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| 1 | Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock显示文摘Inflammasomes 是触发 caspase-1 的激活和 interleukin-1β 的成熟的多蛋白质建筑群;(IL-1β) ,然而,这些建筑群的规定仍然保持糟糕描绘了。这里,我们显示出那氮的氧化物(没有) 禁止了调停 NLRP3 的 ASC pyroptosome 形成, caspase-1 激活和 IL-1β在从老鼠和人的 myeloid 房间的分泌物。同时,内长不否定地也源于 iNOS (没有 synthase 的可诱导的形式) 调整 NLRP3 inflammasome 激活。iNOS 的弄空响应 LPS 和 ATP 导致了不正常的线粒体的增加的累积,它为增加的 IL-1β 负责;生产和 caspase-1 激活。没有生产的 iNOS 缺乏或药理学抑制在 vivo 提高了 NLRP3 依赖的 cytokine 生产,因此在老鼠从导致 LPS 的败血增加死亡,它被 NLRP3 阻止缺乏。我们的结果因此经由线粒体的稳定作为 NLRP3 inflammasome 的一个批评否定管理者不识别。这研究有重要含意让新策略的设计控制 NLRP3 相关的疾病。 | Kairui Mao Shuzhen Chen Mingkuan Chen Yonglei Ma Yan Wang Bo Huang Zhengyu He Yan Zeng Yu Htl Shuhui Sun Jing Li Xiaodong Wu Xiangrui Wang Warren Strober Chang Chen Guangxun Meng Bing Sun | 2013 | Cell Research2013，23，2： | 59 |
| 2 | Evolution on qualities of leachate and landfill gas in the semi-aerobic landfill显示文摘在半氧气的垃圾堆学习稳定的特征,大规模模仿的垃圾堆基于半被构造氧气的垃圾堆理论。因而,化学的氧需求(货到付款) 的集中,氨氮,和亚硝酸根氮,和 pH 在沥滤吃,以及在垃圾堆的垃圾堆气体作文(甲烷,二氧化碳,和氧) 的成分含量定期被监视 52 个星期。结果证明货到付款和氨集中很快衰退了并且没显示出象厌氧的垃圾堆一样的积累的规则,并且分别地,在 48 个星期以后在大约 300 和 100 mg/L 留下。同时,下降的率分别地到达了 98.9% 和 96.9% 。硝酸盐集中在 24 个星期以后很快增加了并且在 43 个星期以后在 220 280 mg/L 之间波动。pH 在开始的 8 个星期期间并且在以后低于 7 沥滤 ates 看起来碱。二氧化碳是在通过整个稳定过程在高水平仍然是的垃圾堆气体和它的集中的主要作文。二氧化碳,氧,和甲烷的平均内容在 19 vol.% 之间改变了 28 vol.% , 2 vol.% 8 vol.% ,和 5 vol.% 13 vol.% 分别地。相对平衡在 48 个星期以后被到达。在垃圾堆房间的最高的温度能等于摄氏的 75.8 度。 | HUANG Qifei YANG Yufei PANG Xiangrui WANG Qi | 2008 | Journal of Environmental Sciences2008，20，4： | 11 |
| 3 | SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target显示文摘Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death.However,the origin of excessive damages caused by SARS-CoV-2 remains largely unknown.Here we show that the SARS-CoV-2 envelope(2-E)protein alone is able to cause acute respiratory distress syndrome(ARDS)-like damages in vitro and in vivo. | Bingqing Xia Xurui Shen Yang He Xiaoyan Pan Feng-Liang Liu Yi Wang Feipu Yang Sui Fang Yan Wu Zilei Duan Xiaoli Zuo Zhuqing Xie Xiangrui Jiang Ling Xu Hao Chi Shuangqu Li Qian Meng Hu Zhou Yubo Zhou Xi Cheng Xiaoming Xin Lin Jin Hai-Lin Zhang Dan-Dan Yu Ming-Hua Li Xiao-Li Feng Jiekai Chen Hualiang Jiang Gengfu Xiao Yong-Tang Zheng Lei-Ke Zhang Jingshan Shen Jia Li Zhaobing Gao | 2021 | Cell Research2021，31，8： | 7 |
| 4 | Synthesis and evaluation of a paclitaxel-binding polymeric micelle for efficient breast cancer therapy显示文摘Paclitaxel(PTX) is one of the most effective anticancer drugs for the treatment of various solid tumors, but its clinical use is limited by its poor solubility, low bioavailability, and severe systemic toxicity. Encapsulation of PTX in polymeric nanoparticles is used to overcome these problems but these micelles still need improvements in stability, pharmacokinetics, therapeutic efficacy, and safety profiles. In this study, we demonstrate a facile fabrication of a stable PTX-binding micelle made from poly(ethylene glycol)-block-dendritic polylysine, whose primary amines were reacted with phenethyl isothiocyanate(PEITC), a hydrophobic anticancer agent under clinical study. The amphiphilic conjugate(PEG-Gx-PEITC; Gx, the generation of the polylysine dendron) formed well-defined micelles whose core was composed of phenyl groups and thiourea groups binding PTX via π-π stacking and hydrogen bonding. Compared with the PTX-loaded poly(ethylene glycol)-block-poly(D,L-lactide)(PEGPDLLA/PTX) micelles in clinical use, PTX-loaded PEG-Gx-PEITC third-generation(PEG-G3-PEITC/PTX) micelles showed slowed blood clearance, enhanced tumor accumulation, and thus much improved in vivo therapeutic efficacy in both subcutaneous and orthotopic human breast cancer xenografts. Therefore, PEG-G3-PEITC is a promising drug delivery system for PTX in the treatment of breast cancer. | Jiajia Xiang Bihan Wu Zhuxian Zhou Shiqi Hu Ying Piao Quan Zhou Guowei Wang Jianbin Tang Xiangrui Liu Youqing Shen | 2018 | Science China(Life Sciences)2018，61，4： | 6 |
| 5 | A ROBUST FINITE ELEMENT METHOD FOR A 3-D ELLIPTIC SINGULAR PERTURBATION PROBLEM显示文摘这篇论文为一个三维的第四顺序的椭圆形的单个不安问题建议一个柔韧的有限元素方法。方法使用三维的莫利元素并且在相应于秒顺序的双线性的形式的部分代替有限元素功能由合适的近似的微分操作员。给如此的近似,为秒顺序问题的一个会聚的非一致的元素被构造。方法在不安参数一致地收敛,这被显示出。 | Ming Wang Xiangrui Meng | 2007 | Journal of Computational Mathematics2007，25，6： | 4 |
| 6 | Colonization of endophyte Acremonium sp. D212 in Panax notoginseng and rice mediated by auxin and jasmonic acid显示文摘Endophytic fungi can be beneficial to plant growth. However, the molecular mechanisms under-lying colonization of Acremonium spp. remain unclear. In this study, a novel endophytic Acremonium strain was isolated from the buds of Panax notoginseng and named Acremonium sp. D212. The Acremonium sp. D212 could colonize the roots of P. notoginseng, enhance the resistance of P. notoginseng to root rot disease, and promote root growth and saponin bio-synthesis in P. notoginseng. Acremonium sp. D212 could secrete indole-3-acetic acid (IAA) and jasmonic acid (JA), and inoculation with the fungus increased the endogenous levels of IAA and JA in P. noto-ginseng. Colonization of the Acremonium sp. D212 in the roots of the rice line Nipponbare was dependent on the concentration of methyl jasmonate (MeJA) (2–15μmol/L) and 1-naphthalenacetic acid (NAA) (10–20μmol/L). Moreover, the roots of the JA signaling-defective coi1-18 mutant were colonized by Acremonium sp. D212 to a lesser degree than those of the wild-type Nipponbare and miR393b-overexpressing lines, and the colonization was res-cued by MeJA but not by NAA. It suggests that the cross-talk between JA signaling and the auxin biosynthetic pathway plays a crucial role in the colonization of Acremonium sp. D212 in host plants. | Li Han Xuan Zhou Yiting Zhao Shusheng Zhu Lixia Wu Yunlu He Xiangrui Ping Xinqi Lu Wuying Huang Jie Qian Lina Zhang Xi Jiang Dan Zhu Chongyu Luo Saijie Li Qian Dong Qijing Fu Kaiyuan Deng Xin Wang Lei Wang Sheng Peng Jinsong Wu Weimin Li JiǐíFriml Youyong Zhu Xiahong He Yunlong Du | 2020 | Journal of Integrative Plant Biology2020，62，9： | 2 |
| 7 | Research on an active and continuous monitoring system for human respiratory system显示文摘 | 于莲芝 Yan Guozheng Zhang Wenqiang Wang Xiangrui | 2006 | High Technology Letters2006，12，1： | 2 |
| 8 | The linear accumulation of atmospheric mercury by vegetable and grass leaves: Potential biomonitors for atmospheric mercury pollution显示文摘 | Zhenchuan Niu Xiaoshan Zhang Sen Wang Zhijia Ci Xiangrui Kong Zhangwei Wang | 2013 | Environmental Science and Pollution Research2013，，9： | 1 |
| 9 | A Quantification Algorithm for a Repairable System in the GO Methodology 显示文摘 | Shen Zupei Wang Yao Huang Xiangrui | 2003 | Reliability Eng and Syst Safety2003，80，3： | 1 |
| 10 | A quantification algorithm for a repairable system in the GO methodology显示文摘 | SHEN Zupei WANG Yao HUANG Xiangrui | 2003 | Reliability Engineering and System Safety2003，80，3： | 1 |
| 11 | A quantification algorithm for a repairable system in the GO methodology显示文摘 | SHEN Zupei WANG Yao HUANG Xiangrui | 2003 | Reliability Eng and Syst Safety2003，80，3： | 1 |
| 12 | Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken显示文摘 | Xiangfeng Kong Yuanliang Hu Rong Rui Deyun Wang Xiangrui Li | 2004 | International Immunopharmacology2004，，7： | 1 |
| 13 | Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken显示文摘 | Xiangfeng Kong Yuanliang Hu Rong Rui Deyun Wang Xiangrui Li | 2004 | International Immunopharmacology2004，，7： | 1 |
| 14 | A quantification algorithm for a repairable system in the GO methodology显示文摘 | Shen Zupei Wang Yao Huang Xiangrui | 2003 | Reliability Engineering & System Safety2003，80，3： | 1 |
| 15 | A quantification algorithm for a repairable system in the GO methodology显示文摘 | Shen Zupei Wang Yao Huang Xiangrui | 2003 | Reliability Engineering and System Safety2003，80，3： | 1 |
| 16 | A quantification algorithm for a repairable system in the GO Methodology显示文摘 | Shen Zupei Wang Yao Huang Xiangrui | 2003 | Reliability Engineering and System Safety2003，80，3： | 1 |
| 17 | Prevalence of antifolate drug resistance markers in Plasmodium vivax in China显示文摘The dihydrofolate reductase(dhfr)and dihydropteroate synthetase(dhps)genes of Plasmodium vivax,as antifolate resistance-associated genes were used for drug resistance surveillance.A total of 375 P.vivax isolates collected from different geographical locations in China in 2009–2019 were used to sequence Pvdhfr and Pvdhps.The majority of the isolates harbored a mutant type allele for Pvdhfr(94.5%)and Pvdhps(68.2%).The most predominant point mutations were S117T/N(77.7%)in Pvdhfr and A383G(66.8%)in Pvdhps.Amino acid changes were identified at nine residues in Pvdhfr.A quadruple-mutant haplotype at 57,58,61,and 117 was the most frequent(57.4%)among 16 distinct Pvdhfr haplotypes.Mutations in Pvdhps were detected at six codons,and the double-mutant A383G/A553G was the most prevalent(39.3%).Pvdhfr exhibited a higher mutation prevalence and greater diversity than Pvdhps in China.Most isolates from Yunnan carried multiple mutant haplotypes,while the majority of samples from temperate regions and Hainan Island harbored the wild type or single mutant type.This study indicated that the antifolate resistance levels of P.vivax parasites were different across China and molecular markers could be used to rapidly monitor drug resistance.Results provided evidence for updating national drug policy and treatment guidelines. | Fang Huang Yanwen Cui He Yan Hui Liu Xiangrui Guo Guangze Wang Shuisen Zhou Zhigui Xia | 2022 | Frontiers of Medicine2022，16，1： | 1 |
| 18 | A quantification algorithm for a repairable system in the GO methodology显示文摘 | Shen Zupei Wang Yao Huang Xiangrui | 2003 | Reliability and System Safety2003，，3： | 1 |
| 19 | A quantification on algorithm for a repairable system in the GO methodology 显示文摘 | SHEN Zupei WANG Yao HUANG Xiangrui | 2003 | Reliability Engineering and System Safety2003，80，： | 1 |
| 20 | A Quanti fication Algorithm for a Repairable System in the GO Methodology显示文摘 | SHEN Zupei WANG Yao HUANG Xiangrui | 2003 | Reliability Eng and Syst Safety2003，80，3： | 1 |
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