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| 1 | Climate change regionalization in China(1961–2010)显示文摘Since climatic condition is the important foundation for human subsistence and development and the key factor in sustainable development of economy and society, climate change has been a global issue attracting great attentions of politicians, scientists, governments, and the public alike throughout the world. Existing climate regionalization in China aims to characterize the regional differences in climate based on years of the mean value of different climate indexes. However, with the accelerating climate change nowadays, existing climate regionalization cannot represent the regional difference of climate change, nor can it reflect the disasters and environmental risks incurred from climate changes. This paper utilizes the tendency value and fluctuation value of temperature and precipitation from 1961 to 2010 to identify the climate change quantitatively, and completes the climate change regionalization in China(1961–2010) with county administrative regionalization as the unit in combination with China's terrain feature. Level-I regionalization divides China's climate change(1961–2010) into five tendency zones based on the tendency of temperature and precipitation, which are respectively Northeast China-North China warm-dry trend zone, East China-Central China wet-warm trend zone, Southwest China-South China dry-warm trend zone, Southeast Tibet-Southwest China wet-warm trend zone, and Northwest China-Qinghai-Tibet Plateau warm-wet trend zone; level-II regionalization refers to fourteen fluctuation regions based on level-I regionalization according to the fluctuation of temperature and precipitation. | SHI PeiJun SUN Shao WANG Ming LI Ning WANG JingAi JIN YunYun GU XiaoTian YIN WeiXia | 2014 | Science China Earth Sciences2014，57，11： | 22 |
| 2 | Resistance to rice blast (Pyricularia oryzae) caused by the expression of trichosanthin gene in transgenic rice plants transferred through agrobacterium method显示文摘The gene of trichosanthin has been transferred into rice plants through agrobacterium method. The single copy insertion and the expression of foreign gene have been proved in regenerated plants. In antifungal assay the degrees of rice blast (Pyricularia oryzae) infection of the transgenic plants expressing trichosanthin and expressing GUS gene as control have been evaluated. The differences such as the time of disease symptom observed, the number of infected plants and damaged leaves, the growth of infected plants of the two transgenic plants after being inoculated by rice blast (Pyricularia oryzae) are significant. The transgenic plants with trichosanthin gene grew faster than the plants with GUS gene, even when humidity environment was removed. The results show that the transgenic plants that expressed trichosanthin are able to delay the infection of rice blast compared with the plants as control. In addition, no damage caused by the expression of trichosanthin gene in transgenic plants has been | Xiaotian Ming Lijiang Wang Chengcai An Huayi Yuan Zhangliang Chen | 2000 | Chinese Science Bulletin2000，45，19： | 12 |
| 3 | Construction of chimeric inducible promoters by elicitors of rice fungal blast pathogen and their expression in transgenic rice显示文摘The promoter fragments of wheat GstA1 and potato Gst1 have been amplified by PCR, cloned and fused respectively to the minimal promoter sequence of rice actin gene (Act1)) and its 5’ untranslated leader sequence together with GUS. The constructs with 2 chimeric promoters (WGA and PGA) have been transferred into rice in order to analyze their inducibility patterns in transgenic rice plants. The results show that: WGA and PGA are both inducible by elicitors of Pyricularia oryzae in transgenic rice cells; the intron I of rice Act1 gene is important for the heterogenic expression of monocot and dicot promoter elements in rice; and the Act1 minimal promoter and its 5’untranslated leader sequence produced low level background expression in rice. | LU Huafei MING Xiaotian QU Lijia LIU Meihua LI Jing GU Hongya CHEN Zhangliang | 2000 | Chinese Science Bulletin2000，45，3： | 5 |
| 4 | Copy number alteration profiling facilitates differential diagnosis between ossifying fibroma and fibrous dysplasia of the jaws显示文摘Ossifying fibroma(OF)and fibrous dysplasia(FD)are two fibro-osseous lesions with overlapping clinicopathological features,making diagnosis challenging.In this study,we applied a whole-genome shallow sequencing approach to facilitate differential diagnosis via precise profiling of copy number alterations(CNAs)using minute amounts of DNA extracted from morphologically correlated microdissected tissue samples.Freshly frozen tissue specimens from OF(n=29)and FD(n=28)patients were obtained for analysis.Lesion fibrous tissues and surrounding normal tissues were obtained by laser capture microdissection(LCM),with~30–50 cells(5000–10000µm2)per sample.We found that the rate of recurrent CNAs in OF cases was much higher(44.8%,13 of 29)than that in FD cases(3.6%,1 of 28).Sixty-nine percent(9 of 13)of the CNA-containing OF cases involved segmental amplifications and deletions on Chrs 7 and 12.We also identified eight CNA-associated genes(HILPDA,CALD1,C1GALT1,MICALL2,PHF14,AIMP2,MDM2,and CDK4)with amplified expression,which was consistent with the copy number changes.We further confirmed a jaw lesion with a previous uncertain diagnosis due to its ambiguous morphological features and the absence of GNAS mutation as OF based on the typical Chr 12 amplification pattern in its CNA profile.Moreover,analysis of a set of longitudinal samples collected from an individual with a cellular lesion in suspicion of OF at the first surgery,recurrence and the latest malignant transformation revealed identical CNA patterns at the three time points,suggesting that copy number profiling can be used as an important tool to identify borderline lesions or lesions with malignant potential.Overall,CNA profiling of fibro-osseous lesions can greatly improve differential diagnosis between OF and FD and help predict disease progression. | Ming Ma Lu Liu Ruirui Shi Jianyun Zhang Xiaotian Li Xuefen Li Jiaying Bai Jianbin Wang Yanyi Huang Tiejun Li | 2021 | International Journal of Oral Science2021，13，2： | 3 |
| 5 | Improvement in the risk assessment of oral leukoplakia through morphology-related copy number analysis显示文摘Oral leukoplakia is the most common type of oral potentially malignant disorders and considered a precursor lesion to oral squamous cell carcinoma.However,a predictor of oral leukoplakia prognosis has not yet been identified.We investigated whether copy number alteration patterns may effectively predict the prognostic outcomes of oral leukoplakia using routinely processed paraffin sections.Comparison of copy number alteration patterns between oral leukoplakia with hyperplasia(HOL,n=22)and dysplasia(DOL,n=21)showed that oral leukoplakia with dysplasia had a higher copy number alteration rate(86%)than oral leukoplakia with hyperplasia(46%).Oral leukoplakia with dysplasia exhibited a wider range of genomic variations across all chromosomes compared with oral leukoplakia with hyperplasia.We also examined a retrospective cohort of 477 patients with oral leukoplakia with hyperplasia with detailed follow-up information.The malignant transformation(MT,n=19)and leukoplakia recurrence(LR,n=253)groups had higher frequencies of aneuploidy events and copy number loss rate than the free of disease(FD,n=205)group.Together,our results revealed the association between the degree of copy number alterations and the histological grade of oral leukoplakia and demonstrated that copy number alteration may be effective for prognosis prediction in oral leukoplakia patients with hyperplasia. | Xiaotian Li Lu Liu Jianyun Zhang Ming Ma Lisha Sun Xuefen Li Heyu Zhang Jianbin Wang Yanyi Huang Tiejun Li | 2021 | Science China(Life Sciences)2021，64，9： | 2 |
| 6 | Agrobacterium- mediated transformation of rice with help of bombardment 显示文摘 | Ming Xiaotian Yuan Huayi Wang Lijiang | 2001 | Acta Botaniea Sinica2001，43，1： | 1 |
| 7 | Maternal genetic history of ancient Tibetans over the past 4000 years显示文摘The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity.Here,we reconstruct a 4000-year maternal genetic history of Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet.The phylogeny of haplotypes M9a1a,M9a1b,D4g2,G2a’c,and D4i show that ancient Tibetans share the most recent common ancestor with ancient Middle and Upper Yellow River populations around the Early and Middle Holocene.In addition,the connections between Tibetans and Northeastern Asians vary over the past 4000 years,with a stronger matrilineal connection between the two during 4000 BPe3000 BP,and a weakened connection after 3000 BP,that are coincident with climate change,followed by a reinforced connection after the Tubo period(1400 BPe1100 BP).Besides,an over 4000-year matrilineal continuity is observed in some of the maternal lineages.We also find the maternal genetic structure of ancient Tibetans is correlated to the geography and interactions between ancient Tibetans and ancient Nepal and Pakistan populations.Overall,the maternal genetic history of Tibetans can be characterized as a long-term matrilineal continuity with frequent internal and external population interactions that are dynamically shaped by geography,climate changes,as well as historical events. | Ganyu Zhang Can Cui Shargan Wangdue Hongliang Lu Honghai Chen Lin Xi Wei He Haibing Yuan Tinley Tsring Zujun Chen Feng Yang Tashi Tsering Shuai Li Norbu Tashi Tsho Yang Yan Tong Xiaohong Wu Linhui Li Yuanhong He Peng Cao Qingyan Dai Feng Liu Xiaotian Feng Tianyi Wang Ruowei Yang Wanjing Ping Ming Zhang Xing Gao Yichen Liu Wenjun Wang Qiaomei Fu | 2023 | Journal of Genetics and Genomics2023，50，10： | 1 |
| 8 | Agrobacterium-mediated genetic transformation of a Dendrobium orchid显示文摘 | MEN Shuzhen MING Xiaotian LIU Rongwei | 2003 | Plant Cell Tissue Organ Cult2003，75，： | 1 |
| 9 | Agrobacterium-mediated genetic transformation of a Den- drobium orchid 显示文摘 | MEN Shuzhen MING Xiaotian LIU Rongwei | 2003 | Plant Cell Tissue Organ Cult2003，75，1： | 1 |
| 10 | Studieson the Grinding Characteristics of Directionally So-lidified Nickel Based Super Alloy显示文摘 | Chen Ming Li Xiaotian Sun Fanhong | | 0，，2： | 1 |
| 11 | Studies on the grinding characteristics of directionally solidified nickel-based superalloy 显示文摘 | Ming C Xiaotian L Fanghong S | 2001 | Journal of Materials Processing Technology2001，116，2： | 1 |
| 12 | Agrobacterium-mediated genetic transformation of a Dendrobium orchid显示文摘 | Shuzhen Men Xiaotian Ming Rongwei Liu Chunhong Wei Yi Li | 2003 | Plant Cell Tissue and Organ Culture2003，，1： | 1 |
| 13 | Studies on the grinding characteristics of directionally solidified nickel-based superalloy 显示文摘 | Chen Ming Li Xiaotian Sun Fanghong | 2001 | Journal of Materials Processing Technology2001，，116： | 1 |
| 14 | Studies on the Grinding Characteristics of Directionally So- lidified Nickel Based Super Alloy显示文摘 | Chen Ming Li Xiaotian Sun Fanhong | 2001 | Journal of Material Processing Technology2001，116，23： | 1 |
| 15 | Maternal genetic structure of a neolithic population of the Yangshao culture显示文摘The Yangshao culture is one of the most influential Neolithic cultures in East Asia.The populations associated with the Yangshao culture were widely distributed along the Yellow River basin and were suggested to play a profound role in the present-day East Asians.To date,the population of the Yangshao culture is largely investigated through archaeological studies. | Bo Miao Yichen Liu Wanfa Gu Qingli Wei Qian Wu Wenjun Wang Ming Zhang Manyu Ding Tianyi Wang Juncen Liu Feng Liu Peng Cao Qingyan Dai Ruowei Yang Xiaotian Feng Wanjing Ping Weihong Hou Haibing Yuan Qiaomei Fu | 2021 | Journal of Genetics and Genomics2021，48，8： | 0 |
| 16 | Chinese quality control indices for standardized diagnosis and treatment of gastric cancer(2022 edition)显示文摘Gastric cancer is one of the most common malignancies of the digestive system,and the number of deaths continues to increase.The standardized management of the diagnosis and treatment of gastric cancer is challenging due to the great differences in the diagnosis and treatment of gastric cancer in different regions.The Gastric Cancer Expert Committee of the National Cancer Quality Control Center(NCQCC)identified a lack of authoritative quality control standards as an opportunity to utilize its multidisciplinary membership to improve the standardized diagnosis and treatment of gastric cancer.The Gastric Cancer Expert Committee of the NCQCC aims to promote quality control and national standardization,uniformity,and normalization of gastric cancer diagnosis and treatment,which ultimately improved the survival rate and quality of life of gastric cancer patients.A panel of experts with gastrointestinal cancer surgery,gastrointestinal cancer medicine,medical imaging,pathology and radiotherapy were drawn together and determined the quality control standards for the standardized diagnosis and treatment of gastric cancer.The authors then utilized a modified Delphi approach to generate consensus recommendations. | Shen Li Fei Shan Xiaotian Zhang Yongheng Li Yu Sun Lei Tang Qi Wu Wenjing Yang Jincheng Yang Yu An Ming Deng Jiafu Ji | 2022 | Chinese Journal of Cancer Research2022，34，6： | 0 |
| 17 | Cooperative effect of Cr and Al elements on passivation enhancement of eutectic high-entropy alloy AlCoCrFeNi_(2.1)with precipitates显示文摘In conventional corrosion-resistant alloys,precipitation usually reduces corrosion resistance severely by weakening passive films locally.In this work,we found that the aging-treated AlCoCrFeNi_(2.1)sam-ples,which have abundant nanosized L 12 and body-centered cubic(BCC)precipitates in the lamellar face-centered cubic(FCC)and B2 phases,displayed better corrosion resistance than solution-treated AlCoCrFeNi_(2.1)samples without precipitates.In the AlCoCrFeNi_(2.1)alloy,the FCC phase with L1_(2)precipi-tates and the B2 phase with BCC precipitates were protected by passive films enriched with Cr and Al elements,respectively.Moreover,the Al-rich passive film of the B2 phase was less stable than the Cr-rich passive film of the FCC phase,so B2 phase dissolved preferentially.The Cr-rich passive film of the FCC phase remained stable with the formation of Al-rich L1_(2)precipitates inside the phase because those precipitates with the size of∼5 nm were too small to affect the composition of the Cr-rich passive film.The formation of Cr-rich BCC precipitates within the B2 phase increased the content of the Al element inside the phase,improving the stability of Al-rich passive film on the B2 phase.Furthermore,BCC precip-itates with the size of∼30 nm were protected by Cr-rich passive film,which could inhibit the expansion of corrosion pits.Thus,the corrosion resistance of eutectic high-entropy alloy AlCoCrFeN 2.1 was unprece-dentedly enhanced by the precipitation of BCC precipitates.Our study could provide an attractive strategy for designing high-entropy alloys with excellent corrosion resistance and high strength. | Xiaotian Duan Tiezhuang Han Xiao Guan Yuning Wang Huhu Su Kaisheng Ming Jing Wang Shijian Zheng | 2023 | Journal of Materials Science & Technology2023，，5： | 0 |
| 18 | Ancient DNA reveals the maternal genetic history of East Asian domestic pigs显示文摘Zoo-archaeological and genetic evidence suggest that pigs were domesticated independently in Central China and Eastern Anatolia along with the development of agricultural communities and civilizations.However,the genetic history of domestic pigs,especially in China,has not been fully explored.In this study,we generate 42 complete mitochondrial DNA sequences from~7500-to 2750-year-old individuals from the Yellow River basin.Our results show that the maternal genetic continuity of East Asian domestic pigs dates back to at least the Early to Middle Neolithic.In contrast,the Near Eastern ancestry in European domestic pigs saw a near-complete genomic replacement by the European wild boar.The majority of East Asian domestic pigs share close haplotypes,and the most recent common ancestor of most branches dates back to less than 20,000 years before present,inferred using new substitution rates of whole mitogenomes or combined protein-coding regions.Two major population expansion events of East Asian domestic pigs coincided with changes in climate,widespread adoption of introduced crops,and the development of agrarian societies.These findings add to our understanding of the maternal genetic composition and help to complete the picture of domestic pig evolutionary history in East Asia. | Ming Zhang Yichen Liu Zhipeng Li Peng Lü Jacob D.Gardner Maolin Ye Jihuai Wang Miaomiao Yang Jing Shao Weilin Wang Qingyan Dai Peng Cao Ruowei Yang Feng Liu Xiaotian Feng Lizhao Zhang Enwei Li Yunzheng Shi Zehui Chen Shilun Zhu Weiwei Zhai Tao Deng Ziyuan Duan E.Andrew Bennett Songmei Hu Qiaomei Fu | 2022 | Journal of Genetics and Genomics2022，49，6： | 0 |
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