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| 1 | Enhanced recovery program is safe and improves postoperative insulin resistance in gastrectomy显示文摘AIM: To assess the safety of enhanced recovery after surgery(ERAS) program in gastrectomy and influences on nutrition state and insulin-resistance. METHODS: Our ERAS program involved shortening the fasting periods and preoperative carbohydrate loading. Eighty gastrectomy patients were randomly assigned to either the conventional group(CG) or ERAS group(EG). We assessed the clinical characteristics and postoperative outcomes prospectively. The primary endpoint was noninferiority in timely discharge from the hospital within 12 d. Secondary endpoints were the incidence of aspiration at anesthesia induction, incidence of postoperative complications, health related quality of life(HRQOL) using the SF8 Health Survey questionnaire, nutrition state [e.g., albumin, transthyretin(TTR), retinal-binding protein(RBP), and transferrin(Tf)], the homeostasis model assessment-insulin resistance(HOMA-R) index, postoperative urine volume,postoperative weight change, and postoperative oral intake.RESULTS: The ERAS program was noninferior to the conventional program in achieving discharge from the hospital within 12 d(95.0% vs 92.5% respectively; 95%CI:-10.0%-16.0%). There was no significant difference in postoperative morbidity between the two groups. Adverse events such as vomiting and aspiration associated with the induction of general anesthesia were not observed. There were no significant differences with respect to postoperative urine volume, weight change, and oral intake between the two groups. EG patients with preoperative HOMA-R scores above 2.5 experienced significant attenuation of their HOMA-R scores on postoperative day 1 compared to CG patients(P = 0.014). There were no significant differences with respect to rapid turnover proteins(TTR, RBP and Tf) or HRQOL scores using the SF8 method.CONCLUSION: Applying the ERAS program to patients who undergo gastrectomy is safe, and improves insulin resistance with no deterioration in QOL. | Nobuaki Fujikuni Kazuaki Tanabe Noriaki Tokumoto Takahisa Suzuki Minoru Hattori Toshihiro Misumi Hideki Ohdan | 2016 | World Journal of Gastrointestinal Surgery2016，8，5： | 23 |
| 2 | Cellular pH regulators: potentially promising molecular targets for cancer chemotherapy显示文摘 | Hiroto Izumi Takayuki Torigoe Hiroshi Ishiguchi Hidetaka Uramoto Yoichiro Yoshida Mizuho Tanabe Tomoko Ise Tadashi Murakami Takeshi Yoshida Minoru Nomoto Kimitoshi Kohno | 2003 | Cancer Treatment Reviews2003，，6： | 2 |
| 3 | The influence of donor age on liver regeneration and hepatic progenitor cell populations显示文摘 | Yoshihiro Ono Shigeyuki Kawachi Tetsu Hayashida Masatoshi Wakui Minoru Tanabe Osamu Itano Hideaki Obara Masahiro Shinoda Taizo Hibi Go Oshima Noriyuki Tani Kisyo Mihara Yuko Kitagawa | 2011 | Surgery2011，，2： | 2 |
| 4 | Liver atrophy after percutaneous transhepatic portal embolization occurs in two histological phases: Hepatocellular atrophy followed by apoptosis显示文摘AIM To clarify the histological changes associated with liver atrophy after percutaneous transhepatic portalembolization(PTPE) in pigs and humans. METHODS As a preliminary study, we performed pathological examinations of liver specimens from five pigs that had undergone PTPE in a time-dependent model of liver atrophy. In specimens from embolized lobes(EMB) and nonembolized lobes(controls), we measured the portal vein to central vein distance(PV-CV), the area and number of hepatocytes per lobule, and apoptotic activity using the terminal deoxynucleotidyl transferase dU TP nickend labeling assay. Immunohistochemical reactivities were evaluated for light chain 3(LC3) and lysosomal-associated membrane protein 2(LAMP2) as autophagy markers and for glutamine synthetase and cytochrome P450 2 E1(CYP2 E1) as metabolic zonation markers. Samples from ten human livers taken 20-36 d after PTPE were similarly examined. RESULTS PV-CVs and lobule areas did not differ between EMB and controls at day 0, but were lower in EMB than in controls at weeks 2, 4, and 6(P ≤ 0.001). Hepatocyte numbers were not significantly reduced in EMB at day 0 and week 2 but were reduced at weeks 4 and 6(P ≤ 0.05). Apoptotic activity was higher in EMB than in controls at day 0 and week 4. LC3 and LAMP2 staining peaked in EMB at week 2, with no significant difference between EMB and controls at weeks 4 and 6. Glutamine synthetase and CYP2 E1 zonation in EMB at weeks 2, 4, and 6 were narrower than those in controls. Human results were consistent with those of porcine specimens. CONCLUSION The mechanism of liver atrophy after PTPE has two histological phases: Hepatocellular atrophy is likely caused by autophagy in the first 2 wk and apoptosis thereafter. | Yasuhito Iwao Hidenori Ojima Tatsushi Kobayashi Yoji Kishi Satoshi Nara Minoru Esaki Kazuaki Shimada Nobuyoshi Hiraoka Minoru Tanabe Yae Kanai | 2017 | World Journal of Hepatology2017，9，32： | 1 |
| 5 | Gallbladder carcinoma with osteoclast-like giant cells显示文摘 | Tomotaka Akatsu Kaori Kameyama Shigeyuki Kawachi Minoru Tanabe Koichi Aiura Go Wakabayashi Masakazu Ueda Motohide Shimazu Masaki Kitajima | 2006 | Journal of Gastroenterology2006，，1： | 1 |
| 6 | Suppressive Effects of Interleukin-18 on Liver Function in Rat Liver Allografts显示文摘 | Shigeshi Ono Hideaki Obara Atsushi Takayanagi Minoru Tanabe Shigeyuki Kawachi Osamu Itano Masahiro Shinoda Minoru Kitago Taizo Hibi Tomohiro Chiba Wenlin Du Kenji Matsumoto Arno W. Tilles Martin L. Yarmush Sadakazu Aiso Nobuyoshi Shimizu Michiie Sakamoto | 2012 | Journal of Surgical Research2012，，1： | 1 |
| 7 | Clinicopathological characteristics and prognostic impact of colorectalcancers with NRAS mutations显示文摘 | Toshiro Ogura Miho Kakuta Toshimasa Yatsuoka Yoji Nishimura Hirohiko Sakamoto Kensei Yamaguchi Minoru Tanabe Yoichi Tanaka Kiwamu Akagi | 2014 | Oncology Reports2014，，1： | 1 |
| 8 | Advances in reduced port laparoscopic liver resection显示文摘 | Daisuke Ban Atsushi Kudo Takumi Irie Takanori Ochiai Arihiro Aihara Satoshi Matsumura Shinji Tanaka Minoru Tanabe | 2015 | Asian J Endosc Surg2015，，1： | 1 |
| 9 | Consequences of Living-Donor Liver Transplantation for Upper Gastrointestinal Lesions: High Incidence of Reflux Esophagitis显示文摘 | Tomotaka Akatsu Masashi Yoshida Shigeyuki Kawachi Minoru Tanabe Motohide Shimazu Koichiro Kumai Masaki Kitajima | 2006 | Digestive Diseases and Sciences2006，，11： | 1 |
| 10 | Protective Effect of High-Mobility Group Box 1 Blockade on Acute Liver Failure in Rats显示文摘 | Kiminori Takano Masahiro Shinoda Minoru Tanabe Taku Miyasho Shingo Yamada Shigeshi Ono Yohei Masugi Koichi Suda Koichi Fukunaga Tetsu Hayashida Taizo Hibi Hideaki Obara Hiroya Takeuchi Shigeyuki Kawachi Kazufumi Kawasako Minoru Okamoto Hiroshi Yokota Ikur | 2010 | Shock2010，，6： | 1 |
| 11 | Small hepatocellular carcinomas in cirrhosis: differences in contrast enhancement effects between helical CT and MR imaging during multiphasic dynamic imaging显示文摘 | Minoru Hayashida Katsuyoshi Ito Takeshi Fujita Ayame Shimizu Katsumi Sasaki Masahiro Tanabe Naofumi Matsunaga | 2008 | Magnetic Resonance Imaging2008，，1： | 1 |
| 12 | A novel difficulty scoring system for laparoscopic liver resection显示文摘 | Daisuke Ban Minoru Tanabe Hiromitsu Ito Yuichiro Otsuka Hiroyuki Nitta Yuta Abe Yasushi Hasegawa Toshio Katagiri Chisato Takagi Osamu Itano Hironori Kaneko Go Wakabayashi | 2014 | J Hepatobiliary Pancreat Sci2014，，10： | 1 |
| 13 | Transvaginal hybrid natural orifice translumenal endoscopic surgery appendectomy显示文摘 | Norihito Wada Minoru Tanabe Fumio | 2013 | Nihon Geka Gakkai zasshi2013，114，6： | 1 |
| 14 | Biliary complications in adult living donor liver transplantation with duct-to-duct hepaticocholedochostomy or Roux-en-Y hepaticojejunostomy biliary reconstruction显示文摘 | Shigeyuki Kawachi Motohide Shimazu Go Wakabayashi Ken Hoshino Minoru Tanabe Masashi Yoshida Yasuhide Morikawa Masaki Kitajima | 2002 | Surgery2002，，1： | 1 |
| 15 | Squamous cell carcinoma of the liver originating from non-parasitic cysts after a 15 year follow-up显示文摘 | Hiroshi Yagi Masakazu Ueda Shigeyuki Kawachi Minoru Tanabe Kouichi Aiura Go Wakabayashi Motohide Shimazu Mituie Sakamoto Masaki Kitajima | 2004 | European Journal of Gastroenterology & Hepatology2004，，10： | 1 |
| 16 | Pseudoaneurysm of the Cystic Artery Secondary to Cholecystitis as a Cause of Hemobilia: Report of a Case显示文摘 | Tomotaka Akatsu Minoru Tanabe Tomohiro Shimizu Kan Handa Shigeyuki Kawachi Koichi Aiura Masakazu Ueda Motohide Shimazu Masaki Kitajima | 2007 | Surgery Today2007，，5： | 1 |
| 17 | Intraportal infusion therapy as a novel approach to adult ABO-incompatible liver transplantation1显示文摘 | Minoru Tanabe Motohide Shimazu Go Wakabayashi Ken Hoshino Shigeyuki Kawachi Tomohisa Kadomura Hiroaki Seki Yasuhide Morikawa Masaki Kitajima | 2002 | Transplantation2002，，12： | 1 |
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