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| 1 | Effect of branched-chain amino acids in patients receiving intervention for hepatocellular carcinoma显示文摘AIM:To investigate the usefulness of branched-chain amino acids(BCAA)before transarterial chemoembolization(TACE)or radiofrequency ablation(RFA).METHODS:We investigated the usefulness of preintervention with BCAAs by comparing patients treated with BCAAs at 12.45 g/d orally for at least 2 wk before TACE or RFA and those not receiving such pretreatment.A total of 270 patients with hepatocellular carcinoma complicated by cirrhosis were included in the study.Mean changes from baseline(Δ)in serum albumin(Alb),C-reactive protein(CRP),and transaminase levels,as well as peak body temperature were also determined and compared at days 2,5,and 10 after the start of TACE or RFA.RESULTS:In patients who underwent TACE or RFA,BCAA pre-intervention significantly suppressed the development of post-intervention hypoalbuminemia and reduced inflammatory reactions during the subsequent clinical course.After TACE,theΔAlb peaked on day 2,remained constantly lower in BCAA-treated patients,compared to the control group,and was-0.13±0.42g/dL in BCAA-treated patients and-0.33±0.51 g/dL in untreated patients on day 10.TheΔCRP was also significantly lower in BCAA-treated patients on days2,5 and 10 after TACE.Like the trends noted after TACE,a similar tendency was noted as to theΔAlb andΔCRP after RFA.The changes in serum Alb level were inversely correlated with CRP changes;therefore,a possible involvement of the anti-inflammatory effect of BCAAs was inferred as a factor contributory to the suppression of decrease in serum Alb level.CONCLUSION:Pre-intervention with BCAAs may hasten the recovery of serum Alb level and mitigate postoperative complications in patients undergoing TACE or RFA. | Tomoaki Ishihara Motoh Iwasa Hideaki Tanaka Masahiko Kaito Jiro Ikoma Toshiya Shibata Yoshiyuki Takei | 2014 | World Journal of Gastroenterology2014，20，10： | 2 |
| 2 | Improvement of regional cerebral blood flow after oral intake of ranched-chain amino acids in patients with cirrhosis显示文摘AIM: To evaluate the effect of oral intake of branchedchain amino acids (BCAA) on brain perfusion in patients with liver cirrhosis.METHODS: Single photon emission computed tomography scans were performed in 43 patients with cirrhosis and in 15 age-matched healthy subjects.Twenty-nine out of forty-three patients were randomly treated with either BCAA granules or placebo, and single photon emission computed tomography was performed before and after the treatment. We measured the regional cerebral blood flow values using a threedimensional stereotaxic region of interest template.RESULTS: Cirrhotic patients had regions of significant hypoperfusion in the bilateral central (right P=0.039,P<0.05; left P = 0.006 P<0.01), parietal (right P=0.018, P<0.05;left P=0.009, P<0.01), angular (right P=0.039, P<0.05;left P = 0.008, P<0.01), and left pericallosal segments (P= 0.038 P<0.05) as compared with healthy subjects. A significant increase in cerebral perfusion was observed 70 min after the oral intake of BCAA in the angular (right P=0.012,P<0.05;left P=0.049, P<0.05), temporal (right P=0.012, P<0.05; left P=0.038, P<0.05), pericallosal segments (right P = 0.025,P<0.05; left P = 0.049, P<0.05) and left precentral (P=0.044, P<0.05), parietal (P=0.040, P<0.05) and thalamus (P=0.033, P<0.05). No significant change in perfusion was observed in the placebo group.CONCLUSION: Administration of BCAA rapidly improves cerebral perfusion. | Mika Yamamoto Motoh Iwasa Kaname Matsumura Yuri Nakagawa Naoki Fujita Yoshinao Kobayashi Masahiko Kaito Kan Takeda Yukihiko Adachi | 2005 | World Journal of Gastroenterology2005，11，43： | 1 |
| 3 | Influence of phlebotomy on iron-related gene expression levels in the livers of patients with chronic hepatitis C显示文摘 | Naoki Fujita Ryosuke Sugimoto Naohito Urawa Hideaki Tanaka Masayoshi Konishi Yoshinao Kobayashi Motoh Iwasa Shozo Watanabe Masahiko Kaito | 2007 | Journal of Gastroenterology2007，，4： | 1 |
| 4 | Analysis of K- ras, APC, and β- Catenin in Aberrant Crypt Foci in Sporadic Adenoma, Cancer, and Familial Adenomatous Polyposis显示文摘 | Tetsuji Takayama Motoh Ohi Tsuyoshi Hayashi Koji Miyanishi Atsushi Nobuoka Takaharu Nakajima Tsutomu Satoh Rishu Takimoto Junji Kato Sumio Sakamaki Yoshiro Niitsu | 2001 | Gastroenterology2001，，3： | 1 |
| 5 | A method for MPPT controlwhile searching for parameters corresponding to weatherconditions for PV generation systems显示文摘 | Motoh N Ohno M Lnoue T | 2006 | IEEE Transactionson Industrial Electronics2006，53，4： | 1 |
| 6 | Fourier transform profilometry for the automatic measurement of 3-D object shapes 显示文摘 | TAKEDA M MOTOH K | 1983 | Applied Optics1983，22，24： | 1 |
| 7 | Fourier transform profilometry for the automatic measurement of 3-D object shapes 显示文摘 | TAKEDA M MOTOH K | 1983 | Applied Optics1983，22，24： | 1 |
| 8 | Suppression by flavoids of cyclooxygenase-2 promoter-dependent tran scription activity in colon cancer cells:structure-activity relationship显示文摘 | MOTOH M TAKAHASHI M FUKUDA K etal | 2000 | J pn J Cancer Res2000，91，68： | 1 |
| 9 | Development of the external genitalia of the giant prawn, Penaeus monodon 显示文摘 | Motoh H Buri P | 1980 | Bulletin of the Japanese Society of Scientific Fisheries1980，46，2： | 1 |
| 10 | Cut-off value of the ankle- brachial pressure index at which the accuracy of brachial-ankle pulse wave velocity measurement is diminished 显示文摘 | Motohe K Tomiyama H Koji Y | 2005 | Circ J2005，69，1： | 1 |
| 11 | Fourier transform profilometry for the automatic measurement of 3-D object shapes显示文摘 | TAKEDA M MOTOH K | 1983 | Appl Opt1983，22，24： | 1 |
| 12 | Nutrition therapy using a multidisciplinary team improves survival rates in patients with liver cirrhosis显示文摘 | Motoh Iwasa Kazuko Iwata Nagisa Hara Ayana Hattori Masumi Ishidome Noriko Sekoguchi-Fujikawa Rumi Mifuji-Moroka Ryosuke Sugimoto Naoki Fujita Yoshinao Kobayashi Yoshiyuki Takei | 2013 | Nutrition2013，，： | 1 |
| 13 | Fourier transform profilometry for the automaticmeasurement of 3-D object shapes显示文摘 | Takeda M Motoh K | 1983 | Applied Optics1983，22，24： | 1 |
| 14 | Fourier transform profilometry for the automatic measurement of 3-D object shapes显示文摘 | TAKEDA M MOTOH K | 1983 | Appl Opt1983，22，24： | 1 |
| 15 | Fourier transform profilometry for the automatic measurement of 3-D object shapes显示文摘 | Takeda M Motoh K | 1983 | Appl Opt1983，22，24： | 1 |
| 16 | Suppression by flavoids of cyclooxygenase-2 promoter-dependent transcription activity in colon cancer cells:structure-activity relationship显示文摘 | Motoh M Takahashi M Fukuda K | 2000 | Jpa J Cancer Res2000，91，7： | 1 |
| 17 | Magnetiztion transfer contrast of various regions of the brain in liver cirrhosis显示文摘 | Yasutomi Kinosada | 1999 | AJNR1999，20，4： | 1 |
| 18 | Lactoferrin inhibits lipid peroxidation in patients with chronic hepatitis C显示文摘 | MASAYGSHI KONISHI MOTOH IWASE KOJI YAMAUCHI | 2006 | Hepatology Research2006，36，1： | 1 |
| 19 | Two alkaloids from Zephyranthes carinata 显示文摘 | Keisuke K Motoh M Makoto I | 1998 | Phytochemistry1998，48，12： | 1 |
| 20 | suppression by flavoids of cyclooxygenase-2 promoter-dependent transcription activity in colon cancer cells:structure-activity relationship显示文摘 | MOTOH M TAKAHASHI M FUKUDA K | 2000 | Jpa J Cancer Res2000，91，7： | 1 |
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