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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis显示文摘指导暗示的裂缝家庭绑在环岛(Robo ) 受体并且调制房间移植。我们这里报导 Slit2 的那宫外的表情和上皮的癌房间招募了的表示 Robo1 colorectal 的 Robo1 或 recombinant Slit2 处理为 E-cadherin (电子恶棍) ubiquitination 和 lysosomal 降级,上皮间充质的转变(EMT ) ,和肿瘤生长和肝转移的 ubiquitin ligase Hakai,它被救由 Hakai 击倒。相反,内长的 Robo1 或对 Robo1 有约束力的 Slit2 的特定的封锁击倒阻止的电子恶棍降级和颠倒的 EMT,导致减少的肿瘤生长和肝转移。Robo1 的宫外的表示也在 Slit2 积极的人的胚胎的肾触发了恶意的转变 293 个房间。重要地, Slit2 和 Robo1 的表示显著地在 colorectal 癌病人与增加的变形风险和更差的全面幸存被联系。我们断定由 Slit2 的 Robo1 的那个约会在 colorectal 期间通过调停 Hakai 的电子恶棍 ubiquitination 和 lysosomal 降级导致恶意的转变上皮的房间 carcinogenesis。 | Wei-Jie Zhou Zhen H Geng Shan Chi Wenli Zhang Xiao-Feng Niu Shu-Jue Lan Li Ma Xuesong Yang Li-Jing Wang Yan-Qing Ding Jian-Guo Geng | 2011 | Cell Research2011，21，4： | 14 |
| 3 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 4 | The Surgical Treatment and Outcome of Nonmetastatic Extremity Osteosarcoma with Pathological Fractures显示文摘 | Zhi-Ping Deng Yi Ding Ajay Puri Edward H M Wang Ashish Gulia Claire Durban Xiao-Hui Niu | 2015 | Chinese Medical Journal2015，，19： | 2 |
| 5 | Digital watermarking of still images with gray-level digital watermarks显示文摘 | Niu X M Lu Z M Sun S H | 2000 | IEEE Trans on Consumer Electronics2000，46，1： | 2 |
| 6 | Alternating copolymerization of carbon dioxide and propylene oxide catalyzed by cobalt schiff base complex显示文摘 | Niu Y Li H Chen X | 2009 | Macromolecular Chemistry and Physics2009，210，15： | 1 |
| 7 | Studies on electrochemical behavior of copper in acrsted NaBr solutions with Schiff bases 显示文摘 | Ma H Chen S H Niu L | 2001 | Journal of Electrochemical Society2001，148，5： | 1 |
| 8 | Selective laser sintering of gas and water atomized high speed steel powders 显示文摘 | Niu H J Chang I T H | 1999 | Scripta Materialia1999，41，1： | 1 |
| 9 | Strong adsorption of chlorotetracycline on magnetite nanoparticles 显示文摘 | Zhang D Niu H Y Zhang X L | 2011 | Journal of Hazardous Materials2011，192，3： | 1 |
| 10 | The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate,a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase显示文摘 | Murakami E Niu C Bao H Micolochick Steuer H M Whitaker T Nachman T Sofia | | 0，，02： | 1 |
| 11 | 查看详情显示文摘 | Fan H Xu X F Niu X J | | 0，，： | 1 |
| 12 | Yin and Yang of PDGF-mediated signaling pathway in the context of HIV infection and drug abuse 显示文摘 | Yao H Bethel-Brown C Niu F | 2014 | J Neuroimmune Pharmacol2014，9，2： | 1 |
| 13 | Nitrogen vacancy-promoted photocatalytic activity of graphitic carbon nitride显示文摘 | Niu P Liu G Cheng H M | 2012 | The Journal of Physical Chemistry C2012，116，11： | 1 |
| 14 | Talanta显示文摘 | Li Y H Niu W F Lu J R | 2007 | 71:11242007，71，： | 1 |
| 15 | Optimised ultrasonic-assisted extrac- tion of flavonoids from Folium eucommiae and evaluation of antioxi- dant activity in multi-test systems in v/tro显示文摘 | HUANG W XUE A NIU H | 2009 | Food Chem2009，114，3： | 1 |
| 16 | Agonists at PPAR-gamma suppress angiotensin II induced production of plasminogen activator inhibitor 1 and extracellular matrix in rat cardiac fibroblasts 显示文摘 | HAO G H NIU X L GAO D F | 2008 | Br J Pharmacol2008，153，7： | 1 |
| 17 | Selective laser sintering of gas and water atomized high speed steel powders 显示文摘 | Niu H J Chang I T H | 1999 | Scripta Materialia1999，41，1： | 1 |
| 18 | Anal Chim Acta显示文摘 | Jing T Xia H Guan Q Lu W H Dai Q Niu J W Lim J M Hao Q L Lee Y Zhou Y K Mei S R | 2011 | 692:732011，692，： | 1 |
| 19 | Optimised ultrasonic- assisted extraction of flavonoids from Folium eucommiae and evaluation of antioxidant activity in multi- test systems in vitro 显示文摘 | Huang W Xue A Niu H | 2009 | Food Chemistry2009，114，3： | 1 |
| 20 | Long-term monitoring of wind characteristics at Sutong Bridge site显示文摘 | WANG H LI A Q NIU J | 2013 | Journal of Wind Engi-neering and Industrial Aerodynamics2013，115，4： | 1 |
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