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| 1 | Anti-loosening performance of coatings on fasteners subjected to dynamic shear load显示文摘This paper investigates the self-loosening of threaded fasteners subjected to dynamic shear load. Three kinds of typical coatings, PTFE, MoS_2, and TiN applied to bolts and nuts, are tested in this investigation. The study experimentally examines the loosening mechanisms of fasteners and assesses the anti-loosening performance of the three tested coatings based on their tightening characteristics, loosening curves, and the damage of thread surface. Additionally, the anti-loosening performance of the three coatings is compared under different load forms. The results indicate that the PTFE and MoS_2 coatings have significant anti-loosening effect, whereas the anti-loosening performance of Ti N coating is not satisfactory. It is also found that an appropriate increase of the initial tightening torque can significantly improve the anti-loosening effect. In addition, the microscopic analyses of PTFE and MoS2 coating reveal that a reduced initial tightening torque leads to fretting wear on the thread contact surfaces of fasteners, thereby aggravating the damage. | Junbo ZHOU Jianhua LIU Huajiang OUYANG Zhenbing CAI Jinfang PENG Minhao ZHU | 2018 | Friction2018，6，1： | 10 |
| 2 | Structure-based assessment of disease- related mutations in human voltage-gated sodium channels显示文摘电压门钠(Nav ) 隧道为行动潜力和在神经和肌肉的电的信号的繁殖的快速的向上的一击是必要的。Nav 隧道的缺点与许多 channelopathies 被联系。超过 1000 个疾病相关的变化在 Nav 隧道被识别了,与怀有超过 400 个变化的 Nav1.1 和 Nav1.5 各个。Nav 隧道为神经毒素和药的一个宽数组代表主要目标。Nav 隧道的原子结构被要求理解他们的功能和疾病机制。兔子电压门钙(Cav ) 的最近坚定的原子结构隧道 Cav1.1 为 evolutionarily 相关的 Nav 隧道的基于相同的结构的建模提供一个模板。在这篇资源文章,我们在人的 Nav 隧道总结了所有报导疾病相关的变化,产生了人的 Nav1.7 的一个相应模型,并且在结构上印射联系疾病的变化。在人的 Nav 隧道的结构的决心前,这里介绍的分析为 Nav channelopathies 的机械学的调查并且为潜在的基于结构的药发现用作基础框架。 | Weiyun Huang Minhao Liu S. Frank Yan Nieng Yan | 2017 | Protein & Cell2017，8，6： | 8 |
| 3 | Fermentation characteristics and probiotic activity of a purified fraction of polysaccharides from Fuzhuan brick tea显示文摘Polysaccharides from Fuzhuan brick tea(FBTPS),one of most important bioactive components in tea,showed various health-promoting functions.Our previous work demonstrated that the crude FBTPS(CFBTPS)could modulate the gut microbiota.However,which purified fraction in CFBTPS contributing to the modulation of gut microbiota remains unclear.Thus,the fermentation characteristics and probiotic activity of a purified fraction(FBTPS-2-1)of CFBTPS were evaluated in this work.The results showed that gut microbiota could utilize FBTPS-2-1 to produce short-chain fatty acids including acetic,propionic,n-butyric and n-valeric acids.FBTPS-2-1 could modulate the structure and metabolic pathways of gut microbiota.FBTPS-2-1 could increase the health-promoting gut microbiota such as Prevotellaceae and Bifidobacteriaceae,and decreased the harmful bacteria such as Enterobacteriaceae and Fusobacteriaceae.The results of metagenomics showed that Prevotella copri and Megamonas funiformis were the dominant bacteria after fermentation of FBTPS-2-1.Furthermore,FBTPS-2-1 could regulate the biosynthesis and metabolism pathways of gut microbiota.Thus,the enrichment of food with FBTPS-2-1 is expected as a potential strategy for promoting human health due to modulation of gut microbiota. | Guijie Chen Ziqi Zeng Minhao Xie Yujia Peng Wangting Zhou Weiqi Xu Yi Sun Xiaoxiong Zeng Zhonghua Liu | 2022 | Food Science and Human Wellness2022，11，3： | 4 |
| 4 | Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex显示文摘The nuclear pore complex(NPC)mediates the flow of substances between the nucleus and cytoplasm in eukaryotic cells.Here we report the cryo-electron tomography(cryo-ET)structure of the luminal ring(LR)of the NPC from Xenopus laevis oocyte.The observed key structural features of the LR are independently confirmed by single-particle cryo-electron microscopy(cryo-EM)analysis.The LR comprises eight butterfly-shaped subunits,each containing two symmetric wings.Each wing consists of four elongated,tubular protomers.Within the LR subunit,the eight protomers form a Finger domain,which directly contacts the fusion between the inner and outer nuclear membranes and a Grid domain,which serves as a rigid base for the Finger domain.Two neighboring LR subunits interact with each other through the lateral edges of their wings to constitute a Bumper domain,which displays two major conformations and appears to cushion neighboring NPCs.Our study reveals previously unknown features of the LR and potentially explains the elastic property of the NPC. | Yanqing Zhang Sai Li Chao Zeng Gaoxingyu Huang Xuechen Zhu Qifan Wang Kunpeng Wang Qiang Zhou Chuangye Yan Wusheng Zhang Guangwen Yang Minhao Liu Qinghua Tao Jianlin Lei Yigong Shi | 2020 | Cell Research2020，30，6： | 4 |
| 5 | Functional characterization of humar equilibrative nucleoside transporter 1显示文摘 | Weiyun Huang Xin Zeng Yigong Shi Minhao Liu | 2017 | Protein & Cell2017，8，4： | 3 |
| 6 | Bioactivities and molecular mechanisms of polysaccharides from Hericium erinaceus显示文摘Hericium erinaceus,an edible and medicinal mushroom,has been utilized since ancient China due to its delicious taste and health benefits.The polysaccharide from H.erinaceus(HEP)is supposed to be one of the major bioactive compounds,which garnered widespread attention in seeking innovative applications for precision nutrition.Both in vitro and in vivo studies have shown that HEP possesses antioxidant and anti-aging,gastrointestinal protecting,anti-tumor,hypolipidemic and hypoglycemic,immune-enhancing,neuroprotective,and hepatoprotective activities,verifying its functional benefits to human health.This review provides an overview of the extraction and structure of HEP,and concluded that HEP had different structures with different sources of H.erinaceus and extraction methods.Besides,the biochemical and pharmacological properties of HEP as well as the relative mechanism were highlighted and summarized on the basis of in vivo and in vitro studies,which could be helpful for the healthy application of HEP.Finally,the research prospects of HEP for specific populations or precision nutrition were proposed. | Jianhui Liu Weiwei Wang Qiuhui Hu Xuyang Wu Hui Xu Anxiang Su Minhao Xie Wenjian Yang | 2022 | Journal of Future Foods2022，2，2： | 3 |
| 7 | Heterostructured ZnFe_2O_4/Fe_2TiO_5/TiO_2 Composite Nanotube Arrays with an Improved Photocatalysis Degradation Efficiency Under Simulated Sunlight Irradiation显示文摘To improve the visible light absorption and photocatalytic activity of titanium dioxide nanotube arrays(TONTAs), ZnFe_2O_4(ZFO) nanocrystals were perfused into pristine TONTA pipelines using a novel bias voltageassisted perfusion method. ZFO nanocrystals were well anchored on the inner walls of the pristine TONTAs when the ZFO suspensions(0.025 mg m L^(-1)) were kept under a60 V bias voltage for 1 h. After annealing at 750 °C for2 h, the heterostructured ZFO/Fe_2 TiO_5(FTO)/TiO_2 composite nanotube arrays were successfully obtained. Furthermore, Fe^(3+)was reduced to Fe^(2+)when solid solution reactions occurred at the interface of ZFO and the pristine TONTAs. Introducing ZFO significantly enhanced thevisible light absorption of the ZFO/FTO/TONTAs relative to that of the annealed TONTAs. The coexistence of type I and staggered type II band alignment in the ZFO/FTO/TONTAs facilitated the separation of photogenerated electrons and holes, thereby improving the efficiency of the ZFO/FTO/TONTAs for photocatalytic degradation of methylene blue when irradiated with simulated sunlight. | Kun Xiong Kunzhou Wang Lin Chen Xinqing Wang Qingbo Fan Jérémie Courtois Yuliang Liu Xianguo Tuo Minhao Yan | 2018 | Nano-Micro Letters2018，10，1： | 2 |
| 8 | Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis显示文摘The nuclear pore complex(NPC)exhibits structural plasticity and has only been characterized at local resolutions of up to 15 A for the cytoplasmic ring(CR).Here we present a single-particle cryo-electron microscopy(cryo-EM)structure of the CR from Xenopus laevis NPC at average resolutions of 5.5-7.9A,with local resolutions reaching 4.5 A.Improved resolutions allow identification and placement of secondary structural elements in the majority of the CR components.The two Y complexes in each CR subunit interact with each other and associate with those from flanking subunits,forming a circular scaffold.Within each CR subunit,the Nup358-containing region wraps around the stems of both Y complexes,likely stabilizing the scaffold.Nup205 connects the short arms of the two Y complexes and associates with the stem of a neighboring Y complex.The Nup214-containing region uses an extended coiled-coil to link Nup85 of the two Y complexes and protrudes into the axial pore of the NPC.These previously uncharacterized structural features reveal insights into NPC assembly. | Gaoxingyu Huang Yanqing Zhang Xuechen Zhu Chao Zeng Qifan Wang Qiang Zhou Qinghua Tao Minhao Liu Jianlin Lei Chuangye Yan Yigong Shi | 2020 | Cell Research2020，30，6： | 2 |
| 9 | Finite-element analysis for surface discharge on polyimide insulation in air at atmospheric pressure under pulsed electrical stress显示文摘A surface discharge non-equilibrium plasma model of air–polyimide under pulsed electrical stress is established, byconsidering the reaction of charged particles on the dielectric surface and the secondary electron emission caused by thecondition that high-energy particles bombard the material surface. The model defines the chemical reaction of air discharge byusing simplified set of reactions, which greatly reduces the complexity of the model. To avoid the negative value of particledensity in the process of solution, the logarithmic finite-element method is used to solve the model established, so as toimplement the dynamic simulation of the surface discharge process. Also, the temporal and spatial evolution of themicroparameters such as charge and electric field distribution during discharge are obtained, and the reliability of the model isverified by experiments in terms of discharge development pattern and surface charge accumulation. By comparing thedevelopment process of surface discharge under single pulse and repetitive pulses, it can be seen that surface dischargedevelops from needle electrode to ground electrode under both repetitive pulses and single pulse stress, but the relationshipbetween the discharge propagation time under repetitive pulses and pulse repetition rate is a ‘u’ curve, and the inflection pointmoves to higher repetition rate region with the increase of voltage. | Guojing Dong Qingmin Li Tao Liu Haoyu Gao Minhao Zhang | 2020 | High Voltage2020，5，2： | 2 |
| 10 | Cryo-EM structure of the inner ring from the Xenopus laevis nuclear pore complex显示文摘Nuclear pore complex(NPC)mediates nucleocytoplasmic shuttling.Here we present single-particle cryo-electron microscopy structure of the inner ring(IR)subunit from the Xenopus laevis NPC at an average resolution of 4.2Å.A homo-dimer of Nup205 resides at the center of the IR subunit,flanked by two molecules of Nup188.Four molecules of Nup93 each places an extended helix into the axial groove of Nup205 or Nup188,together constituting the central scaffold.The channel nucleoporin hetero-trimer of Nup62/58/54 is anchored on the central scaffold.Six Nup155 molecules interact with the central scaffold and together with the NDC1–ALADIN hetero-dimers anchor the IR subunit to the nuclear envelope and to outer rings.The scarce inter-subunit contacts may allow sufficient latitude in conformation and diameter of the IR.Our structure reveals the molecular basis for the IR subunit assembly of a vertebrate NPC. | Gaoxingyu Huang Xiechao Zhan Chao Zeng Ke Liang Xuechen Zhu Yanyu Zhao Pan Wang Qifan Wang Qiang Zhou Qinghua Tao Minhao Liu Jianlin Lei Chuangye Yan Yigong Shi | 2022 | Cell Research2022，32，5： | 1 |
| 11 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 12 | Hepatic Expression of Long-Chain Acyl-CoA Synthetase 3 is Upregulated in Hyperlipidemic Hamsters显示文摘 | Minhao Wu Haiyan Liu Wei Chen Yasuyuki Fujimoto Jingwen Liu | 2009 | Lipids2009，，11： | 1 |
| 13 | Natural incidence of Fusarium species and fumonisins B1 and B2 associated with maize kernels from nine provinces in China in 2012显示文摘 | Meng Fu Renjie Li Congcong Guo Minhao Pang Yingchao Liu Jingao Dong | 2015 | Food Additives & Contaminants: Part A2015，，4： | 1 |
| 14 | Tunable Microwave Phase Shifter Based on Silicon- on- Insulator Microring Resonator显示文摘 | Minhao Pu Liu Liu Weiqi Xue | 2010 | Photonics Technology Letters IEEE2010，22，12： | 1 |
| 15 | Hepatitis B virus infection eontributes to oxidative stress in a population exposed to aflatoxin B1 and high risk for hepatocellular carcinoma显示文摘 | Liu Zhiming Li Lequn Peng Minhao | 2008 | Cancer Lett2008，263，2： | 1 |
| 16 | Detector development at the Back-n white neutron source显示文摘Purpose Back-n is a white neutron beamline at China spallation neutron source,which was established in the year of 2018.It is a powerful facility for nuclear data measurement,neutron detector calibration,and radiation effect research.Method A series of detectors were built for different experiments,including beam monitoring,beam profile measurement,neutron induced secondaries(fission fragments,light charged particles and gamma)cross section measurement,and neutron resonance radiography,etc.A common digitization electronics and a cluster-based DAQ were developed for these detector systems.Most detectors have been employed at Back-n and serviced for experiments from the beginning of the beamline running.Results and conclusion As an overview of detectors of Back-n,the details of the detector design and the experiment performing are described in this paper.Some developing systems,e.g.,MTPC and B-MCP,are also included. | Fan Ruirui Li Qiang Bao Jie Li Yang Liu Rong Jiang Wei Ren Jie Zhang Qiwei Cao Ping Gu Minhao Ren Zhizhou Yi Han Tang Jingyu An Qi Bai Haofan Bai Jiangbo Chen Qiping Chen Yonghao Chen Zhen Cui Zengqi Fan Anchuan Feng Changqing Feng Fanzhen Gao Keqing Han Changcai Han Zijie He Guozhu He Yongcheng Hong Yang Hu Yiwei Huang Hanxiong Jia Weihua Jiang Haoyu Jiang Zhijie Jin Zhengyao Kang Ling Li Bo Li Chao Li Gong Li Jiawen Li Xiao Liu Jie Liu Shubin Luan Guangyuan Ning Changjun Qi Binbin Ruan Xichao Song Zhaohui Sun Kang Tan Zhixin Tang Shengda Wang Pengcheng Wang Zhaohui Wen Zhongwei Wu Xiaoguang Wu Xuan Xie Likun Yang Yiwei Yu Yongji Zhang Guohui Zhang Linhao Zhang Mohan Zhang Xianpeng Zhang Yuliang Zhang Yue Zhang Zhiyong Zhao Maoyuan Zhou Luping Zhou Zhihao Zhu Kejun The CSNS Back-n Collaboration | 2023 | Radiation Detection Technology and Methods2023，7，2： | 0 |
| 17 | Protective effects of peptide KSPLY derived from Hericium erinaceus on H_(2)O_(2)-induced oxidative damage in HepG2 cells显示文摘Reactive oxygen species(ROS)-induced oxidative damage is strongly associated with the pathogenesis of chronic diseases,and natural antioxidant peptides have good abilities of scavenging ROS.The antioxidant activity of peptide Lys-Ser-Pro-Leu-Tyr(KSPLY)derived from Hericium erinaceus remains unclear.In the present study,the antioxidant effect and mechanism of KSPLY on H_(2)O_(2)-induced oxidative damage in HepG2 cells were investigated.The results indicated that KSPLY exhibited the antioxidant capacity in H_(2)O_(2)-induced HepG2 cells by enhancing superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),and catalase(CAT)activities.In comparison with the H_(2)O_(2)-treated damage group,the apoptosis rate,ROS level,and malondialdehyde(MDA)content of HepG2 cells treated with KSPLY were significantly decreased.The H.erinaceus-derived peptide KSPLY pretreatment promoted the expression of detoxification and antioxidant enzymes via the Keap1/Nrf2 signal pathway,thereby inhibiting the generation of ROS and MDA.In conclusion,the H.erinaceus-derived peptide KSPLY effectively protected HepG2 cells against H_(2)O_(2)-induced oxidative damage,and it provided a theoretical basis for the further development of new natural antioxidants. | Zhengli Xu Qiuhui Hu Minhao Xie Jianhui Liu Anxiang Su Hui Xu Wenjian Yang | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
| 18 | Optimization of several surface treatment processes for alleviating fretting damage of a locking pin显示文摘The operational safety and reliability of a variable gauge train are affected by the anti-fretting wear performance of the locking mechanism.The main purpose of this study is to optimize the surface treatment process for a locking pin material under actual service conditions to alleviate fretting damage.Based on the two basic principles of surface strengthening and friction reduction,a substrate(AISI 4135 steel)surface was treated by laser quenching(LQ),plasma nitriding(PN),and bonded MoS2 coating.Systematic fretting wear tests were conducted,and the wear behavior and damage mechanism of various treated surfaces were comprehensively investigated.The results indicate that the wear resistances of the LQ-and PN-treated surfaces were significantly improved,and their main wear mechanisms were abrasive wear,delamination,and oxidation wear.The MoS_(2) coating exhibits the lowest friction coefficient and energy dissipation due to its self-lubricating property,but it incurs the highest wear rate and failure in the form of plastic deformation.Furthermore,the rough compound layer with a high hardness on the PN-treated surface is conducive to the formation and maintenance of the third-body contact at the fretting interface,consequently resulting in a significant reduction in wear.An optimal surface treatment process for alleviating fretting damage of the locking pin is recommended via comprehensive evaluation,which provides a reference for the anti-fretting protection of related mechanical components. | Jifan HE Zhenbing CAI Yanping REN Jinfang PENG Jianhua LIU Minhao ZHU | 2022 | Friction2022，10，8： | 0 |
| 19 | Tribological properties of spherical and mesoporous NiAl particles as ionic liquid additives显示文摘In this study,spherical and mesoporous NiAl particles(abbreviated as sNiAl and mNiAl)were introduced as lubricant additives into two alkyl-imidazolium ionic liquids(ILs)(l-butyl-3-methylimidazolium tetrafluoroborate(LB104)and l-butyl-3-methyl imidazolium hexafluorophosphate(LP104))to explore their tribological properties.The sNiAl and mNiAl particles were modified in-situ by anion and cation moieties of ILs through chemical interaction,thereby enhancing their dispersibility and stability in ILs.The mNiAl particles have better dispersibility than the sNiAl ones in ILs because of high specific surface area.LP104-modified sNiAl particles show better friction reduction and wear resistance,mainly relying on the synergy of the hybrid lubricant.These particles form a protective layer that prevents friction pairs from straight asperity contact and improves the tribological behaviors. | Yao YAO Yi XU Xiaoqiang FAN Minhao ZHU Guangfei LIU | 2020 | Friction2020，8，2： | 0 |
| 20 | Typical synergistic effect of graphite nanoplatelets and carbon nanotubes and its influence on polymer-based dielectric composites显示文摘Graphite nanoplatelets(GNPs)with their intrinsic two-dimensional structure make an excellent compromise of advantages of both graphite and graphene.Due to their outstanding inherent properties,GNPs have been widely used as the functional fillers to improve certain performances of polymer-based composites.However,the multi-layer stacked construction of GNPs could form aggregations easily,which limits their application in polymer-based dielectric composites.Here,the authors exhibit a polydimethylsilicone(PDMS)-based nanocomposite which loading equivalent carbon nanotubes(CNTs)and GNPs as co-loading fillers,whose dielectric properties are improved significantly.The composites were fabricated through a highly-shearing mechanical mixing process.During the mixing process,both intrinsic CNTs entanglements and GNPs stacked aggregation could be ameliorated due to the interaction between these two types of fillers.Compared with the GNPs solely loaded composites,a small quantity of CNTs addition endows GNPs/CNTs/PDMS ternary composites with a significantly decreased percolation threshold(f_(c)∼1.7 vol.%).Both GNPs and CNTs,these two representative conductive carbon constructions with high aspect ratios are able to effectively enhance the establishing efficiency of internal conductive network inner composites.These results indicate that the development of internal conductive network and dielectric performance of nanocomposites are able to be optimised through the strategy of taking advantage of the synergistic effect of multi-type fillers reasonably. | Hang Zhao Minhao Yang Delong He Yu Liu Jintao Bai Hui Wang Haowei Chen Jinbo Bai | 2016 | High Voltage2016，1，4： | 0 |
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