|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A combination extract of Renshen(Panax Ginseng),Yinyanghuo(Herba Epimedii Brevicornus),Yuanzhi(Radix Palygalae) and Jianghuang(Rhizoma Curcumae Longae) decreases glycogen synthase kinase 3β expression in brain cortex of APPV717I transgenic mice显示文摘OBJECTIVE:To investigate the neuroprotective mechanism of combination extract of Renshen(Panax Ginseng),Yinyanghuo(Herba Epimedii Brevicornus),Yuanzhi(Radix Palygalae) and Jianghuang(Rhizoma Curcumae Longae)(GEPT) in treating Alzheimer's disease on the target of glycogen synthase kinase 3β(GSK-3β).METHODS:Three-month-old APPV717I transgenic mice were randomly divided into ten groups(n=12 per group) and intragastrically administrated vehicle or medicines:APP group was given 0.5% CMC,donepezil group was given donepezil(APP + D group)(0.92 mg/kg-1·day-1),and GEPT groups were given small dose of GEPT(APP+Gs group)(0.075 g/kg-1·day-1),medium dose(APP+Gm group)(0.15 g/kg-1·day-1),and large dose(APP+Gl group)(0.30 g/kg-1·day-1) for 4 or 8 months,respectively.Three-month-old C57BL/6J mice as vehicle controls(n=12) were given 0.5% CMC for 4 or 8 months as well.The GSK-3β expression in the cortex of 7-and 11-month-old APPV717I transgenic mice with and without GEPT or donepezil treatment and normal C57BL/6J mice were measured via Western blotting and Immunohistochemistry.RESULTS:Immunohistochemistry analysis showed significant increase of GSK-3β in the cerebral cortex of 7-month-old APP group(compare to control group P=0.003),while the GSK-3β expression of donepezil or GEPT group were all significantly decreased(Donepezil vs APP:P=0.041;Gl vs APP:P= 0.049;Gm vs APP:P=0.029;Gh vs APP:P=0.036).Western blot analysis showed similar results.The densitometric measures of GSK-3β in APP mice increased significantly as compared with the control group(P=0.008).And the GSK-3β expression in donepezil and GEPT groups were all decreased.There was significant difference between Gh group or donepezil group and the control group(P=0.05).Similar findings were shown in the 11-month-old mice in each group,except for greater decrease of GSK-3β in the GEPT group.CONCLUSION:GEPT can effectively decrease the level of GSK-3β expression in the brain cortex of APPV717I transgenic mice,and such effect is more significant in 11-month-old mice.This partially explains the neuroprotecting mechanism of GEPT in preventing and treating of AD. | Jing Shi Jinzhou Tian Xuekai Zhang Chuiyou Zeng Mingqing Wei Pengwen Wang Yongyan Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 6 |
| 2 | Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis显示文摘The adenoma-carcinoma sequence is a well-accepted roadmap for the development of sporadic colorectal cancer.However,cellular heterogeneity in aberrant epithelial cells limits our understanding of carcinogenesis in colorectal tissues.Here,we performed a single-cell RNA sequencing survey of 54,788 cells from patient-matched tissue samples,including blood,normal tissue,para-cancer,polyp,and colorectal cancer. | Xiaobo Zheng Jinen Song Chune Yu Zongguang Zhou Xiaowei Liu Jing Yu Guangchao Xu Jiqiao Yang Xiujing He Xin Bai Ya Luo Yu Bao Huifang Li Lie Yang Mingqing Xu Nan Song Xiaodong Su Jie Xu Xuelei Ma Hubing Shi | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 3 | Effect of pruning and ground treatments on the populations of Hylobitelus xiaoi Zhang,a new debarking weevil in slash pine plantations显示文摘 | Wen Xiaosui Shi Mingqing Zhu Liubo De-Lu Fu | 2006 | Agricultural and Forest Entomology2006，8，4： | 1 |
| 4 | Generative artificial intelligence and its applications in materials science:Current situation and future perspectives显示文摘Generative Artificial Intelligence(GAI)is attracting the increasing attention of materials community for its excellent capability of generating required contents.With the introduction of Prompt paradigm and reinforcement learning from human feedback(RLHF),GAI shifts from the task-specific to general pattern gradually,enabling to tackle multiple complicated tasks involved in resolving the structure-activity relationships.Here,we review the development status of GAI comprehensively and analyze pros and cons of various generative models in the view of methodology.The applications of task-specific generative models involving materials inverse design and data augmentation are also dissected.Taking ChatGPT as an example,we explore the potential applications of general GAI in generating multiple materials content,solving differential equation as well as querying materials FAQs.Furthermore,we summarize six challenges encountered for the use of GAI in materials science and provide the corresponding solutions.This work paves the way for providing effective and explainable materials data generation and analysis approaches to accelerate the materials research and development. | Yue Liu Zhengwei Yang Zhenyao Yu Zitu Liu Dahui Liu Hailong Lin Mingqing Li Shuchang Ma Maxim Avdeev Siqi Shi | 2023 | Journal of Materiomics2023，9，4： | 1 |
| 5 | Effect of pruning and ground treatment on the populations of Hylobitelus xiaoi, a new debarking weevil in slash pine plantations显示文摘 | Xiaosui Wen Mingqing Shi Liubo Zhu l | 2006 | Agricutural and Foresty Entomology2006，8，： | 1 |
| 6 | Preparation and Stability Evaluation of Size-Controllable PDHCA-β-CD Nanoparticles as Drug Carrier显示文摘新奇 biocompatible 聚合物被 grafting 准备 -cyclodextrin (6-SH--CD ) 的 derivate 到上 poly (3,4-dihydroxycinnamic 酸)(PDHCA ) 经由迈克尔增加。PDHCA -- CD nanoparticles 被准备由 amphiphilic PDHCA 自己组装 -- 有 N 的 CD 聚合物, N-dimethylformamide (DMF ) 同样好的溶剂和水作为穷人溶剂。PDHCA -- CD nanoparticles 是有在扫描电子出现的球形的形态学的 monodispersed 显微镜(SEM ) 与动态轻散布的结果(DLS ) 一致想象测量。nanoparticles 的尺寸能被调节 PDHCA 的 grafting 度(GD ) 从 60 ~ 180 nm 控制 -- CD 聚合物并且显著地也由在这进程期间使用的水的数量影响了。没有任何重要变化,这些同样准备的 nanoparticles 是稳定的在紫外 > 280 nm 几个小时。PDHCA 的形成机制 -- CD nanoparticles 被探索。装载到 nanoparticles 上的 doxorubicin (纪录影片) 的内容与相对高的装载效率直到 39%( 介绍的约 78.8% 起始的纪录影片被装载) 。在 vitro,版本研究建议了慢慢地免除 PDHCA 的那部纪录影片 -- CD nanoparticles。这些特征强烈支持开发 PDHCA 的潜力 -- 是的 CD nanoparticles 为药的控制交货的搬运人。 | Hong Chu Xue Zhao Shirong Liu Zhongbin Ni Dongjian Shi Mingqing Chen | 2017 | Chinese Journal of Chemistry2017，35，7： | 0 |
| 7 | Efficacy of Chinese herbal compound GAPT for the treatment of Alzheimer’s disease during mouse/rat studies:A systematic review and meta-analysis显示文摘Objective:To evaluate the efficacy of the Chinese herbal compound GAPT for the treatment of Alzheimer’s disease(AD)and to provide current evidence for potential treatment mechanisms.Methods:A comprehensive search of PubMed,Embase,Web of Science,SinoMed,China Network Knowledge Infrastructure,Wanfang Data,and Chinese Scientific Journals Database was performed to identify GAPT mouse/rat studies published from inception to July 2019.The outcomes extracted were Morris water maze results and molecular biological quantifications.Results:A total of 19 studies were included in this analysis.The analysis indicated that GAPT was able to significantly improve learning and memory abilities compared with model mice/rats,as assessed by Morris water maze,and showed similar efficacy as donepezil.Subgroup analyses showed that low,medium,and high doses resulted in no obvious dose-dependent effects.Additionally,the GAPT group had significantly reduced expression levels of amyloid-beta peptide,presenilin 1,phosphorylated tau,acetylcholinesterase,and glycogen synthase kinase-3b,but increased expression levels of Shank1,and protein phosphatase-2A,and improved synapses structures compared with the model group,and subgroup analyses showed the medium dose of GAPT was superior to the low and high doses.Conclusions:Based on the pooled analysis,GAPT improved the learning and memory abilities and regulated the expression levels of related proteins during the progression of AD in mouse/rat studies.Notably,the medium dose of GAPT exhibited better performance than the other two doses,providing experimental evidence for further applications of GAPT during clinical practice. | Qingling Sun Jing Shi Jingnian Ni Mingqing Wei Xuekai Zhang Ting Li Pengwen Wang Baoqiang Guo Jinzhou Tian | 2019 | Journal of Traditional Chinese Medical Sciences2019，6，4： | 0 |
| 8 | Molecular recognition triggered aptazyme cascade for ultrasensitive detection of exosomes in clinical serum samples显示文摘Exosomes have attracted widespread interest due to their inherent advantages in tumor diagnosis and treatment monitoring.However,it is still a big challenge for highly sensitive and specific detection of exosome in real complexed samples.Herein,a molecular recognition triggered aptazyme cascade strategy was developed for ultrasensitive detection of cancer exosomes in clinical serum samples.In this design,one target exosome could capture a large quantity of aptazymes for the first-step signal amplification.And then the captured aptazyme was activated and recycled to release the fluorophore-labelled substrate strand for a cascaded signal amplification.Notably,the activation of aptazyme only occurs whenithas bound with target exosome,ensuring a low background.The experimental results show that the limit of detection(LOD)and the limit of quantification(LOQ)are 3.5×10^(3) particles/μL and 1.7×10^(4) particles/μL,respectively,which is comparable to the results of most existed fluorescence-based exosome probes.Moreover,this assay possesses high specificity to distinguish exosomes derived from other cell lines.Furthermore,this fluorescence probe was utilized in cancer patient and healthy serum samples successfully,suggesting its great potential for clinical diagnosis and biological studies. | Kemei Jiang Yanan Wu Juan Chen Mingqing Shi Hong-Min Meng Zhaohui Li | 2021 | Chinese Chemical Letters2021，32，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员