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| 1 | Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma. | Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 2 | E6 molecular variants of human papillomavirus (HPV) type 16: An updated and unified criterion for clustering and nomenclature显示文摘 | Antonio Huertas-Salgado Diana C. Martín-Gámez Pablo Moreno Raúl Murillo María Mercedes Bravo Luisa Villa Mónica Molano | 2010 | Virology2010，，： | 2 |
| 3 | Effect of tall oil fatty acids content on the properties of novel hyperbranched alkyd resins 显示文摘 | Murillo E A Vallejo P P Lopez B L | 2011 | Journal of Applied Polymer Science2011，120，6： | 1 |
| 4 | Peripheral T-cell lymphoma with follicular T-cell markers显示文摘 | Rodriguez-Pinilla SM Atienza L Murillo C | 2008 | Am J Surg Pathol2008，32，12： | 1 |
| 5 | CD14 and TLR4 gene polymorphisms in adult periodontitis 显示文摘 | LAINE M L MORRE S A MURILLO L S | 2005 | Dent Res2005，84，11： | 1 |
| 6 | Agricultural use of three (sugar-beet) vinasse composts: effect on crops and chemical properties of a Cambisol soil in the Guadalquivir river valley (SW Spain)显示文摘 | Engracia Madejón Rafael López José M Murillo Francisco Cabrera | 2001 | Agriculture Ecosystems and Environment2001，，1： | 1 |
| 7 | Changes in organic matter and residual effect of amendment with two-phase olive-mill waste on degraded agricultural soils显示文摘 | Antonio López-Pi?eiro Sergio Murillo Carla Barreto Ana Mu?oz José M. Rato Angel Albarrán Arturo García | 2007 | Science of the Total Environment2007，，1： | 1 |
| 8 | Prospective study of single and multiple lacunar infarcts using magnetic resonance imaging 显示文摘 | Arauz A Murillo L Cantu L | 2003 | Stroke2003，34，： | 1 |
| 9 | Substitution of peat for municipal solid waste- and sewage sludge-based composts in nursery growing media: Effects on growth and nutrition of the native shrub Pistacia lentiscus L.显示文摘 | J.C. Ostos R. López-Garrido J.M. Murillo R. López | 2007 | Bioresource Technology2007，，6： | 1 |
| 10 | Buttock augmentation: case studies of fat injection monitored by magnetic resonance imaging显示文摘 | MURILLO W L | 2004 | Plast Reconstr Surg2004，114，6： | 1 |
| 11 | Determination of napropamide in technical formulations,soil and vegetable samples by sensitised fluorescence:validation of the method显示文摘 | Murillo Pulgarín J A García Bermejo L F | 2003 | Analytica Chimica Acta2003，491，1： | 1 |
| 12 | The maize pathogenesis-related PRms protein localizes to plasmodesmata in maize radicles显示文摘 | Murillo I Cavallarin L Segundo B S | 1997 | Plant Cell1997，9，2： | 1 |
| 13 | Tyrphostin AG825 trigger p38 mitogen-activated protein kinase-dependent apoptosis in androgen-independent prostate cancer cells C4 and C4-2显示文摘 | MuriLlo H Schmidt L J Tindall D J | 2001 | Cancer Res2001，61，20： | 1 |
| 14 | Study of the impact resistance of physi- cally and dynamically vulcanized mixtures of PP/EPDM显示文摘 | Murillo E A L 6 pez B L | 2006 | Macromolecular Symposia2006，242，1： | 1 |
| 15 | Serum uricacid and outcome after acute is chemic stroke:PREMIER study显示文摘 | Chiquete E Ruiz Sandoval J I Murillo Bonilla L M | | Cerebrovasic Dis0，35，： | 1 |
| 16 | Prospective study of single and multiple lacunar infarcts using magnetic resonance imaging:risk factors,recurrence,and outcome in 175 consecutive cases显示文摘 | Arauz A Murillo L Cantu C | 2003 | Storke2003，，： | 1 |
| 17 | Inhibition of protein kinase C de- creases sensitivity of GABA receptor subtype to fipronil insecticide in insect neurosecretory cells显示文摘 | MURILLO L HAMON A ES-SALAH-LAMOUREUX Z ITIER V QUINCHARD S LAPIED B | 2011 | Neurotoxicology2011，32，6： | 1 |
| 18 | Effect of tall oil fatty acids content on the properties of novel hyperbranched alkyd resins 显示文摘 | MURILLO E A VALLEJO P P LOPEZ B L | 2011 | Journal of Applied Polymer Science2011，120，6： | 1 |
| 19 | Synthesis and charac- terization of novel alkyd - silicone hyperbranched nanoresins with high solid contents 显示文摘 | MURILLO E A LOPEZ B L BROSTOW W | 2011 | Progress in Organic Coatings2011，72，3： | 1 |
| 20 | Olive Tree Response to Irrigation with Wastewater from the Table Olive Industry显示文摘 | MURILLO J M LPEZ R FERNNDEZ J E | 2000 | Irrigation Science2000，19，4： | 1 |
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