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| 1 | Bone Morphogenetic Protein (BMP) signaling in development and human diseases显示文摘Bone Morphogenetic Proteins(BMPs)are a group of signaling molecules that belongs to the Transforming Growth Factor-b(TGF-b)superfamily of proteins.Initially discovered for their ability to induce bone formation,BMPs are now known to play crucial roles in all organ systems.BMPs are important in embryogenesis and development,and also in maintenance of adult tissue homeostasis.Mouse knockout models of various components of the BMP signaling pathway result in embryonic lethality or marked defects,highlighting the essential functions of BMPs.In this review,we first outline the basic aspects of BMP signaling and then focus on genetically manipulated mouse knockout models that have helped elucidate the role of BMPs in development.A significant portion of this review is devoted to the prominent human pathologies associated with dysregulated BMP signaling. | Richard N.Wang Jordan Green Zhongliang Wang Youlin Deng Min Qiao Michael Peabody Qian Zhang Jixing Ye Zhengjian Yan Sahitya Denduluri Olumuyiwa Idowu Melissa Li Christine Shen Alan Hu Rex C.Haydon Richard Kang James Mok Michael J.Lee Hue L.Luu Lewis L.Shi | 2014 | Genes & Diseases2014，1，1： | 47 |
| 2 | Nanoporous membrane device for ultra high heat flux thermal management显示文摘High power density electronics are severely limited by current thermal management solutions which are unable to dissipate the necessary heat flux while maintaining safe junction temperatures for reliable operation.We designed,fabricated,and experimentally characterized a microfluidic device for ultra-high heat flux dissipation using evaporation from a nanoporous silicon membrane.With~100 nm diameter pores,the membrane can generate high capillary pressure even with low surface tension fluids such as pentane and R245fa.The suspended ultra-thin membrane structure facilitates efficient liquid transport with minimal viscous pressure losses.We fabricated the membrane in silicon using interference lithography and reactive ion etching and then bonded it to a high permeability silicon microchannel array to create a biporous wick which achieves high capillary pressure with enhanced permeability.The back side consisted of a thin film platinum heater and resistive temperature sensors to emulate the heat dissipation in transistors and measure the temperature,respectively.We experimentally characterized the devices in pure vaporambient conditions in an environmental chamber.Accordingly,we demonstrated heat fluxes of 665±74 W/cm^(2) using pentane over an area of 0.172mm×10mm with a temperature rise of 28.5±1.8 K from the heated substrate to ambient vapor.This heat flux,which is normalized by the evaporation area,is the highest reported to date in the pure evaporation regime,that is,without nucleate boiling.The experimental results are in good agreement with a high fidelity model which captures heat conduction in the suspended membrane structure as well as non-equilibrium and sub-continuum effects at the liquid–vapor interface.This work suggests that evaporative membrane-based approaches can be promising towards realizing an efficient,high flux thermal management strategy over large areas for high-performance electronics. | Daniel F.Hanks Zhengmao Lu Jay Sircar Todd R.Salamon Dion S.Antao Kevin R.Bagnall Banafsheh Barabadi Evelyn N.Wang | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 3 | 查看详情显示文摘 | N.Wang D.Stamenovic | | 0，，： | 1 |
| 4 | 查看详情显示文摘 | N.Wang Z.G.Suo | | 0，，： | 1 |
| 5 | 查看详情显示文摘 | H.D.Li Z.Y.Wang X.Kan X.Guo H.T.He Z.Wang J.N.Wang T.L.Wong N.Wang and M.H.Xie | | 0，，10： | 1 |
| 6 | 查看详情显示文摘 | N.Wang J.Cheng A.Pyatakov A.K.Zvezdin J.F.Li L.E.Cross and D.Viehland | | 0，，10： | 1 |
| 7 | 查看详情显示文摘 | X.Z.Sun N.Wang D.Cao | | 0，，： | 1 |
| 8 | Development of a 750-mm-long stripline kicker for HEPS显示文摘Purpose The superfast kickers are required for the HEPS storage ring on-axis injection system due to its very small dynamic aperture.A 750-mm-long stripline pair type of kicker prototype was researched and developed to demonstrate achieved performance of bandwidth,impedance,kicker strength,field uniformity and beam power loss.Methods The cross sections of the kicker main body and the end of taper part are optimized for a good impedance matching and field uniformity.3D simulation further optimizes the taper part to minimize the beam power loss and maintain a lower reflection.The high-voltage feedthrough is also designed and optimized by 3D CST.RF and high-voltage measurements are taken to verify the design of kicker assembly.Results The testing transmission odd-mode impedance is 50±0.5Ω,the even-mode impedance is 60±0.5Ω,and return loss is less than−13 dB.The peak voltage and the rise time of pulse width inserting kicker assembly just decrease 3%of 20 kV and slow down 80 ps,respectively.Conclusions RF testing results agree well with the simulation ones,which meet the design specification.The kicker assembly works well at±20 kV pulse. | H.Shi J.H.Chen L.Wang N.Wang L.H.Huo G.W.Wang P.Liu X.L.Shi | 2018 | Radiation Detection Technology and Methods2018，2，2： | 1 |
| 9 | Serum adiponectin levels in cholesterol and pigment cholelithiasis显示文摘 | S.‐N.Wang Y.‐T.Yeh M.‐L.Yu C.‐L.Wang K.‐T.Lee | 2006 | Br J Surg2006，，8： | 1 |
| 10 | The Size‐Dependent Growth Direction of ZnSe Nanowires显示文摘 | Y.Cai S.?K.Chan I.?K.Sou Y.?F.Chan D.?S.Su N.Wang | 2005 | Adv Mater2005，，1： | 1 |
| 11 | 查看详情显示文摘 | H.D.Li Z.Y.Wang X.Kan X.Guo H.T.He Z.Wang J.N.Wang T.L.Wong N.Wang and M.H.Xie | | 0，，： | 1 |
| 12 | NEW INSIGHT INTO MECHANISMS OF AQUEOUS OUTFLOW DEFICIENCY: ROLE OF THE STRESS RESPONSE显示文摘The glaucomas are a group of optic neuropathies comprising the leading cause of irreversible blindness worldwide. Elevated intraocular pressure due to a reduction in normal aqueous outflow is a major causal risk factor. We recently reported that En-dothelial Leukocyte Adhesion Molecule-1 (ELAM-1), the earliest marker for the atherosclerotic plaque in the vasculature, | M.E.Fini K.A.Erickson E.L.Ginsberg P.F.Olson N.Wang K.R.Wollen-berg X.Zhang J.S.Schuman | 2003 | 国际眼科杂志2003，3，1： | 0 |
| 13 | A Strong Stability-Preserving Predictor-Corrector Method for the Simulation of Elastic Wave Propagation in Anisotropic Media显示文摘In this paper,we propose a strong stability-preserving predictor-corrector(SSPC)method based on an implicit Runge-Kutta method to solve the acoustic-and elastic-wave equations.We first transform the wave equations into a system of ordinary differential equations(ODEs)and apply the local extrapolation method to discretize the spatial high-order derivatives,resulting in a system of semi-discrete ODEs.Then we use the SSPC method based on an implicit Runge-Kutta method to solve the semi-discrete ODEs and introduce a weighting parameter into the SSPC method.On top of such a structure,we develop a robust numerical algorithm to effectively suppress the numerical dispersion,which is usually caused by the discretization of wave equations when coarse grids are used or geological models have large velocity contrasts between adjacent layers.Meanwhile,we investigate the performance of the SSPC method including numerical errors and convergence rate,numerical dispersion,and stability criteria with different choices of the weighting parameter to solve 1-D and 2-D acoustic-and elastic-wave equations.When the SSPC is applied to seismic simulations,the computational efficiency is also investigated by comparing the SSPC,the fourth-order Lax-Wendroff correction(LWC)method,and the staggered-grid(SG)finite differencemethod.Comparisons of synthetic waveforms computed by the SSPC and analytic solutions for acoustic and elastic models are given to illustrate the accuracy and the validity of the SSPCmethod.Furthermore,several numerical experiments are conducted for the geological models including a 2-D homogeneous transversely isotropic(TI)medium,a two-layer elastic model,and the 2-D SEG/EAGE salt model.The results show that the SSPC can be used as a practical tool for large-scale seismic simulation because of its effectiveness in suppressing numerical dispersion even in the situations such as coarse grids,strong interfaces,or high frequencies. | D.H.Yang N.Wang E.Liu | 2012 | Communications in Computational Physics2012，12，9： | 0 |
| 14 | Research and development of the back-end electronics for the two-dimensional improved resistive plate chambers in CMS upgrade显示文摘Purpose To complement and ensure redundancy in the endcap muon system of the Compact Muon Solenoid(CMS)detector and to extend the Resistive Plate Chamber(RPC)system coverage,improved RPCs(iRPCs)with either orthogonal layer strips with one-end electronics or single layer strips with two-end electronics providing more precise time measurement will be installed in the very forward pseudorapidity region of|η|<2.4.The iRPC readout system needs to support twodimensional(2D)or two-end readout.In addition,it must combine detector data with Timing,Trigger and fast Control(TTC)and Slow Control(SC)into one data stream over a bi-directional optical link with a line rate of 4.8 Gb/s between the Front-End Electronics(FEE)and the Back-End Electronics(BEE).To fulfill these requirements,a prototype BEE for the iRPC 2D chamber has been researched and designed.Methods A Micro-Telecommunication and Computing Architecture(μTCA)-based processing card was designed in this study to establish a prototype system together with aμTCA crate.The Giga-Bit Transceiver(GBT)protocol is integrated to provide bi-directional communication between the FEE and BEE.A server is connected with the BEE by a Gigabit Ethernet(GbE)link for SC and a 10-GbE link for Data AcQuisition(DAQ).Results The Bit Error Rate(BER)test of the back-end board and a joint test with the iRPC 2D prototype chamber were performed.ABERof less than 1.331×10−16 was obtained.The timemeasurement with a resolution of 3.05 nswas successfully realized,and detector efficiencies of 97.7%for longitudinal strips and 96.0%for orthogonal strips were measured.Test results demonstrate the correctness and reliability of the prototype BEE.Conclusion The BEE prototype satisfies the requirements for the iRPC 2D chamber,and it worked stably and reliably during a long-term joint test run. | P.Cao Z-A.Liu J.Zhao H.Kou J.Tao J.Song W.Gong N.Wang A.Samalan M.Tytgat N.Zaganidis G.A.Alves F.Marujo F.Torres.Da.S.ilva.De.Araujo E.M.Da Costa D.De Jesus Damiao H.Nogima A.Santoro S.Fonseca De Souza A.Aleksandrov R.Hadjiiska P.Iaydjiev M.Rodozov M.Shopova G.Sultanov M.Bonchev A.Dimitrov L.Litov B.Pavlov P.Petkov A.Petrov S.J.Qian C.Bernal A.Cabrera J.Fraga A.Sarkar S.Elsayed Y.Assran M.El Sawy M.A.Mahmoud Y.Mohammed X.Chen C.Combaret M.Gouzevitch G.Grenier I.Laktineh L.Mirabito K.Shchablo I.Bagaturia D.Lomidze I.Lomidze V.Bhatnagar R.Gupta P.Kumari J.Singh V.Amoozegar B.Boghrati M.Ebraimi R.Ghasemi M.Mohammadi Najafabadi E.Zareian M.Abbrescia R.Aly W.Elmetenawee N.De Filippis A.Gelmi G.Iaselli S.Leszki F.Loddo I.Margjeka G.Pugliese D.Ramos L.Benussi S.Bianco D.Piccolo S.Buontempo A.Di Crescenzo F.Fienga G.De Lellis L.Lista S.Meola P.Paolucci A.Braghieri P.Salvini P.Montagna C.Riccardi P.Vitulo B.Francois T.J.Kim J.Park S.Y.Choi B.Hong K.S.Lee J.Goh H.Lee J.Eysermans C.Uribe Estrada I.Pedraza H.Castilla-Valdez A.Sanchez-Hernandez C.A.Mondragon Herrera D.A.Perez Navarro G.A.Ayala Sanchez S.Carrillo E.Vazquez A.Radi A.Ahmad I.Asghar H.Hoorani S.Muhammad M.A.Shah I.Crotty | 2021 | Radiation Detection Technology and Methods2021，5，2： | 0 |
| 15 | R&D of back-end electronics for improved resistive plate chambers for the phase 2 upgrade of the CMS end-capmuon system显示文摘Purpose The Large Hadron Collider(LHC)at European Organization for Nuclear Research is planned to be upgraded to the high luminosity LHC.Increasing the luminosity makes muon triggering reliable and offline reconstruction very challenging.To enhance the redundancy of the Compact Muon Solenoid(CMS)Muon system and resolve the ambiguity of track reconstruction in the forward region,an improved Resistive Plate Chamber(iRPC)with excellent time resolution will be installed in the Phase-2 CMS upgrade.The iRPC will be equipped with Front-End Electronics(FEE),which can perform high-precision time measurements of signals from both ends of the strip.New Back-End Electronics(BEE)need to be researched and developed to provide sophisticated functionalities such as interacting with FEE with shared links for fast,slow control(SC)and data,in addition to trigger primitives(TPs)generation and data acquisition(DAQ).Method The BEE prototype uses a homemade hardware board compatible with the MTCA standard,the back-end board(BEB).BEE interacts with FEE via a bidirectional 4.8 Gbps optical paired-link that integrates clock,data,and control information.The clock and fast/slow control commands are distributed from BEB to the FEE via the downlink.The uplink is used for BEB to receive the time information of the iRPC’sfired strips and the responses to the fast/slow control commands.To have a pipelined detector data for clusterfinding operation,recover(DeMux)the time relationship of which is changed due to the transmission protocol for the continuous incoming MUXed data from FEE.Then at each bunch crossing(BX),clusteringfired strips that satisfy time and spatial constraints to generate TPs.Both incoming raw MUXed detector data and TPs in a time window and latency based on the trigger signal are read out to the DAQ system.Gigabit Ethernet(GbE)of SiTCP and commercial 10-GbE are used as link standards for SC and DAQ,respectively,for the BEB to interact with the server.Results The joint test results of the BEB with iRPC and Front-End Board(FEB)show a Bit Error Rate of the transmission links less than 1×10-16,a time resolution of the FEB Time-to-Digital Converter of 16 ps,and the resolution of the time difference between both ends of 160 ps which corresponding a spatial resolution of the iRPC of approximately 1.5 cm.Conclusion Test results showed the correctness and stable running of the BEB prototype,of which the functionalities fulfill the iRPC requirements. | H.Kou Z.-A.Liu J.Zhao J.Song Q.Hou W.Diao P.Cao W.Gong N.Wang A.Samalan M.Tytgat M.El Sawy G.A.Alves F.Marujo E.A.Coelho F.Torres Da Silva De Araujo E.M.Da Costa H.Nogima A.Santoro S.Fonseca De Souza D.De Jesus Damiao M.Thiel M.Barroso Ferreira Filho K.Mota Amarilo A.Aleksandrov R.Hadjiiska P.Iaydjiev M.Rodozov M.Shopova G.Sultanov A.Dimitrov L.Litov B.Pavlov P.Petkov A.Petrov E.Shumka S.J.Qian C.Avila D.Barbosa A.Cabrera A.Florez J.Fraga J.Reyes Y.Assran M.A.Mahmoud Y.Mohammed I.Laktineh G.Grenier M.Gouzevitch L.Mirabito K.Shchablo C.Combaret W.Tromeur G.Galbit A.Luciol X.Chen I.Bagaturia I.Lomidze Z.Tsamalaidze V.Amoozegar B.Boghrati M.Ebraimi E.Zareian M.Mohammadi Najafabadi M.Abbrescia G.Iaselli G.Pugliese F.Loddo N.De Filippis R.Aly D.Ramos W.Elmetenawee S.Leszki I.Margjeka D.Paesani L.Benussi S.Bianco D.Piccolo S.Meola S.Buontempo F.Carnevali L.Lista P.Paolucci F.Fienga A.Braghieri P.Salvini P.Montagna C.Riccardi P.Vitulo E.Asilar J.Choi T.J.Kim S.Y.Choi B.Hong K.S.Lee H.Y.Oh J.Goh I.Yu C.Uribe Estrada I.Pedraza H.Castilla-Valdez R.L.Fernandez A.Sanchez-Hernandez E.Vazquez M.Ramirez-Garcia N.Zaganidis A.Radi H.Hoorani S.Muhammad A.Ahmad I.Asghar M.A.Shah W.A.Khan J.Eysermans I.Crotty on behalf of the CMS Muon Group | 2022 | Radiation Detection Technology and Methods2022，6，3： | 0 |
| 16 | Introduction to the special topic on nanomanufacturing显示文摘The semiconductor industry introduced sub-100-nanometer technology to consumers more than a decade ago,in the early 2000s.The field of‘nanotechnology’has since expanded rapidly,drawing on methods and materials from integrated electronics while adding many others,such as quantum dots,nanowires and self-assembly,and targeting applications in optoelectronics,biomedical devices,sensors,fluidics and many other areas.The isolation of monolayer graphene in 2004,in particular,initiated a massive worldwide research effort in 2D materials.While the volume of papers published in the realm of nanotechnology continues to balloon year-on-year,surprisingly few of the technologies—which are frequently deemed to hold particular promise—have found their way to commercialization. | Eric M.Yeatman Hannah M.Gramling Evelyn N.Wang | 2017 | Microsystems & Nanoengineering2017，3，1： | 0 |
| 17 | The Analytical Parametrization of Fusion Barrier by Using the Skyrme Energy-Density Function Model显示文摘Using the skyrme energy density formalism, a pocket formula is introduced for barrier heights and positions of 95 fusion reactions(48≤ZPZT≤1520) with respect to the charge and mass numbers of the interacting nuclei. It is shown that the parameterized values of RBand VBare able to reproduce the corresponding experimental data with good accuracy. Moreover, the absolute errors of our formulas are less than those obtained using the analytical parametrization forms of the fusion barrier based on the proximity versions. The ability of the parameterized forms of the barrier heights and its positions to reproduce the experimental data of the fusion cross section have been analyzed using the Wong model. | V.Zanganeh M.Mirzaei N.Wang | 2015 | Communications in Theoretical Physics2015，，8： | 0 |
| 18 | Characterization of the first prototype CMOS pixel sensor developed for the CEPC vertex detector显示文摘Purpose CMOS pixel sensor has become extremely attractive for future high-performance tracking devices.It has been proposed for the vertex detector at the Circular Electron Positron Collider,which will allow precision measurements of the properties of the Higgs boson.To meet the stringent requirements for low power consumption,it is necessary to optimize the pixel sensor diode geometry to reach a high charge-over-capacitance ratio that allows reduction in analog power consumption.Methods Collection electrode size and footprint are two critical elements in sensor diode geometry and have deciding impacts on the charge collection performance.A prototype CMOS pixel sensor,named JadePix-1,has been developed with pixel sectors implemented with different electrode sizes and footprints,and its charge collection performance has been characterized with radioactive sources.Results Charge-to-voltage conversion gains for pixel sectors under test have been calibrated with low-energy X-rays.Characterization results have been obtained for equivalent noise charge(below 10e−),charge collection efficiency(around 40%),charge-over-capacitance ratio(above 0.015 V)and signal-to-noise ratio(higher than 55).Conclusion Small collection electrode size and large footprint are preferred to achieve high charge-over-capacitance ratio that promises low analog power consumption.Ongoing studies on sensor performance before and after irradiation,combined with this work,will conclude the diode geometry optimization. | L.J.Chen H.B.Zhu X.C.Ai M.Fu R.Kiuchi Y.Liu Z.A.Liu X.C.Lou Y.P.Lu Q.Ouyang X.Shi J.Tao K.Wang N.Wang C.F.Yang Y.Zhang Y.Zhou | 2019 | Radiation Detection Technology and Methods2019，3，3： | 0 |
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