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| 1 | Bone Morphogenetic Protein (BMP) signaling in development and human diseases显示文摘Bone Morphogenetic Proteins(BMPs)are a group of signaling molecules that belongs to the Transforming Growth Factor-b(TGF-b)superfamily of proteins.Initially discovered for their ability to induce bone formation,BMPs are now known to play crucial roles in all organ systems.BMPs are important in embryogenesis and development,and also in maintenance of adult tissue homeostasis.Mouse knockout models of various components of the BMP signaling pathway result in embryonic lethality or marked defects,highlighting the essential functions of BMPs.In this review,we first outline the basic aspects of BMP signaling and then focus on genetically manipulated mouse knockout models that have helped elucidate the role of BMPs in development.A significant portion of this review is devoted to the prominent human pathologies associated with dysregulated BMP signaling. | Richard N.Wang Jordan Green Zhongliang Wang Youlin Deng Min Qiao Michael Peabody Qian Zhang Jixing Ye Zhengjian Yan Sahitya Denduluri Olumuyiwa Idowu Melissa Li Christine Shen Alan Hu Rex C.Haydon Richard Kang James Mok Michael J.Lee Hue L.Luu Lewis L.Shi | 2014 | Genes & Diseases2014，1，1： | 47 |
| 2 | Multicenter analysis of soluble A xl reveals diagnostic value for very early stage hepatocellular carcinoma显示文摘 | Patrick Reichl Meng Fang Patrick Starlinger Katharina Staufer Rudolf Nenutil Petr Muller Kristina Greplova Dalibor Valik Steven Dooley Christine Brostjan Thomas Gruenberger Jiayun Shen Kwan Man Michael Trauner Jun Yu Chun Fang Gao Wolfgang Mikulits | 2015 | Int. J. Cancer2015，，2： | 2 |
| 3 | Novel genetic va- riants in microRNA genes and familial breast cancer 显示文摘 | Jie Shen Christine B Rodriguez A | 2009 | Int J Cancer2009，124，2： | 1 |
| 4 | The chimpanzee and cynomolgus monkey erythrocyte immune adherence receptors are encoded by CR1-like genes显示文摘 | Wei Chen Christine M. Logar Xiao-Ping Shen Daniel J. Birmingham | 2000 | Immunogenetics (-)2000，，1： | 1 |
| 5 | Spectrum of heart disease associated with murine and human GATA4 mutation显示文摘 | Satish K. Rajagopal Qing Ma Dita Obler Jie Shen Ani Manichaikul Aoy Tomita-Mitchell Kari Boardman Christine Briggs Vidu Garg Deepak Srivastava Elizabeth Goldmuntz Karl W. Broman D. Woodrow Benson Leslie B. Smoot William T. Pu | 2007 | Journal of Molecular and Cellular Cardiology2007，，： | 1 |
| 6 | Establishment and characterization of Fabry disease endothelial cells with an extended lifespan显示文摘 | Jin-Song Shen Xing-Li Meng Raphael Schiffmann Roscoe O. Brady Christine R. Kaneski | 2007 | Molecular Genetics and Metabolism2007，，1： | 1 |
| 7 | Systems biology of human benzene exposure显示文摘 | Luoping Zhang Cliona M. McHale Nathaniel Rothman Guilan Li Zhiying Ji Roel Vermeulen Alan E. Hubbard Xuefeng Ren Min Shen Stephen M. Rappaport Matthew North Christine F. Skibola Songnian Yin Christopher Vulpe Stephen J. Chanock Martyn T. Smith Qing Lan | 2009 | Chemico-Biological Interactions2009，，1： | 1 |
| 8 | Damage control:Harnessing prostaglandin E2 as a potential healing factor of tissue injuries显示文摘Increasing prostaglandin E2 by knocking out its inhibitor 15-hydroxyprostaglandin dehydrogenase(15-PDGH)or administering a compound that inhibits 15-PDGH was recently found to improve healing in hematopoietic stem cell transplants,colitis recovery,and hepatogenesis after transection in mice.These results are suggestive of pharmacologic therapies or even genetic therapy that could improve patient outcomes,especially since the excess PGE2 and the 15-PDGH inhibitor have proven to be non-toxic.However,elevated levels of PGE2 are associated with increased risk of cancer and blood clotting problems.It would be unacceptable to treat a cancer patient with chemotherapy and replenish the hematopoietic stem cells with the help of PGE2,only to have increased expression of PGE2 and induce another cancer.Therefore,to assess the most therapeutic aspects of PGE2,it is important to consider effects that could induce disease. | Connie Shao Christine Shen Emily Lu Rex C.Haydon Hue H.Luu Aravind Athiviraham Tong-Chuan He Michael J.Lee | 2015 | Genes & Diseases2015，2，4： | 0 |
| 9 | 临床研究的系统回顾:关于干细胞治疗椎间盘源性疼痛的安全性和有效性的研究进展显示文摘本研究是一个关于干细胞治疗椎间盘源性疼痛的临床研究的系统性回顾,目的是概述目前临床试验和间充质干细胞治疗椎间盘源性疼痛的可行性。从研究早期至2016年7月,对Ovid数据库和Clinicaltrials.gov进行了搜索。纳入了干细胞治疗椎间盘源性腰背痛疗效评估的临床试验及案例报告。在已发表的研究中,感兴趣的结果包括疼痛评分、腰背痛ODI评分、显示髓核的水含量的MRI T2像强度。在Ovid databases使用特定的搜索词进行初步搜索获得了408条结果,其中有11条搜索结果符合此次研究的纳入标准,其中包含6个已完成的研究和5个在进行的临床试验,这5个临床试验中有4个在检索时处于研究进行状态。在6个已完成的研究中,椎间盘内注射干细胞后其疼痛评分、ODI、T2像髓核信号强度均有改善。目前进行中的临床试验主要在于建立干细胞治疗腰痛的安全性、耐受性以及有效性。虽然已有干细胞治疗改善疼痛和功能的报道,但需要更长期的安全性研究及更多的随机对照试验去验证干细胞治疗椎间盘源性疼痛的安全性和有效性。 | christine l.hunt stephanie shen ahmad nassr 金雨颖(译) 靳天(译) 马柯(校) | 2018 | 中国疼痛医学杂志2018，24，12： | 0 |
| 10 | Visual function restoration with a highly sensitive and fast Channelrhodopsin in blind mice显示文摘Inherited and age-related retinal degenerative diseases cause progressive loss of photoreceptors,ultimately leading to blindness.Optogenetics is a promising strategy for restoring visual function through photosensitive proteins’ectopic expression in surviving retinal neurons.1 Very recently,the optogenetic method with a red-shifted Channelrhodopsin was clinically applied for partial recovery of visual function in a blind patient.2 However,major obstacles to achieving optimal optogenetic vision restoration are either the low light sensitivity or the slow kinetics of existing rhodopsin-based optogenetic tools,which can be improved by molecular engineering to enhance the efficacy of fast Channelrhodopsins(ChRs). | Fei Chen Xiaodong Duan Yao Yu Shang Yang Yuanyuan Chen Christine EGee Georg Nagel Kang Zhang Shiqiang Gao Yin Shen | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 0 |
| 11 | Diversity,community structure,and quantity of eukaryotic phytoplankton revealed using 18S rRNA and plastid 16S rRNA genes and pigment markers:a case study of the Pearl River Estuary显示文摘Understanding consistencies and discrepancies in characterizing diversity and quantity of phytoplankton is essential for better modeling ecosystem change.In this study,eukaryotic phytoplankton in the Pearl River Estuary,South China Sea were investigated using nuclear 18S rRNA and plastid 16S or 23S rRNA genes and pigment analysis.It was found that 18S abundance poorly explained the variations in total chlorophyll a(Chl-a).However,the ratios of log-transformed 18S abundance to Chl-a in the major phytoplankton groups were generally environment dependent,suggesting that the ratio has potential as an indicator of the physiological state of phytoplankton.The richness of 18S-based operational taxonomic units was positively correlated with the richness of 16S-based amplicon sequence variants of the whole phytoplankton community,but insignifcant or weak for individual phytoplankton groups.Overall,the 18S based,rather than the 16S based,community structure had a greater similarity to pigment-based estimations.Relative to the pigment data,the proportion of haptophytes in the 18S dataset,and diatoms and cryptophytes in the 16S dataset,were underestimated.This study highlights that 18S metabarcoding tends to refect biomass-based community organization of eukaryotic phytoplankton.Because there were lower copy numbers of plastid 16S than 18S per genome,metabarcoding of 16S probably approximates cell abundance-based community organization.Changes in biomass organization of the pigment-based community were sensitive to environmental changes.Taken together,multiple methodologies are recommended to be applied to more accurately profle the diversity and community composition of phytoplankton in natural ecosystems. | Shumin Xu Guihao Li Cui He Yi Huang Dan Yu Huiwen Deng Zhuyin Tong Yichong Wang Christine Dupuy Bangqin Huang Zhuo Shen Jie Xu Jun Gong | 2023 | Marine Life Science & Technology2023，5，3： | 0 |
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