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| 1 | Targeting chronic lymphocytic leukemia cells in the tumor microenviroment: A review of the in vitro and clinical trials to date显示文摘Chronic lymphocytic leukemia(CLL) is the most common leukemia in the western world. Despite significantadvances in therapy over the last decade CLL remains incurable. Current front-line therapy often consists of chemoimmunotherapy-based regimens, most commonly the fludarabine, cyclophosphamide plus rituximab combination, but rates of relapse and refractory disease are high among these patients. Several key signaling pathways are now known to mediate the survival and proliferation of CLL cells in vivo, the most notable of which are the pathways mediated by the B-cell receptor(BCR) and cytokine receptors. A better understanding of the pathogenesis of the disease, the underlying biology of the CLL-cell and the roles of the tumour microenvironment has provided the rationale for trials of a range of novel, more targeted therapeutic agents. In particular, clinical trials of ibrutinib and idelalisib, which target the Brutons tyrosine kinase and the delta isoform of phosphoinositol-3 kinase components of the BCR signaling pathway respectively, have shown extremely promising results. Here we review the current literature on the key signaling pathways and interactions of CLL cells that mediate the survival and proliferation of the leukemic cells. For each we describe the results of the recent clinical trials and in vitro studies of novel therapeutic agents. | Kyle Crassini Stephen P Mulligan O Giles Best | 2015 | World Journal of Clinical Cases2015，3，8： | 5 |
| 2 | Alkyl hydroperoxide reductase: A candidate Helicobacter pylori vaccine显示文摘 | Avril A. O’Riordan Veronica Athie Morales Linda Mulligan Nazia Faheem Henry J. Windle Dermot P. Kelleher | 2012 | Vaccine2012，，26： | 4 |
| 3 | Recommendations for Comprehensive Stroke Centers: A Consensus Statement From the Brain Attack Coalition显示文摘 | Mark J. Alberts Richard E. Latchaw Warren R. Selman Timothy Shephard Mark N. Hadley Lawrence M. Brass Walter Koroshetz John R. Marler John Booss Richard D. Zorowitz Janet B. Croft Ellen Magnis Diane Mulligan Andrew Jagoda Robert O’Connor C Michael Cawley | 2005 | Stroke2005，，7： | 2 |
| 4 | Agreement and conversion formula between mini-mental state examination and montreal cognitive assessment in an outpatient sample显示文摘AIM To explore the agreement between the mini-mental state examination(MMSE) and montreal cognitive assessment(Mo CA) within community dwelling older patients attending an old age psychiatry service and to derive and test a conversion formula between the two scales.METHODS Prospective study of consecutive patients attending outpatient services.Both tests were administered by the same researcher on the same day in random order.RESULTS The total sample(n = 135) was randomly divided into two groups.One to derive a conversion rule(n = 70),and a second(n = 65) in which this rule was tested.The agreement(Pearson's r) of MMSE and Mo CA was 0.86(P < 0.001),and Lin's concordance correlation coefficient(CCC) was 0.57(95%CI:0.45-0.66).In the second sample Mo CA scores were converted to MMSE scores according to a conversion rule from the first sample which achieved agreement with the original MMSE scoresof 0.89(Pearson's r,P < 0.001) and CCC of 0.88(95%CI:0.82-0.92).CONCLUSION Although the two scales overlap considerably,the agreement is modest.The conversion rule derived herein demonstrated promising accuracy and warrants further testing in other populations. | Luqman Helmi David Meagher Edmond O'Mahony Donagh O'Neill Owen Mulligan Sutha Murthy Geraldine McCarthy Dimitrios Adamis | 2016 | World Journal of Psychiatry2016，6，3： | 2 |
| 5 | Metastatic potential of encapsulated (intracystic) papillary carcinoma of the breast: a report of 2 cases with axillary lymph node micrometastases 显示文摘 | Mulligan AM O' Malley FP | 2007 | Int J Surg Pathol2007，15，2： | 1 |
| 6 | Ccurrence of arsenic contamination in Canada: Sources, behavior and distribution 显示文摘 | Suiling Wang Catherine N Mulligan O | 2006 | Science of the Total Environment2006，366，： | 1 |
| 7 | Autism symptoms in attention-deficit/hyperactivity disorder: a familial trait which correlates with conduct, oppositional defiant, lan- guage and motor disorders显示文摘 | Mulligan A Anney RJ O'Regan M | 2009 | J Autism Dev Disord2009，39，2： | 1 |
| 8 | The effect of body condition at calving and supplementation with Saccharomyces cerevisiae on energy status and some reproductive parameters in early lactation dairy cows显示文摘 | R.M. AlIbrahim M.A. Crowe P. Duffy L. O‘Grady M.E. Beltman F.J. Mulligan | 2010 | Animal Reproduction Science2010，，1： | 1 |
| 9 | High-level JAG1 mRNA and protein predict poor outcome in breast cancer显示文摘 | Dickson B C Mulligan A M Zhang H Lockwood G O' Malley F P Egan S E | 2007 | Mod Pathol2007，20，： | 1 |
| 10 | Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges显示文摘 | Danos O Mulligan RC | 1988 | Proc Natl Acad Sci USA1988，85，17： | 1 |
| 11 | A herd health approach to dairy cow nutrition and production diseases of the transition cow显示文摘 | F.J. Mulligan L. O’Grady D.A. Rice M.L. Doherty | 2006 | Animal Reproduction Science2006，，3： | 1 |
| 12 | Comparison of 11C-PiB and 18F-florbetaben for Aβ imaging in ageing and Alzheimer’s disease显示文摘 | Victor Villemagne Rachel Mulligan Svetlana Pejoska Kevin Ong Gareth Jones Graeme O’Keefe J. Chan Kenneth Young Henri Tochon-Danguy Colin Masters Christopher Rowe | 2012 | European Journal of Nuclear Medicine and Molecular Imaging2012，，： | 1 |
| 13 | Papillary lesions of the breast : a review 显示文摘 | Mulligan AM O' Malley FP | 2007 | Adv Anat Pathol2007，14，2： | 1 |
| 14 | Papillary lesions of the breast:a review显示文摘 | Mulligan AM O'Malley FP | 2007 | Adv Anat Pathol2007，14，2： | 1 |
| 15 | Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer显示文摘 | Mulligan AM O'Malley FP Ennis M | 2007 | Breast Cancer Res Treat2007，106，1： | 1 |
| 16 | Home environment: association with hyperactivity/impulsivity in children with ADHD and their non‐ADHD siblings显示文摘 | A. Mulligan R. Anney L. Butler M. O’Regan T. Richardson E. M. Tulewicz M. Fitzgerald M. Gill | 2011 | Child: Care Health and Development2011，，2： | 1 |
| 17 | A herd health ap- proach to dairy cow nutrition and production diseases of the transition cow显示文摘 | Mulligan F J O'Grady L Rice D A | 2006 | Anim Reprod Sci2006，96，34： | 1 |
| 18 | Production diseases of the transition cow:Milk fever and subclinical hypocalcaemia显示文摘 | Mulligan F O'Grady L Rice D | 2006 | Irish Vet J2006，59，12： | 1 |
| 19 | Subacute ruminal acidosis(SARA)in grazing dairy cows显示文摘 | O GRADY L Doherty M L Mulligan F J | 2008 | Veterinary Journal2008，176，： | 1 |
| 20 | C5a-dependent up-regulation in vivo of lung vascular P-selectin显示文摘 | MULLIGAN M S SCHMID E TILL G O | 1997 | J Immunol1997，158，4： | 1 |
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