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| 1 | Highly-Sensitive Multiplexed in vivo Imaging Using PEGylated Upconversion Nanoparticles显示文摘Lanthanide-based upconversion nanoparticles(UCNPs)have been widely explored in various fields,including optical imaging,in recent years.Although earlier work has shown that UCNPs with different lanthanide(Ln3+)dopants exhibit various colors,multicolor-especially in vivo multiplexed biomedical imaging-using UCNPs has rarely been reported.In this work,we synthesize a series of UCNPs with different emission colors and functionalize them with an amphiphilic polymer to confer water solubility.Multicolor in vivo upconversion luminescence(UCL)imaging is demonstrated by imaging subcutaneously injected UCNPs and applied in multiplexed in vivo lymph node mapping.We also use UCNPs for multicolor cancer cell labeling and realize in vivo cell tracking by UCL imaging.Moreover,for the first time we compare the in vivo imaging sensitivity of quantum dot(QD)-based fluorescence imaging and UCNP-based UCL imaging side by side,and find the in vivo detection limit of UCNPs to be at least one order of magnitude lower than that of QDs in our current non-optimized imaging system.Our data suggest that,by virtue of their unique optical properties,UCNPs have great potential for use in highly-sensitive multiplexed biomedical imaging. | Liang Cheng Kai Yang Shuai Zhang Mingwang Shao Shuittong Lee Zhuang Liu | 2010 | Nano Research2010，3，10： | 17 |
| 2 | Effect of reinforcing kidney-essence, removing phlegm, and promoting mental therapy on treating Alzheimer's disease显示文摘OBJECTIVE: To explore the mechanism of reinforcing kidney-essence, removing phlegm, and promoting mental therapy in treating Alzheimer's disease (AD). METHODS: Sixty patients with AD in Wuhan No.1 Hospital of Traditional Chinese Medicine for Geriatrics from May 2009 to April 2011 were randomly divided into two groups, with 30 in each group. Patients in Bushenhuatanyizhi group (BHY group) took BHY instant granules (6 g, twice per day). Patients in the control group took piracetam (0.8 g, 3 times per day). There were twelve weeks in a course. Changes in the mini-mental state examination (MMSE) score and Activity of Daily Living Scale (ADL) score were analyzed before and after treatment. RESULTS: MMSE scores in the two groups in-creased and ADL scores decreased after treatment, compared with those before treatment (both P< 0.05).The total effective rate was 86.67% in the BHY group (10 very effective, 13 effective, 7 non-responsive). The control group was 57.69% (5 very effective, 16 effective, 9 non-responsive) (P<0.05). Superoxide dismutase levels were increased, lipid peroxide and triglyceride levels decreased after treatment in the BHY group as compared with the control group. CONCLUSION: Reinforcing kidney-essence, removing phlegm, and promoting mental therapy can improve cognitive function and daily life of AD patients. The mechanism of the therapy might be related to improving blood fat, scavenging free radicals, and inhibiting lipid peroxides. | Ping Liu Mingwang Kong Songlin Liu Gang Chen Ping Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 5 |
| 3 | Interaction of polyhydroxy fullerenes with ferrihydrite:adsorption and aggregation显示文摘The rapid development of nanoscience and nanotechnology, with thousands types of nanomaterials being produced, will lead to various environmental impacts. Thus,understanding the behaviors and fate of these nanomaterials is essential. This study focused on the interaction between polyhydroxy fullerenes(PHF) and ferrihydrite(Fh), a widespread iron(oxyhydr)oxide nanomineral and geosorbent. Our results showed that PHF were effectively adsorbed by Fh. The adsorption isotherm fitted the D-R model well, with an adsorption capacity of 67.1 mg/g. The adsorption mean free energy of 10.72 k J/mol suggested that PHF were chemisorbed on Fh. An increase in the solution p H and a decrease of the Fh surface zeta potential were observed after the adsorption of PHF on Fh; moreover, increasing initial solution p H led to a reduction of adsorption. The Fourier transform infrared spectra detected a red shift of C–O stretching from 1075 to 1062 cm-1 and a decrease of Fe–O bending, implying the interaction between PHF oxygenic functional groups and Fh surface hydroxyls. On the other hand, PHF affected the aggregation and reactivity of Fh by changing its surface physicochemical properties. Aggregation of PHF and Fh with individual particle sizes increasing from 2 nm to larger than 5 nm was measured by atomic force microscopy. The uniform distribution of C and Fe suggested that the aggregates of Fh were possibly bridged by PHF. Our results indicated that the interaction between PHF and Fh could evidently influence the migration of PHF, as well as the aggregation and reactivity of Fh. | Jing Liu Runliang Zhu Tianyuan Xu Mingwang Laipan Yanping Zhu Qing Zhou Jianxi Zhu Hongping He | 2018 | Journal of Environmental Sciences2018，30，2： | 5 |
| 4 | In-situ transient photovoltage study on interface electron transfer regulation of carbon dots/NiCo_(2)O_(4) photocatalyst for the enhanced overall water splitting activity显示文摘Photocatalytic hydrogen production by overall water solar-splitting is a prospective strategy to solve energy crisis.However,the rapid recombination of photogenerated electron–hole pairs deeply restricts photocatalytic activity of catalysts.Here,the in-situ transient photovoltage(TPV)technique was developed to investigate the interfacial photogenerated carrier extraction,photogenerated carrier recombination and the interfacial electron delivery kinetics of the photocatalyst.The carbon dots/NiCo_(2)O_(4)(CDs/NiCo_(2)O_(4))composite shows weakened recombination rate of photogenerated carriers due to charge storage of CDs,which enhances the photocatalytic water decomposition activity without any scavenger.CDs can accelerate the interface electron extraction about 0.09 ms,while the maximum electron storage time by CDs is up to 0.7 ms.The optimal CDs/NiCo_(2)O_(4)composite(5 wt.%CDs)displays the hydrogen production of 62µmol·h^(−1)·g^(−1) and oxygen production of 29µmol·h^(−1)·g^(−1) at normal atmosphere,which is about 4 times greater than that of pristine NiCo_(2)O_(4).This work provides sufficient evidence on the charge storage of CDs and the interfacial charge kinetics of photocatalysts on the basis of in-situ TPV tests. | Haodong Nie Yan Liu Yi Li Kaiqiang Wei Zhenyu Wu Hong Shi Hui Huang Yang Liu Mingwang Shao Zhenhui Kang | 2022 | Nano Research2022，15，3： | 2 |
| 5 | Large scale synthesis of carbon nanotubes by an ethanol thermal reduction process显示文摘 | JIANWEI LIU MINGWANG SHAO XIANGYING CHEN WEICHAO YU XIANMING LIU YITAI QIAN | 2003 | J Am Chem Soc2003，125，： | 1 |
| 6 | Optical properties of carbon materials filled HDPE composites in THz region显示文摘The optical and electrical properties of several composites, formed by filling the high density polyethylene (HDPE) with similar amount of carbon black (CB), multi-walled carbon nanotubes (MWNT) and fullerene (C60), respectively, were characterized using a THz-TDS setup. It was found that the optical parameters and the details of their variation with frequency differ significantly for different kinds of carbon materials. The results are analyzed by using Cole-Cole formula of dipole relaxation under the assumption that carbon particles dispersed in the matrix behave like dipoles and contribute mainly to the dielectric loss in the THz frequency range. Fitting results indicate that MWNT and CB filled composites have a broader distribution of the relaxation time compared with C60 which possesses a nearly single relaxation time. Compared with CB and C60, MWNT filled composite possesses the larger relaxation strength due to its higher electron density and larger conductive clusters. The real part of conductivity for three kinds of composites all follows power law behavior with respect to frequency but the exponents are quite different. These phenomena may be related to the special properties of the fillers as well as their particulate structures, such as aspect ratio, particle size, and aggregate structure, etc. | CHEN Xiliang MA Mingwang YANG Xiaomin YANG Kang LIU Dan JI Te WU Shengwei ZHU Zhiyong | 2009 | Nuclear Science and Techniques2009，20，5： | 1 |
| 7 | Application of a venous conduit as a stent for repairing rabbit facial nerve injury显示文摘BACKGROUND: Recently, many investigators have tried to use natural biomaterials, such as, artery, vein, decalcified bone, etc., as conduits for nerve repair. However, immunological rejection of conduits made of natural biomaterials limits their application. Therefore, it is essential to identify more suitable types of biomaterials. OBJECTIVE: To observe the characteristics of a bioengineering processing method using venous conduit as a stent for repairing facial nerve injury. DESIGN: A controlled observational experiment. SETTING: Animal Laboratories of the Third Hospital Affiliated to Sun Yat-sen University and the 157 Hospital. MATERIALS: Thirty-three male New Zealand rabbits of pure breed, weighing 1.5 to 2.0 kg, were provided by Medical Experimental Animal Room of Sun Yat-sen University. The protocol was carried out in accordance with animal ethics guidelines for the use and care of animals. Venous conduits and autogenous nerves were transplanted into the left and right cheeks, respectively. Eleven animals were chosen for anatomical observations at 5, 10 and 15 weeks after surgery. METHODS: This experiment was carried out in the Animal Laboratories of the Third Hospital Affiliated to Sun Yat-sen University and the 157 Hospital between May and November 2006. After animals were anesthetized, 15 mm of retromandibular vein was harvested for preparing a venous conduit. Approximately 3 cm of low buccal branch of facial nerve was exposed. A segment of 1.2 cm nerve was resected from the middle, and a gap of 1.5 cm formed due to bilateral retraction. The prepared venous conduit of 1.5 cm was sutured to the outer membrane of the severed ends of the nerve. Muscle and skin were sutured layer by layer. Using the same above-mentioned method, the low buccal branch of right autogenous facial nerve was resected, and the left facial nerve segment from the same animal was transplanted using end-to-end neurorrhaphy for control. MAIN OUTCOME MEASURES: ①Post-operatively, food intake, vibrissae activity and wound healing of each animal were observed daily. ② Animals were anesthetized at 5, 10 and 15 weeks after operation for observing the structural change of the venous conduit, the appearance of regenerated nerve, and the relationship between conduit and peripheral muscle tissue. ③ The action potential and latency of bilateral nerves of animals were measured by electrophysiologic examination, and nerve conduction velocity was calculated. ④Neural myelination and neurite growth were observed by histological staining using an optical microscope. RESULTS: Thirty-three New Zealand rabbits were involved in the final analysis. ①Immediately following the operation, vibrissae activity and orbicularis oris muscle activity of the upper lip on venous conduit side were more prominent, and their amplitudes of movement were larger as compared with autogenous nerve side. ② At postoperative 10 weeks, by visual inspection, we found that on the venous conduit side, the venous conduit exhibited membrane structure which encased regenerated nerve. Regenerated nerve adhered to the muscle edge of orbicularis oris muscle. Muscle and nerve could be separated with a forceps. The muscle of musculus orbicularis oris of rabbit was darker and thicker as compared with autogenous nerve side. After the venous conduit was longitudinally split, the regenerated nerve and nerves at two the severed ends were connected together. When compared with postoperative 5 weeks, the connected nerve was thickened, texture was tough and its middle part was thicker than its two ends. On the autogenous nerve side, the regenerated nerve stem was enwrapped by scar tissue. It was bulky and adhered to peripheral muscle. Its neural profile structure was unclear. The two stomas were obviously enlarged. ③At postoperative 10 weeks and 15 weeks, nerve action potentials could be elicited from both the venous conduit and autologous nerve side. The mean nerve conduction velocity on the venous conduit side was greater than that of the autologous nerve side. ④At postoperative 10 weeks, using histochemical staining, it was found that in the venous conduit, regenerated medullated nerve fibers were densely distributed, with well split facial nerve structure, while on the autologous nerve side, nerve fibers were sparsely scattered, with immature medullated nerve structure. CONCLUSION: Biological natural venous conduit processed by bioengineering technology overcomes the tissue inflammatory reactions and connective tissue reactions caused by natural biomaterials. It is more conducive to promote neural regeneration and functional recovery than autologous nerve transplantation. | Zhidong Shi Mingwang Liu Zhongzong Qin Qinmei Wang Ying Guo Zhuopeng Ye Zhonghe Yu | 2007 | Neural Regeneration Research2007，2，12： | 1 |
| 8 | Highly efficient metal-free catalyst from cellulose for hydrogen peroxide photoproduction instructed by machine learning and transient photovoltage technology显示文摘Great attention has been paid to green procedures and technologies for the design of environmental catalytic systems.Biomassderived catalysts represent one of the greener alternatives for green catalysis.Photocatalytic production of hydrogen peroxide(H_(2)O_(2))from O_(2) and H_(2)O is an ideal green way and has attracted widespread attention.Here,we show a metal-free photocatalyst from cellulose,which has a high photocatalytic activity for the photoproduction of H_(2)O_(2) with the reaction rate up to 2,093μmol/(h·g)and the apparent quantum efficiency of 2.33%.Importantly,a machine learning model was constructed to guide the synthesis of this metal-free photocatalyst.With the help of transient photovoltage(TPV)tests,we optimized their fabrication and catalytic activity,and clearly showed that the formation of carbon dots(CDs)facilitates the generation,separation,and transfer of photo-induced charges on the catalyst surface.This work provides a green way for the highly efficient metal-free photocatalyst design and study from biomass materials with the machine learning and TPV technology. | Yan Liu Xiao Wang Yajie Zhao Qingyao Wu Haodong Nie Honglin Si Hui Huang Yang Liu Mingwang Shao Zhenhui Kang | 2022 | Nano Research2022，15，5： | 1 |
| 9 | A photoactive process cascaded electrocatalysis for enhanced methanol oxidation over Pt-MXene-TiO2 composite显示文摘Highly efficient photo-assisted electrocatalysis for methanol oxidation reaction(MOR)realizes the conversion of solar and chemical energy into electric energy simultaneously.Here we report a Pt-MXene-TiO2 composite for highly efficient MOR via a photoactive cascaded electro-catalytic process.With light(UV and visible light)irradiation,MXene-TiO2 serves as the photo active centre(photoinduced hole)to activate the methanol molecules,while Pt particles are the active centre for the following electro-catalytic oxidation of those activated methanol molecules.Pt-MXene-TiO2 catalyst exhibits a lower onset potential(0.33 V)and an impressive mass activity of 2,750.42 mA·mg^−1 Pt under light illumination.It represents the highest MOR activity ever reported for photo-assisted electrocatalysts.Pt-MXene-TiO2 also shows excellent CO tolerance ability and stability,in which,after long-term(5,000 s)reaction,still keeps a high mass activity of 1,269.81 mA·mg−1Pt(62.66%of its initial activity).The photo-electro-catalytic system proposed in this work offers novel opportunities for exploiting photo-assisted enhancement of highly efficient and stable catalysts for MOR. | Yue Sun Yunjie Zhou Yan Liu Qingyao Wu Mengmeng Zhu Hui Huang Yang Liu Mingwang Shao Zhenhui Kang | 2020 | Nano Research2020，13，10： | 1 |
| 10 | A trajectory planning method on error compensation of residual height for aero-engine blades of robotic belt grinding显示文摘While the traditional trajectory planning methods are used in robotic belt grinding of blades with an uneven machining allowance distribution, it is hard to obtain the preferable profile accuracy and surface quality to meet the high-performance requirements of aero-engine. To solve this problem, a novel trajectory planning method is proposed in this paper by considering the developed interpolation algorithm and the machining allowance threshold. The residual height error obtained from grinding experiments of titanium alloy sample was compensated to modify the calculation model of row spacing, and a new geometric algorithm was presented to dynamically calculate the cutter contact points based on this revised calculation model and the dichotomy method. Subsequently, the off-line machining program is generated based on a double-vector controlling method to obtain an optimal contact posture. On this basis, three sets of robotic grinding tests of titanium alloy blades were conducted to investigate the advantages of the proposed method.The comparative experimental results revealed that the presented algorithm had improved the surface profile accuracy of blade by 34.2% and 55.1%, respectively. Moreover, the average machined surface roughness was achieved to 0.3 μm and the machining efficiency was obviously promoted. It is concluded that this research work is beneficial to comprehensively improve the machined quality of blades in robotic belt grinding. | Chong LV Lai ZOU Yun HUANG Xifan LIU Zhaorui LI Mingwang GONG Heng LI | 2022 | Chinese Journal of Aeronautics2022，35，4： | 1 |
| 11 | Nonlinear finite element analysis of crack growth at the interface of rubber-like bimaterials显示文摘This paper presents the characteristics of the crack growth at the interface of rubber-rubber and rubber-steel bimaterials undertensile deformation using the non-linear finite element method. By using the commercial finite element software ABAQUS,the J integral calculations are carried out for the initial interface crack in the interfaces in-between two Neo-Hookean materials,two Mooney-Rivlin materials, Neo-Hookean and Mooney-Rivlin rubbers, Neo-Hookean and Polynomial, Mooney-Rivlin andPolynomial, and the Mooney-Rivlin and steel bi-materials. The computational results of the maximum J integral directionaround the crack tip illustrate the possible direction of crack growth initiation. Furthermore, it is found that the crack bends tothe softer rubber material at a certain angle with the initial crack direction if the crack depth is relatively small. For the crackwith a larger depth, the crack propagates to grow along the interface in-between the bimaterials. | YANG XiaoXiang FU MingWang WANG XiuRong LIU XiaoYing | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，10： | 1 |
| 12 | Polymer-controlled growth of Sb2Se3 nanoribbons via a hydrothermal process显示文摘 | Xie Qin Liu Zhaoping Shao Mingwang | 2003 | J Crystal Growth2003，252，4： | 1 |
| 13 | Carbon dots regulate the interface electron transfer and catalytic kinetics of Pt-based alloys catalyst for highly efficient hydrogen oxidation显示文摘The regulation of interface electron-transfer and catalytic kinetics is very important to design the efficient electrocatalyst for alkaline hydrogen oxidation reaction(HOR).Here,we show the Pt-Ni alloy nanoparticles(PtNi_(2))have an enhanced HOR activity compared with single component Pt catalyst.While,the interface electron-transfer kinetics of PtNi_(2)catalyst exhibits a very wide electron-transfer speed distribution.When combined with carbon dots(CDs),the interface charge transfer of PtNi_(2)-CDs composite is optimized,and then the PtNi_(2)-5 mg CDs exhibits about 2.67 times and 4.04 times higher mass and specific activity in 0.1 M KOH than that of 20%commercial Pt/C.In this system,CDs also contribute to trapping H^(+)and H_(2)O generated during HOR,tuning hydrogen binding energy(HBE),and regulating interface electron transfer.This work provides a deep understanding of the interface catalytic kinetics of Pt-based alloys towards highly efficient HOR catalysts design. | Jie Wu Yunjie Zhou Haodong Nie Kaiqiang Wei Hui Huang Fan Liao Yang Liu Mingwang Shao Zhenhui Kang | 2022 | Journal of Energy Chemistry2022，31，3： | 1 |
| 14 | Carbon dots modified Ti_(3)C_(2)T_(x)-based fibrous supercapacitor with photo-enhanced capacitance显示文摘The energy crisis has always been a widely concerned problem. It is an urgent need for green and renewable energy technologies to achieve sustainable development, and the photo-assisted charging energy storage devices provide a new way to realize the sustainable utilization of solar energy. Here, we fabricated a photo-assisted charging fibrous supercapacitor (NM2P1) with Ti_(3)C_(2)T_(x)-based hybrid fibre modified by nitrogen-doped carbon dots (NCDs). The NM2P1 fibre provides a volumetric capacitance of 1,445 F·cm^(−3) (630 F·g^(−1)) at 10 A·cm^(−3) under photo-assisted charging, which increases by 35.9% than that of dark condition (1,063 F·cm^(−3)/464 F·g^(−1)). Furthermore, the NM2P1 fibrous supercapacitor device shows that the maximum volumetric energy density and volumetric power density are 18.75 mWh·cm^(−3) and 8,382 mW·cm^(−3). Notably, the transient photovoltage (TPV) test was used to further confirm that NCDs as a photosensitizer enhance the light absorption capacity and faster charge transfer kinetics of NM2P1 fibre. This work directly exploits solar energy to improve the overall performance of supercapacitor, which opens up opportunities for the utilization of renewable energy and the development of photosensitive energy equipment. | Hui Wang Jingjing Cao Yunjie Zhou Xiao Wang Hui Huang Yang Liu Mingwang Shao Zhenhui Kang | 2021 | Nano Research2021，14，11： | 1 |
| 15 | Highly crystalline core dominated the catalytic performance of carbon dot for cyclohexane to adipic acid reaction显示文摘Carbon dots(CDs)have uniquely structural,physicochemical and photochemical properties,suggesting a promising platform for catalysis applications.The in-depth understanding of the structure-activity relationship in the CDs-based catalyst system needs to know the effect of the crystalline core on their catalytic performance.The efficient catalytic oxidation of cyclohexane is an urgent challenge in current chemical industry,in which,adipic acid(AA)plays an important role in industry for synthesis of nylon6 and nylon-66.Here,we fabricated the pristine CDs by electrochemical etching graphite rod method and derived CDs with high crystalline core(CD-600,CD-800,and CD-1100)through a thermal treatment method in tube furnace.Furthermore,these CDs performed an outstanding catalytic performance for one-step synthesis of AA from cyclohexane.With the help of machine learning(ML),the deep correlations between features(structures of CDs,catalytic conditions)and catalytic performances were investigated by XGBoost(XGB)model.Then under the optimization and prediction of XGB,it was found that high crystalline core preceded the other features and CD-1100 could get the best conversion of 30.696%and selectivity to AA of 92.52%at reaction conditions of 130℃,1.5 MPa,and 10 h.This work pioneered the application of ML in industrial issues and demonstrated a comprehensive understanding on CDs as catalyst to realize one-step synthesis of AA. | Xiao Wang Wenyi Bian Tianyang Zhang Yajie Zhao Mingwang Shao Haiping Lin Yang Liu Hui Huang Zhenhui Kang | 2022 | Nano Research2022，15，8： | 0 |
| 16 | Carbon dots/Bi_(2)WO_(6) composite with compensatory photo-electronic effect for overall water photo-splitting at normal pressure显示文摘Overall water photo-splitting is a prospective ideal pathway to produce ultra-clean H_(2) energy by semiconductors.However,the band structure of many semiconductors cannot satisfy the requirement of H_(2) and O_(2) production at the same time.Herein,we illustrate that carbon dots(CDs)/Bi_(2)WO_(6) photocatalyst with compensatory photo-electronic effect has enhanced activity for overall water photo-splitting without any sacrificial agent.In this complex photocatalytic system,the photo-potential provided by CDs makes the CDs/Bi2WO6(C-BWO)composite could satisfy the band structure conditions for overall water photo-splitting.The C-BWO composite(3 wt%CDs content)exhibits optimized hydrogen evolution(oxygen evolution)of 0.28μmol/h(0.12μmol/h)with an approximate 2:1(H_(2):O_(2))stoichiometry at normal pressure.We further employed the in-situ transient photovoltage(TPV)technique to study the photoelectron extraction and the interface charge transfer kinetics of this composite catalyst. | Haodong Nie Kaiqiang Wei Yi Li Yan Liu Yajie Zhao Hui Huang Mingwang Shao Yang Liu Zhenhui Kang | 2021 | Chinese Chemical Letters2021，32，7： | 0 |
| 17 | Metal atom doping-induced S-scheme heterojunction boosts the photoelectric response显示文摘Carrier migration path and driving forces are two crucial factors for charge separation of heterojunction with efficient photoelectric response from the thermodynamic and kinetic perspectives,respectively.Constructing the S-scheme heterojunction and achieving an efficient migration path for space charge separation have aroused great interest,while a thorough insight into tuning interfacial band bending for S-scheme heterojunction is absent.Herein,we report a class of Zn atom-doped CeO_(2)/g-C_(3)N_(4) heterostructure for achieving a new carrier migration path conversion from inferior type-II to advanced S-scheme.Zn-dependent volcano-type plot for Zn-CeO_(2) is established to tune the Fermi level of CeO_(2).The built-in electric field for carrier flow dynamics strengthens when coupling with g-C_(3)N_(4),which significantly boosts the photoelectric response.Based on the intrinsic enzymelike activity of Zn-CeO_(2),we further demonstrate that the Zn-CeO_(2)/g-C_(3)N_(4) S-scheme heterojunction can be explored for constructing a sensitive nanozymatic photoelectrochemical biosensor for the detection of acetylcholinesterase. | Mingwang Liu Jing Wen Ying Qin Jinli Li Yinjun Tang Lei Jiao Yu Wu Qie Fang Lirong Zheng Xiaowen Cui Wenling Gu Chengzhou Zhu Liuyong Hu Shaojun Guo | 2023 | Science China Chemistry2023，66，4： | 0 |
| 18 | Compound soft regenerated skull material for repairing dog skull defects using bone morphogenetic protein as an inductor and nanohydroxyapatite as a scaffold显示文摘BACKGROUND:In previous studies of skull defects and regeneration, bone morphogenetic protein as an inductor and nanohydroxyapatite as a scaffold have been cocultured with osteoblasts. OBJECTIVE: To verify the characteristics of the new skull regenerated material after compound soft regenerated skull material implantation. DESIGN, TIME AND SETTING: The self-control and inter-group control animal experiment was performed at the Sun Yat-sen University, China from February to July 2007. MATERIALS: Twenty-four healthy adult dogs of both genders weighing 15–20 kg were used in this study. Nanohydroxyapatite as a scaffold was cocultured with osteoblasts. Using demineralized canine bone matrix as a carrier, recombinant human bone morphogenetic protein-2 was employed to prepare compound soft regenerated skull material. Self-designed compound soft regenerated skull material was implanted in models of skull defects. METHODS: Animals were randomly assigned into two groups, Group A (n = 16) and Group B (n = 8). Bilateral 2.5-cm-diameter full-thickness parietal skull defects were made in all animals. In Group A, the right side was reconstructed with calcium alginate gel, osteoblasts, and nanometer bone meal composite; the left side was reconstructed with calcium alginate gel, osteoblasts, nanometer bone meal and recombinant human bone morphogenetic protein-2 composite. In Group B, the right side was kept as a simple skull defect, and the left side was reconstructed with calcium alginate gel, osteoblasts, nanometer bone meal and recombinant human bone morphogenetic protein-2 composite. MAIN OUTCOME MEASURES: Bone regeneration and histopathological changes at the site of the skull defect were observed with an optical microscope and a scanning electron microscope after surgery. The ability to form bone was measured by alizarin red S staining. In vitro cultured osteoblasts were observed for morphology. RESULTS: One month following surgery, newly formed bone trabeculae mostly covered the broken ends of the fractured bone and grew towards the defect regions. Two months after surgery, many disordered bone islands had formed. Three months after surgery, mature bone, medullary cavities and a large number of new bones were detected in the defect regions. Six months after surgery, the left defect was mostly repaired, with a high bone density compared with the right side in Groups A and B. The right defect was mostly repaired in Group A, but only a small fraction of the right defects was repaired in Group B. CONCLUSION: A composite of calcium alginate gel, osteoblasts, nanometer bone meal and recombinant human bone morphogenetic protein-2 can metabolize by itself, gradually ossify and form new bone. | Zhidong Shi Mingwang Liu Zhongzong Qin Qinmei Wang Ying Guo Haiyong He Zhonghe Yu | 2008 | Neural Regeneration Research2008，3，8： | 0 |
| 19 | What Is Required to Prevent a Second Major Outbreak of SARS-CoV-2 upon Lifting Quarantine in Wuhan City,China显示文摘BACKGROUND The Chinese government implemented a metropolitan-wide quarantine of Wuhan city on 23rd January 2020 to curb the epidemic of the coronavirus COVID-19.Lifting of this quarantine is imminent.We modelled the effects of two key health interventions on the epidemic when the quarantine is lifted. | Lei Zhang Mingwang Shen Xiaomeng Ma Shu Su Wenfeng Gong Jing Wang Yusha Tao Zhuoru Zou Rui Zhao Joseph T.F.Lau Wei Li Feng Liu Kai Ye Youfa Wang Guihua Zhuang Christopher K.Fairley | 2020 | The Innovation2020，1，1： | 0 |
| 20 | Travel-related Importation and Exportation Risks of SARS-CoV-2 Omicron Variant in 367 Prefectures(Cities)-China,2022显示文摘Introduction:Minimizing the importation and exportation risks of coronavirus disease 2019(COVID-19)is a primary concern for sustaining the“Dynamic COVID-zero”strategy in China.Risk estimation is essential for cities to conduct before relaxing border control measures.Methods:Informed by the daily number of passengers traveling between 367 prefectures(cities)in China,this study used a stochastic metapopulation model parameterized with COVID-19 epidemic characteristics to estimate the importation and exportation risks.Results:Under the transmission scenario(R0=5.49),this study estimated the cumulative case incidence of Changchun City,Jilin Province as 3,233(95%confidence interval:1,480,4,986)before a lockdown on March 14,2022,which is close to the 3,168 cases reported in real life by March 16,2022.In a total of 367 prefectures(cities),127(35%)had high exportation risks according to the simulation and could transmit the disease to 50%of all other regions within a period from 17 to 94 days.The average time until a new infection arrives in a location in 1 of the 367 prefectures(cities)ranged from 26 to 101 days.Conclusions:Estimating COVID-19 importation and exportation risks is necessary for preparedness,prevention,and control measures of COVID-19—especially when new variants emerge. | Yuan Bai Mingda Xu Caifen Liu Mingwang Shen Lin Wang Linwei Tian Suoyi Tan Lei Zhang Petter Holme Xin Lu Eric H.Y.Lau Benjamin J.Cowling Zhanwei Du | 2022 | China CDC weekly2022，4，40： | 0 |
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