lam Michael Gr?tzel Subodh Mhaisalkar Tze Chien Sum | 2013 | 2013 (6156)2013,,6156: | 3 |
| 5 | An Enhanced Direct Anonymous Attestation Scheme with Mutual Authentication for Network-Connected UAV Communication Systems显示文摘In network-connected UAV(NCUAV) communication systems, user authentication is replaced by platform identity authentication and integrity check because many NC-UAVs are operated without human intervention. Direct anonymous attestation(DAA) is an attractive cryptographic scheme that provides an elegant balance between platform authentication and anonymity. However, because of the low-level computing capability and limited transmission bandwidth in UAV, the existing DAA schemes are not suitable for NC-UAV communication systems. In this paper, we propose an enhanced DAA scheme with mutual authentication(MA-DAA scheme), which meets the security requirements of NC-UAV communication systems. The proposed MA-DAA scheme, which is based on asymmetric pairings, bundles the identities of trusted platform module(TPM) and Host to solve the malicious module changing attacks. Credential randomization, batch proof and verification, and mutual authentication are realized in the MA-DAA scheme. The computational workload in TPM and Host is reduced in order to meet the low computation and resource requirements in TPM and Host.The entire scheme and protocols are presented,and the security and efficiency of the proposed MA-DAA scheme are proved and analyzed.Our experiment results also confirm the high efficiency of the proposed scheme. | Liquan Chen Sijie Qian Ming Lim Shihui Wang | 2018 | China Communications2018,15,5: | 2 |
| 6 | Functional micro‐concrete 3D hybrid structures f abricated by two‐photon polymerization显示文摘Arbitrary micro-scale three-dimensional(3D)structures fabrication is a dream to achieve many exciting goals that have been pursued for a long time.Among all these applications,the direct 3D printing to fabricate human organs and integrated photonic circuits are extraordinary attractive as they can promote the current technology to a new level.Among all the 3D printing methods available,two-photon polymerization(2PP)is very competitive as it is the unique method to achieve sub-micron resolution to make any desired tiny structures.For the conventional 2PP,the building block is the photoresist.However,the requirement for the building block is different for different purposes.It is very necessary to investigate and improve the photoresist properties according to different requirements.In this paper,we presented one hybrid method to modify the mechanical strength and light trapping efficiency of the photoresist,which transfers the photoresist into the micro-concretes.The micro-concrete structure can achieve±22%strength modification via a silica nano-particles doping.The structures doped with gold nano-particles show tunable plasmonic absorption.Dye doped hybrid structure shows great potential to fabricate 3D micro-chip laser. | Yang Li Lianwei Chen Fang Kong Zuyong Wang Ming Dao Chwee Teck Lim Fengping Li Minghui Hong | 2017 | 光电工程2017,44,4: | 2 |
| 7 | A pilot study of lens extraction in the management of acute primary angle-closure glaucoma显示文摘 | Ming Zhi Z Lim AS Yin Wong T | | 0,,04: | 1 |
| 8 | A pilot study ;of lens extrac- tion in the management of acute primary angle-closure glaucoma显示文摘 | Ming Zhi Z Lim AS Yin Wang T | 2003 | Am J Ophthalmol2003,135,4: | 1 |
| 9 | TLR3 agonists improve the immunostimulatory potential of cetuximab against EGFR+ head and neck cancer cells显示文摘 | Ming Lim C Stephenson R Salazar AM | | 0,,6: | 1 |
| 10 | Self- cali- bration of three-legged modular reconfigurable parallel robots based on leg-end distance errors 显示文摘 | Yang Guilin Chen I Ming Lim Wee Kiat | 2001 | Robotica2001,19,2: | 1 |
| 11 | Optimization of cold-formed steel portal frame topography using real-coded genetic algorithm显示文摘 | PHAN D T LIM J B P MING C S Y | 2011 | Procedia Engineering2011,,14: | 1 |
| 12 | Early hemofiltration improves survival in post-cardiotomy patients with acute renal failure显示文摘 | Maqsood M. Elahi Ming Yann Lim Robin N. Joseph Ramana Rao V. Dhannapuneni Tomasz J. Spyt | 2004 | European Journal of Cardio-Thoracic Surgery2004,,5: | 1 |
| 13 | In vitro degradation behavior of M1A magnesium alloy in protein-containing simulated body fluid显示文摘 | Yongsheng Wang Chu Sing Lim Chao Voon Lim Ming Shyan Yong Eng Kiong Teo Law Ngai Moh | 2010 | Materials Science & Engineering C2010,,3: | 1 |
| 14 | Feasibility, cost-effectiveness and patients' acceptance of point-of-care INR testing in a hospital-based anticoagulation clicic显示文摘 | Ming Chai Kong Teong Guan Lim Heng Joo Ng Yiong Huak Chan Lai Heng Lee | 2008 | Ann Hematol2008,,87: | 1 |
| 15 | Usefulness of pulsed arterial spin labeling MR imaging in mesial temporal lobe epilepsy显示文摘 | Young-Min Lim Yong-Won Cho Sadat Shamim Jeffrey Solomon Rasmus Birn Wen Ming Luh William D. Gaillard Eva K. Ritzl William H. Theodore | 2008 | Epilepsy Research2008,,2: | 1 |
| 16 | Laser cladding of nickelbased hardfacing alloys显示文摘 | LIM L C CHEN Z D | 1998 | Surface and Coatings Technology1998,106,: | 1 |
| 17 | Effects of habitat disturbance on mixed species bird flocks in a tropical sub-montane rainforest显示文摘 | Tien Ming Lee Malcolm C.K. Soh Navjot Sodhi Lian Pin Koh Susan L.-H. Lim | 2004 | Biological Conservation2004,,: | 1 |
| 18 | A pilot study of lens extraction in the management of acute primary angle-closure glaucoma 显示文摘 | Ming Zhi Z Lim AS Yin WT | 2003 | Am J Ophthalmol2003,135,4: | 1 |
| 19 | A pilot study of lens extractionin the management of acute primary angle-closure glaucoma显示文摘 | Ming Zhi Z Lim AS Yin Wong T | 2003 | Am J Ophthalmol2003,135,4: | 1 |
| 20 | Behavioral models of managerial decision-making显示文摘 | Avi Goldfarb Teck-Hua Ho Wilfred Amaldoss Alexander Brown Yan Chen Tony Cui Alberto Galasso Tanjim Hossain Ming Hsu Noah Lim Mo Xiao Botao Yang | 2012 | Marketing Letters2012,,2: | 1 |