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| 1 | Acute kidney injury and post-reperfusion syndrome in liver transplantation显示文摘In the past decades liver transplantation(LT) has become the treatment of choice for patients with end stage liver disease(ESLD). The chronic shortage of cadaveric organs for transplantation led to the utilization of a greater number of marginal donors such as older donors or donors after circulatory death(DCD). The improved survival of transplanted patients has increased the frequency of long-term complications, in particular chronic kidney disease(CKD). Acute kidney injury(AKI) post-LT has been recently recognized as an important risk factor for the occurrence of denovo CKD in the long-term outcome. The onset of AKI post-LT is multifactorial, with pre-LT risk factors involved, including higher Model for End-stage Liver Disease score, more sever ESLD and pre-existing renal dysfunction, either with intra-operative conditions, in particular ischaemia reperfusion injury responsible for post-reperfusion syndrome(PRS) that can influence recipient's morbidity and mortality. Post-reperfusion syndrome-induced AKI is an important complication post-LT that characterizes kidney involvement caused by PRS with mechanisms not clearly understood and implication on graft and patient survival. Since preLT risk factors may influence intra-operative events responsible for PRS-induced AKI, we aim to consider all the relevant aspects involved in PRS-induced AKI in the setting of LT and to identify all studies that better clarified the specific mechanisms linking PRS and AKI. A Pub Med search was conducted using the terms liver transplantation AND acute kidney injury; liver transplantation AND post-reperfusion syndrome; acute kidney injury AND post-reperfusion syndrome; acute kidney injury AND DCD AND liver transplantation. Five hundred seventy four articles were retrieved on Pub Med search. Results were limited to title/abstract of English-language articles published between 2000 and 2015. Twenty-three studies were identified that specifically evaluated incidence, risk factors and outcome for patients developing PRS-induced AKI in liver transplantation. In order to identify intra-operative risk factors/mechanisms specifically involved in PRSinduced AKI, avoiding confounding factors, we have limited our study to 'acute kidney injury AND DCD AND liver transplantation'. Accordingly, three out of five studies were selected for our purpose. | Ilaria Umbro Francesca Tinti Irene Scalera Felicity Evison Bridget Gunson Adnan Sharif James Ferguson Paolo Muiesan Anna Paola Mitterhofer | 2016 | World Journal of Gastroenterology2016,22,42: | 16 |
| 2 | Cardiovascular morbidity and mortality after orthotopic liver transplantation显示文摘 | Simon D. Johnston Joan K. Morris Rob Cramb Bridget K. Gunson James Neuberger | 2002 | Transplantation2002,,6: | 2 |
| 3 | Portal hypertension in polycystic liver disease patients does not affect wait-list or immediate post-liver transplantation outcomes显示文摘AIM To establish the impact of portal hypertension(PH) on wait-list/post-transplant outcomes in patients with polycystic liver disease(PCLD) listed for liver transplantation. METHODS A retrospective single-centre case controlled study of consecutive patients listed for liver transplantation over 12 years was performed from our centre. PH in the PCLD cohort was defined by the one or more of following parameters:(1) presence of radiological or endoscopic documented varices from our own centre or the referral centre;(2) splenomegaly(> 11 cm) on radiology inabsence of splenic cysts accounting for increased imaging size;(3) thrombocytopenia(platelets < 150 × 109/L); or(4) ascites without radiological evidence of hepatic venous outflow obstruction from a single cyst. RESULTS Forty-seven PCLD patients(F: M = 42: 5) were listed for liver transplantation(LT)(single organ, n = 35; combined liver-kidney transplantation, n = 12) with 19 patients(40.4%) having PH. When comparing the PH group with non-PH group, the mean listing age(PH group, 50.6(6.4); non-PH group, 47.1(7.4) years; P = 0.101), median listing MELD(PH group, 12; non-PH group, 11; P = 0.422) median listing UKELD score(PH group, 48; non-PH group, 46; P = 0.344) and need for renal replacement therapy(P = 0.317) were similar. In the patients who underwent LT alone, there was no difference in the duration of ICU stay(PH, 3 d; non-PH, 2 d; P = 0.188), hospital stay length(PH, 9 d; non-PH, 10 d; P = 0.973), or frequency of renal replacement therapy(PH, 2/8; non-PH, 1/14; P = 0.121) in the immediate post-transplantation period. CONCLUSION Clinically apparent portal hypertension in patients with PCLD listed for liver transplantation does not appear to have a major impact on wait-list or peri-transplant morbidity. | Neil Rajoriya Dhiraj Tripathi Joanna A Leithead Bridget K Gunson Sophie Lord James W Ferguson Gideon M Hirschfield | 2016 | World Journal of Gastroenterology2016,22,45: | 2 |
| 4 | PORTAL VEIN THROMBOSIS IN ADULTS UNDERGOING LIVER TRANSPLANTATION : Risk Factors, Screening, Management, and Outcome1显示文摘 | Mehmet Ali Yerdel Bridget Gunson Darius Mirza Kaan Karayal?in Simon Olliff John Buckels David Mayer Paul McMaster Jacques Pirenne | 2000 | Transplantation2000,,9: | 1 |
| 5 | The impact of disease recurrence on graft survival following liver transplantation: a single centre experience显示文摘 | Ian A Rowe Kerry Webb Bridget K Gunson Naimish Mehta Sayeed Haque James Neuberger | 2008 | Transplant International2008,,5: | 1 |
| 6 | Conventional versus piggyback technique of caval implantation; without extra‐corporeal veno‐venous bypass. A comparative study显示文摘 | Saboor Khan Michael A. Silva Yu Meng Tan Abraham John Bridget Gunson John A. C. Buckels A. David Mayer Simon R. Bramhall Darius F. Mirza | 2006 | Transplant International2006,,10: | 1 |
| 7 | Colorectal cancer in patients with inflammatory bowel disease after liver transplantation for primary sclerosing cholangitis显示文摘 | Alonso Vera Bridget K. Gunson Val Ussatoff Peter Nightingale Daniel Candinas Simon Radley A. David Mayer John A.C. Buckels Paul McMaster James Neuberger Darius F. Mirza | 2003 | Transplantation2003,,12: | 1 |
| 8 | Outcome of liver transplantation for patients with pulmonary hypertension显示文摘 | Peter Starkel Alonso Vera Bridget Gunson David Mutimer | 2002 | Liver Transplantation2002,,4: | 1 |
| 9 | Incidence of Cancers Following Orthotopic Liver Transplantation in a Single Center: Comparison with National Cancer Incidence Rates for England and Wales显示文摘 | Ye H. Oo Bridget K. Gunson Robert J. Lancashire Kar K. Cheng James M. Neuberger | 2005 | Transplantation2005,,6: | 1 |
| 10 | Impact of Donor Age and Year of Transplantation on Graft and Patient Survival Following Liver Transplantation for Hepatitis C Virus显示文摘 | David J. Mutimer Bridget Gunson John Chen J Berenguer Peter Neuhaus D Castaing J C. Garcia-Valdecasas M Salizzoni Gonzalez E. Moreno Darius Mirza | 2006 | Transplantation2006,,1: | 1 |
| 11 | Liver transplantation for polycystic liver disease显示文摘 | Jacques Pirenne Raymond Aerts Kim Yoong Bridget Gunson Takaaki Koshiba Inge Fourneau David Mayer John Buckels Darius Mirza Tania Roskams Elwin Elias Frederik Nevens Johan Fevery Paul McMaster | 2001 | Liver Transplantation2001,,3: | 1 |
| 12 | Increasing the Donor Pool: Consideration of Prehospital Cardiac Arrest in Controlled Donation After Circulatory Death for Liver Transplantation显示文摘 | Ahmed H. Elaffandi Glenn K. Bonney Bridget Gunson Irene Scalera Hynek Mergental John R. Isaac Simon R. Bramhall Darius F. Mirza M. Thamara P.R. Perera Paolo Muiesan | 2014 | Liver Transpl2014,,1: | 1 |
| 13 | Orthotopic liver transplantation for alcoholic liver disease: A retrospective analysis of survival, recidivism, and risk factors predisposing to recidivism显示文摘 | Joanna Mackie Katherine Groves Angela Hoyle Christian Garcia Raquel Garcia Bridget Gunson James Neuberger | 2001 | Liver Transplantation2001,,5: | 1 |
| 14 | PORTAL VEIN THROMBOSIS IN ADULTS UNDERGOING LIVER TRANSPLANTATION : Risk Factors, Screening, Management, and Outcome1显示文摘 | Mehmet Ali Yerdel Bridget Gunson Darius Mirza Kaan Karayal?in Simon Olliff John Buckels David Mayer Paul McMaster Jacques Pirenne | 2000 | Transplantation2000,,: | 1 |
| 15 | Type of donor aortic preservation solution and not cold ischemia time is a major determinant of biliary strictures after liver transplantation显示文摘 | Jacques Pirenne Frank Van Gelder Willy Coosemans Raymond Aerts Bridget Gunson Takaaki Koshiba Inge Fourneau Darius Mirza Werner Van Steenbergen Johan Fevery Frederik Nevens Paul McMaster | 2001 | Liver Transplantation2001,,6: | 1 |