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| 1 | Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock显示文摘Inflammasomes 是触发 caspase-1 的激活和 interleukin-1β 的成熟的多蛋白质建筑群;(IL-1β) ,然而,这些建筑群的规定仍然保持糟糕描绘了。这里,我们显示出那氮的氧化物(没有) 禁止了调停 NLRP3 的 ASC pyroptosome 形成, caspase-1 激活和 IL-1β在从老鼠和人的 myeloid 房间的分泌物。同时,内长不否定地也源于 iNOS (没有 synthase 的可诱导的形式) 调整 NLRP3 inflammasome 激活。iNOS 的弄空响应 LPS 和 ATP 导致了不正常的线粒体的增加的累积,它为增加的 IL-1β 负责;生产和 caspase-1 激活。没有生产的 iNOS 缺乏或药理学抑制在 vivo 提高了 NLRP3 依赖的 cytokine 生产,因此在老鼠从导致 LPS 的败血增加死亡,它被 NLRP3 阻止缺乏。我们的结果因此经由线粒体的稳定作为 NLRP3 inflammasome 的一个批评否定管理者不识别。这研究有重要含意让新策略的设计控制 NLRP3 相关的疾病。 | Kairui Mao Shuzhen Chen Mingkuan Chen Yonglei Ma Yan Wang Bo Huang Zhengyu He Yan Zeng Yu Htl Shuhui Sun Jing Li Xiaodong Wu Xiangrui Wang Warren Strober Chang Chen Guangxun Meng Bing Sun | 2013 | Cell Research2013，23，2： | 59 |
| 2 | Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome显示文摘 | Guowei Lei Mingkuan Chen Hua Li Jun-Ling Niu Shuxian Wu Liming Mao Ailing Lu Hongbin Wang Wei Chen Bin Xu Qibin-Leng Cunshuan Xu Guiwen Yang Liguo An Li-Ping Zhu Guangxun Meng | 2013 | Cell Research2013，23，7： | 5 |
| 3 | A Theoretical Insight into the Mechanism of Cu(I)-Catalyzed C--N Coupling between Aryl Halides and Aqueous Ammonia显示文摘Cu (I) 的计算调查催化没有任何底的增加,在芳基卤化物和水的氨之间联合的 CN 或 ligand 被报导。密度功能的理论计算被执行为主要的芳香的胺的准备揭示 ligand 免费的胺化作用反应的机制。通过在答案的可能的 Cu 种类的相对集中的系统的评估,我们建议活跃催化剂是中立 Cu (I) 建筑群而非 Cu (I) 阳离子;芳基溴化物的氧化增加是催化周期的灵巧的步;反应物(NH 3) 和溶剂分子(NMP ) 能充当 Cu 种类的 ligands 帮助减少前面的反应的激活精力并且增加反向的反应的激活精力;除了小径 B, deprotonation 步由于极端发热的特征是不可逆的;H 2 O 运动地被赞成,当 HBr 的热力学地被比较喜欢时。这些调查结果应该为 ligand 免费的催化 Cu 的 CN 跨 coupling 反应的机制理解并且为高度有效的胺化作用催化剂系统的进一步的开发是珍贵的。 | Ting Chen Mingkuan Yan Chao Zheng Jie Yuan Shen Xu Runfeng Chen Wei Huang | 2015 | Chinese Journal of Chemistry2015，33，8： | 1 |
| 4 | The S267F variant of sodium taurocholate co-transporting polypeptide is strongly associated with resistance to chronic hepatitis B and high level of serum total bile acids显示文摘Background and aims:The sodium taurocholate co-transporting polypeptide(NTCP)is a functional receptor for the hepatitis B virus(HBV),and it is critical for bile acid homeostasis.Previous studies of the association between the S267F variant and chronic hepatitis B(CHB)have generated conflicting results.This study analyzed the correlation between the NTCP S267F variant and CHB susceptibility by using a large sample of participants classified by gender and age,and this study also analyzed the relationship between this variant and the level of serum total bile acids.Methods:In total,543 patients with CHB and 429 control subjects underwent S267F variant genotyping using SNaPshot technology.Logistic regression was utilized to evaluate any association of the NTCP S267F variant with CHB susceptibility.Results:The S267F variant was inversely correlated with the risk of chronic HBV infection in both the dominant model(GG genotype vs.AG genotype:odds ratio(OR)=0.46,95%confidence interval(CI)0.30 -0.71,P<0.001)and the allele model(G allele vs.A allele:OR=0.50,95%CI 0.33-0.76,P=0.001),and this correlation was not affected by gender and age stratification.The carriers of the heterozygous NTCP variant exhibited higher total bile acids levels than the carriers of wild-type NTCP,regardless of whether they were control subjects or patients with CHB.Heterozygous carriers exhibited reduced hepatitis B e antigen(HBeAg)-positivity rates and had lower ALT,AST,and lg DNA concentrations compared with wild-type carriers in patients with CHB.Conclusions:The S267F variant of NTCP is a protective factor that reduces the risk of chronic HBV infection and exhibits a higher total bile acids level.Patients with CHB who carry this variant may have a better prognosis than those carrying wild-type NTCP. | Jiancheng Huang Mingkuan Su Hongbin Chen Shuiqing Wu Zongyun Chen | 2022 | Liver Research2022，6，3： | 0 |
| 5 | A rare variation of popliteal artery continued from inferior gluteal artery was found by CTA显示文摘The transition of the inferior gluteal artery to the popliteal artery is an.extremely rare arterial variation.By using CT angiography(CTA),we found a case whose right inferior gluteal artery transferred to the popliteal artery.A 73-year-old female patient was admitted to our hospital with num bness,pain and low skin temperature in the right foot without obvious inducement'.On physical examination,right dorsal foot artery pulsation disappeared,and lower limb artery embolism or thrombosis were considered clinically.Double lower limbs CTA examination found that the right internal iliac artery ran down the lateral wall of the pelvic cavity to the lesser pelvis,then dividing into main trunk,wall branch and the visceral branch. | Jiang Mingkuan Chen Qiang | 2021 | 解剖学杂志2021，44，S01： | 0 |
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