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| 1 | Effect of burden and origin sites of premature ventricular contractions on left ventricular function by 7-day Holter monitor显示文摘Recent studies have shown that premature ventricular contractions(PVCs) could enlarge the heart,but its risk factors are incompletely understood as a single 24-hour recording cannot reflect the true PVC burden due to day-to-day variability.Our purpose was to investigate the effect of burden and origin sites on left ventricular(LV) function in patients with PVCs by 7-day Holter electrocardiography(ECG).From May 2012 to August2013,112 consecutive patients with PVCs were recruited from the authors' affiliated hospital.All patients received2-dimensional transthoracic echocardiography,12-lead routing ECG and 7-days Holter ECG.Serum N-terminal probrain natriuretic peptide(NT-proBNP) levels were measured.A total of 102 participants with PVCs were included in the final analysis.Origin of PVCs from the tricuspid annulus had the highest burden and NT-proBNP level.LV papillary muscle had a higher LV ejection fraction(EF) level and a lower LV end-systolic dimension(ESD) than other PVC foci(P<0.05).The high burden group had a higher LV end-diastolic dimension(EDD) and LVESD but lower LVEF than the other two groups(P<0.05).Female,older age,physical work,and history of PVCs had a significantly positive correlation with symptoms.Male,older age,physical work,and high burden were positive predictors of enlarged LVEDD,LVESD and higher serum NT-proBNP level,but lower LVEF.Seven-day dynamic ECG Holter monitor showed the true PVC burden on patients with PVCs.PVCs with a lower burden or origin from the LV papillary muscle and the fascicle were relatively benign,while PVCs with a higher burden or origin from the tricuspid annulus may lead to cardiac dysfunction. | Wenhua Xu Mingfang Li Minglong Chen Bing Yang Daowu Wang Xiangqing Kong Hongwu Chen Weizhu Ju Kai Gu Kejiang Cao Hailei Liu Qi Jiang Jiaojiao Shi Yan Cui Hong Wang | 2015 | The Journal of Biomedical Research2015，29，6： | 4 |
| 2 | Association between essential hypertension and polymorphisms of beta 1 adrenergic receptor gene G1165C (Gly389Arg) in Chinese Mongolian population显示文摘BACKGROUND: The prevalences of hypertension, cerebrovascular diseases, etc. are higher in Mongolian population because of the influence of various factors including genetics, geography, diet, etc. Therefore, it is helpful to develop researches on the genetics of various diseases including hypertension in Mongolian population. OBJECTIVE: To analyze the association between the polymorphism of beta1 adrenergic receptor (β1-AR) gene G1165C (Arg389Gly), an important candidate gene for various diseases of cardiovascular system, and essential hypertension in Mongolian population. DESIGN: A cross-sectional study. SETTINGS: Department of Neurology, the First Affiliated Hospital of Inner Mongolia Medical College; Wulate Houqi Red Cross Society. PARTICIPANTS: The survey was carried out from February 2003 to March 2005. Totally 239 Mongolian residents, whose blood relations of 3 generations were all Mongolians, were selected from Wulate Houqi, Inner Mongolia, and they were all informed with the survey and detected items. Based on the diagnostic standard of hypertension set by WHO in 1999, the subjects were divided into two groups according to the level blood pressure: ① Normal blood pressure group (n=117): systolic blood pressure (SBP) < 140 mm Hg (1 mm Hg =0.133 kPa), diastolic blood pressure (DBP) < 90 mm Hg, and those having histories of cerebrovascular disease, heart disease, diseases of liver, kidney and tiroides, and diabetes mellitus were excluded. ② Essential hypertension group (n=122): including 51 patients with simple high SBP. All the enrolled subjects had no blood relationship with each other, and had no history of miscegenation. METHODS: The body height, body mass, waist circumference and blood lipids were measured routinely, and their habits of smoking and drinking were also investigated. Peripheral venous blood (5 mL) was drawn, the genome DNA was extracted, and the polymorphisms of the β1-AR G1165C (Gly389Arg) genotype were detected with the Sequenom system. Polymerase chain reaction (PCR) experiment and SNP detection were performed in Huada Gene Laboratory of Bejing, then the univariate analysis of variance was applied in the sample comparison among groups, and the chi-square test was used to compare the genotypes and allele frequencies. The odd ratio (OR) and 95% confidence interval (CI) were calculated. MAIN OUTCOME MEASURES: The distributions of β1-AR G1165C (Gly389Arg) genotypes and alleles were observed. RESULTS: All the 239 subjects were involved in the analysis of results, and no one missed. ①Comparison of β1-AR G1165C (Gly389Arg) genotypes and allele distributions: In Mongolian population, the frequencies of CC and GG+GC genotypes at β1-AR G1165C (Gly389Arg) site in the essential hypertension group (72%, 28%) were not significantly different from those in the normal blood pressure group (67%, 33%) (χ2=0.841, P=0.359; OR: 0.773, 95%CI: 0.445-1.342); The frequencies of C and G alleles also had no significant differences between the essential hypertension group (85%, 15%) and the normal blood pressure group (82%, 18%) (χ2=1.136, P=0.287; OR: 0.769, 95%CI: 0.747-1.248). ②The frequencies of CC and GG+GC genotypes at β1-AR G1165C (Gly389Arg) site had no significant differences between the patients with simple high SBP (71%, 29%) and the normal blood pressure group (χ2=0.250, P=0.617; OR: 0.833, 95%CI: 0.408-1.703); The frequencies of C and G alleles were not significantly different between the patients with simple high SBP (86%, 14%) and the normal blood pressure group (χ2=0.670, P=0.413; OR: 0.766, 95%CI: 0.404-1.453). CONCLUSION: In Mongolian population, the distributions of the genotypes and alleles of β1-AR G1165C (Gly389Arg) have no obvious differences between the subjects with normal blood pressure and the patients with essential hypertension (including simple SBP increase), which suggests that G1165C (Glu389Asp) site of β1-AR gene may be not a genetic mark of essential hypertension and simple high SBP in Mongolian population. | Rile Hu Rile Hu Shigang Zhao Guangming Niu Chunyu Zhang Zhiguang Wang Mingfang Jiang | 2006 | Neural Regeneration Research2006，1，3： | 2 |
| 3 | Genetic predisposition to essential hypertension in a Mongolian population Detecting the C825T polymorphism of the G-protein beta 3 subunit gene显示文摘BACKGROUND: The prevalences of hypertension, cerebrovascular diseases, etc. are higher in Mongolian population because of the influence of various factors including genetics, geography, diet, etc. Therefore, it is helpful for prevention to develop researches on the genetics of various diseases including hypertension in Mongolian population. OBJECTIVE: To analyze the association between C825T polymorphisms of G-protein beta 3 subunit gene (GNB3), the important candidate gene of various disease of cardiovascular system, and Mongolian patients with essential hypertension. DESIGN: A comparative observation. SETTINGS: Department of Neurology, the First Affiliated Hospital of Inner Mongolia Medical College; Wulate Houqi Red Cross Society. PARTICIPANTS: Totally 267 Mongolian residents, whose blood relations of 3 generations were all Mongolians, were selected from Wulate Houqi, Inner Mongolia. The patients were screened based on the diagnostic standard of hypertension set by WHO in 1999, and the enrolled subjects were divided into two groups according to the level of blood pressure: ① Normal blood pressure group (n =124): 64 males and 60 females, systolic blood pressure (SBP) < 140 mm Hg (1 mm Hg=0.133 kPa), diastolic blood pressure (DBP) < 90 mm Hg; ② Essential hypertension group (n =143): 71 males and 72 females, including 60 patients with simple high SBP (SBP ranged 145 to 195 mm Hg, whereas DBP < 90 mm Hg). METHODS: Peripheral venous blood (5 mL) was drawn from all the subjects, the genome DNA was extracted, and the polymorphisms of the GNB3 C825T genotype were detected with the Sequenom system. Polymerase chain reaction (PCR) experiment and SNP detection were performed in Beijing Huada gene laboratory. Then the univariate analysis of variance was applied in the sample comparison among groups, and the chi-square test was used to compare the genotypes and allele frequencies. The odd ratio (OR) and 95% confidence interval (CI) were calculated. MAIN OUTCOME MEASURES: The distributions of GNB3 C825T genotypes and alleles were observed. RESULTS: All the 267 Mongolian subjects were involved in the analysis of results. ① GNB3 C825T genotypes: In Mongolian population, the frequencies of CC, CT and TT genotypes at GNB3 C825T site in the essential hypertension group (48%, 41%, 11%) were not obvious different from those in the normal blood pressure group (43%, 47%, 10%,χ2 =0.162, P =0.688; OR:1.176, 95%CI: 0.533–2.592), whereas there were also no obvious differences between the simple high SBP group (57%, 35%, 8%) and the normal blood pressure group (χ2 =0.733, P =0.392; OR:1.957, 95%CI: 0.623–6.143). ② GNB3 C825T alleles: In Mongolian population, The frequencies of C and T alleles in the essential hypertension group (69%, 31%) were not obviously different from those in the normal blood pressure group (67%, 33%, χ2 =0.094, P = 0.759; OR:0.945, 95%CI: 0.657–1.358), whereas there were also no obvious differences between the simple high SBP group (74%, 26%) and the normal blood pressure group (χ2 =2.133, P =0.144; OR:0.697, 95%CI: 0.428–1.133). CONCLUSION: GNB3 C825T site may be not a genetic marker of essential hypertension and simple highSBP in Mongolian population. | Chunyu Zhang Shigang Zhao Guangming Niu Rile Hu Zhiguang Wang Mingfang Jiang | 2007 | Neural Regeneration Research2007，2，3： | 1 |
| 4 | Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase显示文摘Human 5-lipoxygenase(5-LOX)is a well-validated drug target and its inhibitors are potential drugs for treating leukotriene-related disorders.Our previous work on structural optimization of the hit compound 2 from our in-house collection identified two lead compounds,3a and 3b,exhibiting a potent inhibitory profile against 5-LOX with IC_(50) values less than 1 mmol/L in cell-based assays.Here,we further optimized these compounds to prepare a class of novel pyrazole derivatives by opening the fusedring system.Several new compounds exhibited more potent inhibitory activity than the lead compounds against 5-LOX.In particular,compound 4e not only suppressed lipopolysaccharide-induced inflammation in brain inflammatory cells and protected neurons from oxidative toxicity,but also significantly decreased infarct damage in a mouse model of cerebral ischemia.Molecular docking analysis further confirmed the consistency of our theoretical results and experimental data.In conclusion,the excellent in vitro andin vivo inhibitory activities of these compounds against 5-LOX suggested that these novel chemical structures have a promising therapeutic potential to treat leukotriene-related disorders. | Yu Zhou Jun Liu Mingyue Zheng Shuli Zheng Chunyi Jiang Xiaomei Zhou Dong Zhang Jihui Zhao Deju Ye Mingfang Zheng Hualiang Jiang Dongxiang Liu Jian Cheng Hong Liu | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 1 |
| 5 | De novo transcriptome characterization of Lilium ' Sorbonne' and key en- zymes related to the flavonoid biosynthesis显示文摘 | Zhang Mingfang Jiang Lingmin Zhang Dongmei | 2015 | Molecular Genetics and Genomics2015，290，： | 1 |
| 6 | A Secure Rotation Invariant LBP Feature Computation in Cloud Environment显示文摘In the era of big data,outsourcing massive data to a remote cloud server is a promising approach.Outsourcing storage and computation services can reduce storage costs and computational burdens.However,public cloud storage brings about new privacy and security concerns since the cloud servers can be shared by multiple users.Privacy-preserving feature extraction techniques are an effective solution to this issue.Because the Rotation Invariant Local Binary Pattern(RILBP)has been widely used in various image processing fields,we propose a new privacy-preserving outsourcing computation of RILBP over encrypted images in this paper(called PPRILBP).To protect image content,original images are encrypted using block scrambling,pixel circular shift,and pixel diffusion when uploaded to the cloud server.It is proved that RILBP features remain unchanged before and after encryption.Moreover,the server can directly extract RILBP features from encrypted images.Analyses and experiments confirm that the proposed scheme is secure and effective,and outperforms previous secure LBP feature computing methods. | Shiqi Wang Mingfang Jiang Jiaohua Qin Hengfu Yang Zhichen Gao | 2021 | Computers, Materials & Continua2021，，9： | 0 |
| 7 | Adaptive Reversible Visible Watermarking Based on Total Variation for BTC-Compressed Images显示文摘Few previous Reversible Visible Watermarking(RVW)schemes have both good transparency and watermark visibility.An adaptive RVW scheme that integrates Total Variation and visual perception in Block Truncation Coding(BTC)compressed domain,called TVB-RVW is proposed in this paper.A new mean image estimation method for BTC-compressed images is first developed with the help of Total Variation.Then,a visual perception factor computation model is devised by fusing texture and luminance characteristics.An adaptive watermark embedding strategy is used to embed the visible watermark with the effect of the visual perception factor in the BTC domain.Moreover,a lossless embedding method of the encrypted visible watermark is exploited to deter illegal watermark removal.The visible watermark can be removed since the visual perception factor and the estimated mean image remain unchanged before and after watermark embedding.Extensive experiments validate the superiority of the proposed algorithm over previous RVW schemes in BTC in terms of the visual quality of watermarked images and watermark visibility,and it can achieve a good balance between transparency and watermark visibility. | Hengfu Yang Mingfang Jiang Zhichen Gao | 2023 | Computers, Materials & Continua2023，，3： | 0 |
| 8 | Light quality regulates plant biomass and fruit quality through a photoreceptor-dependent HY5-LHC/CYCB module in tomato显示文摘Increasing photosynthesis and light capture offers possibilities for improving crop yield and provides a sustainable way to meet the increasing global demand for food.However,the poor light transmittance of transparent plastic films and shade avoidance at high planting density seriously reduce photosynthesis and alter fruit quality in vegetable crops,and therefore it is important to investigate the mechanisms of light signaling regulation of photosynthesis and metabolism in tomato(Solanum lycopersicum).Here,a combination of red,blue,and white(R1W1B0.5)light promoted the accumulation of chlorophyll,carotenoid,and anthocyanin,and enhanced photosynthesis and electron transport rates by increasing the density of active reaction centers and the expression of the genes LIGHT-HARVESTING COMPLEX B(SlLHCB)and A(SlLHCA),resulting in increased plant biomass.In addition,R1W1B0.5 light induced carotenoid accumulation and fruit ripening by decreasing the expression of LYCOPENEβ-CYCLASE(SlCYCB).Disruption of SlCYCB largely induced fruit lycopene accumulation,and reduced chlorophyll content and photosynthesis in leaves under red,blue,and white light.Molecular studies showed that ELONGATED HYPOCOTYL 5(SlHY5)directly activated SlCYCB,SlLHCB,and SlLHCA expression to enhance chlorophyll accumulation and photosynthesis.Furthermore,R1W1B0.5 light-induced chlorophyll accumulation,photosynthesis,and SlHY5 expression were largely decreased in the slphyb1cry1 mutant.Collectively,R1W1B0.5 light noticeably promoted photosynthesis,biomass,and fruit quality through the photoreceptor(SlPHYB1 and SlCRY1)-SlHY5-SlLHCA/B/SlCYCB module in tomato.Thus,the manipulation of light environments in protected agriculture is a crucial tool to regulate the two vital agronomic traits related to crop production efficiency and fruit nutritional quality in tomato. | Jiarong Yan Juan Liu Shengdie Yang Chenghao Jiang Yanan Liu Nan Zhang Xin Sun Ying Zhang Kangyou Zhu Yinxia Peng Xin Bu Xiujie Wang Golam Jalal Ahammed Sida Meng Changhua Tan Yufeng Liu Zhouping Sun Mingfang Qi Feng Wang Tianlai Li | 2023 | Horticulture Research2023，10，12： | 0 |
| 9 | Effects of Sodium Nitroprussiate on the Metabolites and Key Enzyme Activities of Carbon-nitrogen Metabolism from Seed Germination to Seedling Period of Cherry Tomato显示文摘This study was conducted to elucidate the regulating mechanism of sodium nitroprussiate on seed germination and seedling growth of cherry tomato. After the treatment with different concentrations of sodium nitroprusside,the effects on the metabolites and key enzyme activities in carbon-nitrogen metabolism of cherry tomato cultivar Zhuyun as an experimental material were investigated. The results showed that from seed germination to seedling period,the contents of starch and total nitrogen decreased,but the contents of soluble sugar,reducing sugar,sucrose and soluble protein increased firstly and then decreased; and free amino acids content increased gradually. Sodium nitroprusside made the contents of starch,sucrose and free amino acids higher than CK. From seed germination to seedling period in cherry tomato,the activities of amylase,glutamine synthetase( GS) and sucrose phosphate synthase( SPS) decreased; the activities of nitrate reductase( NR) and glutamate synthase( GOGAT) increased at first and decreased then; and the CK and the 0. 25 mmol/L sodium nitroprusside treatments exhibited decreased sucrose synthase( SS) activity,and the trend was increasing at first and decreasing then after the treatment with 0. 50 and 1. 00 mmol/L sodium nitroprusside. Sodium nitroprusside treatment improved amylase activity; and the carbon-nitrogen ratio of the CK increased at first and decreased then,while the values of other treatments tended to decrease. In addition,sodium nitroprusside did not affect seed germination potential and germination rate,but significantly improved biomass accumulation,root length and height of seedlings. These data suggest that sodium nitroprusside could affect the conversion of starch and sugar accumulation,delay the decomposition of total nitrogen and soluble protein,and achieve the effects of accelerating the accumulation of free amino acids,and promoting seed germination and seedling growth,and 0. 50 mmol/L sodium nitroprusside has the best effect. | Yongfu ZHANG Lihong GUO Shuping JIANG Song JIN Liyuan YAO Mingfang ZHAO | 2018 | Agricultural Biotechnology2018，7，1： | 0 |
| 10 | Correlation between Microstructures and Yield Strength of a High Strength Enameling Steel显示文摘Numerical estimates of the components of yield strength of a high strength Fe-C-Mn-P-N-Si enameling steel were determined using empirical relationships between microstructure and yield strength. Results are reported for both the hot rolled (HR) and cold rolled (CR) forms before and after simulating an enamel-fire anneal (EFA). To determine the solubilities of alloying elements, thermodynamic calculations were performed in combination with the considerations of process conditions and the element diffusivities. The results show that the main solid solution strengtheners were the elements Mn, Si, and P, while the elements C and N were nearly completely tied up as precipitates. The yield strength reduction, due to the EFA, resulted primarily from an increase in grain size and a decrease in dislocation density, and the EFA appeared to have a negligible effect on the element solubilities. | Ming Jiang Xuefeng Yang Shiyan Pan Bruce W.Krakauer Mingfang Zhu | 2012 | Journal of Materials Science & Technology2012，28，8： | 0 |
| 11 | Epicardial adipose tissue around the superior vena cava: A single center study of factors related to atrial fibrillation显示文摘The superior vena cava(SVC)is the main component of non-pulmonary vein(PV)ectopy in patients with atrial fibrillation(AF).Researchers have found that epicardial adipose tissue(EAT)volume is related to the AF substrate,which can be defined by the low voltage area(LVA).This study aimed to investigate the relationship between SVC-EAT and SVC-AF.Twenty-six patients with SVC-AF triggers were identified as the SVC-AF group.Other three groups were defined and included as the LVA-AF group(LVA>5%),non-LVA-AF group(LVA<5%),and physical examination(PE)group.EAT around left atrium(LA-EAT)and SVC-EAT volumes were obtained using a cardiac risk assessment module.According to the SVC/LA-EAT ratio,there are significant differences between the SVC-AF group and the three control groups(the SVC-AF group 0.092±0.041 vs.the LVA-AF group 0.054±0.026,the non-LVA-AF group 0.052±0.022,and the PE group 0.052±0.019,all P<0.001).Receiver operating characteristic curve analysis suggests the optimal cut-off point of SVC/LA-EAT ratio is 6.8%for detecting SVC-AF patients,with 81.1%sensitivity,73.1%specificity,and an area under the curve of 0.83(95%confidence interval,0.75-0.91).Those with SVC-AF have a higher SVC/LA-EAT ratio and empirical SVC isolation could be considered if the SVC/LA-EAT ratio was over 6.8%. | Xingxing Sun Jun Wang Qing Yan Weizhu Ju Fengxiang Zhang Gang Yang Kai Gu Hailei Liu Zidun wang Xiaohong Jiang Mingfang Li Di Xu Yi Xu Hongwu Chen Minglong Chen | 2022 | The Journal of Biomedical Research2022，36，6： | 0 |
| 12 | Screening of additives to reduce grain damage risk on unhairing by proteinase K显示文摘Enzymatic unhairing is a cleaner strategy for leather-making.It is a potential alternative to the traditional hairburning process.However,several shortcomings,such as uncontrolled enzymatic reaction,and risk of grain looseness and damage have restricted the broad application of enzymatic unhairing.In this work,metal ions and organic additives were screened for lessening the hydrolytic activity of proteinase K to collagen fiber.Then,the selected additives were applied to the enzymatic unhairing process for bovine hide.The results showed that a suitable concentration of metal ions(Cu(Ⅱ),Fe(Ⅲ)and Al(Ⅲ))and organic additives(salicylate,laurate,adipate,gallate and epicatechin(ECG))could diminish approximately 35% of the hydrolytic activity of proteinase K to collagen fibers.Then,the additives were applied for the bovine hide enzymatic unhairing process.Hydroxyproline determination in the unhairing float shows that applying additives could reduce collagen hydrolysis.The morphology results showed that the grain damage could be significantly reduced with the addition of the screened additives in the proteinase K enzymatic unhairing system,whereas the addition of ECG and gallate significantly slowed down the unhairing speed.This outcome provides new potential to reduce the risk of grain damage in enzymatic unhairing process. | Mei Chen Mingfang Jiang He Li Haiming Cheng | 2020 | Journal of Leather Science and Engineering2020，2，1： | 0 |
| 13 | Image Feature Computation in Encrypted Domain Based on Mean Value显示文摘In smart environments,more and more teaching data sources are uploaded to remote cloud centers which promote the development of the smart campus.The outsourcing of massive teaching data can reduce storage burden and computational cost,but causes some privacy concerns because those teaching data(especially personal image data)may contain personal private information.In this paper,a privacy-preserving image feature extraction algorithm is proposed by using mean value features.Clients use block scrambling and chaotic map to encrypt original images before uploading to the remote servers.Cloud servers can directly extract image mean value features from encrypted images.Experiments show the effectiveness and security of our algorithm.It can achieve information search over the encrypted images on the smart campus. | Xiangshu Ou Mingfang Jiang Shuai Li Yao Bai | 2020 | Journal of Cyber Security2020，2，3： | 0 |
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