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| 1 | Identification of Flowering Regulatory Genes in Allopolyploid Brassica juncea显示文摘Brassica juncea is an allopolyploid originating from the interspecific hybridization between Brassica rapa and Brassica nigra, which is of multiple usage as a vegetable, oilseed and condiment worldwide. Both vernalization and non-vernalization under long-day photoperiod can promote floral transition in B. juncea suggesting merged flowering pathways of its ancestors and better environmental adaptability. We identified genomewide flowering regulatory genes in B. juncea, which include 84 and 79 genes from A and B sub-genomes, respectively. Ka/Ks analysis revealed a purification effect on both photoperiod and vernalization flowering regulation pathways during evolution. Expression profile of those genes during long-day and vernalization treatments suggested Bju ACO4, Bju AFT1, Bju BFT4, Bju ASOC1 and Bju ASOC4 may be the major functional copies of B. juncea flowering regulation. Further functional studies about Bju COs showed three days delayed flowering time in Bju ACO4 or Bju BCO3 silenced plants. Increased transcription of all BjuFLCs in Bju ACO4 or Bju BCO3 silenced plants suggested interactions between photoperiod and vernalization pathways governing flowering time. Our findings provided flowering regulating networks in allopolyploid B. juncea. | Ning Zhao Chang Liu Yiqing Meng Zhongyuan Hu Mingfang Zhang Jinghua Yang | 2019 | Horticultural Plant Journal2019，5，3： | 6 |
| 2 | Epidemiological characteristics and temporal-spatial analysis of overseas imported dengue fever cases in outbreak provinces of China, 2005–2019显示文摘Background Overseas imported dengue fever is an important factor in local outbreaks of this disease in the mainland of China.To better prevent and control such local outbreaks,the epidemiological characteristics and temporal-spatial distribution of overseas imported dengue fever cases in provincial-level administrative divisions(PLADs)where dengue fever is outbreak in the mainland of China were explored.Methods Using the Chinese National Notifiable Infectious Disease Reporting Information System(CNNDS),we identified overseas imported dengue fever cases in dengue fever outbreak areas in the mainland of China from 2005 to 2019 to draw the epidemic curve and population characteristic distribution of overseas imported cases in each PLAD.Based on spatial autocorrelation analysis of ArcGIS 10.5 and temporal-spatial scanning analysis of SaTScan 9.5,we analyzed the temporal-spatial distribution of overseas imported dengue fever in dengue fever outbreak areas in the mainland of China.Results A total of 11,407 imported cases,mainly from Southeast Asia,were recorded from 2005 to 2019 in these 13 PLADs.Of which 62.1%were imported into Yunnan and Guangdong Provinces.Among the imported cases,there were more males than females,mainly from the 21–50 age group.The hot spots were concentrated in parts of Yunnan,Guangdong and Fujian Provinces.We found the cluster of infected areas were expanding northward.Conclusions Based on the analysis of overseas imported dengue cases in 13 PLADs of the mainland of China from 2005 to 2019,we obtained the epidemiological characteristics and spatial distribution of imported dengue cases.Border controls need to pay attention to key population sectors,such as 21–50 years old men and education of key populations on dengue prevention.There is a need to improve the awareness of the prevention and control of imported cases in border areas.At the same time,northern regions cannot relax their vigilance. | Xinchang Lun Yiguan Wang Chunchun Zhao Haixia Wu Caiying Zhu Delong Ma Mingfang Xu Jun Wang Qiyong Liu Lei Xu Fengxia Meng | 2022 | Infectious Diseases of Poverty2022，11，1： | 3 |
| 3 | Association between essential hypertension and polymorphisms of beta 1 adrenergic receptor gene G1165C (Gly389Arg) in Chinese Mongolian population显示文摘BACKGROUND: The prevalences of hypertension, cerebrovascular diseases, etc. are higher in Mongolian population because of the influence of various factors including genetics, geography, diet, etc. Therefore, it is helpful to develop researches on the genetics of various diseases including hypertension in Mongolian population. OBJECTIVE: To analyze the association between the polymorphism of beta1 adrenergic receptor (β1-AR) gene G1165C (Arg389Gly), an important candidate gene for various diseases of cardiovascular system, and essential hypertension in Mongolian population. DESIGN: A cross-sectional study. SETTINGS: Department of Neurology, the First Affiliated Hospital of Inner Mongolia Medical College; Wulate Houqi Red Cross Society. PARTICIPANTS: The survey was carried out from February 2003 to March 2005. Totally 239 Mongolian residents, whose blood relations of 3 generations were all Mongolians, were selected from Wulate Houqi, Inner Mongolia, and they were all informed with the survey and detected items. Based on the diagnostic standard of hypertension set by WHO in 1999, the subjects were divided into two groups according to the level blood pressure: ① Normal blood pressure group (n=117): systolic blood pressure (SBP) < 140 mm Hg (1 mm Hg =0.133 kPa), diastolic blood pressure (DBP) < 90 mm Hg, and those having histories of cerebrovascular disease, heart disease, diseases of liver, kidney and tiroides, and diabetes mellitus were excluded. ② Essential hypertension group (n=122): including 51 patients with simple high SBP. All the enrolled subjects had no blood relationship with each other, and had no history of miscegenation. METHODS: The body height, body mass, waist circumference and blood lipids were measured routinely, and their habits of smoking and drinking were also investigated. Peripheral venous blood (5 mL) was drawn, the genome DNA was extracted, and the polymorphisms of the β1-AR G1165C (Gly389Arg) genotype were detected with the Sequenom system. Polymerase chain reaction (PCR) experiment and SNP detection were performed in Huada Gene Laboratory of Bejing, then the univariate analysis of variance was applied in the sample comparison among groups, and the chi-square test was used to compare the genotypes and allele frequencies. The odd ratio (OR) and 95% confidence interval (CI) were calculated. MAIN OUTCOME MEASURES: The distributions of β1-AR G1165C (Gly389Arg) genotypes and alleles were observed. RESULTS: All the 239 subjects were involved in the analysis of results, and no one missed. ①Comparison of β1-AR G1165C (Gly389Arg) genotypes and allele distributions: In Mongolian population, the frequencies of CC and GG+GC genotypes at β1-AR G1165C (Gly389Arg) site in the essential hypertension group (72%, 28%) were not significantly different from those in the normal blood pressure group (67%, 33%) (χ2=0.841, P=0.359; OR: 0.773, 95%CI: 0.445-1.342); The frequencies of C and G alleles also had no significant differences between the essential hypertension group (85%, 15%) and the normal blood pressure group (82%, 18%) (χ2=1.136, P=0.287; OR: 0.769, 95%CI: 0.747-1.248). ②The frequencies of CC and GG+GC genotypes at β1-AR G1165C (Gly389Arg) site had no significant differences between the patients with simple high SBP (71%, 29%) and the normal blood pressure group (χ2=0.250, P=0.617; OR: 0.833, 95%CI: 0.408-1.703); The frequencies of C and G alleles were not significantly different between the patients with simple high SBP (86%, 14%) and the normal blood pressure group (χ2=0.670, P=0.413; OR: 0.766, 95%CI: 0.404-1.453). CONCLUSION: In Mongolian population, the distributions of the genotypes and alleles of β1-AR G1165C (Gly389Arg) have no obvious differences between the subjects with normal blood pressure and the patients with essential hypertension (including simple SBP increase), which suggests that G1165C (Glu389Asp) site of β1-AR gene may be not a genetic mark of essential hypertension and simple high SBP in Mongolian population. | Rile Hu Rile Hu Shigang Zhao Guangming Niu Chunyu Zhang Zhiguang Wang Mingfang Jiang | 2006 | Neural Regeneration Research2006，1，3： | 2 |
| 4 | Genetic predisposition to essential hypertension in a Mongolian population Detecting the C825T polymorphism of the G-protein beta 3 subunit gene显示文摘BACKGROUND: The prevalences of hypertension, cerebrovascular diseases, etc. are higher in Mongolian population because of the influence of various factors including genetics, geography, diet, etc. Therefore, it is helpful for prevention to develop researches on the genetics of various diseases including hypertension in Mongolian population. OBJECTIVE: To analyze the association between C825T polymorphisms of G-protein beta 3 subunit gene (GNB3), the important candidate gene of various disease of cardiovascular system, and Mongolian patients with essential hypertension. DESIGN: A comparative observation. SETTINGS: Department of Neurology, the First Affiliated Hospital of Inner Mongolia Medical College; Wulate Houqi Red Cross Society. PARTICIPANTS: Totally 267 Mongolian residents, whose blood relations of 3 generations were all Mongolians, were selected from Wulate Houqi, Inner Mongolia. The patients were screened based on the diagnostic standard of hypertension set by WHO in 1999, and the enrolled subjects were divided into two groups according to the level of blood pressure: ① Normal blood pressure group (n =124): 64 males and 60 females, systolic blood pressure (SBP) < 140 mm Hg (1 mm Hg=0.133 kPa), diastolic blood pressure (DBP) < 90 mm Hg; ② Essential hypertension group (n =143): 71 males and 72 females, including 60 patients with simple high SBP (SBP ranged 145 to 195 mm Hg, whereas DBP < 90 mm Hg). METHODS: Peripheral venous blood (5 mL) was drawn from all the subjects, the genome DNA was extracted, and the polymorphisms of the GNB3 C825T genotype were detected with the Sequenom system. Polymerase chain reaction (PCR) experiment and SNP detection were performed in Beijing Huada gene laboratory. Then the univariate analysis of variance was applied in the sample comparison among groups, and the chi-square test was used to compare the genotypes and allele frequencies. The odd ratio (OR) and 95% confidence interval (CI) were calculated. MAIN OUTCOME MEASURES: The distributions of GNB3 C825T genotypes and alleles were observed. RESULTS: All the 267 Mongolian subjects were involved in the analysis of results. ① GNB3 C825T genotypes: In Mongolian population, the frequencies of CC, CT and TT genotypes at GNB3 C825T site in the essential hypertension group (48%, 41%, 11%) were not obvious different from those in the normal blood pressure group (43%, 47%, 10%,χ2 =0.162, P =0.688; OR:1.176, 95%CI: 0.533–2.592), whereas there were also no obvious differences between the simple high SBP group (57%, 35%, 8%) and the normal blood pressure group (χ2 =0.733, P =0.392; OR:1.957, 95%CI: 0.623–6.143). ② GNB3 C825T alleles: In Mongolian population, The frequencies of C and T alleles in the essential hypertension group (69%, 31%) were not obviously different from those in the normal blood pressure group (67%, 33%, χ2 =0.094, P = 0.759; OR:0.945, 95%CI: 0.657–1.358), whereas there were also no obvious differences between the simple high SBP group (74%, 26%) and the normal blood pressure group (χ2 =2.133, P =0.144; OR:0.697, 95%CI: 0.428–1.133). CONCLUSION: GNB3 C825T site may be not a genetic marker of essential hypertension and simple highSBP in Mongolian population. | Chunyu Zhang Shigang Zhao Guangming Niu Rile Hu Zhiguang Wang Mingfang Jiang | 2007 | Neural Regeneration Research2007，2，3： | 1 |
| 5 | Synergistic antitumor effect of β-elemene and etoposide is mediatedvia induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinomacells显示文摘 | Fan Zhang Ling Xu Xiujuan Qu Mingfang Zhao Bo Jin Jian Kang Yunpeng Liu Xuejun Hu | 2011 | Molecular Medicine Reports2011，，6： | 1 |
| 6 | Adaptation and mitigation for combating climate change - from singletojoint显示文摘Introduction:Adaptation and mitigation are two main approaches to combating climate change.Mitigation is considered as the most important tasks in dealing with climate change in scientific res earch,financial support and technical practices as global warming intensifes;while currently the warming trend still cannot be reversed,and adaptation task seemed to gain urgency although it is late-starting.The synergies and tradeoffs of these two strategies revealed increasingly importance on reduding adverse dimate effects.Research on synergistic relationships has developed from definition and feasible analysis,to the development of quantitative tools and exploration in practice and application,though the latter aspect is still in its initial stage.Outcomes/other.Our review shows that the traits of mitigation and adaptation,the difer-ences and similarities between them,then ilustrate the significance and mechanism of their synergies and tradeoffs.And it is explained that methods and applications of single and integrated models,and cost-effectiveness analysis.Discussion/Conclusion:We hold the opinion that the future research and applications should be enhanced in terms of four aspects:reinforcement of interrelations and common mecha nisms between mitigation and adaptation actions study;building and improving the monitoring and evaluating systems;promoting departmental and regional scale investiga-tions and applications;and establishing policy and security systems. | Chunli Zhao Yan Yan Chenxing Wang Mingfang Tang Gang Wu Ding Ding Yang Song | 2018 | Ecosystem Health and Sustainability2018，4，4： | 1 |
| 7 | Short-term Wind Speed Prediction with a Two-layer Attention-based LSTM显示文摘Wind speed prediction is of great importance because it affects the efficiency and stability of power systems with a high proportion of wind power.Temporal-spatial wind speed features contain rich information;however,their use to predict wind speed remains one of the most challenging and less studied areas.This paper investigates the problem of predicting wind speeds for multiple sites using temporal and spatial features and proposes a novel two-layer attentionbased long short-term memory(LSTM),termed 2Attn-LSTM,a unified framework of encoder and decoder mechanisms to handle temporal-spatial wind speed data.To eliminate the unevenness of the original wind speed,we initially decompose the preprocessing data into IMF components by variational mode decomposition(VMD).Then,it encodes the spatial features of IMF components at the bottom of the model and decodes the temporal features to obtain each component's predicted value on the second layer.Finally,we obtain the ultimate prediction value after denormalization and superposition.We have performed extensive experiments for short-term predictions on real-world data,demonstrating that 2Attn-LSTM outperforms the four baseline methods.It is worth pointing out that the presented 2Atts-LSTM is a general model suitable for other spatial-temporal features. | Jingcheng Qian Mingfang Zhu Yingnan Zhao Xiangjian He | 2021 | Computer Systems Science & Engineering2021，39，11： | 1 |
| 8 | The mechanism and kinetics of ultrasound-enhanced electrochemical oxidation of phenol on boron-doped diamond and Pt electrodes 显示文摘 | ZHAO Guohua SHEN Shihao LI Mingfang | 2008 | Chemosphere2008，73，9： | 1 |
| 9 | Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase显示文摘Human 5-lipoxygenase(5-LOX)is a well-validated drug target and its inhibitors are potential drugs for treating leukotriene-related disorders.Our previous work on structural optimization of the hit compound 2 from our in-house collection identified two lead compounds,3a and 3b,exhibiting a potent inhibitory profile against 5-LOX with IC_(50) values less than 1 mmol/L in cell-based assays.Here,we further optimized these compounds to prepare a class of novel pyrazole derivatives by opening the fusedring system.Several new compounds exhibited more potent inhibitory activity than the lead compounds against 5-LOX.In particular,compound 4e not only suppressed lipopolysaccharide-induced inflammation in brain inflammatory cells and protected neurons from oxidative toxicity,but also significantly decreased infarct damage in a mouse model of cerebral ischemia.Molecular docking analysis further confirmed the consistency of our theoretical results and experimental data.In conclusion,the excellent in vitro andin vivo inhibitory activities of these compounds against 5-LOX suggested that these novel chemical structures have a promising therapeutic potential to treat leukotriene-related disorders. | Yu Zhou Jun Liu Mingyue Zheng Shuli Zheng Chunyi Jiang Xiaomei Zhou Dong Zhang Jihui Zhao Deju Ye Mingfang Zheng Hualiang Jiang Dongxiang Liu Jian Cheng Hong Liu | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 1 |
| 10 | Akt-mTOR signaling is involved in Notch-1-mediated glioma cell survivaland proliferation显示文摘 | Nengjiang Zhao Ya Guo Mingfang Zhang Ling Lin Zhihong Zheng | 2010 | Oncology Reports2010，，5： | 1 |
| 11 | Electrosorptive photocatalytic degradation of highly concentrated p-nitroaniline with TiO 2 nanorod-clusters/carbon aerogel electrode under visible light显示文摘 | Yabo Wang Ya-nan Zhang Guohua Zhao Meifen Wu Mingfang Li Dongming Li Yonggang Zhang Yalei Zhang | 2013 | Separation and Purification Technology2013，，： | 1 |
| 12 | Photocatalysis-enhanced electrosorption process for degradation of high-concentration dye wastewater on TiO 2 /carbon aerogel显示文摘 | Yuning Jin Meifen Wu Guohua Zhao Mingfang Li | 2011 | Chemical Engineering Journal2011，，3： | 1 |
| 13 | The mechanism and kinetics of electrochemical oxidation of phenol on boron-doped diamond and Pt electrodes 显示文摘 | Zhao Guohua Shen Shihao Li Mingfang | 2008 | Chemosphere2008，73，9： | 1 |
| 14 | Preparation and characterization of CuO/SiO2 and NiO/SiO2 with bimodal pore structure by sol-gel method显示文摘 | Zheng Mingfang Zhao Tianbo Xu Wenguo | 2006 | J Sol-Gel Sci Techn2006，39，： | 1 |
| 15 | Ambient Temperature and Years of Life Lost:A National Study in China显示文摘Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and quantified the YLL per death caused by temperature in China.We collected daily meteorological and mortality data,and calculated the daily YLL values for 364 locations(2013–2017 in Yunnan,Guangdong,Hunan,Zhejiang,and Jilin provinces,and 2006–2011 in other locations)in China.A time-series design with a distributed lag nonlinear model was first employed to estimate the location-specific associations between temperature and YLL rates(YLL/100,000 population),and a multivariate meta-analysis model was used to pool location-specific associations.Then,YLL per death caused by temperatures was calculated.The temperature and YLL rates consistently showed U-shaped associations.A mean of 1.02(95%confidence interval:0.67,1.37)YLL per death was attributable to temperature.Cold temperature caused 0.98 YLL per death with most from moderate cold(0.84).The mean YLL per death was higher in those with cardiovascular diseases(1.14),males(1.15),younger age categories(1.31 in people aged 65–74 years),and in central China(1.34)than in those with respiratory diseases(0.47),females(0.87),older people(0.85 in people R75 years old),and northern China(0.64)or southern China(1.19).The mortality burden was modified by annual temperature and temperature variability,relative humidity,latitude,longitude,altitude,education attainment,and central heating use.Temperatures caused substantial YLL per death in China,which was modified by demographic and regional characteristics. | Tao Liu Chunliang Zhou Haoming Zhang Biao Huang Yanjun Xu Lifeng Lin Lijun Wang Ruying Hu Zhulin Hou Yize Xiao Junhua Li Xiaojun Xu Donghui Jin Mingfang Qin Qinglong Zhao Weiwei Gong Peng Yin Yiqing Xu Jianxiong Hu Jianpeng Xiao Weilin Zeng Xing Li Siqi Chen Lingchuan Guo Zuhua Rong Yonghui Zhang Cunrui Huang Yaodong Du Yuming Guo Shannon Rutherford Min Yu Maigeng Zhou Wenjun Ma | 2021 | The Innovation2021，2，1： | 1 |
| 16 | Impacts of regional land-use patterns on ecosystem services in the typical agro-pastoral ecotone of northern China显示文摘A comprehensive understanding of the spatial-temporal evolution and driving forces on ecosystem services(ES)is essential for the agro-pastoral ecotone’s ecological security in northern China.However,the land-use pattern(LULC)agglomeration with spatial differentiation in the pastoral and agricultural areas has been rarely concerned.Taking distinct LULC(1980-2018)in Chifeng as an example,we compared four crucial categories of ESs with InVEST.Using SEM,we further contrasted the effects of several variables on regional ES variations in pastoral-dominated(North)and agriculture-dominated(South)regions,respectively.Results revealed the conversion between forest and grassland oriented the LULC transformation in the North.In contrast,human-activitiy-oriented land tended to occupy environmentally sensitive places in the South.Similar ES variations were supplied with the North outperforming the South when soil conservation was omitted.As for the impacts of regional ES variations,the natural and LULC policies both showed positive effects,whereas the anthropogenic factors showed positive in the North,which was negative in the South.Therefore,the ecologicallymaintained-dominant and ecologically-restored-dominant strategies should be separately adopted in the North and South.Our study provided appropriate regional ecological management suggestions for balancing the LULC-driven conflicts between ecological protection and regional development. | Huimin Chen Yu Zhao Xiao Fu Mingfang Tang Mingjie Guo Shiqi Zhang Yu Zhu Laiye Qu Gang Wu | 2022 | Ecosystem Health and Sustainability2022，8，1： | 0 |
| 17 | A wake-up call: signaling in regulating ornamental geophytes dormancy显示文摘Ornamental geophytes are a group of important flowers worldwide.As perennial plants,geophytes go through several rounds of life cycle under seasonal climates.The dormant trait of underground modified organs in geophytes is critical for the process of storage,planting as well as breeding.Although the dormant physiology in geophytes is complex and largely unknown,several advancements have been achieved in this field.Here,we review the knowledge on the role of environmental factors,endogenous hormones,carbohydrates,and epigenetics in the regulation of geophytes dormancy release(GDR).We also discuss dormancy release(DR)methods and their roles in geophytes,including small molecular chemicals and wounding treatments. | Yajie Zhao Chang Liu Juanjuan Sui Jiahui Liang Jintao Ge Jingru Li Wenqiang Pan Mingfang Yi Yunpeng Du Jian Wu | 2022 | Ornamental Plant Research2022，2，1： | 0 |
| 18 | Effects of Sodium Nitroprussiate on the Metabolites and Key Enzyme Activities of Carbon-nitrogen Metabolism from Seed Germination to Seedling Period of Cherry Tomato显示文摘This study was conducted to elucidate the regulating mechanism of sodium nitroprussiate on seed germination and seedling growth of cherry tomato. After the treatment with different concentrations of sodium nitroprusside,the effects on the metabolites and key enzyme activities in carbon-nitrogen metabolism of cherry tomato cultivar Zhuyun as an experimental material were investigated. The results showed that from seed germination to seedling period,the contents of starch and total nitrogen decreased,but the contents of soluble sugar,reducing sugar,sucrose and soluble protein increased firstly and then decreased; and free amino acids content increased gradually. Sodium nitroprusside made the contents of starch,sucrose and free amino acids higher than CK. From seed germination to seedling period in cherry tomato,the activities of amylase,glutamine synthetase( GS) and sucrose phosphate synthase( SPS) decreased; the activities of nitrate reductase( NR) and glutamate synthase( GOGAT) increased at first and decreased then; and the CK and the 0. 25 mmol/L sodium nitroprusside treatments exhibited decreased sucrose synthase( SS) activity,and the trend was increasing at first and decreasing then after the treatment with 0. 50 and 1. 00 mmol/L sodium nitroprusside. Sodium nitroprusside treatment improved amylase activity; and the carbon-nitrogen ratio of the CK increased at first and decreased then,while the values of other treatments tended to decrease. In addition,sodium nitroprusside did not affect seed germination potential and germination rate,but significantly improved biomass accumulation,root length and height of seedlings. These data suggest that sodium nitroprusside could affect the conversion of starch and sugar accumulation,delay the decomposition of total nitrogen and soluble protein,and achieve the effects of accelerating the accumulation of free amino acids,and promoting seed germination and seedling growth,and 0. 50 mmol/L sodium nitroprusside has the best effect. | Yongfu ZHANG Lihong GUO Shuping JIANG Song JIN Liyuan YAO Mingfang ZHAO | 2018 | Agricultural Biotechnology2018，7，1： | 0 |
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