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| 1 | Proteomic changes in mammalian spermatozoa during epididymal maturation显示文摘附睾成熟与 cAMP-inducedtyrosine 磷酸化串联的激活被联系,它最终与表达式被联系 ofcapacitation 依赖的精子工作,例如亢奋的激活的运动和 acrosomal exocytosis。通过附睾的 Asspermatozoa 进步他们首先在主要的片上在目标上获得能力到 phosphorylatetyrosine,由中间的片列在后面。等到这些房间 haver eached 附睾尾他们装 phosphorylate 从颈的全部尾巴到结束片。磷酸化的 Thisparticular 模式与能够使肥沃的充分功能的精子的个体发生被联系卵母细胞。这改变的 Proteomic 分析 indicate 与几 mitochondrial 蛋白质的磷酸化被联系, amitochondrial 膜电位的创造和 mitochondrial 自由基产生的激活。至少在啮齿类动物种类,精子线粒体的激活看起来是特别地重要的部分 ofepididymal 成熟。 | R. John Aitken Brett Nixon Minjie Lin Adam J. Koppers Yun H. Lee Mark A. Baker | 2007 | Asian Journal of Andrology2007，9，4： | 14 |
| 2 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 3 | Composites of graphene and encapsulated silicon for practically viable high-performance lithium-ion batteries显示文摘综合的一条灵巧、可伸缩的途径硅合成阳极被包含 Si 粒子经由开发了在 situ 聚合和 phloroglucinol 甲醛胶化的碳化,由 graphene nanoplatelets 的加入列在后面。由于它的结构的完整,高收拾行李密度和亲密电的接触由传导性的网络巩固了,合成阳极以费用存储能力,骑车的生活和 coulombic 效率产出优秀电气化学的性能。一半房间完成了 1,600 mAh 灵楬慣 | Xin Zhao Minjie Li Kuo-Hsin Chang Yu-Ming Lin | 2014 | Nano Research2014，7，10： | 4 |
| 4 | Soil total organic carbon/total nitrogen ratio as a key driver deterministically shapes diazotrophic community assemblages during the succession of biological soil crusts显示文摘The diazotrophic community in biological soil crusts(biocrusts)is the key supplier of nitrogen in dryland.To date,there is still limited information on how biocrust development influences the succession of diazotrophic community,and what are the most important factors mediating diazotrophic communities during biocrust succession.Using the high throughput nifH amplicon sequencing,the diazotrophs in soils at different developmental stages of biocrust were comparatively studied.The results evidenced the decreases of TOC/TN ratio and pH value with biocrust development.Nostoc and Scytonema were the most dominant diazotrophic genera at all biocrust stages,while Azospirillum and Bradyrhizobium were abundant only in bare soil.Diazotrophic co-occurrence networks tended to be less complex and less connected with biocrust succession.The soil TOC/TN ratio was the most dominant factor mediating diazotrophic diversity,community composition and assembly processes,while diazotrophic-diversity and NO3–-N/NH4+-N ratio were positively correlated with the nitrogenase activity during biocrust succession.This study provided novel understandings of nitrogen fixation and succession patterns of diazotrophic community,by showing the effects of biocrust succession on diazotrophic diversity,community composition,community assembly and co-occurrence networks,and recognizing TOC/TN ratio as the most dominant factor mediating diazotrophs during biocrust succession. | Lin Xu Bingchang Zhang Entao Wang Bingjian Zhu Minjie Yao Chaonan Li Xiangzhen Li | 2021 | Soil Ecology Letters2021，3，4： | 3 |
| 5 | Inversion of Stress Fields in the Middle Section of the Xiaojiang Fault and Its Adjacent Area显示文摘With waveform data of 613 earthquakes with ML ≥ 2. 5 in the middle section of the Xiaojiang fault and its adjacent area which occurred during January,1998 to September 2007,focal mechanisms were calculated by the direct wave amplitude ratio of S /P in the vertical component and their characteristics were analyzed. According to regional tectonic features of the middle section of the Xiaojiang fault and its adjacent area,the study region was partitioned into two zones with the Xiaojiang fault as the boundary,e. g. zone A and zone B (including the Xiaojiang fault). In order to research the faults stress in detail,the Xiaojiang fault zone was picked out for independent analysis. The study region was also partitioned into 1°× 1° cells with a 0. 5° step. The stress fields of zone A,B and the fault zone were inverted with the FMSI method (Gephart,1990). The results show that first, the faults are mainly of strike-slip in the middle section and its adjacent area,amounting to 81. 28%,69. 23% and 72. 97% in the A,B and fault zones,respectively. Secondly,the stress inversion also indicates that the directions of maximum principal stress σ1 in the A, B,and fault zones are approximately NNW,NWW and NWW,the stress action is mainly horizontal,and strike-slip faulting is dominant in the study area. On the other hand,the direction of the principal stress field in the central Yunnan block changed from NNW to NWW,however,in the region between the Yuanmou and Pudu River faults,the azimuth of the main compressive stress shows that the north-south slip is obvious. While the direction of the main compressive stress of the Xiaojiang fault zone is nearly NW; in the east of the Xiaojiang fault,the direction of principal compressive stress is NW to NNW in the eastern Yunnan block. | Lin Xiangdong Xu Ping Wu Minjie Gao Ling Wu Anxu | 2011 | Earthquake Research in China2011，25，1： | 2 |
| 6 | MiR-181a enhances drug sensitivity in mitoxantone-resistant breast cancer cells by targeting breast cancer resistance protein (BCRP/ABCG2)显示文摘 | Xuyang Jiao Lin Zhao Mengtao Ma Xuefeng Bai Miao He Yuanyuan Yan Yan Wang Qiuchen Chen Xinnan Zhao Mingyi Zhou Zeshi Cui Zhihong Zheng Enhua Wang Minjie Wei | 2013 | Breast Cancer Research and Treatment2013，，3： | 1 |
| 7 | Artificial Intelligence in Pharmaceutical Sciences显示文摘Drug discovery and development affects various aspects of human health and dramatically impacts the pharmaceutical market.However,investments in a new drug often go unrewarded due to the long and complex process of drug research and development(R&D).With the advancement of experimental technology and computer hardware,artificial intelligence(AI)has recently emerged as a leading tool in analyzing abundant and high-dimensional data.Explosive growth in the size of biomedical data provides advantages in applying AI in all stages of drug R&D.Driven by big data in biomedicine,AI has led to a revolution in drug R&D,due to its ability to discover new drugs more efficiently and at lower cost.This review begins with a brief overview of common AI models in the field of drug discovery;then,it summarizes and discusses in depth their specific applications in various stages of drug R&D,such as target discovery,drug discovery and design,preclinical research,automated drug synthesis,and influences in the pharmaceutical market.Finally,the major limitations of AI in drug R&D are fully discussed and possible solutions are proposed. | Mingkun Lu Jiayi Yin Qi Zhu Gaole Lin Minjie Mou Fuyao Liu Ziqi Pan Nanxin You Xichen Lian Fengcheng Li Hongning Zhang Lingyan Zheng Wei Zhang Hanyu Zhang Zihao Shen Zhen Gu Honglin Li Feng Zhu | 2023 | Engineering2023，，8： | 1 |
| 8 | Clinical implications of ERβ methylation on sporadic breast cancers in Chinese women显示文摘 | Lin Zhao Zhaojin Yu Yunan Li Xiaoyan Wen Wenfeng Ma Lin Wang Jie Ren Caigang Liu Miao He Xuefeng Bai Mingli Sun Zhihong Zheng Xiaoyi Mi Enhua Wang Olufunmilayo I. Olopade Feng Jin Minjie Wei | 2012 | Medical Oncology2012，，3： | 1 |
| 9 | Earth energy evolution, human development and carbon neutral strategy显示文摘Energy is the basis of human development and the impetus of society progress. There are three sources of energy: energy of celestial body outside the Earth, the Earth energy and energy of interaction between the Earth and other celestial bodies. Meanwhile, there are three scales of co-evolution: the evolution of the Sun-Earth-Moon system on an ultra-long time scale has provided energy sources and extra-terrestrial environmental conditions for the formation of the Earth system;the evolution of the Earth system on a long time scale has provided the material preconditions such as energy resources and suitable sphere environment for life birth and the human development;on a short time scale, the development of human civilization makes the human circle break through the Earth system, expanding the extraterrestrial civilization. With the co-evolution, there are three processes in the carbon cycle: inorganic carbon cycle, short-term organic carbon cycle and long-term organic carbon cycle, which records human immoderate utilization of fossil energy and global sphere reforming activities, breaking the natural balance and closed-loop path of the carbon cycle of the Earth, causing the increase of greenhouse gases and global climate change, affecting human happiness and development. The energy transition is inevitable, and carbon neutrality must be realized. Building the green energy community is a fundamental measure to create the new energy system under carbon neutrality target. China is speeding up its energy revolution and developing a powerful energy nation. It is necessary to secure the cornerstone of the supply of fossil energy and forge a strong growing pole for green and sustainable development of new energy. China energy production and consumption structure will make a revolutionary transformation from the type of fossil energy domination to the type of new energy domination, depending on a high-level self-reliance of science and technology and a high-quality green energy system of cleaning, low-carbon, safety, efficiency and independence. Energy development has three major trends: low-carbon fossil energy, large-scale new energy and intelligent energy system, relying on the green innovation, contributing the green energy and constructing the green homeland. | ZOU Caineng MA Feng PAN Songqi LIN Minjie ZHANG Guosheng XIONG Bo WANG Ying LIANG Yingbo YANG Zhi | 2022 | Petroleum Exploration and Development2022，49，2： | 1 |
| 10 | The effect of agricultural practices on methane and nitrous oxide emissions from rice field and pot experi-ment显示文摘 | LI Yue LIN Erda RAO Minjie | 2005 | Nutrient Cycling in Agro-ecosystems2005，49，： | 1 |
| 11 | Alkaline-lacustrine deposition and paleoenvironmental evolution in Permian Fengcheng Formation at the Mahu sag, Junggar Basin,NW China显示文摘Alkaline-lacustrine deposition and its evolution model in Permian Fengcheng Formation at the Mahu sag, Junggar Basin were investigated through core and thin-section observation, geochemical and elemental analysis, logging response and lithofacies identification. Six lithofacies are developed in the Fengcheng Formation. The Feng 2 Member(P1 f2) is dominated by lithofacies with alkaline minerals, while the upper part of the Feng 1 Member(P1 f1) and the lower part of the Feng 3 Member(P1 f3) are primarily organic-rich mudstones that are interbedded with dolomite and dolomitic rock. Paleoenvironment evolution of Fengcheng Formation can be divided into 5 stages, which was controlled by volcanic activity and paleoclimate. The first stage(the early phase of P1 f1) was characterized by intensive volcanic activity and arid climate, developing pyroclastics and sedimentary volcaniclastic rocks. The secondary stage(the later phase of P1 f1) had weak volcanic activity and humid climate that contributed to the development of organic-rich mudstone, forming primary source rock in the Fengcheng Formation. The increasing arid climate at the third stage(the early phase of P1 f2) resulted in shrinking of lake basin and increasing of salinity, giving rise to dolomite and dolomitic rocks. The continuous aird climate, low lake level and high salinity at the fourth stage(the later phase of P1 f2) generated special alkaline minerals, e.g., trona, indicating the formation of alkaline-lacustrine. The humid climate made lake level rise and desalted lake water, therefore, the fifth stage(P1 f3) dominated by the deposition of terrigenous clastic rocks and dolomitic rocks. | ZHANG Zhijie YUAN Xuanjun WANG Mengshi ZHOU Chuanmin TANG Yong CHEN Xingyu LIN Minjie CHENG Dawei | 2018 | Petroleum Exploration and Development2018，45，6： | 0 |
| 12 | Sedimentary diagenesis of rudist shoal and its control on reservoirs: A case study of Cretaceous Mishrif Formation, H Oilfield, Iraq显示文摘Based on the core, cast thin section, whole rock analysis, conventional physical properties and high pressure mercury intrusion test, the sedimentary diagenesis characteristics of rudist shoal in Cretaceous Mishrif Formation of H Oilfield, Iraq and its control on the reservoir were studied. The rudist shoal of the Mishrif Formation develops in the high-stand systems tract and is distributed in the high places of paleogeomorphology on the edge of platform with strong hydrodynamic force. According to the relative sea level changes, lithologic evolution and sedimentary structure characteristics of the rudist shoal, the single rudist shoal is divided into four lithologic sections: A, B, C and D, that is, low-angle cross-bedding pelletoids-rudist packstone, low-angle cross-bedding and parallel bedding arene-rudist grainstone, parallel bedding rudist gravel limestone, and horizontal bedding carbonaceous mudstone. The complete sedimentary sequence of a single rudist shoal is often disrupted. Several rudist shoals superimpose to form thick rudist shoal sediment. The single rudist shoal thickness and lithologic sections assemblage change regularly in vertical direction. The rudist shoal has the characteristics of 'strong dissolution, weak cementation and strong compaction', forming pore-type reservoir with intergranular pores, intergranular dissolved pores, mold pores, and dissolved pores. With mainly coarse pore throats larger than 5 μm, the reservoir is of medium-high porosity and high permeability. There is lithological reverse cycles inside single shoals and between single shoals, with content of mud crystals decreasing from the bottom to the top, dissolution increasing, cementation decreasing in strength, pore throats getting larger, and physical properties turning better. The rudist shoal of MB2-1 at the top of the high-stand systems tract has the largest thickness, moreover, subject to the strongest atmospheric freshwater leaching, this layer has the most significant dissolution and the largest pore throat, so it is the best reservoir of the Mishrif Formation. | YU Yichang SUN Longde SONG Xinmin GUO Rui GAO Xingjun LIN Minjie YI Liping HAN Haiying LI Fengfeng LIU Hangyu | 2018 | Petroleum Exploration and Development2018，45，6： | 0 |
| 13 | Comprehensive Research on Focal Mechanism Solutions in the Capital Circle Area of China显示文摘Comprehensive statistical analysis was performed on the basic features of focal mechanisms of 619 ML≥2. 0 earthquakes which occurred in the capital circle area from January 2002 to June 2010. By dividing the capital area into three studying regions based on regional tectonic characteristics,cluster analysis was conducted on the focal mechanisms of all subregions using the longest distance method in the statistical cluster analysis to study the characteristics of tectonic stress tensors. The result shows that dominant P-axis azimuth distribution is NNE-NEE and that of T-axis is NNW-NWW,most of the focal areas are controlled by a horizontal stress field and rupture is mainly of horizontal strike-slip. The maximum principal compression stress orientation is NE75° in the west,NE62° in the middle,and near EW in the east of the capital area. The regional tectonic stress field is characterized by horizontal compression. | Wu Minjie Wu Anxu Xu Ping Lin Xiangdong Dong Hongyan Xin Xuexia Li Layue | 2014 | Earthquake Research in China2014，28，1： | 0 |
| 14 | Global energy transition revolution and the connotation and pathway of the green and intelligent energy system显示文摘The essence of energy system transition is the'energy revolution':The development of the'resource-dominated'energy system with fossil energy as the mainstay has promoted human progress,but it has also triggered energy crisis and ecological environment crisis,which is not compatible with the new demands of the new round of scientific and technological revolution,industrial transformation,and sustainable human development.It is in urgent need to research and develop a new-type energy system in the context of carbon neutrality.In the framework of'technique-dominated'new green and intelligent energy system with'three new'of new energy,new power and new energy storage as the mainstay,the'super energy basin'concepts with the Ordos Basin,Nw China as a representative will reshape the concept and model of future energy exploration and development.In view of the'six inequalities'in global energy and the resource conditions of'abundant coal,insufficient oil and gas and infinite new energy'in China,it is suggested to deeply boost'China energy revolution',sticking to the six principles of independent energy production,green energy supply,secure energy reserve,efficient energy consumption,intelligent energy management,economical energy cost;enhance'energy scientific and technological innovation'by implementing technique-dominated'four major science and technology innovation projects',namely,clean coal project,oil production stabilization and gas production increasing project,new energy acceleration project,and green-intelligent energy project;implement'energy transition'by accelerating the green-dominated'four-modernization development',namely,fossil energy cleaning,large-scale new energy,coordinated centralized energy distribution,intelligent multi-energy management,so as to promote the exchange of two 80%s'in China's energy structure and construct the new green and intelligent energy system. | ZOU Caineng MA Feng PAN Songqi ZHAO Qun FU Guoyou ZHANG Guosheng YANG Yichao YU Hao LIANG Yingbo LIN Minjie WANG Ying XIONG Bo LIU Hanlin | 2023 | Petroleum Exploration and Development2023，50，3： | 0 |
| 15 | Transgenerational analysis of H3K4me3 and H3K27me3 by ChIP-Seq links epigenetic inheritance to metabolism显示文摘Histone methylation is a kind of important epigenetic modification which occurs on the lysine residue or arginine residue of histone tails(Zhang and Reinberg,2001).It takes part in multiple biological processes,including gene expression,genomic stability,stem cell maturity,genetic imprinting,mitosis and development(Fischle et al.,2005).Abnormal histone methylation pattern | Ke An Fengxia Du Hao Meng Guochao Li Minjie Zhang Zongzhi Liu Zitong Zhao Zilong Zhang Di Yu Dong Wang Caiyun Yang Wencui Ma Lin Yuan Meiting Zhou Lili Duan Li Jin Hui Li Yan Zhang Jianzhong Su Jie Qiao Yingli Sun | 2018 | Journal of Genetics and Genomics2018，45，3： | 0 |
| 16 | Protective effects of (-)-epigallocatechin-3-gallate on D-galactose-induced neuronal apoptosis in mice显示文摘BACKGROUND: The neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG), the mainpolyphenolic constituent of green tea, have been widely reported. However, the action mechanisms,in particular in D-galactose-induced aging mice, remain poorly understood.OBJECTIVE: The present study investigated the protective effects of EGCG onD-galactose-induced hippocampus neuronal apoptosis in aging mice, as well as the relationship withexpression of p75ICD, JNK2, and p53 proteins.DESIGN, TIME AND SETTING: A randomized, controlled, molecular biological, animal experimentwas performed at the Laboratory of Pharmacology, Pharmaceutical College of China MedicalUniversity, China, from September 2006 to July 2008.MATERIALS: D-galactose and EGCG (Sigma, USA), as well as terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick-end labeling (TUNEL) In Situ Cell Apoptosis Detection Kit(Promega, USA), were used in this study.METHODS: A total of 64 mice were equally and randomly divided into D-galactose model, low-doseEGCG, high-dose EGCG, and control groups. Mice in the D-galactose model, low-dose EGCG,and high-dose EGCG groups were subcutaneously injected with 3% D-galactose (150 mg/kg),daily for 6 weeks, to establish a mouse model of aging. Mice in the control group were treated withsaline (5 mL/kg). At 3 weeks following injection, mice in the low-dose EGCG and high-dose EGCGgroups were orally administered EGCG at a dose of 2 mg/kg and 6 mg/kg, respectively, once a day,for 4 consecutive days. Mice in the control and D-galactose model groups received distilled water(5 mL/kg).MAIN OUTCOME MEASURES: Memory function was evaluated using a step-through passiveavoidance test. Neuronal apoptosis in the mouse hippocampus was detected using TUNEL staining.Expression levels of the intracellular domain of the p75 neurotrophin receptor (p75NTR)-p75ICD,JNK2, and p53 proteins in the hippocampus were determined using Western blot analysis.RESULTS: The aging mouse model was induced by subcutaneous injection of D-galactose, whichresulted in obvious memory impairment, increased apoptotic index, and increased proteinexpression levels of p75ICD, JNK2, and p53 in the hippocampus, compared with control mice (P <0.01). Oral EGCG administration (2 or 6 mg/kg) for 4 weeks significantly improved levels of memorydeficit in the aging mice and reduced apoptotic indices and protein expression levels of p75ICD,JNK2, and p53 in the mouse hippocampus (P < 0.01).CONCLUSION: Results from this study demonstrated increased protein expression levels ofp75ICD, JNK2, and p53, as well as increased hippocampal neuronal apoptosis in aD-galactose-induced mouse model of aging. EGCG provided protective effects againstD-galactose-induced neuronal apoptosis in the hippocampus by reducing protein expression levelsof p75ICD, JNK2, and p53 proteins in the hippocampus of aging mice. | Miao He Lin Zhao Weifan Yao Haishan Zhao Fujun Chen Minjie Wei | 2009 | Neural Regeneration Research2009，4，12： | 0 |
| 17 | Management and operation of extra-large Fangcang hospitals:experience and lessons from containing the highly contagious SARS-CoV-2 Omicron in Shanghai,China显示文摘Introduction Omicron is more contagious and stealthier than the previous strains.The basic reproduction number of Omicron is around 8–12,whereas that of the previous mainstream strain Delta is only 5–8[1].Omicron’s symptoms are relatively mild[2]compared with Delta’s symptoms;however,Omicron’s transmission ability is very strong,and its risk to children and the elderly remains high[3].In addition,the vaccine’s preventive effect on Omicron has weakened.Therefore,Omicron can easily cause a rapid outbreak in a city.The population density of megacities and the limited public health resources further exacerbate the difficulty of Omicron prevention and control. | Yun Xian Chenhao Yu Minjie Chen Lin Zhang Xinyi Zheng Shijian Li Erzhen Chen Zhongwan Chen Weihua Chen Chaoying Wang Qingrong Xu Tao Han Weidong Ye Wenyi Xu Xu Zhuang Yu Zheng Min Chen Jun Qin Yu Feng Shun Wei Yiling Fan Zhiruo Zhang Junhua Zheng | 2023 | Frontiers of Medicine2023，17，1： | 0 |
| 18 | 人工智能白内障协同管理的通用平台显示文摘目的:建立和验证一个涉及多级临床场景的白内障协作通用的人工智能(artificial intelligence,AI)管理平台,探索基于AI的医疗转诊模式,以提高协作效率和资源覆盖率。方法:训练和验证的数据集来自中国AI医学联盟,涵盖多级医疗机构和采集模式。使用三步策略对数据集进行标记:1)识别采集模式;2)白内障诊断包括正常晶体眼、白内障眼或白内障术后眼;3)从病因和严重程度检测需转诊的白内障患者。此外,将白内障AI系统与真实世界中的居家自我监测、初级医疗保健机构和专科医院等多级转诊模式相结合。结果:通用AI平台和多级协作模式在三步任务中表现出可靠的诊断性能:1)识别采集模式的受试者操作特征(receiver operating characteristic curve,ROC)曲线下面积(area under the curve,AUC)为99.28%~99.71%);2)白内障诊断对正常晶体眼、白内障或术后眼,在散瞳-裂隙灯模式下的AUC分别为99.82%、99.96%和99.93%,其他采集模式的AUC均>99%;3)需转诊白内障的检测(在所有测试中AUC>91%)。在真实世界的三级转诊模式中,该系统建议30.3%的人转诊,与传统模式相比,眼科医生与人群服务比率大幅提高了10.2倍。结论:通用AI平台和多级协作模式显示了准确的白内障诊断性能和有效的白内障转诊服务。建议AI的医疗转诊模式扩展应用到其他常见疾病和资源密集型情景当中。 | WU Xiaohang HUANG Yelin LIU Zhenzhen LAI Weiyi LONG Erping ZHANG Kai JIANG Jiewei LIN Duoru CHEN Kexin YU Tongyong WU Dongxuan LI Cong CHEN Yanyi ZOU Minjie CHEN Chuan ZHU Yi GUO Chong ZHANG Xiayin WANG Ruixin YANG Yahan XIANG Yifan CHEN Lijian LIU Congxin XIONG Jianhao GE Zongyuan WANG Dingding XU Guihua DU Shaolin XIAO Chi WU Jianghao ZHU Ke NIE Danyao XU Fan LV Jian CHEN Weirong LIU Yizhi 林浩添 无 王厚硕(审校) 罗明杰(审校) | 2023 | 眼科学报2023，38，10： | 0 |
| 19 | CircUCP2 promotes the tumor progression of non-small cell lungcancer through the miR-149/UCP2 pathway显示文摘Non-small cell lung cancer(NSCLC)is a highly lethal cancer,and better treatments are urgently needed.Many studies have implicated circular RNAs(circRNAs)in the progression of multiple malignant tumors.Nonetheless,the functions of circRNAs in NSCLC remain unclear.To study new targets for the treatment of NSCLC,circRNA expression profiling was performed on NSCLC tissues and para-carcinoma nonmalignant tissues.RNA was isolated and used for circRNA sequencing.Biological studies were performed in vitro and in vivo to determine the functions of circRNAs in NSCLC,including their functions in cell proliferation and migration.How circRNAs function in NSCLC was explored to clarify the underlying regulatory mechanisms.We found that circUCP2 was upregulated in NSCLC tissues compared with neighboring nonmalignant tissues.circUCP2 promoted the proliferation and metastasis of NSCLC cells.circUCP2 promoted NSCLC progression by sponging miR-149 and upregulating UCP2.The circUCP2/miR-149/UCP2 axis accelerates the progression of NSCLC,and circUCP2 may therefore be a novel diagnostic biomarker for the progression of NSCLC. | WEI DU FANG YIN YATING ZHONG MINJIE LUO ZHEN WANG PENG LIN QING LIU HAN YANG | 2023 | Oncology Research2023，31，6： | 0 |
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