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| 1 | Contrasting trends of PM2.5 and surface-ozone concentrations in China from 2013 to 2017显示文摘Although much attention has been paid to investigating and controlling air pollution in China,the trends of air-pollutant concentrations on a national scale have remained unclear.Here,we quantitatively investigated the variation of air pollutants in China using long-term comprehensive data sets from 2013 to 2017,during which Chinese government made major efforts to reduce anthropogenic emission in polluted regions.Our results show a significant decreasing trend in the PM2.5 concentration in heavily polluted regions of eastern China,with an annual decrease of〜7%compared with measurements in 2013.The measured decreased concentrations of SO2>NO2 and CO(a proxy for anthropogenic volatile organic compounds)could explain a large fraction of the decreased PM2.5 concentrations in different regions.As a consequence;the heavily polluted days decreased significantly in corresponding regions.Concentrations of organic aerosol;nitrate;sulfate,ammonium and chloride measured in urban Beijing revealed a remarkable reduction from 2013 to 2017;connecting the decreases in aerosol precursors with corresponding chemical components closely.However;surface-ozone concentrations showed increasing trends in most urban stations from 2013 to 2017;which indicates stronger photochemical pollution.The boundary-layer height in capital c让ies of eastern China showed no significant trends over the Beijing-Tianjin-Hebei,Yangtze River Delta and Pearl River Delta regions from 2013 to 2017;which confirmed the reduction in anthropogenic emissions.Our results demonstrated that the Chinese government was successful in the reduction of particulate matter in urban areas from 2013 to 2017,although the ozone concentration has increased significantly;suggesting a more complex mechanism of improving Chinese air quality in the future. | Yonghong Wang Wenkang Gao Shuai Wang Tao Song Zhengyu Gong Dongsheng Ji Lili Wang Zirui Liu Guiqian Tang Yanfeng Huo Shili Tian Jiayun Li Mingge Li Yuan Yang Biwu Chu Tuukka Petaja Veli-Matti Kerminen Hong He Jiming Hao Markku Kulmala Yuesi Wang Yuanhang Zhang | 2020 | National Science Review2020，7，8： | 51 |
| 2 | Malate transported from chloroplast to mitochondrion triggers production of ROS and PCD in Arabidopsis thaliana显示文摘规划房间死亡(PCD ) 是一个基本生物过程。在马赛克死亡 1 的缺乏(MOD1 ) ,质体局部性的 enoyl-ACP reductase,导致反应的氧种类(ROS ) 和 PCD 的累积,它能被 mitochondrial 建筑群压制我变化,从叶绿体显示一个信号到线粒体。然而,这个信号尚待被阐明。在这研究,通过克隆并且分析一系列 mod1 suppressors,我们揭示调整 mitochondrial ROS 和扳机 PCD 的产生的一条全面细胞器通讯小径。我们证明在 PLASTIDIAL NAD 依赖的 MALATE 脱氢酶(plNAD-MDH ) 的变化, chloroplastic DICARBOXYLATE TRANSPORTER 1 (DiT1 ) 并且(mMDH1 ) MITOCHONDRIAL MALATE 脱氢酶 1 能各在 mod1 救 ROS 累积和 PCD 显型,经由 malate 梭从叶绿体表明直接通讯到线粒体。进一步的研究证明这些元素在不同光周期条件下面在氧化还原作用动态平衡和植物生长起关键作用。而且,我们表明 ROS 水平和 PCD 显著地在房间,它能是戏剧性地稀释了由的对待 malate 的 HeLa 被增加人的基因 MDH2 击倒, Arabidopsis mMDH1 的 ortholog。这些结果揭开在植物和动物系统的一条保存导致 malate 的 PCD 小径,革命化我们在细胞器之间的通讯的理解。 | Yannan Zhao Lilan Luo Jiesi Xu Peiyong Xin Hongyan Guo Jian Wu Lin Bai Guodong Wang Jinfang Chu Jianru Zuo Hong Yu Xun Huang Jiayang Li | 2018 | Cell Research2018，28，4： | 24 |
| 3 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 4 | Significant concurrent decrease in PM_(2.5) and NO_(2) concentrations in China during COVID-19 epidemic显示文摘The strict control measures and social lockdowns initiated to combat COVID-19 epidemic have had a notable impact on air pollutant concentrations.According to observation data obtained from the China National Environmental Monitoring Center,compared to levels in 2019,the average concentration of NO_(2) in early 2020 during COVID-19 epidemic has decreased by 53%,50%,and 30%in Wuhan city,Hubei Province(Wuhan excluded),and China(Hubei excluded),respectively.Simultaneously,PM_(2.5) concentration has decreased by 35%,29%,and 19%in Wuhan,Hubei(Wuhan excluded),and China(Hubei excluded),respectively.Less significant declines have also been found for SO_(2) and CO concentrations.We also analyzed the temporal variation and spatial distribution of air pollutant concentrations in China during COVID-19 epidemic.The decreases in PM_(2.5) and NO_(2) concentrations showed relatively consistent temporal variation and spatial distribution.These results support control of NO x to further reduce PM_(2.5) pollution in China.The concurrent decrease in NOx and PM_(2.5) concentrations resulted in an increase of O3 concentrations across China during COVID-19 epidemic,indicating that coordinated control of other pollutants is needed. | Biiuu Chu Shuping Zhang Jun Liu Qingxin Ma Hong He | 2021 | Journal of Environmental Sciences2021，33，1： | 21 |
| 5 | The trend on runoff variations in the Lhasa River Basin显示文摘作为一个学习区域在西藏的高原在拉萨水文学车站上面拿拉萨河盆,年度、每月的吝啬的流量的特征在 1956 ¨ C 期间, 2003 被分析。 | LIN Xuedong ZHANG Yili YAO Zhijun GONG Tongliang WANG Hong CHU Duo LIU Linshan ZHANG Fei | 2008 | Journal of Geographical Sciences2008，18，1： | 18 |
| 6 | Microstructure and thermal conductivity of copper matrix composites reinforced with mixtures of diamond and SiC particles显示文摘The thermal conductivity of diamond hybrid SiC/Cu,diamond/Cu and SiC/Cu composite were calculated by using the extended differential effective medium (DEM) theoretical model in this paper.The effects of the particle volume fraction,the particle size and the volume ratio of the diamond particles to the total particles on the thermal conductivity of the composite were studied.The DEM theoretical calculation results show that,for the diamond hybrid SiC/Cu composite,when the particle volume fraction is above 46% and the volume ratio of the diamond particles to the SiC particles is above 13:12,the thermal conductivity of the composite can reach 500 W·m-1·K-1.The thermal conduc-tivity of the composite has little change when the particle size is above 200μm.The experimental results show that Ti can improve the wettability of the SiC and Cu.The thermal conductivity of the diamond hybrid SiCTi/Cu is almost two times better than that of the diamond hybrid SiC/Cu.It is feasible to predict the thermal conductivity of the composite by DEM theoretical model. | Han, Yuanyuan Guo, Hong Yin, Fazhang Zhang, Ximin Chu, Ke Fan, Yeming | 2012 | Rare Metals2012，31，1： | 14 |
| 7 | Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination显示文摘 | Yiqiang Cui Yuyu Niu Jiankui Zhou Yongchang Chen Yiwei Cheng Shangang Li Zongyong Ai Chu Chu Hong Wang Bo Zheng Xuejin Chen Jiahao Sha Xuejiang Guo Xingxu Huang Weizhi Ji | 2018 | Cell Research2018，28，3： | 13 |
| 8 | A hybrid invisibility cloak based on integration of transparent metasurfaces and zero-index materials显示文摘The invisibility cloak,a long-standing fantastic dream for humans,has become more tangible with the development of metamaterials.Recently,metasurface-based invisibility cloaks have been proposed and realized with significantly reduced thickness and complexity of the cloaking shell.However,the previous scheme is based on reflection-type metasurfaces and is thus limited to reflection geometry.In this work,by integrating the wavefront tailoring functionality of transparent metasurfaces and the wave tunneling functionality of zero-index materials,we have realized a unique type of hybrid invisibility cloak that functions in transmission geometry.The principle is general and applicable to arbitrary shapes.For experimental demonstration,we constructed a rhombic double-layer cloaking shell composed of a highly transparent metasurface and a double-zero medium consisting of dielectric photonic crystals with Dirac cone dispersions.The cloaking effect is verified by both full-wave simulations and microwave experimental results.The principle also reveals exciting possibilities for realizing skin-thick ultrathin cloaking shells in transmission geometry,which can eliminate the need for spatially varying extreme parameters.Our work paves a path for novel optical and electromagnetic devices based on the integration of metasurfaces and metamaterials. | Hongchen Chu Qi Li Bingbing Liu Jie Luo Shulin Sun Zhi Hong Hang Lei Zhou Yun Lai | 2018 | Light(Science & Applications)2018，7，1： | 13 |
| 9 | Damage identification method of girder bridges based on finite element model updating and modal strain energy显示文摘A timely and accurate damage identification for bridge structures is essential to prevent sudden failures/collapses and other catastrophic accidents.Based on response surface model(RSM)updating and element modal strain energy(EMSE)damage index,this paper proposes a novel damage identification method for girder bridge structures.The effectiveness of the proposed damage identification method is investigated using experiments on four simply supported steel beams.With Xiabaishi Bridge,a prestressed continuous rigid frame bridge with large span,as the engineering background,the proposed damage identification method is validated by using numerical simulation to generate different bearing damage scenarios.Finally,the efficiency of the method is justified by considering its application to identifying cracking damage for a real continuous beam bridge called Xinyihe Bridge.It is concluded that the EMSE damage index is sensitive to the cracking damage and the bearing damage.The locations and levels of multiple cracking damages and bearing damages can be also identified.The results illuminate a great potential of the proposed method in identifying damages of real bridge structures. | NIU Jie ZONG Zhou Hong CHU Fu Peng | 2015 | Science China(Technological Sciences)2015，58，4： | 12 |
| 10 | LEAFY HEAD2,which encodes a putative RNA-binding protein,regulates shoot development of rice显示文摘在植物的开发期间,更高的植物连续地在常规空间、时间的模式形成新叶子。有反常的叶的异种发展模式不仅提供大卓见进理解植物建筑学的规章的机制,而且充实方法到它庄稼产量能被改进的修正。这里,我们报导了米饭 leafy-head2 (lhd2 ) 的描述展览弄短的异种阶段的 plastochron,侏儒症,减少的 tiller 数字,和失败转移从对繁殖生长植物。而减少的 tiller 数字是 tiller 芽长出的抑制的后果,解剖、组织学的学习表明在 lhd2 的叶子的快速的出现从叶 primordia 的快速的开始被结果。分子、基因的分析证明 LHD2 与 67% 类似编码通常认为的 RNA 有约束力的蛋白质到玉米 TE1。染色体规模表示侧面在之间的比较野类型并且 lhd2 植物建议 LHD2 可以通过 KNOX 和荷尔蒙相关的基因调整米饭射击开发。LHD2 变化和 LHD2 的保存表示模式引起的类似的显型在在草控制时间的叶开始显示了保存机制。 | Guo Sheng Xiong Xing Ming Hu Yong Qing Jiao Yan Chun Yu Cheng Cai Chu Jia Yang Li Qian Qian Yong Hong Wang | 2006 | Cell Research2006，16，3： | 11 |
| 11 | Human organoids in basic research and clinical applications显示文摘Organoids are three-dimensional(3D)miniature structures cultured in vitro produced from either human pluripotent stem cells(hPSCs)or adult stem cells(AdSCs)derived from healthy individuals or patients that recapitulate the cellular heterogeneity,structure,and functions of human organs.The advent of human 3D organoid systems is now possible to allow remarkably detailed observation of stem cell morphogens,maintenance and differentiation resemble primary tissues,enhancing the potential to study both human physiology and developmental stage.As they are similar to their original organs and carry human genetic information,organoids derived from patient hold great promise for biomedical research and preclinical drug testing and is currently used for personalized,regenerative medicine,gene repair and transplantation therapy.In recent decades,researchers have succeeded in generating various types of organoids mimicking in vivo organs.Herein,we provide an update on current in vitro differentiation technologies of brain,retinal,kidney,liver,lung,gastrointestinal,cardiac,vascularized and multi-lineage organoids,discuss the differences between PSC-and AdSC-derived organoids,summarize the potential applications of stem cell-derived organoids systems in the laboratory and clinic,and outline the current challenges for the application of organoids,which would deepen the understanding of mechanisms of human development and enhance further utility of organoids in basic research and clinical studies. | Xiao-Yan Tang Shanshan Wu Da Wang Chu Chu Yuan Hong Mengdan Tao Hao Hu Min Xu Xing Guo Yan Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 10 |
| 12 | Unsuspected Gallbladder Cancer During or After Laparoscopic Cholecystectomy显示文摘Objective To summarize the clinical features and outcomes of unsuspected gallbladder carcinoma (UGC) detected during or after laparoscopic cholecystectomy.Methods Medical records of 8005 patients,who underwent laparoscopic cholecystectomy in Peking Union Medical College Hospital between June 1993 and June 2011,were reviewed.Patients that pathologically diagnosed as UGC were retrospectively studied in terms of clinical features,preoperative and postoperative diagnosis,surviving period,and complications.Results In the 8005 patients who received laparoscopic cholecystectomy,36 (0.45%) were diagnosed as UGC during (25 patients) or after (11 patients) laparoscopic cholecystectomy.The gallbladder cancer was staged as T1 in 16 patients,T2 in 11 patients,and T3 in 9 patients.The 1-,3-,and 5-year survival rates of all the patients were 88.9% (32/36),63.9% (23/36),and 58.3% (21/36).The 5-year survival rates in T1 stage,T2 stage,and T3 stage patients were 100%,75.0%,and 0.0%,respectively.Conclusions The survival rate of UGC is associated with tumor stage,not with operation approaches.Laparoscopic cholecystectomy is appropriate for T1 patients. | Xie-qun Xu Wei Liu Bing-lu Li Tao Hong Chao-ji Zheng Chu Wang Yu-pei Zhao | 2013 | Chinese Medical Sciences Journal2013，28，2： | 10 |
| 13 | Alterations in enterocyte mitochondrial respiratory function and enzyme activities in gastrointestinal dysfunction following brain injury显示文摘AIM:To determine the alterations in rat enterocyte mitochondrial respiratory function and enzyme activities following traumatic brain injury(TBI).METHODS:Fifty-six male SD rats were randomly divided into seven groups(8 rats in each group):a control group(rats with sham operation)and traumatic brain injury groups at 6,12,24 h,days 2,3,and 7after operation.TBI models were induced by Feendy’s free-falling method.Mitochondrial respiratory function(respiratory control ratio and ADP/O ratio)was measured with a Clark oxygen electrode.The activities of respiratory chain complexⅠ-Ⅳand related enzymes were determined by spectrophotometry.RESULTS:Compared with the control group,the mitochondrial respiratory control ratio(RCR)declined at 6 h and remained at a low level until day 7 after TBI(control,5.42±0.46;6 h,5.20±0.18;12 h,4.55±0.35;24 h,3.75±0.22;2 d,4.12±0.53;3 d,3.45±0.41;7 d,5.23±0.24,P<0.01).The value of phosphate-to-oxygen(P/O)significantly decreased at12,24 h,day 2 and day 3,respectively(12 h,3.30±0.10;24 h,2.61±0.21;2 d,2.95±0.18;3 d,2.76±0.09,P<0.01)compared with the control group(3.46±0.12).Two troughs of mitochondrial respiratory function were seen at 24 h and day 3 after TBI.The activities of mitochondrial complex Ⅰ (6 h:110±10,12 h:115±12,24 h:85±9,day 2:80±15,day 3:65±16,P<0.01)and complexⅡ(6 h:105±8,12 h:110±92,24 h:80±10,day 2:76±8,day 3:68±12,P<0.01)were increased at 6 h and 12 h following TBI,and then significantly decreased at 24 h,day 2 and day3,respectively.However,there were no differences in complex Ⅰ andⅡactivities between the control and TBI groups.Furthermore,pyruvate dehydrogenase(PDH)activity was significantly decreased at 6 h and continued up to 7 d after TBI compared with the control group(6 h:90±8,12 h:85±10,24 h:65±12,day 2:60±9,day 3:55±6,day 7:88±11,P<0.01).The changes inα-ketoglutaric dehydrogenase(KGDH)activity were similar to PDH,except that the decrease in KGDH activity began at 12 h after TBI(12 h:90±12,24 h:80±9,day 2:76±15,day 3:68±7,day7:90±13,P<0.01).No significant change in malate dehydrogenase(MDH)activity was observed.CONCLUSION:Rat enterocyte mitochondrial respiratory function and enzyme activities are inhibited following TBI.Mitochondrial dysfunction may play an important role in TBI-induced gastrointestinal dysfunction. | Ke-Jun Zhu Hong Huang Hui Chu Hang Yu Shi-Ming Zhang | 2014 | World Journal of Gastroenterology2014，20，28： | 10 |
| 14 | Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics显示文摘几个抄写因素的宫外的表示能恢复胚胎的房间命运到有教养的体的房间并且产生导致的 pluripotent 干细胞(iPSCs ) ,揭示到 pluripotency 的一条以前未知的小径。然而,这种技术被低效率,慢动力学和多因素的要求当前限制。这里,我们证明 reprogramming 能被优化文化条件改进并且戏剧性地加速了。首先,我们开发了优化定义媒介, iCD1,它允许 Oct4/Sox2/Klf4 (OSK ) 完成的调停的 reprogramming 超离频效率(~10% 在白天 8 点) 。我们也发现这个优化条件使 Sox2 和 Klf4 变为非必需,尽管这二个因素的消除导致更低的效率和更慢的动力学。我们的研究定义一条弄短的线路,两个在预定和因素要求,向 pluripotency。这个新范例不仅提供一个基本原理进一步改进 iPSC 产生而且由定义因素简化 reprogramming 的概念的理解。 | Jiekai Chen Jing Liu You Chen Jiaqi Yang Jing Chen He Liu Xiangjie Zhao Kunlun Mo Hong Song Lin Guo Shilong Chu Deping Wang Ke Ding Duanqing Pei | 2011 | Cell Research2011，21，6： | 9 |
| 15 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 16 | Do neutrophils actively participate in airway inflammation and remodeling in asthma?显示文摘 | 孙永昌 Hong Wei Chu | 2004 | Chinese Medical Journal2004，，11： | 9 |
| 17 | 小胶质细胞对星形胶质细胞的免疫和神经保护功能的调节作用(英文)显示文摘在中枢神经系统中,小胶质细胞和星形胶质细胞对神经元的发育、功能维持及细胞存活具有重要的作用。但在炎症反应过程中,星形胶质细胞增生的作用及其对神经元的影响目前并不十分清楚。因此,本研究对不同种类的细胞进行培养,给予细菌脂多糖(lipopolysaccharide,LPS)刺激,观察各种细胞的反应。结果显示,星形胶质细胞可以减轻炎症反应的神经元毒性,提示星形胶质细胞增生主要具有神经保护作用。如果去掉上清液中由星形胶质细胞分泌的胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF),这种神经保护作用显著降低。为了研究星形胶质细胞的免疫功能,本研究培养了高浓度的星形胶质细胞,并发现LPS不能诱导肿瘤坏死因子(tumor necrosis factor,TNF)-α及诱导型一氧化氮合酶(inducible nitric oxide synthase,iN OS)/一氧化氮(nitric oxide,NO)(iN OS/NO)释放。但如果在培养的高浓度星形胶质细胞中增加0.5%~1%的小胶质细胞,则可以诱导TNF-α及iN OS/NO的释放。这提示小胶质细胞和星形胶质细胞间的相互作用对于LPS诱导星形胶质细胞释放前炎症因子及GDNF是必须的。我们还发现,小胶质细胞释放的TNF-α可以通过旁分泌作用调节星形胶质细胞的神经保护功能。综上所述,本研究结果提示星形胶质细胞可能不会直接被LPS激活,而是通过与小胶质细胞相互作用被激活,释放神经营养因子,减少因炎症反应激活的小胶质细胞释放的毒性物质对神经元的损害作用。 | Chen SH Oyarzabal EA Sung YF Chu CH Wang Q Chen SL Lu RB Hong JS 唐颖馨 | 2015 | 神经损伤与功能重建2015，10，1： | 9 |
| 18 | Prevention and control of HIV/AIDS in China:lessons from the past three decades显示文摘In the past 37 years,human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS)has undergone various major transmission routes in China,with the world most complex co-circulating HIV-1 subtypes,even the prevalence is still low.In response to the first epidemic outbreak of HIV in injecting drug users and the second one by illegal commercial blood collection,China issued the Anti-Drug Law and launched the Blood Donation Act and nationwide nucleic acid testing,which has avoided 98,232 to 211,200 estimated infections and almost ended the blood product-related infection.China has been providing free antiretroviral therapy(ART)since 2003,which covered>80%of the identified patients and achieved a viral suppression rate of 91%.To bend the curve of increasing the disease burden of HIV and finally end the epidemic,China should consider constraining HIV spread through sexual transmission,narrowing the gaps in identifying HIV cases,and the long-term effectiveness and safety of ART in the future. | Jun-Jie Xu Meng-Jie Han Yong-Jun Jiang Hai-Bo Ding Xi Li Xiao-Xu Han Fan Lv Qing-Feng Chen Zi-Ning Zhang Hua-Lu Cui Wen-Qing Geng Jing Zhang Qi Wang Jing Kang Xiao-Lin Li Hong Sun Ya-Jing Fu Ming-Hui An Qing-Hai Hu Zhen-Xing Chu Ying-Jie Liu Hong Shang | 2021 | Chinese Medical Journal2021，，23： | 9 |
| 19 | Design of the Metal Precursors Molecular Structures in Impregnating Solutions for Preparation of Efficient Ni Mo/Al_2O_3 Hydrodesulfurization Catalysts显示文摘The molecular structures of metal precursors in the impregnating solution were designed so as to prepare efficient Ni Mo/Al_2O_3 hydrodesulfurization(HDS) catalysts. At first, five typical impregnating solutions were designed; the existing metal precursors, such as [Mo4(citrate)2O11]^(4-)-like, [P2Mo18O62]^(6-)-like and [P2Mo5O23]^(6-)-like species in the solutions were confirmed by laser Raman spectroscopy(LRS). The UV-Vis spectra results indicated that the solutions containing both phosphoric acid and citric acid could change the existing form of nickel species. Five corresponding Ni Mo/Al_2O_3 catalysts were prepared by the incipient wetness impregnation method. The LRS analysis results of dried catalysts showed that the above metal precursors could be partly retained on alumina support after impregnation and drying, although the interface reaction between different metal precursors and alumina support unavoidably took place. Then the catalysts were sulfided and characterized by N2 physisorption, TEM and XPS analyses. The results showed that different metal precursors in impregnating solution could mainly result in the difference in both the morphology of(Ni)Mo S2 slabs and the promoting effect of Ni species. The catalyst prepared mainly with [P2Mo5O23]^(6-)-like species used as precursors exhibited worse dispersion of(Ni)Mo S2 slabs and lower ratio of Ni–Mo–S active phases than the one with [Mo4(citrate)2O11]^(4-)-like species. Promisingly, the catalyst prepared with co-existing [Mo4(citrate)2O11]^(4-)-like, [P2Mo18O62]^(6-)-like and [P2Mo5O23]^(6-)-like species showed better hydrodesulfurization activity for 4,6-DMDBT thanks to its more well-dispersed Ni–Mo–S active phases. | Li Huifeng Li Mingfeng Chu Yang Liu Feng Nie Hong | 2015 | China Petroleum Processing & Petrochemical Technology2015，17，4： | 8 |
| 20 | Antimyeloma effects of resveratrol through inhibition of angiogenesis显示文摘有疾病活动的在多重骨髓瘤(公里) 的背景,骨头髓 angiogenesis 平行瘤前进和相互关联。最近的研究证明了 resveratrol 在 vitro 并且在 vivo 拥有 antiangiogenic 活动。在这研究,我们在 RPMI 8226 cells.Methods RPMI 8226 房间的一些重要 angiogenic 因素上在骨髓瘤房间依赖者 angiogenesis 和 resveratrol 的效果上检验了 resveratrol 的效果是有人的脐的静脉 endothelial 房间(HUVEC ) 的 cocultured 在 angiogenesis 上评估骨髓瘤房间的效果。RPMI 8226 房间在不同时间(12-72 小时) 与 resveratrol (6.25-50.00 mol/L ) 的各种各样的集中被对待。反向的 transcriptase 聚合酶链反应(RT-PCR ) 习惯于试金脉管的 endothelial 生长因素(VEGF ) ,基本成纤维细胞生长因素(bFGF ) , metalloproteinases (MMP )-2 和 MMP-9 mRNA。明胶 zymography 被用来分析 MMP-2 和 MMP-9 活动。房间在媒介分泌的 VEGF 和 bFGF 蛋白质被 HUVEC 的连接 immunosorbent 试金(ELISA ).Results 房间增长,移植和区别显著地与 RPMI 8226 房间由 coculture 增加了的酶确定。Resveratrol 以一种剂量依赖者方式与骨髓瘤房间禁止了增长,移植和 HUVEC cocultured 的试管形成。有 resveratrol 的房间在 MMP-2 和 MMP-9 activity.Resveratrol 引起了减少的 RPMI 8226 的处理在剂量和时间依赖者举止禁止了 VEGF 和 bFGF 蛋白质表示。而且,减少了从与 resveratrol 的各种各样的集中对待的房间的 VEGF, bFGF, MMP-2 和 MMP-9 mRNA 的层次证实它在基因 expression.Conclusions Resveratrol 的水平的 antiangiogenic 行动由调整 VEGF, bFGF, MMP-2 和 MMP-9 的表示和分泌物禁止多重骨髓瘤 angiogenesis。Resveratrol 可以是多重骨髓瘤的治疗的一个潜在的候选人。 | HU Yu SUN Chun-yan HUANG Jing HONG Liu ZHANG Lu CHU Zhang-bo | 2007 | Chinese Medical Journal2007，，19： | 7 |
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