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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Statistical analysis and online monitoring for handling multiphase batch processes with varying du- rations 显示文摘 | ZHAO C H MO S GAO F R | 2011 | Journal of Process Control2011，21，6： | 1 |
| 3 | Phar-macokinetics of intraperitoneeal hyperthermic perfusion with mitoxantrone in orarian caner显示文摘 | Nicoletto MO Di Filippo F Padrini R | | 0，，06： | 1 |
| 4 | Serum immunoreactivity of SMP30 and its tissues expression in hepatocellular carcinoma显示文摘 | Zhou S F Mo F R Bin Y H | 2011 | Clinical Biochemistry2011，44，4： | 1 |
| 5 | Nickel-catalyzed propylene dimerization in organochloroaluminate ionic liq uids: control of the isomerization reaction显示文摘 | SOUZA R F D LEAL B C MO D S | 2007 | J Mol Catal A: Chem2007，272，12： | 1 |
| 6 | Multi{unctional magnetic nanoparticles {or targeted delivery显示文摘 | Kumar A Jena P K Behera S Lockey R F Mohapatra S Mo hapatra S | | Nanomedicine0，6，： | 1 |
| 7 | Tech- nological Change and Network Dy- namics Lessons from the Pharmaceu- tical Industry 显示文摘 | LORSENIGO F P AMMOLL I MASSI MO R I CCABON I | 2001 | Research Policy2001，30，3： | 1 |
| 8 | Immediate internal fixation of open fractures of the diaphysis of the arm显示文摘 | MOED B R KELLAM J F FOSTER R J | 1986 | J Bone Joint Surg Am1986，68，7： | 1 |
| 9 | Sensitive voltammetric determination of Sudan I in food samples by using gemini surfaetant - ionic liquid- multiwalled carbon nanotube composite film modified glassy carbon electrodes显示文摘 | Mo Z R Zhang Y F Zhao F Q | 2010 | Food Chemistry2010，121，： | 1 |
| 10 | New Bibliometric Tools for the Assess-ment of National Research Peiformance 显示文摘 | Moed H F Debruin R E | 1995 | Scientometrics1995，33，： | 1 |
| 11 | Pharmacokinetics of intraperitoneal hyerthermic perfusion with mitoxantrone in ovarian cancer显示文摘 | Nicoletto MO Padrini R Galeotti F | 2000 | Cancer Chemother Pharmacol2000，45，6： | 1 |
| 12 | New bibliometric tools for the as-sessment of national research performance 显示文摘 | MOED H F BRUIN R E D E | 1995 | Scientometrics1995，33，3： | 1 |
| 13 | New Bibliometric Tools for the Assessment of National Research Performance: Database Description, Overview of Indicators and First Applications 显示文摘 | Moed H F de Bruin R E van Leeuwen T N | 1995 | Scientometrics1995，33，3： | 1 |
| 14 | Determination of the electromagnetic fields radiated from the ARES EMP simulator 显示文摘 | Tesche F M Mo C Shoup R W | 1994 | IEEE Transactions on Electromagnetic Compatibility1994，364，： | 1 |
| 15 | Two different neurodegenerative diseases caused by proteins with similar structures显示文摘 | Mo H Moore R C Cohen F E | 2001 | Proc Natl Acad Sci2001，98，： | 1 |
| 16 | Mapping of Science byCombined Co-citation and Word Analysis II : Dynamical As- pects显示文摘 | Braam R R Moed H F Van Raan AFJ | 1991 | Journal of the American Society for Information Sci- ence1991，42，4： | 1 |
| 17 | Pharmacokinetics of intraperitoneal hyperthennic perfusion with mitoxantrone in ovarian cancer显示文摘 | Nicoletto MO Padrini R Galeotti F | 2000 | Cancer Chemother Pharmacol2000，45，6： | 1 |
| 18 | Improved electric field measurements with the T-28 armored research airplane显示文摘 | MO Q FEIND R E KOPP F J | 1999 | Journal of Geophysical Research1999，104，24： | 1 |
| 19 | New bibliometric tools for the assessent of national research performance: Database description overview of indicators and first applications 显示文摘 | Moed H F 'DeBruin R E Vanleeuwen T N | 1995 | Scitentometrics1995，33，3： | 1 |
| 20 | Age does not influence early and late tumor-related outcome for bronchogenic carcinoma显示文摘 | Bernet F Brodbeck R Guenin MO | 2000 | Ann Thorac Surg2000，69，3： | 1 |
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