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| 1 | The application of CAR-T cell therapy in hematological malignancies: advantages and challenges显示文摘Chimeric antigen receptor T cell(CAR-T cell) therapy is a novel adoptive immunotherapy where T lymphocytes are engineered with synthetic receptors known as chimeric antigen receptors(CAR).The CAR-T cell is an effector T cell that recognizes and eliminates specific cancer cells, independent of major histocompatibility complex molecules. The whole procedure of CAR-T cell production is not well understood. The CAR-T cell has been used predominantly in the treatment of hematological malignancies,including acute lymphoblastic leukemia, chronic lymphocytic leukemia, lymphoma, and multiple myeloma. Solid tumors including melanoma, breast cancer and sarcoma offer great promise in CAR-T cell research and development. CD19 CAR-T cell is most commonly used, and other targets, including CD20, CD30, CD38 and CD138 are being studied. Although this novel therapy is promising, there are several disadvantages. In this review we discuss the applications of CAR-T cells in different hematological malignancies, and pave a way for future improvement on the effectiveness and persistence of these adoptive cell therapies. | Zijun Zhao Yu Chen Ngiambudulu M.Francisco Yuanqing Zhang Minhao Wu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 22 |
| 2 | Exosomes-the enigmatic regulators of bone homeostasis显示文摘Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells.Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins, lipids and nucleic acids, which then to regulate osteoclastogenesis and osteogenesis. However, the network of regulatory activities of exosomes in bone homeostasis as well as their therapeutic potential in bone injury remain largely unknown. This review will detail and discuss the characteristics of exosomes, the regulatory activities of exosomes in bone homeostasis as well as the clinical potential of exosomes in bone injury. | Minhao Gao Weiyang Gao J. M. Papadimitriou Changqing Zhang Junjie Gao Minghao Zheng | 2018 | Bone Research2018，6，4： | 13 |
| 3 | Anti-loosening performance of coatings on fasteners subjected to dynamic shear load显示文摘This paper investigates the self-loosening of threaded fasteners subjected to dynamic shear load. Three kinds of typical coatings, PTFE, MoS_2, and TiN applied to bolts and nuts, are tested in this investigation. The study experimentally examines the loosening mechanisms of fasteners and assesses the anti-loosening performance of the three tested coatings based on their tightening characteristics, loosening curves, and the damage of thread surface. Additionally, the anti-loosening performance of the three coatings is compared under different load forms. The results indicate that the PTFE and MoS_2 coatings have significant anti-loosening effect, whereas the anti-loosening performance of Ti N coating is not satisfactory. It is also found that an appropriate increase of the initial tightening torque can significantly improve the anti-loosening effect. In addition, the microscopic analyses of PTFE and MoS2 coating reveal that a reduced initial tightening torque leads to fretting wear on the thread contact surfaces of fasteners, thereby aggravating the damage. | Junbo ZHOU Jianhua LIU Huajiang OUYANG Zhenbing CAI Jinfang PENG Minhao ZHU | 2018 | Friction2018，6，1： | 10 |
| 4 | Perchlorate removal using granular activated carbon supported iron compounds: Synthesis, characterization and reactivity显示文摘Synthesis and use of the iron compounds supported on granular activated carbon (ICs/GAC) have shown significant environmental implications for perchlorate (ClO 4 ) removal. ICs/GAC was synthesized via hydrolyzing FeSO 4 ·7H 2 O on GAC, reduced by NaBH 4 solution in polyethylene glycol 6000 and ethanol solution, dried in vacuum condition and exposed to air. Synthesized ICs/GAC was characterized using transmission electron micrograph (TEM), Brunauer-Emmett-Teller, X-ray photoelectron spectroscopy (XPS). ICs/GAC was determined to be containing a large amount of FeOHSO 4 , Fe 2 O 3 and a small amount of zero-valent iron (ZVI) nanoparticles according to TEM and XPS measurements. Batch static kinetic tests showed that 97% of ClO 4 was removed within 10 hr at 90°C and 86% of ClO 4 was removed within 12 hr at 25°C, at ICs/GAC dosage of 20 g/L. The experimental results also showed that FeOHSO 4 and Fe 2 O 3 nanoparticles have the function of perchlorate adsorption and play important roles in ClO 4 removal. The activation energy (E a ) was determined to be 9.56 kJ/mol. | Jianhong Xu Naiyun Gao Yulin Tang Yang Deng Minhao Sui | 2010 | Journal of Environmental Sciences2010，22，11： | 8 |
| 5 | Structure-based assessment of disease- related mutations in human voltage-gated sodium channels显示文摘电压门钠(Nav ) 隧道为行动潜力和在神经和肌肉的电的信号的繁殖的快速的向上的一击是必要的。Nav 隧道的缺点与许多 channelopathies 被联系。超过 1000 个疾病相关的变化在 Nav 隧道被识别了,与怀有超过 400 个变化的 Nav1.1 和 Nav1.5 各个。Nav 隧道为神经毒素和药的一个宽数组代表主要目标。Nav 隧道的原子结构被要求理解他们的功能和疾病机制。兔子电压门钙(Cav ) 的最近坚定的原子结构隧道 Cav1.1 为 evolutionarily 相关的 Nav 隧道的基于相同的结构的建模提供一个模板。在这篇资源文章,我们在人的 Nav 隧道总结了所有报导疾病相关的变化,产生了人的 Nav1.7 的一个相应模型,并且在结构上印射联系疾病的变化。在人的 Nav 隧道的结构的决心前,这里介绍的分析为 Nav channelopathies 的机械学的调查并且为潜在的基于结构的药发现用作基础框架。 | Weiyun Huang Minhao Liu S. Frank Yan Nieng Yan | 2017 | Protein & Cell2017，8，6： | 8 |
| 6 | Amino-functionalized Ti_(3)C_(2)T_(x) with anti-corrosive/wear function for waterborne epoxy coating显示文摘Two-dimensional Ti_(3)C_(2)T_(x) flakes have great application potential in various areas due to their optical,electronic,electrochemical and mechanical properties,but their anti-corrosion and wear-resistance performance were not well understood.The difficulties in achieving good dispersity and interface interaction of inorganic additives in organic coatings hinder the incorporation of Ti_(3)C_(2)T_(x) into the epoxy coating.Here,few-layered Ti_(3)C_(2)T_(x) sheets with amino-functionalization were prepared,and as reinforced-additives were added into the waterborne epoxy coating.Anti-corrosion and tribological properties of as-prepared composite coatings were investigated in detail.The results reveal that the composite coating with 0.5 wt.%amino-functionalized Ti_(3)C_(2)T_(x) sheets shows excellent corrosion protection(the lowest frequency impedance was 3.12×10^(9) cm^(2))and wear resistance(wear rate was reduced by 72.74%).The greatly improving performance of composite coatings mainly depends on:(a)good dispersity and compatibility of amino-functionalized Ti_(3)C_(2)T_(x) in organic matrix,(b)high adhesion strength between coating and metal substrate and(c)the intrinsic properties of Ti3C2Tx sheets.The work provides a good path for applications of MXene as multifunctional additives. | Han Yan Meng Cai Wen Li Xiaoqiang Fan Minhao Zhu | 2020 | Journal of Materials Science & Technology2020，54，19： | 7 |
| 7 | Comparative study on corrosion resistance and lubrication function of lithium complex grease and polyurea grease显示文摘In this study,lithium complex grease(LCG)and polyurea grease(PUG)were synthesized using mineral oil(500 SN)and polyalphaolefin(PAO40)as base oil,adsorbed onto lithium complex soap and polyurea as thickeners,respectively.The effects of grease formulation(thickener and base oil with different amounts(80,85,and 90 wt%)on the corrosion resistance and lubrication function were investigated in detail.The results have verified that the as-prepared greases have good anti-corrosion ability,ascribed to good salt-spray resistance and sealing function.Furthermore,the increase in the amount of base oil reduces the friction of the contact interface to some extent,whereas the wear resistance of these greases is not consistent with the friction reduction,because the thickener has a significant influence on the tribological property of greases,especially load-carrying capacity.PUG displays better physicochemical performance and lubrication function than LCG under the same conditions,mainly depending on the component/structure of polyurea thickener.The polyurea grease with 90 wt%PAO displays the best wear resistance owing to the synergistic lubrication of grease-film and tribochemical film,composed of Fe_(2)O_(3),FeO(OH),and nitrogen oxide. | Guanlin REN Pengfei ZHANG Xiangyuan YE Wen LI Xiaoqiang FAN Minhao ZHU | 2021 | Friction2021，9，1： | 5 |
| 8 | Improving the lubrication and anti-corrosion performance of polyurea grease via ingredient optimization显示文摘Thickener formulation plays a significant role in the performance characteristics of grease.The polyurea greases(PUGs)were synthesized using mineral oil(500SN)as the base oil,and by regulating the reaction of diphenylmethane diisocyanate(MDI)and different organic amines.The as‐prepared PUGs from the reaction of MDI and cyclohexylamine/p‐toluidine exhibit the optimum physicochemical and friction‐wear properties,confirming that the regulation of thickener formulation can improve the performance characteristics of grease,including friction reduction,wear,corrosion resistance,and load‐carrying capacity.The anticorrosion and lubrication properties of as‐prepared PUGs depend on good sealing functions and a boundary lubrication film(synergy of grease‐film and tribo‐chemical reaction film),as well as their chemical components and structure. | Guanlin REN Xiaowen SUN Wen LI Hao LI Lin ZHANG Xiaoqiang FAN Dongshan LI Minhao ZHU | 2021 | Friction2021，9，5： | 4 |
| 9 | Fermentation characteristics and probiotic activity of a purified fraction of polysaccharides from Fuzhuan brick tea显示文摘Polysaccharides from Fuzhuan brick tea(FBTPS),one of most important bioactive components in tea,showed various health-promoting functions.Our previous work demonstrated that the crude FBTPS(CFBTPS)could modulate the gut microbiota.However,which purified fraction in CFBTPS contributing to the modulation of gut microbiota remains unclear.Thus,the fermentation characteristics and probiotic activity of a purified fraction(FBTPS-2-1)of CFBTPS were evaluated in this work.The results showed that gut microbiota could utilize FBTPS-2-1 to produce short-chain fatty acids including acetic,propionic,n-butyric and n-valeric acids.FBTPS-2-1 could modulate the structure and metabolic pathways of gut microbiota.FBTPS-2-1 could increase the health-promoting gut microbiota such as Prevotellaceae and Bifidobacteriaceae,and decreased the harmful bacteria such as Enterobacteriaceae and Fusobacteriaceae.The results of metagenomics showed that Prevotella copri and Megamonas funiformis were the dominant bacteria after fermentation of FBTPS-2-1.Furthermore,FBTPS-2-1 could regulate the biosynthesis and metabolism pathways of gut microbiota.Thus,the enrichment of food with FBTPS-2-1 is expected as a potential strategy for promoting human health due to modulation of gut microbiota. | Guijie Chen Ziqi Zeng Minhao Xie Yujia Peng Wangting Zhou Weiqi Xu Yi Sun Xiaoxiong Zeng Zhonghua Liu | 2022 | Food Science and Human Wellness2022，11，3： | 4 |
| 10 | Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex显示文摘The nuclear pore complex(NPC)mediates the flow of substances between the nucleus and cytoplasm in eukaryotic cells.Here we report the cryo-electron tomography(cryo-ET)structure of the luminal ring(LR)of the NPC from Xenopus laevis oocyte.The observed key structural features of the LR are independently confirmed by single-particle cryo-electron microscopy(cryo-EM)analysis.The LR comprises eight butterfly-shaped subunits,each containing two symmetric wings.Each wing consists of four elongated,tubular protomers.Within the LR subunit,the eight protomers form a Finger domain,which directly contacts the fusion between the inner and outer nuclear membranes and a Grid domain,which serves as a rigid base for the Finger domain.Two neighboring LR subunits interact with each other through the lateral edges of their wings to constitute a Bumper domain,which displays two major conformations and appears to cushion neighboring NPCs.Our study reveals previously unknown features of the LR and potentially explains the elastic property of the NPC. | Yanqing Zhang Sai Li Chao Zeng Gaoxingyu Huang Xuechen Zhu Qifan Wang Kunpeng Wang Qiang Zhou Chuangye Yan Wusheng Zhang Guangwen Yang Minhao Liu Qinghua Tao Jianlin Lei Yigong Shi | 2020 | Cell Research2020，30，6： | 4 |
| 11 | Analysis of steering performance of differential coupling wheelset显示文摘In order to improve the curving performance of the conventional wheelset in sharp curves and resolve the steering ability problem of the independently rotating wheel in large radius curves and tangent lines, a differential coupling wheelset(DCW) was developed in this work. The DCW was composed of two independently rotating wheels(IRWs) coupled by a clutch-type limited slip differential.The differential contains a static pre-stress clutch, which could lock both sides of IRWs of the DCW to ensure a good steering performance in curves with large radius and tangent track. In contrast, the clutch could unlock the two IRWs of the DCW in a sharp curve to endue it with the characteristic of an IRW, so that the vehicles can go through the tight curve smoothly. To study the dynamic performance of the DCW, a multi-body dynamic model of single bogie with DCWs was established. The self-centering capability, hunting stability,and self-steering performance on a curved track were analyzed and then compared with those of the conventional wheelset and IRW. Finally, the effect of coupling parameters of the DCW on the dynamic performance was investigated. | Xingwen Wu Maoru Chi Jing Zeng Weihua Zhang Minhao Zhu | 2014 | Journal of Modern Transportation2014，22，2： | 4 |
| 12 | Functional characterization of humar equilibrative nucleoside transporter 1显示文摘 | Weiyun Huang Xin Zeng Yigong Shi Minhao Liu | 2017 | Protein & Cell2017，8，4： | 3 |
| 13 | Bioactivities and molecular mechanisms of polysaccharides from Hericium erinaceus显示文摘Hericium erinaceus,an edible and medicinal mushroom,has been utilized since ancient China due to its delicious taste and health benefits.The polysaccharide from H.erinaceus(HEP)is supposed to be one of the major bioactive compounds,which garnered widespread attention in seeking innovative applications for precision nutrition.Both in vitro and in vivo studies have shown that HEP possesses antioxidant and anti-aging,gastrointestinal protecting,anti-tumor,hypolipidemic and hypoglycemic,immune-enhancing,neuroprotective,and hepatoprotective activities,verifying its functional benefits to human health.This review provides an overview of the extraction and structure of HEP,and concluded that HEP had different structures with different sources of H.erinaceus and extraction methods.Besides,the biochemical and pharmacological properties of HEP as well as the relative mechanism were highlighted and summarized on the basis of in vivo and in vitro studies,which could be helpful for the healthy application of HEP.Finally,the research prospects of HEP for specific populations or precision nutrition were proposed. | Jianhui Liu Weiwei Wang Qiuhui Hu Xuyang Wu Hui Xu Anxiang Su Minhao Xie Wenjian Yang | 2022 | Journal of Future Foods2022，2，2： | 3 |
| 14 | Fretting Wear Behavior of Medium Carbon Steel Modified by Low Temperature Gas Multi-component Thermo-chemical Treatment显示文摘The introduction of surface engineering is expected to be an effective strategy against fretting damage. A large number of studies show that the low gas multi-component (such as carbon, nitrogen, sulphur and oxygen, etc) thermo-chemical treatment(LTGMTT) can overcome the brittleness of nitriding process, and upgrade the surface hardness and improve the wear resistance and fatigue properties of the work-pieces significantly. However, there are few reports on the anti-fretting properties of the LTGMTT modified layer up to now, which limits the applications of fretting. So this paper discusses the fretting wear behavior of modified layer on the surface of LZ50 (0.48%C) steel prepared by low temperature gas multi-component thermo-chemical treatment (LTGMTT) technology. The fretting wear tests of the modified layer flat specimens and its substrate (LZ50 steel) against 52100 steel balls with diameter of 40 mm are carried out under normal load of 150 N and displacement amplitudes varied from 2 μm to 40 μm. Characterization of the modified layer and dynamic analyses in combination with microscopic examinations were performed through the means of scanning electron microscope(SEM), optical microscope(OM), X-ray diffraction(XRD) and surface profilometer. The experimental results showed that the modified layer with a total thickness of 60 μm was consisted of three parts, i.e., loose layer, compound layer and diffusion layer. Compared with the substrate, the range of the mixed fretting regime(MFR) of the LTGMTT modified layer diminished, and the slip regime(SR) of the modified layer shifted to the direction of smaller displacement amplitude. The coefficient of friction(COF) of the modified layer was lower than that of the substrate in the initial stage. For the modified layer, the damage in partial slip regime(PSR) was very slight. The fretting wear mechanism of the modified layer both in MFR and SR was abrasive wear and delamination. The modified layer presented better wear resistance than the substrate in PSR and MFR; however, in SR, the wear resistance of the modified layer decreased with the increase of the displacement amplitudes. The experimental results can provide some experimental bases for promoting industrial application of LTGMTT modified layer in anti-fretting wear. | LUO Jun ZHENG Jianfeng PENG Jinfang HE Liping ZHU Minhao | 2010 | Chinese Journal of Mechanical Engineering2010，23，3： | 3 |
| 15 | Heterostructured ZnFe_2O_4/Fe_2TiO_5/TiO_2 Composite Nanotube Arrays with an Improved Photocatalysis Degradation Efficiency Under Simulated Sunlight Irradiation显示文摘To improve the visible light absorption and photocatalytic activity of titanium dioxide nanotube arrays(TONTAs), ZnFe_2O_4(ZFO) nanocrystals were perfused into pristine TONTA pipelines using a novel bias voltageassisted perfusion method. ZFO nanocrystals were well anchored on the inner walls of the pristine TONTAs when the ZFO suspensions(0.025 mg m L^(-1)) were kept under a60 V bias voltage for 1 h. After annealing at 750 °C for2 h, the heterostructured ZFO/Fe_2 TiO_5(FTO)/TiO_2 composite nanotube arrays were successfully obtained. Furthermore, Fe^(3+)was reduced to Fe^(2+)when solid solution reactions occurred at the interface of ZFO and the pristine TONTAs. Introducing ZFO significantly enhanced thevisible light absorption of the ZFO/FTO/TONTAs relative to that of the annealed TONTAs. The coexistence of type I and staggered type II band alignment in the ZFO/FTO/TONTAs facilitated the separation of photogenerated electrons and holes, thereby improving the efficiency of the ZFO/FTO/TONTAs for photocatalytic degradation of methylene blue when irradiated with simulated sunlight. | Kun Xiong Kunzhou Wang Lin Chen Xinqing Wang Qingbo Fan Jérémie Courtois Yuliang Liu Xianguo Tuo Minhao Yan | 2018 | Nano-Micro Letters2018，10，1： | 2 |
| 16 | Pyrochlore-based high-entropy ceramics for capacitive energy storage显示文摘High-performance dielectrics are widely used in high-power systems,electric vehicles,and aerospace,as key materials for capacitor devices.Such application scenarios under these extreme conditions require ultra-high stability and reliability of the dielectrics.Herein,a novel pyrochlore component with high-entropy design of Bi1.5Zn_(0.75)Mg_(0.25)Nb_(0.75)Ta_(0.75)O_(7)(BZMNT)bulk endows an excellent energy storage performance of Wrec≈2.72 J/cm3 together with an ultra-high energy efficiency of 91%at a significant enhanced electric field Eb of 650 kV/cm.Meanwhile,the temperature coefficient(TCC)of BZMNT(~−220 ppm/℃)is also found to be greatly improved compared with that of the pure Bi1.5ZnNb1.5O7(BZN)(~−300 ppm/℃),demonstrating its potential application in temperature-reliable conditions.The high-entropy design results in lattice distortion that contributes to the polarization,while the retardation effect results in a reduction of grain size to submicron scale which enhances the Eb.The high-entropy design provides a new strategy for improving the high energy storage performance of ceramic materials. | Yiying CHEN Junlei QI Minhao ZHANG Zixi LUO Yuan-Hua LIN | 2022 | Journal of Advanced Ceramics2022，11，7： | 2 |
| 17 | The effect of oxidation on physicochemical properties and aqueous stabilization of multiwalled carbon nanotubes:comparison of multiple analysis methods显示文摘Surface oxidation can alter physicochemical properties of multiwalled carbon nanotubes(MWCNTs) and influence their aqueous stabilization.Many techniques have been used to characterize the physicochemical properties and aqueous stabilization of MWCNTs.However,the relationship between the change in physicochemical property and the aqueous stabilization of MWCNTs merits more studies,and the multiple characterization techniques have not been well compared.This study systematically and comparatively investigated the effect of oxidation on the physicochemical properties and aqueous stabilization of MWCNTs using multiple analysis methods.Increased surface area,disclosed tube ends,defects on the sidewalls,disruption of the electronic structure,and removal of metal catalysts and amorphous carbon were observed for the oxidized MWCNTs(o-MWCNTs) using the multipoint Brunauer-Emmett-Teller(BET) method,transmission electron microscope observation,Raman spectroscopy,UV-Vis spectroscopy,and thermogravimetric analysis.An oxidation-time-dependent increase in oxygen content of the MWCNTs was verified by the methods of elemental analysis,mass difference calculation,and X-ray photoelectron spectroscopy(XPS).Fourier transform infrared spectroscopy,XPS,and the Boehm titration were employed to study the functionalities on the MWCNT surfaces.Despite the limitations of these techniques,the results indicated that the dramatic increase in carboxyl groups was mainly responsible for the significant increase in oxygen content after the oxidation.The dissociation of the grafted functional groups increased electronegativity of the o-MWCNTs and facilitated the aqueous stabilization of o-MWCNTs through electrostatic repulsions.The oxidation affected the UV-Vis absorbance of MWCNT suspensions.The absorbances at 800 nm of the stabilized MWCNT suspensions had a good correlation with the MWCNT concentrations and could be used to quantify the MWCNT suspensions.The findings of this work are expected to boost the research on carbon nanotubes and their environmental behaviors. | Luqing Zhang Minhao Wang Jing Fang Kun Yang Daohui Lin | 2016 | Science China Chemistry2016，59，11： | 2 |
| 18 | Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis显示文摘The nuclear pore complex(NPC)exhibits structural plasticity and has only been characterized at local resolutions of up to 15 A for the cytoplasmic ring(CR).Here we present a single-particle cryo-electron microscopy(cryo-EM)structure of the CR from Xenopus laevis NPC at average resolutions of 5.5-7.9A,with local resolutions reaching 4.5 A.Improved resolutions allow identification and placement of secondary structural elements in the majority of the CR components.The two Y complexes in each CR subunit interact with each other and associate with those from flanking subunits,forming a circular scaffold.Within each CR subunit,the Nup358-containing region wraps around the stems of both Y complexes,likely stabilizing the scaffold.Nup205 connects the short arms of the two Y complexes and associates with the stem of a neighboring Y complex.The Nup214-containing region uses an extended coiled-coil to link Nup85 of the two Y complexes and protrudes into the axial pore of the NPC.These previously uncharacterized structural features reveal insights into NPC assembly. | Gaoxingyu Huang Yanqing Zhang Xuechen Zhu Chao Zeng Qifan Wang Qiang Zhou Qinghua Tao Minhao Liu Jianlin Lei Chuangye Yan Yigong Shi | 2020 | Cell Research2020，30，6： | 2 |
| 19 | Development of a novel cycling impact–sliding wear rig to investigate the complex friction motion显示文摘In many industrial devices, impact-sliding wear is caused by a variety of complex vibrations between the contacted interfaces. Under actual conditions, impact and sliding motions do not occur in only one direction, and different complex impact-sliding motions exist on the tribology surfaces. In this study, an impact-sliding wear test rig is developed to investigate the wear effect of different complex motions. Using this rig, multi-type impact-sliding wear effects are realized and measured, such as those derived from unidirectional, reciprocating, and multi-mode combination motions. These three types of impact–sliding wear running behavior are tested and the wear damage mechanism is discussed. | Zhenbing CAI Zhiqiang CHEN Yang SUN Jianying JIN Jinfang PENG Minhao ZHU | 2019 | Friction2019，7，1： | 2 |
| 20 | A High Sensitivity Detection Method of Singlet Oxygen and Superoxide Anion显示文摘This paper, for the first time, reports a method that can be used as a highly sensitive probe for singlet oxygen (^1O2) and superoxide anion (O2^-) in vitro or in vivo. FCLA(3,7-dihydro-6-{4-[2-(N'-(5-fluoresceinyl)thioureido)ethoxy]phenyl}-2-methylimidazo{1,2-a}pyrazin-3-one sodium salt), a chemiluminescence (CL) analysis reagent, has been reported to sensitively react with ^1O2 and O2^- to emit photons with a spectral peak of 525nm. In this work,when human serum albumin (HSA) was added into FCLA solution to enhance the CL intensity,approximately 20 times, compared to that without HSA. The enhanced CL had the same 525 nm spectral peak, identical to that without HSA. By gradually reducing the molecular oxygen content in the solution, we find that the auto-oxidation of oxygen molecules dissolved in the solution plays an important role in the CL process. Based on these experimental evidences, we propose a novel and highly sensitive detection method of ^1O2 and O2^- which may have a great potential in chemical and medical applications. | MinHAO DaXING QunCHEN JuanWANG | 2004 | Chinese Chemical Letters2004，15，6： | 2 |
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