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| 1 | Injectable hydrogels for cartilage and bone tissue engineering显示文摘Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix(ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed. | Mei Liu Xin Zeng Chao Ma Huan Yi Zeeshan Ali Xianbo Mou Song Li Yan Deng Nongyue He | 2017 | Bone Research2017，5，2： | 54 |
| 2 | Fracture development in shale and its relationship to gas accumulation显示文摘有高石英,长石和碳酸盐的页岩,将有低泊松比率,高幼仔模量和高易碎物。作为结果,页岩是导致的在外部力量下面生产自然、导致的破裂。一般来说,在在页岩和在场的易碎的矿物质的体积的破裂开发之间有好关联。有高 TOC 或反常地高的压力的页岩开发得好破裂。页岩破裂开发也与全部的煤气的累积和免费煤气的体积显示出积极关联,即,页岩破裂越更好被开发,越 greater 煤气的累积并且因此越多更高煤气的生产。破裂为天然气和形成水提供迁居水管和累积空格,它为免费天然气的容量的增加是有利的。在页岩的更宽的破裂导致煤气的损失。在北美洲,从在页岩的高角度的破裂地区有页岩气体探索和高煤气的生产的高成功比率。在在四川盆的更低的古生代的海洋的器官的充满事的岩石中的好天然气表演或低收益制片人是仔细与在易碎的页岩的破裂开发的度有关。 | Wenlong Ding Chao Li Chunyan Li Changchun Xu Kai Jiu Weite Zeng Liming Wu | 2012 | Geoscience Frontiers2012，3，1： | 32 |
| 3 | Agricultural non-point nitrogen pollution control function of dierent vegetation types in riparian wetlands: A case study in the Yellow River wetland in China显示文摘Riparian wetland is the major transition zone of matter, energy and information transfer between aquatic and terrestrial ecosystems and has important functions of water purification and non-point pollution control. Using the field experiment method and an isotope tracing technique, the agricultural non-point nitrogen pollution control function of dierent vegetation types in riparian wetland was studied in the Kouma Section of the Yellow River. The results showed that the retention of agricultural non-point nitrogen pollution by riparian wetland soil occurs mainly in top 0-10 cm layer. The amount of nitrogen retained by surface soils associated with three types of vegetation are 0.045 mg/g for Phragmites communis Trin Linn, 0.036 mg/g for Scirpus triqueter Linn, and 0.032 mg/g for Typha angustifolia Linn, which account for 59.21%, 56.25%, and 56.14% of the total nitrogen interception, respectively. Exogenous nitrogen in 0-10 cm soil layer changes more quickly than in other layers. One month after adding K15NO3 to the tested vegetation, nitrogen content was 77.78% for P. communis Trin, 68.75% for T. angustifolia, and 8.33% for S. triqueter in the surface soil. After three months, nitrogen content was 93.33% for P. communis Trin, 72.22% for S. triqueter, and 37.50% for T. Angustifolia. There are large dierences among vegetation communities respecting to purification of agricultural non-point nitrogen pollution. The nitrogen uptake amount decreases in the sequence: new shoots of P. communis Trin (9.731 mg/g) > old P. communis Trin (4.939 mg/g) > S. triqueter (0.620 mg/g) > T. angustifolia (0.186 mg/g). Observations indicated that the presence of riparian wetlands as buers on and adjacent to stream banks could be recommended to control agricultural non-point pollution. | ZHAO Tongqian XU Huashan HE Yuxiao TAI Chao MENG Hongqi ZENG Fanfu XING Menglin | 2009 | Journal of Environmental Sciences2009，21，7： | 29 |
| 4 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 5 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 6 | Cancer stem cell markers correlate with early recurrence and survival in hepatocellular carcinoma显示文摘AIM:To investigate whether expression of cancer stem cell(CSC)markers is associated with recurrence and survival in hepatocellular carcinoma(HCC)patients.METHODS:A consecutive series of 90 HCC patients who underwent curative hepatectomy between April2007 and April 2009 were analyzed.Of the 90 patients,38(42%)experienced recurrence within two years of surgery.To adjust for baseline differences between this early recurrence group and the other patients,propensity-score matching was used to generate 25 pairs of patients.Immunohistochemistry was used to compare expression of CD133,CD90,and epithelial cell adhesion molecule(EpCAM)in liver tissues from propensity score-matched patients and from 10 healthy adults.Associations of the three markers with HCC,clinicopathological characteristics,early recurrence,and survival time were explored.RESULTS:The expression of all three CSC markers was significantly higher in HCC tissue than in healthy liver tissue(P<0.001 for all).Among the HCC clinicopathology characteristics examined,the absence of tumor capsule was associated with CD133 expression(P=0.005);higher histopathology grade and larger tumor size were associated with CD90 expression(P=0.010 and 0.034,respectively);and elevated serum alpha-fetoprotein levels were associated with EpCAM expression(P=0.021).Expression of CD90 and EpCAM was significantly higher in the early recurrence group than in other patients(P=0.001 and 0.045,respectively),whereas CD133 expression was not significantly different between the two groups(P=0.440).Multivariate analysis identified only CD90 expression as significantly associated with early recurrence.Log-rank analysis identified expression of both CD90 and EpCAM as significantly associated with survival time of HCC patients.Cox regression identified EpCAM expression as an independent predictor of survival time.CONCLUSION:Expression of CD133,CD90,and EpCAM CSC markers may be linked to HCC tumor onset and/or progression.In addition,EpCAM expression is associated with shorter survival time,while CD90 expression is associated with early HCC recurrence. | Zhe Guo Le-Qun Li Jing-Hang Jiang Chao Ou Li-Xia Zeng Bang-De Xiang | 2014 | World Journal of Gastroenterology2014，20，8： | 18 |
| 7 | Carbon storage in evergreen broad-leaf forests in mid-subtropical region of China at four succession stages显示文摘To better understand the effect of forest succession on carbon sequestration, we investigated carbon stock and allocation of evergreen broadleaf forest, a major zonal forest in subtropical China.We sought to quantify the carbon sequestration potential.We sampled four forest types,shrub(SR), pine(Pinus massoniana) forest(PF), pine and broadleaf mixed forest(MF) and evergreen broadleaf forest(BF).A regression equation was constructed using tree height and diameter at breast height(DBH) and elements of total tree biomass.The equation was subsequently utilized to estimate tree carbon storage.The carbon storage of understory, litter, and soil was also estimated.Carbon storage in biomass increased significantly from the early succession stage SR(6.21 t ha-1) to the late stage BF(134.87 t ha-1).The biomass carbon stock of forest layers generally increased with succession except for the understory.The soil organic carbon storage for the total profile increased with forest succession, from 51.16 to 90.49 t ha-1, but the contribution of SOC to the carbon stock of the forest ecosystem declined from 89.18% to 40.15%.The carbon stock at ecosystem scale increased significantly with succession from SR(57.37 t ha-1), to PF(154.20 t ha-1), to MF(170.96 t ha-1)and to BF(225.36 t ha-1), with carbon stock of BF3.93 times that of SR.The forests in our study have great potential for increasing carbon sequestration, and large areas of secondary or degraded evergreen broadleaf forests in the subtropical zone of China could be a great carbon sink in future. | ZENG Zhangquan WANG Silong ZHANG Canming GONG Chao HU Qing | 2013 | Journal of Forestry Research2013，24，4： | 17 |
| 8 | Single-cell transcriptomic analysis defines the interplay between tumor cells,viral infection,and the microenvironment in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an Epstein-Barr virus(EBV)-associated malignancy with a complex tumor ecosystem.How the interplay between tumor cells,EBV,and the microenvironment contributes to NPC progression and immune evasion remains unclear.Here we performed single-cell RNA sequencing on^104,000 cells from 19 EBV^+NPCs and 7 nonmalignant nasopharyngeal biopsies,simultaneously profiling the transcriptomes of malignant cells,EBV,stromal and immune cells.Overall,we identified global upregulation of interferon responses in the multicellular ecosystem of NPC.Notably,an epithelial–immune dual feature of malignant cells was discovered and associated with poor prognosis.Functional experiments revealed that tumor cells with this dual feature exhibited a higher capacity for tumorigenesis.Further characterization of the cellular components of the tumor microenvironment(TME)and their interactions with tumor cells revealed that the dual feature of tumor cells was positively correlated with the expression of co-inhibitory receptors on CD8^+tumor-infiltrating T cells.In addition,tumor cells with the dual feature were found to repress IFN-γproduction by T cells,demonstrating their capacity for immune suppression.Our results provide new insights into the multicellular ecosystem of NPC and offer important clinical implications. | Shanzhao Jin Ruoyan Li Ming-Yuan Chen Chao Yu Lin-Quan Tang Yan-Min Liu Jiang-Ping Li Yi-Na Liu Yi-Ling Luo Yifan Zhao Yu Zhang Tian-Liang Xia Shang-Xin Liu Qi Liu Guan-Nan Wang Rui You Jing-Yun Peng Jiang Li Feng Han Jianwei Wang Qiu-Yan Chen Li Zhang Hai-Qiang Mai Benjamin E.Gewurz Bo Zhao Lawrence S.Young Qian Zhong Fan Bai Mu-Sheng Zeng | 2020 | Cell Research2020，30，11： | 16 |
| 9 | Effects of simulated carbon dioxide and helium peumoperitoneum on proliferation and apoptosis of gastric cancer cells显示文摘AIM:To investigate the effects of carbon dioxide (CO2) and helium insufflation administered at different pressures on the growth and apoptosis of cultured human gastric cancer cells. METHODS:The gastric cancer cells MKN-45 were exposed to a CO2 and helium environment maintained at different pressures (0, 5, 10 and 15 mmHg). The cells were exposed to simulated pneumoperitoneum environment for 4 h, and pH of the culture media was measured after it was moved to normal conditions for 0, 2, 4, 6 and 8 h. Proliferation viability of MKN-45 was examined by 3-4,5Dimethylthiazol-2-yl,5-diphenyltetrazolium bromide or triazolyl blue (MTT) assay after it was moved to normal conditions. Apoptotic ratio was measured by Annexin V-FITC/PI double labelled staining. RESULTS:The pH of media was acid and recovered to normal after 4 h in the CO2 group while it was basic in the helium group. There was no difference between CO2 groups (under 10 mmHg ) and control group (P > 0.05) in the proliferative viability of the cells. The cultured cells exposed to 15 mmHg CO2 environment grew more slowly than control group from 4 to 7 d (P < 0.01 ) while there was no difference from 1 to 3 d (P > 0.05). The proliferative viability in helium group was not obviously different from the control group (P > 0.05). The apoptotic ratio of the cultured cells was markedly higher than that of the control group (P < 0.01) at 10 and 15 mmHg CO2 insufflation pressure. In helium group, the apoptotic ratio was not obviously different from the control group (P > 0.05). CONCLUSION:There is no obvious effect in the proliferation and apoptosis of MKN-45 cells under 10 mmHg CO2 insufflation pressure and helium in any pressure. Fifteen mmHg CO2 insufflation pressure can inhibit the proliferation of the cells and improve apoptosis. | Ying-Xue Hao Hua Zhong Chao Zhang Dong-Zu Zeng Yan Shi Bo Tang Pei-Wu Yu | 2008 | World Journal of Gastroenterology2008，14，14： | 16 |
| 10 | γ-MnO2 nanorods/graphene composite as efficient cathode for advanced rechargeable aqueous zinc-ion battery显示文摘Aqueous Zn//MnO2 batteries are emerging as promising large-scale energy storage devices owing to their cost-effectiveness,high safety,high output voltage,and energy density.However,the MnO2 cathode suffers from intrinsically poor rate performance and rapid capacity deterioration.Here,we remove the roadblock by compositing MnO2 nanorods with highly conductive graphene,which remarkably enhances the electrochemical properties of the MnO2 cathode.Benefiting from the boosted electric conductivity and ion diffusion rate as well as the structural protection of graphene,the Zn//MnO2-graphene battery presents an admirable capacity of 301 mAh g^-1 at 0.5 A g^-1,corresponding to a high energy density of 411.6 Wh kg^-1.Even at a high current density of 10 A g^-1,a decent capacity of 95.8 mAh g^-1 is still obtained,manifesting its excellent rate property.Furthermore,an impressive power density of 15 kW kg^-1 is achieved by the Zn//MnO2-graphene battery. | Chao Wang Yinxiang Zeng Xiang Xiao Shijia Wu Guobin Zhong Kaiqi Xu Zengfu Wei Wei Su Xihong Lu | 2020 | Journal of Energy Chemistry2020，29，4： | 13 |
| 11 | Trends in geographical disparities for cervical cancer mortality in China from 1973 to 2013:a subnational spatio-temporal study显示文摘Objective: This study was designed to explore the time trends in geographical variations of cervical cancer mortality in China's Mainland over the period 1973 to 2013,to provide subnational spatio-temporal patterns for targeted promotion of human papillomavirus vaccine in China.Methods: Data were extracted from three national retrospective death surveys and cancer registry.The rate ratio(RR) was estimated for the aggregated data for seven geographical regions using generalized linear models to evaluate time trends in geographical disparities of cervical cancer mortality.Results: There was a significant decrease in cervical cancer mortality in China from 1973–1975 to 2004–2005,but leveled off thereafter to 2011–2013.Compared to the period 1973–1975 the RR for the three last time periods were 0.33 [95% confidence interval(95% CI): 0.30–0.37] for 1990–1992,0.21(95% CI: 0.19–0.24) for 2004–2005 and 0.24(95% CI: 0.22–0.26) for 2011–2013.Females living in the Northwest China and Central China have a high risk of mortality from cervical cancer compared to the nationwide,with the RR being 2.09(95% CI:1.83–2.38) and 1.26(95% CI: 1.11–1.44) respectively,while the RRs for South China,Northeast China and Southwest China were below 1.00,indicating the lower death risk.Despite the mortality rate had increased slightly from 2004 to 2013,there was an encouraging sign that the geographical disparities in cervical cancer mortality had gradually narrowed over time across China.Conclusions: Although cervical cancer mortality in China has reduced to very low levels,the high risk of cervical cancer in Northwest China and Central China is still noteworthy.Public health policies including the promotion of vaccine should be targeted to further reduction of geographical disparities in cervical cancer mortality. | Changfa Xia Chao Ding Rongshou Zheng Siwei Zhang Hongmei Zeng Jinfeng Wang Yilan Liao Ningxu Zhang Zhixun Yang Wanqing Chen | 2017 | Chinese Journal of Cancer Research2017，29，6： | 13 |
| 12 | A comprehensive overview of rural solid waste management in China显示文摘这份报纸试图以特征,管理和立法进行农村稳固的废物(RSW ) 的全面评论。调查结果证明 RSW 产生率从 0.25 ~ 2.1 kg (capitad )越过中国的区域的不同农村村庄里的 1 。全部的 RSW 产生一直在增加,它比在 2014 的正式数据高远。RSW 被食物残余和煤灰 / 炉渣 / 灰尘统治(在约 70% 点) 。没有任何处理,大多数 RSW 仍然在中国随机被丢弃。散布 RSW 产生来源,有瑕疵的立法系统,处理和处理上的差的基础结构在中国当前为 RSW 管理作为最大的挑战被识别。为了改进 RSW 管理,增加的金融资源,建立的排序的收集和交通,联网,支持排序收集并且再循环,改进处理技术作为可能的答案被建议。 | Chao ZENG Dongjie NIU Youcai ZHAO | 2015 | Frontiers of Environmental Science & Engineering2015，9，6： | 13 |
| 13 | Prevalence,clinical characteristics,risk factors,and indicators for lean Chinese adults with nonalcoholic fatty liver disease显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic diseases in the world.Nowadays,the percentage of non-obese or lean patients with NAFLD is increasing.NAFLD in non-obese populations,especially the lean subgroup with a normal waist circumference(WC),might lead to more problems than obese individuals,as these individuals may not visit clinics for NAFLD diagnosis or ignore the diagnosis of NAFLD.If the precise characteristics of these populations,especially the lean subgroup,are identified,the clinicians would be able to provide more appropriate advice and treatment to these populations.AIM To investigate the prevalence,clinical characteristics,risk factors,and possible indicators for NAFLD in lean Chinese adults with a normal WC.METHODS People without diabetes mellitus or significant alcohol consumption who underwent routine health examinations were included.Their fatty liver index(FLI),abdominal ultrasonography results,and controlled attenuation parameter were all assessed.Genotyping for single-nucleotide polymorphisms associated with NAFLD was performed in another small group consisting of biopsy-proven NAFLD subjects and healthy controls.RESULTS A total of 2715 subjects who underwent routine health examinations were included in the study.Among 810 lean participants with a normal WC,142(17.5%)fulfilled the diagnostic criteria for NAFLD.Waist-height ratio,hemoglobin,platelets,and triglycerides were significant factors associated with the presence of NAFLD in these participants.The appropriate cut-off value of the FLI score in screening for NAFLD in the lean subjects with a normal WC was 25.15,which had a 77.8%sensitivity and 75.9%specificity.There was no significant difference in the single-nucleotide polymorphisms in the SIRT1,APOC3,PNPLA3,AGTR1,and PPARGC1A genes between lean subjects with and without NAFLD(P<0.05).CONCLUSION NAFLD is not uncommon in lean Chinese adults even with a normal WC.Metabolic factors,rather than genetic factors,may play important roles in the development of NAFLD in this population.A lower cut-off value of the FLI score in screening for NAFLD should be used for lean Chinese adults with a normal WC. | Jing Zeng Rui-Xu Yang Chao Sun Qin Pan Rui-Nan Zhang Guang-Yu Chen Ying Hu Jian-Gao Fan | 2020 | World Journal of Gastroenterology2020，26，15： | 12 |
| 14 | The impact of climate change on forest fire danger rating in China’s boreal forest显示文摘The Great Xing'an Mountains boreal forests were focused on in the northeastern China.The simulated future climate scenarios of IPCC SRES A2a and B2a for both the baseline period of 1961-1990 and the future scenario periods were downscaled by the Delta Method and the Weather Generator to produce daily weather data.After the verification with local weather and fire data,the Canadian Forest Fire Weather Index System was used to assess the forest fire weather situation under climate change in the study region.An increasing trend of fire weather severity was found over the 21st century in the study region under the both future climate change scenarios,compared to the 1961-1990 baseline period.The annual mean/maximum fire weather index was predicted to rise continuously during 2010-2099,and by the end of the 21st century it is predicted to rise by 22%-52% across much of China's boreal forest.The significant increases were predicted in the spring from of April to June and in the summer from July to August.In the summer,the fire weather index was predicted to be higher than the current index by as much as 148% by the end of the 21st century.Under the scenarios of SRES A2a and B2a,both the chance of extremely high fire danger occurrence and the number of days of extremely high fire danger occurrence was predicted to increase in the study region.It is anticipated that the number of extremely high fire danger days would increase from 44 days in 1980s to 53-75 days by the end of the 21st century. | YANG Guang DI Xue-ying GUO Qing-xi SHU Zhan ZENG Tao YU Hong-zhou WANG Chao | 2011 | Journal of Forestry Research2011，22，2： | 12 |
| 15 | Hemodynamic parameters obtained by transthoracic echocardiography and right heart catheterization: a comparative study in patients with pulmonary hypertension显示文摘背景血液动力学的评估为有肺的 hypertention 的病人的管理是关键的。临床医生们经常比较喜欢一个快速、非侵略的方法。这研究试图与肺的 hypertension.Methods A 在病人为血液动力学的参数的大小检验 transthoracic echocardiography 的可行性未来的单个中心的学习在 42 个病人之中被进行,肺的高血压由不同疾病引起了。Transthoracic echocardiography 和正确心的 catheterization 在 24 个小时以内被执行。收缩、心脏舒张、吝啬的压力(PASP, PADP 和 PAMP ) ,心脏的产量(公司) ,和肺的毛状的楔迫使的肺的动脉(PCWP ) 被两个方法测量。线性关联和 Bland-Altman 分析被执行比较好关联在侵略、非侵略的大小之间被发现为的二组血液动力学的 parameters.Results PASP (r=0.96 ) , PADP (r=0.85 ) , PAMP (r=0.88 ) ,公司(r=0.82 ) ,和 PCWP (r=0.81 ) 。Bland-Altman 方法做的进一步的协议分析证明当大差异为 PAMP 和 PCWP.Conclusions 存在时,为 PASP, PADP,和公司的那偏爱和 95% 信心间隔是临床上可接受的由在有肺的高血压的病人的 PASP, PADP,和公司的非侵略的大小与侵略决心相关很好。Transthoracic echocardiography (TTE ) 为估计 PCWP 和 PAMP 是不恰当的。 | TIAN Zhuang LIU Yong-tai FANG Quan NI Chao CHEN Tai-bo FANG Li-gang GAO Peng JIANG Xiu-chun LI Meng-tao ZENG Xiao-feng | 2011 | Chinese Medical Journal2011，，12： | 11 |
| 16 | Diagnostic value of elevated serum carbohydrate antigen 199 level in acute cholangitis secondary to choledocholithiasis显示文摘AIM To investigate the diagnostic value of abnormal serum carbohydrate antigen 199(CA199) level in acute cholangitis secondary to choledocholithiasis.METHODS In this retrospective cohort study, the clinical data of 727 patients with choledocholithiasis admitted to the Third Affiliated Hospital of Zunyi Medical College from June 2011 to June 2017 were collected. Among these patients, 258 patients had secondary acute cholangitis and served as observation group, and the remaining 569 choledocholithiasis patients served as the control group. Serum liver function indexes and tumor markers were detected in both groups, and the receiver operating characteristic(ROC) curves were constructed for markers showing statistical significances. The cutoff value, sensitivity, and specificity of each marker were calculated according to the ROC curves. RESULTS The results of liver function tests showed no significant differences between the two groups(P > 0.05). Tumor markers including serum CA125, CA153, carcinoembryonic antigen, and alpha fetoprotein levels were also not significantly different(P > 0.05); however, the serum CA199 level was significantly higher in the observation group than in the control group(P < 0.05). The ROC curve analysis showed that the area under the curve was 0.885(95%CI: 0.841-0.929) for CA199, and the cutoff value of 52.5 kU/L had the highest diagnostic accuracy, with a sensitivity of 86.8% and a specificity of 81.6%.CONCLUSION Abnormally elevated serum CA199 level has an important value in the diagnosis of acute cholangitis secondary to choledocholithiasis. It may be a specific inflammatory marker for acute cholangitis. | Yong Mei Li Chen Ci-Jun Peng Jun Wang Peng-Fei Zeng Guo-Xing Wang Wen-Ping Li Yan-Qing Luo Chao Du Kai Liu Kun Xiong Kai Leng Chun-Lin Feng Ji-Hu Jia | 2018 | World Journal of Clinical Cases2018，6，11： | 11 |
| 17 | Nonvolatile resistive switching memories-characteristics,mechanisms and challenges | Feng PAN,Chao CHEN,Zhi-shun WANG,Yu-chao YANG,Jing YANG,Fei ZENG Laboratory of Advanced Materials,Department of Materials Science and Engineering, Tsinghua University,Beijing 100084,China | 2010 | Progress in Natural Science:Materials International2010，20，1： | 10 |
| 18 | Generation of coexisting high-energy pulses in a mode-locked all-fiber laser with a nonlinear multimodal interference technique显示文摘We demonstrate a passively mode-locked all-fiber laser incorporating a piece of graded-index multimode fiber as a mode-locking modulator based on a nonlinear multimodal interference technique, which generates two types of coexisting high-energy ultrashort pulses [i.e., the conventional soliton(CS) and the stretched pulse(SP)]. The CS with pulse energy as high as 0.38 n J is obtained at the pump level of 130 mW. When the pump increases to175 mW, the high-energy SP occurs at a suitable nonlinear phase bias and its pulse energy can reach 4 n J at a 610 mW pump. The pulse durations of the generated CS and SP are 2.3 ps and 387 fs, respectively. The theory of nonlinear fiber optics, single-shot spectral measurement by the dispersive Fourier-transform technique, and simulation methods based on the Ginzburg–Landau equation are provided to characterize the laser physics and reveal the underlying principles of the generated CS and SP. A rogue wave, observed between the CS and SP regions, mirrors the laser physics behind the dynamics of generating a high-energy SP from a CS. The proposed all-fiber laser is versatile, cost-effective and easy to integrate, which provides a promising solution for high-energy pulse generation. | GUANGWEI CHEN WENLEI LI GUOMEI WANG WENFU ZHANG CHAO ZENG WEI ZHAO | 2019 | Photonics Research2019，7，2： | 9 |
| 19 | Catastrophic Debris Flows on July 10^(th) 2013 along the Min River in Areas Seriously-hit by the Wenchuan Earthquake显示文摘Over 240 debris flows occurred in hillslopes, gullies( indicated those with single-channel)and watersheds(indicated those with tributaries and channels) on July 10 th 2013 in the Wenchuan county,and caused 29 casualties and about 633×106 USD losses. This work aimed to analyze characteristics,hazards and causes of these events and explore mitigating measures based on field investigation and remote sensing images interpretation. The debris flows contained clay content of 0.1%~3.56%, having densities of 1.72~2.14 t/m3, velocities of 5.0~12.7 m/s,discharges of 335~2353 m3/s and sediment yields of0.10~1.26×106 m3, and also numerously occurred in large watersheds with the area over 10 km2. Large debris flows formed 3 hazard-chains in slopes, gullies,watersheds and rivers, which all evolved in dammed lakes and outburst flood, and 26 dammed lakes and10 newly ones were generated along the rivers of Min and Yuzi. The remarkable spatial difference of loose solid materials accumulation and intense rainfall,with the cumulative of about or more than 150 mm and the hourly of over 16 mm, caused debris flows in the sections from Yingxiu to Miansi and Gengda. The damages on buildings, reconstructions, highways,factories and hydro power station originated from the impacting, scouring, burying of debris flows, the submerging of dammed lake and the scouring of outburst flood, and the huge losses came from the ruinous destructions of control engineering works of debris flows as well as the irrational location and lowresistant capabilities of reconstructions. For hazards mitigating of debris flows in long term, the feasible measures for short term, including risk-reassessing of foregone and potential hazard sites, regional alarming system establishing and integrated control in disastrous sites, and middle-long term, including improving reconstruction standard, rationally disposing river channel bed rise and selecting appropriate reconstruction time and plans, were strongly suggested. | GE Yong-gang CUI Peng ZHANG Jian-qiang ZENG Chao SU Feng-huan | 2015 | Journal of Mountain Science2015，12，1： | 8 |
| 20 | Geometrical feature analysis and disaster assessment of the Xinmo landslide based on remote sensing data显示文摘At 5:39 am on June 24, 2017, a landslide occurred in the village of Xinmo in Maoxian County, Aba Tibet and Qiang Autonomous Prefecture(Sichuan Province, Southwest China). On June 25, aerial images were acquired from an unmanned aerial vehicle(UAV), and a digital elevation model(DEM) was processed. Landslide geometrical features were then analyzed. These are the front and rear edge elevation, accumulation area and horizontal sliding distance. Then, the volume and the spatial distribution of the thickness of the deposit were calculated from the difference between the DEM available before the landslide, and the UAV-derived DEM collected after the landslide. Also, the disaster was assessed using high-resolution satellite images acquired before the landslide. These include Quick Bird, Pleiades-1 and GF-2 images with spatial resolutions of 0.65 m, 0.70 m, and 0.80 m, respectively, and the aerial images acquired from the UAV after the landslide with a spatial resolution of 0.1 m. According to the analysis, the area of the landslide was 1.62 km2, and the volume of the landslide was 7.70 ± 1.46 million m3. The average thickness of the landslide accumulation was approximately 8 m. The landslide destroyed a total of 103 buildings. The area of destroyed farmlands was 2.53 ha, and the orchard area was reduced by 28.67 ha. A 2-km section of Songpinggou River was blocked and a 2.1-km section of township road No. 104 was buried. Constrained by the terrain conditions, densely populated and more economically developed areas in the upper reaches of the Minjiang River basin are mainly located in the bottom of the valleys. This is a dangerous area regarding landslide, debris flow and flash flood events Therefore, in mountainous, high-risk disaster areas, it is important to carefully select residential sites to avoid a large number of casualties. | FAN Jian-rong ZHANG Xi-yu SU Feng-huan GE Yong-gang Paolo TAROLLI YANG Zheng-yin ZENG Chao ZENG Zhen | 2017 | Journal of Mountain Science2017，14，9： | 8 |
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