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| 1 | Acute kidney injury and post-reperfusion syndrome in liver transplantation显示文摘In the past decades liver transplantation(LT) has become the treatment of choice for patients with end stage liver disease(ESLD). The chronic shortage of cadaveric organs for transplantation led to the utilization of a greater number of marginal donors such as older donors or donors after circulatory death(DCD). The improved survival of transplanted patients has increased the frequency of long-term complications, in particular chronic kidney disease(CKD). Acute kidney injury(AKI) post-LT has been recently recognized as an important risk factor for the occurrence of denovo CKD in the long-term outcome. The onset of AKI post-LT is multifactorial, with pre-LT risk factors involved, including higher Model for End-stage Liver Disease score, more sever ESLD and pre-existing renal dysfunction, either with intra-operative conditions, in particular ischaemia reperfusion injury responsible for post-reperfusion syndrome(PRS) that can influence recipient's morbidity and mortality. Post-reperfusion syndrome-induced AKI is an important complication post-LT that characterizes kidney involvement caused by PRS with mechanisms not clearly understood and implication on graft and patient survival. Since preLT risk factors may influence intra-operative events responsible for PRS-induced AKI, we aim to consider all the relevant aspects involved in PRS-induced AKI in the setting of LT and to identify all studies that better clarified the specific mechanisms linking PRS and AKI. A Pub Med search was conducted using the terms liver transplantation AND acute kidney injury; liver transplantation AND post-reperfusion syndrome; acute kidney injury AND post-reperfusion syndrome; acute kidney injury AND DCD AND liver transplantation. Five hundred seventy four articles were retrieved on Pub Med search. Results were limited to title/abstract of English-language articles published between 2000 and 2015. Twenty-three studies were identified that specifically evaluated incidence, risk factors and outcome for patients developing PRS-induced AKI in liver transplantation. In order to identify intra-operative risk factors/mechanisms specifically involved in PRSinduced AKI, avoiding confounding factors, we have limited our study to 'acute kidney injury AND DCD AND liver transplantation'. Accordingly, three out of five studies were selected for our purpose. | Ilaria Umbro Francesca Tinti Irene Scalera Felicity Evison Bridget Gunson Adnan Sharif James Ferguson Paolo Muiesan Anna Paola Mitterhofer | 2016 | World Journal of Gastroenterology2016，22，42： | 16 |
| 2 | Role of gut microbiota-immunity axis in patients undergoing surgery for colorectal cancer:Focus on short and long-term outcomes显示文摘Human body is colonized by a huge amount of microorganisms mostly located in the gastrointestinal tract.These dynamic communities,the environment and their metabolites constitute the microbiota.Growing data suggests a causal role of a dysbiotic microbiota in several pathologies,such as metabolic and neurological disorders,immunity dysregulations and cancer,especially the well-studied colorectal cancer development.However,many were preclinical studies and a complete knowledge of the pathogenetic mechanisms in humans is still absent.The gut microbiota can exert direct or indirect effects in different phases of colorectal cancer genesis.For example,Fusobacterium nucleatum promotes cancer through cellular proliferation and some strains of Escherichia coli and Bacteroides fragilis produce genotoxins.However,dysbiosis may also cause a proinflammatory state and the stimulation of a Th17 response with IL-17 and IL-22 secretion that have a pro-oncogenic activity,as demonstrated for Fusobacterium nucleatum.Microbiota has a crucial role in several stages of postoperative course;dysbiosis in fact seems related with surgical site infections and Enterococcus faecalis(and other collagenase-producers microbes)are suggested as a cause of anastomotic leak.Consequently,unbalanced presence of some species,together with altered immune response may also have a prognostic role.Microbiota has also a substantial role in effectiveness of chemotherapy,chemoresistance and in the related side effects.In other words,a complete knowledge of the fine pathological mechanisms of gut microbiota may provide a wide range of new diagnostic tools other than therapeutic targets in the light of tailored medicine. | Ilenia Bartolini Matteo Risaliti Maria Novella Ringressi Filippo Melli Giulia Nannini Amedeo Amedei Paolo Muiesan Antonio Taddei | 2020 | World Journal of Gastroenterology2020，26，20： | 6 |
| 3 | Gut microbiota and immune system in liver cancer:Promising therapeutic implication from development to treatment显示文摘Liver cancer is a leading cause of death worldwide,and hepatocellular carcinoma(HCC)is the most frequent primary liver tumour,followed by cholangiocarcinoma.Notably,secondary tumours represent up to 90% of liver tumours.Chronic liver disease is a recognised risk factor for liver cancer development.Up to 90% of the patients with HCC and about 20% of those with cholangiocarcinoma have an underlying liver alteration.The gut microbiota-liver axis represents the bidirectional relationship between gut microbiota,its metabolites and the liver through the portal flow.The interplay between the immune system and gut microbiota is also well-known.Although primarily resulting from experiments in animal models and on HCC,growing evidence suggests a causal role for the gut microbiota in the development and progression of chronic liver pathologies and liver tumours.Despite the curative intent of“traditional”treatments,tumour recurrence remains high.Therefore,microbiota modulation is an appealing therapeutic target for liver cancer prevention and treatment.Furthermore,microbiota could represent a non-invasive biomarker for early liver cancer diagnosis.This review summarises the potential role of the microbiota and immune system in primary and secondary liver cancer development,focusing on the potential therapeutic implications. | Ilenia Bartolini Matteo Risaliti Rosaria Tucci Paolo Muiesan Maria Novella Ringressi Antonio Taddei Amedeo Amedei | 2021 | World Journal of Gastrointestinal Oncology2021，13，11： | 3 |
| 4 | 患者独处诊室血压和非独处诊室血压与临床前靶器官损害的关系显示文摘患者独处的自动诊室血压或自动血压测量方法可能优于传统血压测量方法。目前一些国际指南建议自动化测量血压作为血压测量的首选方法。与标准血压测量方法所获数据比较,自动化测量血压与心血管事件的关系并不明确。初步数据显示:自动化测量血压可能与靶器官损害更相关。该研究的目的是评估在欧洲高血压学会卓越中心(excellence center)行超声心动图及颈动脉超声检查的564例患者独处诊室血压、非独处诊室血压与靶器官损害的关系。 | Salvetti M Paini A Aggiusti C Bertacchini F Stassaldi D Capellini S Ciuceis CD Rizzoni D Gatta R Rosei EA Muiesan ML 赵狄(摘译) 练桂丽(审校) | 2019 | 中华高血压杂志2019，0，3： | 2 |
| 5 | Different behaviour of BK-virus infection in liver transplantrecipients显示文摘Polyomavirus BK(BKV) infects up to 90% of the general population. After primary infection, occurring early during childhood, a state of non-replicative infection is established in the reno-urinary tract, without complications for immunocompetent hosts. In immunocompromised individuals, particularly transplanted patients, asymptomatic BKV viremia and/or viruria can be observed. Renal grafts may also be sources of infection as BKV prefers kidneys rather than other solid organs for transplantation such as the liver. The mechanism behind the higher incidence of BKV infection in kidney transplant patients, compared to liver or heart transplantation, is unclear and the prevalence of BKV infection in non-renal solid organ transplants has not been yet thoroughly investigated. We evaluated the prevalence of Polyomavirus BK infection among liver transplant recipients. A Pub Med search was conducted using the terms BKV infection AND liver transplant recipients; BKV AND non-renal solid organ transplant*; BKV infection AND immunosuppression; the search was limited to title/abstract and English-language articles published from 2000, to March 2015. Eleven relevant studies suggest that the prevalence of BKV viruria and/or viremia among liver transplant recipients is less than that reported in kidney or heart transplant recipients, except when chronic kidney disease(CKD) is present at the same time. Data also suggest that viruric and viremic patients have higher levels of serum creatinine than BKV negative patients. Moreover, no specific immunosuppressive drugs are associated with the onset of BKV nephropathy. The comorbidity of transplantation and CKD could play a major role in promoting BKV replication. | Ilaria Umbro Francesca Tinti Paolo Muiesan Anna Paola Mitterhofer | 2016 | World Journal of Gastroenterology2016，22，4： | 2 |
| 6 | Spontaneous rupture of hepatocellular carcinoma: a Western experience显示文摘 | Narendra Battula Mansoor Madanur Oliver Priest Parthi Srinivasan John O’Grady Michael A. Heneghan Matthew Bowles Paolo Muiesan Nigel Heaton Mohamed Rela | 2009 | The American Journal of Surgery2009，，2： | 2 |
| 7 | Compared Efficacy of Preservation Solutions in Liver Transplantation: A Long‐Term Graft Outcome Study From the European Liver Transplant Registry显示文摘 | R. Adam V. Delvart V. Karam C. Ducerf F. Navarro C. Letoublon J. Belghiti D. Pezet D. Castaing Y. P. Le Treut J. Gugenheim P. Bachellier J. Pirenne P. Muiesan | 2015 | American Journal of Transplantation2015，，2： | 2 |
| 8 | 24h动态中心动脉收缩压和左心室质量的关系:一项前瞻性多中心研究显示文摘研究者在7个欧洲中心中调查左心室质量与肱动脉诊室血压以及肱动脉压和中心动脉动态收缩压之间的关系。使用校准的示波装置测量,经平均压/舒张压校准和转换函数计算中心动脉收缩压。由不知道血压值的单个操作者通过M型超声心动图测定左心室质量。研究者调查了未使用抗高血压药物的受试者289人(女性137人,平均年龄50.8岁)。 | 黄洁 叶鹏 Weber T Wassertheurer S Schmidt-Trucks?ss A Rodilla E Ablasser C Jankowski P Lorenza Muiesan M Giannattasio C Mang C Wilkinson I Kellermair J Hametner B Pascual JM Zweiker R Czarnecka D Paini A Salvetti M Maloberti A McEniery C | 2017 | 中华高血压杂志2017，25，11： | 2 |
| 9 | Carotid atherosclero-sis,arterial stiffness and stroke events显示文摘 | AGABITI-ROSEI E MUIESAN M L | 2007 | Adv Cardiol2007，44，： | 1 |
| 10 | Liver transplantation for Wilsons disease:long-term results and quality-of-life assessment显示文摘 | Sutcliffe RP Maguire DD Muiesan P | 2003 | Transplantation2003，75，7： | 1 |
| 11 | In situ normothermic regional perfusion for controlled donation after circulatory death:the United Kingdom experience显示文摘 | Oniscu GC Randle LV Muiesan P | 2014 | Am J Transplant2014，14，12： | 1 |
| 12 | Reduction of cardiovascular structuralchanges by nifedipine GITS in essential hypertensive patients显示文摘 | Agabiti-Rosei E Zulli R Muiesan ML | 1998 | BloodPress1998，7，3： | 1 |
| 13 | Cardiovascular characteristics in normotensive subjects with or without family history of hypertension显示文摘 | Rizzoni D Zulli R | 1996 | Clin Exp Hypertens1996，18，7： | 1 |
| 14 | Hepatic artery pseudoaneurysms fnllowing liver transplantation: incidence, presenting features and management 显示文摘 | Marshall M Muiesan P Srinivasan P | 2001 | Clin Radiol2001，56，： | 1 |
| 15 | Bowel perforation after paediatrie orthotopic liver transplantation 显示文摘 | Vilca MH Vougas V Muiesan P | 1998 | Transpl Int1998，11，4： | 1 |
| 16 | Structural changes in small resistanee arteries and left ventricular geometry in patients with primary and secondary hypertension显示文摘 | Muiesan ML Rizzoni D Salvetti M | 2002 | J Hypertens2002，20，7： | 1 |
| 17 | Repeat liver resection for recurrent colorectal metastases: a single‐centre, 13‐year experience显示文摘 | Narendra Battula Dimitrios Tsapralis David Mayer John Isaac Paolo Muiesan Robert P. Sutcliffe Simon Bramhall Darius Mirza Ravi Marudanayagam | 2014 | HPB2014，，2： | 1 |
| 18 | Flow-mediated dilatation of the brachial artery and left ventricular geommetry in hypertensive patients显示文摘 | Muiesan ML Salvetti M Monteduro C | 2001 | J Hypertens2001，19，32： | 1 |
| 19 | Effect of treatment on flow-dependent vasodilation of the brachial artery in essential hypertension显示文摘 | Muiesan ML Salvetti M Monteduro C | 1999 | Hypertension1999，33，12： | 1 |
| 20 | Angiotensin Ⅱ type 1 receptor A/C1166 polymorphism,Relationships with blood pressure and cardiovasular structure显示文摘 | Castellano M Muiesan ML Beschi M | 1996 | Hypertension1996，28，： | 1 |
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