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| 1 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 2 | Antigen-presenting effects of effector memory Vγ9Vδ2 T cells in rheumatoid arthritis显示文摘 | Chaoying Hu Liu Qian Yi Miao Qiuyu Huang Ping Miao Ping Wang Qiwen Yu Hong Nie Jiying Zhang Dongyi He Rong Xu Xuehua Chen Bingya Liu Dongqing Zhang | 2012 | Cellular & Molecular Immunology2012，9，3： | 18 |
| 3 | Clinical characteristics of human infection with a novel avian-origin influenza A(H10N8) virus显示文摘 | Zhang Wei Wan Jianguo Qian Kejian Liu Xiaoqing Xiao Zuke Sun Jian Zeng Zhenguo Wang Qi Zhang Jinxiang Jiang Guanghui Nie Cheng Jiang Rong Ding Chengzhi Li Ran Horby Peter Gao Zhancheng | 2014 | Chinese Medical Journal2014，，18： | 12 |
| 4 | Effect of metabolic syndrome on prognosis and clinical characteristics of revascularization in patients with coronary artery disease显示文摘Background People with metabolic syndrome are at higher risk for developing coronary artery disease (CAD). The effect of the metabolic syndrome on outcomes in patients with preexisting CAD has not been well studied. This study was conducted to assess the prevalence, characteristics, in hospital and long term prognosis of CAD with metabolic syndrome and to determine the factors influencing the prognosis of the disease. Methods The DESIRE registry contains data of 3696 patients with CAD between 2001 and 2004. Mean long term followup was (829±373) days. Diagnosis of metabolic syndrome was based on modified International Diabetes Federation (IDF) Worldwide Definition of the Metabolic Syndrome,using body mass index (BMI) instead of waist circumference. Results Of 2596 patients with complete records of height, weight, and so on, 1280 (49.3%) were identified with metabolic syndrome. The patients with metabolic syndrome had higher level of body mass index, systolic blood pressure, diastolic blood pressure, fasting glucose and disordered blood lipid (all P<0.0001), with higher creatinine [(10.5±4.3) mg/L vs (9.9±2.9) mg/L, P<0.0001] and the number of white blood cells [(7.49±2.86) ×109/L vs (7.19±2.62) ×109/L, P=0.008) compared with those without metabolic syndrome. The patients with metabolic syndrome showed severer coronary angiographic alterations (left main artery and/or ≥2-vessel) (73.6% vs 69.6%, P=0.031). There were no significant differences of major adverse cardiac and cerebral events (MACCE) or mortality in hospital between the two groups. During followup, the ratio of MACCE in CAD with metabolic syndrome patients increased significantly (11.8% vs 10.0%, P=0.044). Fasting blood glucose (≥1000 mg/L) and triglyceride (TG, ≥1500 mg/L) were responsible for most of the increased risk associated with the metabolic syndrome (adjusted OR 1.465, 95% CI 1.037-1.874, P=0.032; OR 1.378, 95% CI 1.014-1.768, P=0.044). Conclusions The prevalence of metabolic syndrome was very high in CAD patients. The metabolic syndrome confers a higher risk of long term MACCE in patients with CAD, and dysglycaemia and hypertriglycaemia appear to be responsible for most of the associated risk. | HU Rong MA Chang-sheng NIE Shao-ping LU Qiang KANG Jun-ping DU Xin ZHANG Yin GAO Ying-chun HE Li-qun JIA Chang-qi LIU Xin-min DONG Jian-zeng LIU Xiao-hui CHEN Fang ZHOU Yu-jie LU Shu-zheng WU Xue-si | 2006 | Chinese Medical Journal2006，，22： | 9 |
| 5 | Effect of Ticagrelor on Coronary Blood Flow and Prognosis in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention in Real World显示文摘 | Yan-Yan Jin Rong Bai Hui Ai Shao-Pin Nie | 2018 | Chinese Medical Journal2018，，21： | 9 |
| 6 | Clinical applications of MARSALA for preimplantation genetic diagnosis of spinal muscular atrophy显示文摘Conventional PCR methods combined with linkage analysis based on short tandem repeats(STRs) or Karyomapping with single nucleotide polymorphism(SNP) arrays, have been applied to preimplantation genetic diagnosis(PGD) for spinal muscular atrophy(SMA), an autosome recessive disorder. However, it has limitations in SMA diagnosis by Karyomapping, and these methods are unable to distinguish wildtype embryos with carriers effectively. Mutated allele revealed by sequencing with aneuploidy and linkage analyses(MARSALA) is a new method allowing embryo selection by a one-step next-generation sequencing(NGS) procedure, which has been applied in PGD for both autosome dominant and X-linked diseases in our group previously. In this study, we carried out PGD based on MARSALA for two carrier families with SMA affected children. As a result, one of the couples has given birth to a healthy baby free of mutations in SMA-causing gene. It is the first time that MARSALA was applied to PGD for SMA, and we can distinguish the embryos with heterozygous deletion(carriers) from the wild-type(normal) ones accurately through this NGS-based method. In addition, direct mutation detection allows us to identify the affected embryos(homozygous deletion), which can be regarded as probands for linkage analysis, in case that the affected family member is absent. In the future, the NGS-based MARSALA method is expected to be used in PGD for all monogenetic disorders with known pathogenic gene mutation. | Yixin Ren Xu Zhi Xiaohui Zhu Jin Huang Ying Lian Rong Li Hongyan Jin Yan Zhang Wenxin Zhang Yanli Nie Yuan Wei Zhaohui Liu Donghong Song Ping Liu Jie Qiao Liying Yan | 2016 | Journal of Genetics and Genomics2016，43，9： | 9 |
| 7 | High-coverage proteome analysis reveals the first insight of protein modification systems in the pathogenic spirochete Leptospira interrogans显示文摘细螺旋体病是感染人和大量动物的类螺旋体的病原的螺旋菌引起的普遍 zoonotic 疾病。由联合计算预言和高精确性的双人脚踏车团系列,我们修订了螺旋体 interrogans serovar Lai,为细螺旋体病负责的免费生活的病原的螺旋菌,为新奇基因的提供的实质的肽证据和新基因边界的染色体注解。随后,我们介绍了蛋白质表示和多重 posttranslational 修正(PTM ) 的高范围的 proteome 分析。约 64.3% 预言的 L。interrogans 蛋白质被检测 2 编目 540 蛋白质。同时,多重 PTM 的侧面并发地被建立,在总数 32 phosphorylated, 46 acetylated 和 155 methylated 蛋白质包含。在 serovar Lai 的 PTM 系统显示出唯一的特征。L 的唯一的象真核细胞一样特征。interrogans 蛋白质修正在 phosphorylation 和精氨酸 methylation 被表明。这系统的分析在建议的初核质而且一个看法提供高范围的蛋白质表示和多重修正的全面信息不仅 evolutionarily 原始的 L。interrogans 与优核质在蛋白质修正系统分享重要类似。 | Xing-Jun Cao Jie Dai Hao Xu Song Nie Xiao Chang Bao-Yu Hu Quan-Hu Sheng Lian-Shui Wang Zhi-Bin Ning Yi-Xue Li Xiao-Kui Guo Guo-Ping Zhao Rong Zeng | 2010 | Cell Research2010，20，2： | 8 |
| 8 | Clinical Observation of Bevacizumab Combined with S-1 in the Treatment of Pretreated Advanced Esophageal Carcinoma显示文摘Objective To investigate the clinical effects and safety of bevacizumab combined with S-1 as the second-line treatment of recurrent and/or metastatic esophageal cancer after chemoradiation. Methods Patients with recurrent or metastatic esophageal cancer after chemoradiation were treated with bevacizumab and S-1. Bevacizumab was used by intravenous infusion, 7.5mg/kg body weight on day 1; S-1 was used by oral at 80mg/m^2·d on day 1-14, 21 days as a cycle of treatment and repeated until either progressive disease or intolerable toxicity occurred. Chest CT were performed and RECIST 1.1 was used for response evaluation. Kaplan-Meier method was used for survival analysis. Side effects were recorded and analyzed. Results Totally 78 patients were enrolled in the study, including 67 squamous cell carcinoma and 11 adenocarcinoma histologically. The overall response(CR+PR) rate was 22.4%(17/76) and disease control(CR+PR+SD) rate was 61.8%(47/76) respectively. The median follow-up time was 20 months(range from 9 to 44 months). The median progression-free survival(PFS) was 4.9 months(95% CI 4.4-5.5) and the median overall survival(OS) was 8.1 months(95% CI 7.6-9.2). The median PFS and OS of patients with metastasis diseases were 6.2 months(95% CI 3.3 to 6.3) and 8.5 months(95% CI 5.8 to 11.2), where PFS was longer than that of patients with local regional recurrence(median 5.0 months, 95% CI 3.0 to 5.5, P=0.017) and OS was longer than that of patients with regional disease and metastasis(median 8.0 months, 95% CI 4.6 to 9.5, P=0.010). The common adverse effects were mild to moderate neutropenia(84.2%), grade Ⅰ -Ⅱ hand and foot syndrome(51.3%), grade Ⅰ -Ⅱ nausea(48.7%), mild epistaxis(30.1%) and mild vomiting(14.5%). Esophageal bleeding occurred in 7.9% of patients. One patient(1.3%) died from massive bleeding which was caused by esophageal perforation. Conclusion Bevacizumab combined with S-1 was effective and safe for esophageal cancer patients who had recurrent or metastatic diseases after chemoradiation. | Ke-ke Nie Chuan-xin Geng Ling Zhang Shi-chao Liu Zhong-fa Zhang Rong Wang Xiao Zou You-xin Ji | 2016 | Chinese Medical Sciences Journal2016，31，4： | 4 |
| 9 | Attenuation ofβ-Amyloid Toxicity In Vitro and In Vivo by Accelerated Aggregation显示文摘Accumulation and aggregation of β-amyloid(Aβ) peptides result in neuronal death, leading to cognitive dysfunction in Alzheimer's disease. The self-assembled Aβ molecules form various intermediate aggregates including oligomers that are more toxic to neurons than the mature aggregates, including fibrils. Thus, one strategy to alleviate Aβ toxicity is to facilitate the conversion of Aβ intermediates to larger aggregates such as fibrils. In this study, we designed a peptide named A3 that significantly enhanced the formation of amorphous aggregates of Aβ by accelerating the aggregation kinetics. Thioflavin T fluorescence experiments revealed an accelerated aggregation of Aβ monomers, accompanying reduced Aβ cytotoxicity. Transgenic Caenorhabditis elegans over-expressing amyloid precursor protein exhibited paralysis due to the accumulation of Aβ oligomers, and this phenotype was attenuated by feeding the animals with A3 peptide. These findings suggest that the Aβ aggregation-promotion effect can potentially be useful for developing strategies to reduce Aβ toxicity. | Aihua Yang Chenxuan Wang Baomin Song Wendi Zhang Yuanyuan Guo Rong Yang Guangjun Nie Yanlian Yang Chen Wang | 2017 | Neuroscience Bulletin2017，33，4： | 3 |
| 10 | Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expression显示文摘前列腺 transmembrane 蛋白质,导致雄激素(PMEPA1 ) 1 以前被显示了在许多癌症,而是角色支持稳固的恶意,在乳癌的 PMEPA1 的机制充分没被探讨。这里,我们发现 PMEPA1 是在乳癌房间线以及在一套临床的侵略的胸 ductal 癌的 upregulated。有趣地, PMEPA1 的弄空减少了乳癌干细胞(CSC ) 充实人口,当 PMEPA1 的宫外的 overexpression 增加了胸时充实 CSC 的人口。而且,转变生长因素 --(TGF-) 治疗也在三元组否定的乳癌细胞线被发现到 upregulate PMEPA1 表示和充实 CSC 的人口。TGF -- 导致的 PMEPA1 表示部分贡献了 TGF -- 导致的胸 CSC 维护。这些调查结果建议那 TGF -- PMEPA1 轴可能为乳癌治疗提供新诊断和治疗学的目标。 | Zhi Nie Chunyan Wang Zhongmei Zhou Ceshi Chen Rong Liu Dianhua Wang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 3 |
| 11 | Pterygial body epithelium domination of pterygial proliferation with TCF4 as a potential key factor显示文摘AIM: To characterize the proliferative capacity of pterygial epithelium in different regions(head, neck and body) of pterygium and explore the function of transcription factor 4(TCF4) in pterygium proliferation.METHODS: Thirty pterygium tissues and 10 normal conjunctival tissues were obtained from Zhongshan Ophthalmic Center(ZOC) and Guangdong Eye Bank, respectively. Proliferative capacity of head, neck and body in pterygial epithelium was measured using clonal analysis, fold growth analysis and expression profile of proliferative markers revealed by immunofluorescent staining and real-time PCR. The expression of TCF4 was highlighted by double immunofluorescent staining with other proliferation related markers such as proliferating cell nuclear antigen(PCNA) and ATP-binding cassette subfamily G member 2(ABCG2).RESULTS: The proliferative potential of pterygial epithelium was higher than that of normal conjunctival epithelium. High expression levels of proliferative markers(P63α, PCNA and ABCG2) in pterygial body epithelium were observed in immunofluorescent staining and real-time PCR(P<0.05). Also, epithelial cells isolated from pterygial body demonstrated higher proliferative capacity in clonal analysis and fold growth analysis, than those isolated from the head and neck regions. The TCF4 expression in pterygial epithelium was similar to other proliferative markers(P63α, PCNA and ABCG2), as higher in pterygial body than head and neck. Moreover, TCF4 showed coexpression with other proliferation-related markers(PCNA and ABCG2) in the double immunofluorescent staining experiment.CONCLUSION: The proliferative capacity in pterygial body epithelium is prominent than the head and neck regions, and upregulated TCF4 may be associated with enhanced proliferation in the pterygium. | Cong Nie Xin-Chun Zhang Si-Ying Xu Ya-Dan Quan Zhi-Xin Tang Rong Lu | 2018 | International Journal of Ophthalmology(English edition)2018，11，9： | 2 |
| 12 | Influence of CYP3A5 polymorphism on tacrolimus blood concentrations in renal transplant patients显示文摘Objective Tacrolimus is an immunosuppressive drug with narrow therapeutic range and wide interindividual variation in its pharmacokinetics. Tacrolimus is a substrate of cytochrome P450(CYP)3A5. The aim of this study was to evaluate whether the A6986G polymorphism is associated with tacrolimus concentration/dose ratio.Methods Fifty-two Chinese renal transplant patients were enrolled in this study. Their body weight, dosage and concentration of tacrolimus were observed. CYP3A5 genotype was determined by polymerase chain reaction followed by restriction fragment length polymorphism analysis. Results A significant association was found between tacrolimus levels per dose/kg/d and CYP3A5 gene A6986G polymorphism(P<0.001). The CYP3A5 * 3 * 3 patients have a significantly higher tacrolimus level/dose than CYP3A5 * 1 * 1 and CYP3A5 * 1 * 3. Conclusions CYP3A5 gene A6986G polymorphism is associated with tacrolimus pharmacokinetics and dose requirements. Pharmacogenetic methods could be employed prospectively to help the dose selection and to individualize immunosuppressive therapy according to the result. | NIE Xin-min GUI Rong ZHAO Hong-shan MA Da-long LI Deng-qing YUAN Hong HUANG Zu-fa | 2005 | Journal of Central South University of Technology2005，12，z1： | 2 |
| 13 | A novel pathogenic mutation in FBN2 associated with congenital contractural arachnodactyly for preimplantation genetic diagnosis显示文摘Congenital contractural arachnodactyly(CCA,OMIM:121050),also known as Beals syndrome,belongs to a group of rare autosomal dominant(AD)diseases of connective tissue(Maslen et al.,1997).People with CCA share many distinguishing features,such as arachnodactyly,camp tod actyly,multiple joint contractures(especially finger,elbow,and knee joints),crumpled ears,scoliosis,pectus deformities,and muscular hypoplasia(Jurko et al.,2013).It exhibits no specific geographic or ethnic predilection(Frederic et al.,2009). | Jiaxin Li Yuqian Wang Xiaohui Zhu Yanli Nie Ying Kuo Shuo Guan Jin Huang Ying Lian Yangyu Zhao Rong Li Yuan Wei Jie Qiao Liying Yan | 2020 | Journal of Genetics and Genomics2020，47，5： | 2 |
| 14 | Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells显示文摘 | Wei Li Hongxiu Zhang Mingxiu Nie Yanlei Tian Xu Chen Ceshi Chen Haijun Chen Rong Liu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，4： | 2 |
| 15 | Chemically - modified activated carbon with ethylenediamine for selective solid -phase extraction and preconcentration of metal ions显示文摘 | LI Zhenhua CHANG Xijun ZOU Xiaojun ZHU Xiangbing NIE Rong HU Zheng LIRuijun | 2009 | Anal Chim Acta2009，632，2： | 1 |
| 16 | 3D finite element modeling of cogging-down rotary swaging of pure magnesium square billet: Revealing the effect of high-frequency pulse stroking 显示文摘 | RONG Li NIE Zuo-ren ZUO Tie-yong | 2007 | Materials Science & Engineering A2007，464，12： | 1 |
| 17 | An alternative approach for the classification of orange varieties based on near infrared spectroscopy显示文摘 | Warawut Suphamitmongkol Guangli Nie Rong Liu Sumaporn Kasemsumran Yong Shi | 2012 | Computers and Electronics in Agriculture2012，，： | 1 |
| 18 | Geological and geochemical characteristics of the Baogudi Carlintype gold district(Southwest Guizhou, China) and their geological implications显示文摘The newly discovered Baogudi gold district is located in the southwestern Guizhou Province,China,where there are numerous Carlin-type gold deposits.To better understand the geological and geochemical characteristics of the Baogudi gold district,we carried out petrographic observations,elemental analyses,and fluid inclusion and isotopic composition studies.We also compared the results with those of typical Carlin-type gold deposits in southwestern Guizhou.Three mineralization stages,namely,the sedimentation diagenesis,hydrothermal(main-ore and late-ore substages),and supergene stages,were identified based on field and petrographic observations.The main-ore and late-ore stages correspond to Au and Sb mineralization,respectively,which are similar to typical Carlin-type mineralization.The mass transfer associated with alteration and mineralization shows that a significant amount of Au,As,Sb,Hg,Tl,Mo,and S were added to mineralized rocks during the main-ore stage.Remarkably,arsenic,Sb,and S were added to the mineralized rocks during the late-ore stage.Element migration indicates that the sulfidation process was responsible for ore formation.Four types of fluid inclusions were identified in ore-related quartz and fluorite.The main-ore stage fluids are characterized by an H2O–NaCl–CO2–CH4±N2system,with medium to low temperatures(180–260℃)and low salinity(0–9.08%NaCl equivalent).The late-ore stage fluids featured H2O–NaCl±CO2±CH4,with low temperature(120–200℃)and low salinity(0–7.48%Na Cl equivalent).The temperature,salinity,and CO2and CH4concentrations of ore-forming fluids decreased from the main-ore stage to the late-ore stage.The calculated δ^13C,d D,and δ^18O values of the ore-forming fluids range from-14.3 to-7.0%,-76 to-55.7%,and 4.5–15.0%,respectively.Late-ore-stage stibnite had δ^34S values ranging from-0.6 to 1.9%.These stable isotopic compositions indicate that the ore-forming fluids originated mainly from deep magmatic hydrothermal fluids,with minor contributions from strata.Collectively,the Baogudi metallogenic district has geological and geochemical characteristics that are typical of Carlin-type gold deposits in southwest Guizhou.It is likely that the Baogudi gold district,together with other Carlin-type gold deposits in southwestern Guizhou,was formed in response to a single widespread metallogenic event. | Songtao Li Yong Xia Jianzhong Liu Zhuojun Xie Qinping Tan Yimeng Zhao Minghua Meng Lijin Tan Rong Nie Zepeng Wang Guanghong Zhou Haiyan Guo | 2019 | Acta Geochimica2019，38，4： | 1 |
| 19 | Study of buffer and epitaxy technology in two-step growth of aluminium nitride显示文摘AlN (aluminium nitride) films were prepared by metalorganic chemical vapor depo- sition (MOCVD) on c-plane sapphire (α-Al2O3) substrates. By means of studying the traces of in-situ optical reflectivity, it was found that the AlN nucleation layer showed a specific (0001) lattice orientation, which differed from the GaN nucleation layer on (0001) sapphire substrates. The AlN buffer suffered the compressive stress at the initial stage of nucleation. And the compressive strain was relaxed gradually along with the thickness of buffer increasing and consequently annealing. Optical transmission spectra revealed that in the process of growing AlN epilayers, higher V/III ratio could improve the crystal quality but reduce the growth rates. In addition, proper doping of silane (SiH4) could improve the surface morphology of AlN film. | LIU QiJia ZHANG Rong XIE ZiLi LIU Bin XU Feng YAO Jing NIE Chao XIU XiangQian HAN Ping ZHENG YouDou GONG HaiMei | 2008 | Science China(Technological Sciences)2008，51，11： | 1 |
| 20 | Genome-Wide Expression Profile of Maize Root Response to Phosphorus Deficiency Revealed by Deep Sequencing显示文摘Phosphorus(P) is one of the three primary macronutrients that are required in large amounts for plant growth and development. To better understand molecular mechanism of maize and identify relevant genes in response to phosphorus deficiency, we used Solexa/Illumina's digital gene expression(DGE) technology to investigate six genome-wide expression profiles of seedling roots of the low-P tolerant maize inbred line 178. DGE studies were conducted at 6, 24 and 72 h under both phosphorus deficient and sufficient conditions. Approximately 3.93 million raw reads for each sample were sequenced and 6 816 genes exhibited significant levels of differential expressions in at least one of three time points in response to P starvation. The number of genes with increased expression increased over time from 6 to 24 h, whereas genes with decreased expression were more abundant at 72 h, suggesting a gradual response process for P deficiency at different stages. Gene annotations illustrated that most of differentially expressed genes(DEGs) are involved in different cellular and molecular processes such as environmental adaptation and carbohydrate metabolism. The expression of some known genes identified in other plants, such as those involved in root architecture, P metabolism and transport were found to be altered at least two folds, indicating that the mechanisms of molecular and morphological adaptation to P starvation are conserved in plants. This study provides insight into the general molecular mechanisms underlying plant adaptation to low-P stress and thus may facilitate molecular breeding for improving P utilization in maize. | SU Shun-zhong WU Ling LIU Dan LU Yan-li LIN Hai-jian ZHANG Shu-zhi SHEN Ya-ou LIU Hai-lan ZHANG Zhi-ming RONG Ting-zhao ZHANG Xiao TIAN Yue-hui NIE Zhi GAO Shi-bin | 2014 | Journal of Integrative Agriculture2014，13，6： | 1 |
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