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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Massive individual orbital angular momentum channels for multiplexing enabled by Dammann gratings显示文摘Data transmission rates in optical communication systems are approaching the limits of conventional multiplexing methods.Orbital angular momentum(OAM)in optical vortex beams offers a new degree of freedom and the potential to increase the capacity of free-space optical communication systems,with OAM beams acting as information carriers for OAM division multiplexing(OAM-DM).We demonstrate independent collinear OAM channel generation,transmission and simultaneous detection using Dammann optical vortex gratings(DOVGs).We achieve 80/160 Tbit s^(-1) capacity with uniform power distributions along all channels,with 1600 individually modulated quadrature phase-shift keying(QPSK)/16-QAM data channels multiplexed by 10 OAM states,80 wavelengths and two polarizations.DOVG-enabled OAM multiplexing technology removes the bottleneck of massive OAM state parallel detection and offers an opportunity to raise optical communication systems capacity to Pbit s^(-1) level. | Ting Lei Meng Zhang Yuru Li Ping Jia Gordon Ning Liu Xiaogeng Xu Zhaohui Li Changjun Min Jiao Lin Changyuan Yu Hanben Niu Xiaocong Yuan | 2015 | Light(Science & Applications)2015，4，1： | 47 |
| 3 | New incompatible pair of TCM:Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity under immunological stress conditions显示文摘Epimedii Folium(EF)combined with Psoraleae Fructus(PF)is a common modern preparation,but liver injury caused by Chinese patent medicine preparations containing EF and PF has been frequently reported in recent years.Zhuangguguanjiewan pills(ZGW),which contain EF and PF,could induce immune idiosyncratic liver injury according to clinical case reports and a nonhepatotoxic dose of lipopolysaccharide(LPS)model.This present study evaluated the liver injury induced by EF or PF alone or in combination and investigated the related mechanism by using the LPS model.Liver function indexes and pathological results showed that either EF or PF alone or in combination led to liver injury in normal rats;however,EF or PF alone could lead to liver injury in LPS-treated rats.Moreover,EF combined with PF could induce a greater degree of injury than that caused by EF or PF alone in LPS-treated rats.Furthermore,EF or PF alone or in combination enhanced the LPS-stimulated inflammatory cytokine production,implying that IL-1β,which is processed and released by activating the NLRP3 inflammasome,is a specific indicator of EF-induced immune idiosyncratic hepatotoxicity.Thus,EF may induce liver injury through enhancing the LPS-mediated proinflammatory cytokine production and activating the NLRP3 inflammasome.In addition,the metabolomics analysis results showed that PF affected more metabolites in glycerophospholipid and sphingolipid metabolic pathways compared with EF in LPS model,suggesting that PF increased the responsiveness of the liver to LPS or other inflammatory mediators via modulation of multiple metabolic pathways.Therefore,EF and PF combination indicates traditional Chinese medicine incompatibility,considering that it induces idiosyncratic hepatotoxicity under immunological stress conditions. | Yuan Gao Zhilei Wang Jinfa Tang Xiaoyi Liu Wei Shi Nan Qin Xiaoyan Wang Yu Pang Ruisheng Li Yaming Zhang Jiabo Wang Ming Niu Zhaofang Bai Xiaohe Xiao | 2020 | Frontiers of Medicine2020，14，1： | 32 |
| 4 | The Medicinal Herb Panax notoginseng Genome Provides Insights into Ginsenoside Biosynthesis and Genome Evolution显示文摘 | Dan Zhang Wei Li En-hua Xia Qun-jie Zhang Yuan Liu Yun Zhang Yan Tong Yuan Zhao Yong-chao Niu Jia-huan Xu Li-zhi Gao | 2017 | Molecular Plant2017，10，6： | 27 |
| 5 | Toward Wisdom-Evolutionary and Primitive-Concise 6G:A New Paradigm of Semantic Communication Networks显示文摘The sixth generation(6G)mobile networks will reshape the world by offering instant,efficient,and intelligent hyper-connectivity,as envisioned by the previously proposed Ubiquitous-X 6G networks.Such hyper-massive and global connectivity will introduce tremendous challenges into the operation and management of 6G networks,calling for revolutionary theories and technological innovations.To this end,we propose a new route to boost network capabilities toward a wisdom-evolutionary and primitive-concise network(WePCN)vision for the Ubiquitous-X 6G network.In particular,we aim to concretize the evolution path toward the WePCN by first conceiving a new semantic representation framework,namely semantic base,and then establishing an intelligent and efficient semantic communication(IE-SC)network architecture.In the IE-SC architecture,a semantic intelligence plane is employed to interconnect the semantic-empowered physical-bearing layer,network protocol layer,and application-intent layer via semantic information flows.The proposed architecture integrates artificial intelligence and network technologies to enable intelligent interactions among various communication objects in 6G.It features a lower bandwidth requirement,less redundancy,and more accurate intent identification.We also present a brief review of recent advances in semantic communications and highlight potential use cases,complemented by a range of open challenges for 6G. | Ping Zhang Wenjun Xu Hui Gao Kai Niu Xiaodong Xu Xiaoqi Qin Caixia Yuan Zhijin Qin Haitao Zhao Jibo Wei Fangwei Zhang | 2022 | Engineering2022，8，1： | 28 |
| 6 | Lightning activity and precipitation structure of hailstorms显示文摘By using the cloud-to-ground (CG) lightning location data from the lightning detection network of He- nan Province, surface Doppler radar data and standard orbit data of PR, TMI and LIS on TRMM satellite, the spatial and temporal characteristics of CG lightning flashes in 10 severe hailstorms are analyzed. The results show that the percentage of +CG lightning in these hailstorms is high with an average value of 45.5%. There is a distinct increase in CG flash rate during the rapid development stage of hailstorms. The hailstone falling corresponds to an active positive flash period, and the increase of +CG flash rate is generally accompanied with a decrease of –CG flash rate. The flash rate declines rapidly during the dissipating stage of hailstorms. The precipitation structure and lightning activity in two typical hail- storms are studied in detail. It is found that strong convective cells with reflectivity greater than 30dBZ mainly are situated in the front region of hailstorms, whereas the trailing stratiform region is in the rear part of the hailstorms. The maximum heights of echo top are higher than 14 km. Convective rain con- tributes much more rainfall to the total than stratiform rain, and the convective rain takes about 85% and 97% of the total in the two cases, respectively. Total lightning in the hailstorms is very active with the flash rate up to 183 fl/min and 55 fl/min, respectively. The results also indicate that most lightning flashes occurred in the echo region greater than 30 dBZ and its immediate periphery. The probability of lightning occurrence is 20 times higher in the convective region than in the stratiform region. The result suggests that the lightning information is helpful to the identification of convective rain region. The linear relationship between flash rate and ice water content is disclosed primarily. | FENG GuiLi1,2, QIE XiuShu3,1, YUAN Tie1 & NIU ShuZhen4 1 Laboratory of Lightning and Thunderstorm, Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou 730000, China 2 Shandong Research Institute of Meteorology, Jinan 250031, China 3 Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China 4 The Meteorological Observatory of Henan Province, Zhengzhou 450003, China | 2007 | Science China Earth Sciences2007，50，4： | 22 |
| 7 | mm Wave communications for 5G: implementation challenges and advances显示文摘The requirement of the fifth generation(5 G) wireless communication for high throughput motivates the wireless industry to use the mm Wave(millimeter wave) communications for its wide bandwidth advantage. To compensate the heavy path loss and increase the communications capacity, phased array beamforming and massive multiple-input multiple-output(MIMO) techniques are employed at both the user equipment(UE) and base stations(BS). Considering the commercial requirements, 5 G mm Wave large array systems should be implemented in an energy-and cost-efficient way with a small form factor. To address above issues and realize a reliable communications link, taking into account the particular characteristics of5 G mm Wave systems, this paper firstly examines the design challenges and trade-offs in system implementations, then some of the design strategies are summarized. At last, recent advance in RF front-end circuits and receiver sub-systems is then highlighted. | Lianming LI Dongming WANG Xiaokang NIU Yuan CHAI Linhui CHEN Long HE Xu WU Fuchun ZHENG Tiejun CUI Xiaohu YOU | 2018 | Science China(Information Sciences)2018，61，2： | 19 |
| 8 | Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome显示文摘Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic interventions. Cardamonin(CDN), the major active ingredient of the traditional Chinese medicinal herb Alpinia katsumadai, has exerted an excellent anti-inflammatory activity, but the mechanism underlying this role is not fully understood. Here, we show that CDN blocks canonical and noncanonical NLRP3 inflammasome activation triggered by multiple stimuli. Moreover, the suppression of CDN on inflammasome activation is specific to NLRP3, not to NLRC4 or AIM2 inflammasome. Besides, the inhibitory effect is not dependent on the expression of NF-κB-mediated inflammasome precursor proteins. We also demonstrate that CDN suppresses the NLRP3 inflammasome through blocking ASC oligomerization and speckle formation in a dose-dependent manner.Importantly, CDN improves the survival of mice suffering from lethal septic shock and attenuates IL-1βproduction induced by LPS in vivo, which is shown to be NLRP3 dependent. In conclusion, our results identify CDN as a broad-spectrum and specific inhibitor of NLRP3 inflammasome and a candidate therapeutic drug for treating NLRP3 inflammasome-driven diseases. | Zhilei Wang Guang Xu Yuan Gao Xiaoyan Zhan Nan Qin Shubin Fu Ruisheng Li Ming Niu Jiabo Wang Youping Liu Xiaohe Xiao Zhaofang Bai | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 19 |
| 9 | Vegetation NPP Distribution Based on MODIS Data and CASA Model——A Case Study of Northern Hebei Province显示文摘Net Primary Productivity (NPP) is one of the important biophysical variables of vegetation activity, and it plays an important role in studying global carbon cycle, carbon source and sink of ecosystem, and spatial and temporal distri- bution of CO2. Remote sensing can provide broad view quickly, timely and multi-temporally, which makes it an attractive and powerful tool for studying ecosystem primary productivity, at scales ranging from local to global. This paper aims to use Moderate Resolution Imaging Spectroradiometer (MODIS) data to estimate and analyze spatial and temporal dis- tribution of NPP of the northern Hebei Province in 2001 based on Carnegie-Ames-Stanford Approach (CASA) model. The spatial distribution of Absorbed Photosynthetically Active Radiation (APAR) of vegetation and light use efficiency in three geographical subregions, that is, Bashang Plateau Region, Basin Region in the northwestern Hebei Province and Yanshan Mountainous Region in the Northern Hebei Province were analyzed, and total NPP spatial distribution of the study area in 2001 was discussed. Based on 16-day MODIS Fraction of Photosynthetically Active Radiation absorbed by vegetation (FPAR) product, 16-day composite NPP dynamics were calculated using CASA model; the seasonal dy- namics of vegetation NPP in three subregions were also analyzed. Result reveals that the total NPP of the study area in 2001 was 25.1877×106gC/(m2·a), and NPP in 2001 ranged from 2 to 608gC/(m2·a), with an average of 337.516gC/(m2·a). NPP of the study area in 2001 accumulated mainly from May to September (DOY 129–272), high NPP values appeared from June to August (DOY 177–204), and the maximum NPP appeared from late July to mid-August (DOY 209–224). | YUAN Jinguo NIU Zheng WANG Chenli | 2006 | Chinese Geographical Science2006，16，4： | 18 |
| 10 | Western medication plus Traditional Chinese Medicine preparations in patients with chronic heart failure:a prospective,single-blind,randomized,controlled,and multicenter clinical trial显示文摘OBJECTIVE: To assess the efficacy and safety in patients with chronic heart failure(CHF) of Western medication plus Traditional Chinese Medicine(TCM) preparations.METHODS: This prospective, single-blind, randomized, controlled, and multicenter clinical trial began on September 17, 2008, and was completed on June 25, 2011. A total of 340 inpatients, aged 40-79 years, with exacerbating CHF from 10 hospitals were enrolled and randomly allocated within 24 h of admission. The trial included three intervention periods. During hospitalization, the control group received western medication for CHF and the treatment group received Danhong injection with Shenfu injection or Shenmai injection. After discharge,all patients were treated with Qiliqiangxin capsules and Buyiqiangxin tablets or a placebo for 6 months. After the 6-month intervention, both groups received only continuous western medication. The primary endpoint was all-cause mortality.The efficacy assessments were as follows: B-type natriuretic peptide(BNP), Lee's HF score, the 6-minute walking test(6 MWT), left ventricular ejection fraction(LVEF), and the Minnesota Living with Heart Failure Questionnaire(MLHFQ). The safety assessments were as follows: blood and urine routine examination, hepatic and renal function, electrolytes in blood and adverse events.RESULTS: Compared with the control group, the treatment group showed a 30.99% reduction in all-cause mortality and an improved survival rate.The treatment group showed greater improvement in 6 MWT(P = 0.02) than the control group on discharge, after 12-month follow-up, there was a time-group interaction for MLHFQ(P = 0.03). Incidence rate of adverse events and other relevant safety indexes were not statistically significant between the two groups.CONCLUSION: Western medication plus TCM treatment can increase 6-minute walking distance(improve exercise tolerance) and quality of life with heart failure patients. | Wang Xianliang Hou Yazhu Mao Jingyuan Zhao Yingqiang Niu Tianfu Yuan Ruyu Wang Yonggang Cui Jin-rong Shi Le Jia Xiuli Fan Ruihong Lin Qian Zhang Yan Li Zhijun Shang Hongcai Wang Baohe Wang Hongwu Wang Henghe Cui Xiaolei Soh Shanbin Ruan Jishou Zhang Boli | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 15 |
| 11 | Salvianolic acid A attenuates vascular remodeling in a pulmonary arterial hypertension rat model显示文摘瞄准:当前的治疗学的途径在 dysregulated 上有有限效果肺的脉管的改变,它肺的动脉的高血压是特征的(哼) 。在我们检验了 salvianolic 酸 A (SAA ) 是否从繁体中文药提取了的这研究,丹·沈稀释了在一个 PAH 老鼠模型的脉管的改变,并且阐明内在的 mechanisms.Methods:哼被注射 monocrotaline 的单个剂量在老鼠导致(MCT 60 mg/kg, sc ) 。老鼠口头上地与任何一个 SAA 被对待(0.3, 1, 3 mg· kg −1·d−1) 或积极控制 bosentan (30 mg·为 4 个星期的 kg −1·d−1) 。Echocardiography 和血液动力学的大小在 d 上被执行 28。然后,心和肺被收获,机关索引和肺的动脉墙厚度被计算,并且生物化学、组织化学的分析被进行。在肺的 apoptotic 和发信号的蛋白质的层次用 immunoblotting.Results 被测量:有 SAA 或 bosentan 的处理有效地改善了改变的导致 MCT 的肺的动脉,肺的血液动力学的畸形和恰好室的收缩压力(RVSP ) 的随后的增加。而且,处理显著地在肺稀释了心肌层, parenchymal 损害和骨胶原免职的导致 MCT 的 hypertrophic 损坏。而且,处理在肺稀释了导致 MCT 的 apoptosis 和纤维变性。处理部分恢复了骨头的导致 MCT 的减小形态基因的蛋白质类型 II 受体(BMPRII ) 和在 lungs.Conclusion 的 phosphorylated Smad1/5:SAA 改善肺的动脉的改变在导致 MCT 哼经由激活 BMPRII-Smad 小径并且禁止 apoptosis 最可能的老鼠。因此, SAA 可以在高风险为病人有治疗学的潜力哼。 | Yu-cai CHEN Tian-yi YUAN Hui-fang ZHANG Dan-shu WANG Yu YAN Zi-ran NIU Yi-huang LIN Lian-hua FANG Guan-hua DU | 2016 | Acta Pharmacologica Sinica2016，37，6： | 13 |
| 12 | Distribution of serum prostate-specific antigen in Chinese healthy men: a population-based study显示文摘前列腺癌症的病态和死亡在最近的中国很快一直在增加的背景。有很少研究,调查前列腺特定的抗原(PSA ) 在健康中国人口的价值范围。我们执行了这研究从 2001 年 1 月在大健康中国 population.Methods 决定浆液 PSA 的分发到 2008 年 5 月, 30-79 年的 11 150 个健康的中国人为平淡的健康来到了我们的医院检查。没有前列腺癌症,前列腺外科的历史,或尿生殖的道感染的以前的诊断的所有题目被建议经历系统的浆液 PSA 测量和数字直肠的检查(DRE ) 。有正常 DRE 和 PSA 4.0 ng/ml 和那些 PSA 4.0 ng/ml 或反常 DRE,但是没有前列腺活体检视上的不利调查结果的人被包括(n=9358 ) 。年龄和浆液 PSA 集中通过 第95 百分位数浆液 PSA 集中是的逻辑回归 analysis.Results 被记录并且相关为 30~39 年的人,的 1.89 ng/ml 为 40~49 年的人的 2.19 ng/ml ,为人的 2.88 ng/ml 变老 50~59 年,为 60~69 年的人的 4.42 rng/ml ,和为 70~79 年的人的 6.52 ng/ml 。浆液 PSA 集中在 40 年里为人随0.97%的年度增加与年龄( P 0.0001 )相关,1.58%为 50 年里的人,3.04%为 60 年里的人,并且3.99%为在 70 years.Conclusions 的人,浆液 PSA 水平在比 40 年,不是在比 40 岁年轻的中国人老的中国人与年龄直接相关。中国人不到 60 岁超过 60 岁,不是在那些与白人相比有更低的 PSA 水平。 | YUAN Xiao-dong DONG Zhi-gang ZHANG Hui LIN Hai-yan SONG Xin-hong NIU Zhi-hong FU Qiang LIU Shuai SUN Zhi-jian LU Jia-ju | 2011 | Chinese Medical Journal2011，，8： | 12 |
| 13 | Highly reactive, flexible yet green Se precursor for metal selenide nanocrystals: Se-octadecene suspension (Se-SUS)显示文摘在 octadecene (Se 怀疑) 的好硒粉末(100 或 200 网孔) 的暂停证明了是一位高效的、万用的、方便的、可再现的、还绿的硒先锋。Se 怀疑的优点从它的高度反应的化学性质和灵活性产生。这二个特征使与多样的作文和结构执行高质量的金属硒化物 nanocrystals 的合成可能,包括二进制代码,核心 / 壳,做的转变金属,和复杂作文 nanocrystals。这些成功进一步证明 Se 怀疑是为在高质量的硒化物 nanocrystals 的合成解决一些长期的挑战的一位强大的 Se 先锋。例如,Se怀疑成功地作为一位 Se 先锋被采用因为在高质量的核心/壳 nanocrystals 轰炸生长代替昂贵、高度有毒的先锋,例如Se磷化氢和 bis-trimethylsilyl 硒化物,与极大地降低的取向附生的温度(象 150 一样低???????????????? | Chaodan Pu Jianhai Zhou Runchen Lai Yuan Niu Wennuan Nan Xiaogang Peng | 2013 | Nano Research2013，6，9： | 12 |
| 14 | SHP2 promotes proliferation of breast cancer cells through regulating Cyclin D1 stabilityviathe PI3K/AKT/GSK3β signaling pathway显示文摘Objective:The tyrosine phosphatase SHP2 has a dual role in cancer initiation and progression in a tissue type-dependent manner.Several studies have linked SHP2 to the aggressive behavior of breast cancer cells and poorer outcomes in people with cancer.Nevertheless,the mechanistic details of how SHP2 promotes breast cancer progression remain largely undefined.Methods:The relationship between SHP2 expression and the prognosis of patients with breast cancer was investigated by using the TCGA and GEO databases.The expression of SHP2 in breast cancer tissues was analyzed by immunohistochemistry.CRISPR/Cas9 technology was used to generate SHP2-knockout breast cancer cells.Cell-counting kit-8,colony formation,cell cycle,and EdU incorporation assays,as well as a tumor xenograft model were used to examine the function of SHP2 in breast cancer proliferation.Quantitative RT-PCR,western blotting,immunofluorescence staining,and ubiquitination assays were used to explore the molecular mechanism through which SHP2 regulates breast cancer proliferation.Results:High SHP2 expression is correlated with poor prognosis in patients with breast cancer.SHP2 is required for the proliferation of breast cancer cellsin vitro and tumor growthin vivo through regulation of Cyclin D1 abundance,thereby accelerating cell cycle progression.Notably,SHP2 modulates the ubiquitin–proteasome-dependent degradation of Cyclin D1viathe PI3K/AKT/GSK3βsignaling pathway.SHP2 knockout attenuates the activation of PI3K/AKT signaling and causes the dephosphorylation and resultant activation of GSK3β.GSK3βthen mediates phosphorylation of Cyclin D1 at threonine 286,thereby promoting the translocation of Cyclin D1 from the nucleus to the cytoplasm and facilitating Cyclin D1 degradation through the ubiquitin–proteasome system.Conclusions:Our study uncovered the mechanism through which SHP2 regulates breast cancer proliferation.SHP2 may therefore potentially serve as a therapeutic target for breast cancer. | Yue Yuan Yanling Fan Zicong Gao Xuan Sun He Zhang Zhiyong Wang Yanfen Cui Weijie Song Zhaosong Wang Fei Zhang Ruifang Niu | 2020 | Cancer Biology & Medicine2020，17，3： | 11 |
| 15 | Methylprednisolone promotes recovery of neurological function after spinal cord injury: association with Wnt/β-catenin signaling pathway activation显示文摘Some studies have indicated that the Wnt/β-catenin signaling pathway is activated following spinal cord injury,and expression levels of specific proteins,including low-density lipoprotein receptor related protein-6 phosphorylation,β-catenin,and glycogen synthase kinase-3β,are significantly altered.We hypothesized that methylprednisolone treatment contributes to functional recovery after spinal cord injury by inhibiting apoptosis and activating the Wnt/β-catenin signaling pathway.In the current study,30 mg/kg methylprednisolone was injected into rats with spinal cord injury immediately post-injury and at 1 and 2 days post-injury.Basso,Beattie,and Bresnahan scores showed that methylprednisolone treatment significantly promoted locomotor functional recovery between 2 and 6 weeks post-injury.The number of surviving motor neurons increased,whereas the lesion size significantly decreased following methylprednisolone treatment at 7 days post-injury.Additionally,caspase-3,caspase-9,and Bax protein expression levels and the number of apoptotic cells were reduced at 3 and 7days post-injury,while Bcl-2 levels at 7 days post-injury were higher in methylprednisolone-treated rats compared with saline-treated rats.At 3 and 7 days post-injury,methylprednisolone up-regulated expression and activation of the Wnt/β-catenin signaling pathway,including low-density lipoprotein receptor related protein-6 phosphorylation,β-catenin,and glycogen synthase kinase-3β phosphorylation.These results indicate that methylprednisolone-induced neuroprotection may correlate with activation of the Wnt/β-catenin signaling pathway. | Gong-biao Lu Fu-wen Niu Ying-chun Zhang Lin DU Zhi-yuan Liang Yuan Gao Ting-zhen Yan Zhi-kui Nie Kai Gao | 2016 | Neural Regeneration Research2016，11，11： | 11 |
| 16 | Subchondral bone grafting reduces degenerative change of knee joint in patients of giant cell tumor of bone显示文摘 | XU Hai-rong NIU Xiao-hui ZHANG Qing HAO Lin DING Yi LI Yuan | 2013 | Chinese Medical Journal2013，，16： | 11 |
| 17 | Infrared radiation characteristics of a hypersonic vehicle under time-varying angles of attack显示文摘Hypersonic vehicles emit strong infrared(IR) radiation signatures that can be treated as a detecting source for object identification and routine diagnosis. This paper is aimed at examining the intrinsic radiation characteristics of a Boost-Glide Vehicle(BGV) under the condition of various Angles of Attack(AOAs). A two-temperature model considering the thermal and chemical nonequilibrium effects is coupled with Navier-Stokes equations solved by the finite volume technique.A gas–solid conjunction heat transfer model is also added into the fluid solver to simulate the surface temperature of the vehicle. The radiative transfer equation is solved with Line of Sight(LOS)algorithm. The computational results for a Hypersonic Technology Vehicle-2(HTV-2) type vehicle show that radiances of the vehicle are strongly dependent on the surface temperature. The presence of AOA results in the significant difference of the surface temperature. Infrared radiation characteristics are also changed in intensity and spectral band due to the AOA. Simulations are performed with two time-varying AOAs. Transient results indicate that the variation of AOA does have a great effect on the infrared radiance and is closely related to observation angle, spectral band, angle size,angular velocity and time history. | Qinglin NIU Zhichao YUAN Biao CHEN Shikui DONG | 2019 | Chinese Journal of Aeronautics2019，32，4： | 10 |
| 18 | Effects of combined acupuncture and eugenol on learning-memory ability and antioxidation system of hippocampus in Alzheimer disease rats via olfactory system stimulation显示文摘OBJECTIVE: To investigate the effects of combined acupuncture and eugenol on learning-memory ability and the antioxidation system of the hippocampus in Alzheimer disease (AD) rats. METHODS: Sixty Sprague Dawley rats, weighing (300±10) g, were randomly divided with 10 rats per group into a normal control group, AD model group, AD with cut olfactory nerve group, Xiu three-needle group, eugenol group, and combined acupuncture and eugenol group. The AD model was established by injection of amyloid β1-40 (Aβ 1-40). Morris maze tests were conducted for evaluating the learning-memory ability. Content of malo- ndialdehyde (MDA) and activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the hippocampus were detected. RESULTS: The average escape latency and the mean swimming distance in the normal control group, the Xiu three-needle group, the eugenol group, and the combined acupuncture and euge-nol group were significantly shorter than those in the AD model group (all P<0.01). The combined acupuncture and eugenol group had shorter escape latency and mean swimming distance than those in the Xiu three-needle group and the eugenol group. There were no significant differences between the Xiu three-needle group and the eugenol group and between the AD group and the AD with cut olfactory nerve group (P>0.05). Compared with the normal control group, the MDA content in the hippocampus significantly increased (P<0.05) and GSH-Px and SOD activities significantly decreased in the AD model group (P<0.01). Compared with the AD model group, significantly decreased (P< 0.01) and SOD and GSH-Px activities significantly increased in the Xiu three-needle group, eugenol group, and combined acupuncture and eugenol group (P<0.05). Compared with the Xiu three-needle group and eugenol group, the MDA content significantly decreased (P<0.05) and SOD and GSH-Px activities increased (P<0.05) in the combined acupuncture and eugenol group. There were no significant differences among the three indices between the Xiu three-needle group and the eugenol group and between the AD model group and the AD with cut olfactory nerve group (P>0.05). CONCLUSION: Both Xiu three-needle and eugenol can increase learning-memory ability, decrease MDA content, and increase SOD and GSH-Px activities in the hippocampus in AD rats. The combination of acupuncture with eugenol has stronger effects, and the effects depend on the olfactory pathway. | Zhibin Liu Wenmin Niu Xiaohang Yang Yuan Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 10 |
| 19 | Correlation of Vascular Endothelial Growth Factor Production with Photochemical Reaction-induced Retinal Edema显示文摘 | Liang Shan Mi Zheng Yuan Zhang Yuan Qu Tian Niu Qing Gu Xin Xia | 2016 | Chinese Medical Journal2016，，24： | 9 |
| 20 | An Energy-Efficient Data Collection Scheme Using Denoising Autoencoder in Wireless Sensor Networks显示文摘As one of the key operations in Wireless Sensor Networks(WSNs), the energy-efficient data collection schemes have been actively explored in the literature. However, the transform basis for sparsifing the sensed data is usually chosen empirically, and the transformed results are not always the sparsest. In this paper, we propose a Data Collection scheme based on Denoising Autoencoder(DCDA) to solve the above problem. In the data training phase, a Denoising AutoEncoder(DAE) is trained to compute the data measurement matrix and the data reconstruction matrix using the historical sensed data. Then, in the data collection phase, the sensed data of whole network are collected along a data collection tree. The data measurement matrix is utilized to compress the sensed data in each sensor node, and the data reconstruction matrix is utilized to reconstruct the original data in the sink.Finally, the data communication performance and data reconstruction performance of the proposed scheme are evaluated and compared with those of existing schemes using real-world sensed data. The experimental results show that compared to its counterparts, the proposed scheme results in a higher data compression rate, lower energy consumption, more accurate data reconstruction, and faster data reconstruction speed. | Guorui Li Sancheng Peng Cong Wang Jianwei Niu Ying Yuan | 2019 | Tsinghua Science and Technology2019，24，1： | 9 |
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