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| 1 | Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine显示文摘Gegen Qinlian Decoction(GQD),a traditional Chinese medicine(TCM)formula,has long been used for the treatment of common metabolic diseases,including type 2 diabetes mellitus.However,the main limitation of its wider application is ingredient complexity of this formula.Thus,it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action.Here,we compared the effects of GQD and berberine,a hypothetical key active pharmaceutical ingredient of GQD,on a diabetic rat model by comprehensive analyses of gut microbiota,short-chain fatty acids,proinflammatory cytokines,and ileum transcriptomics.Our results show that berberine and GQD had similar effects on lowering blood glucose levels,modulating gut microbiota,inducing ileal gene expression,as well as relieving systemic and local inflammation.As expected,both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria,including Faecalibacterium and Roseburia,thereby attenuating intestinal inflammation and lowering glucose.Levels of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or GQD.Moreover,concentration of serum proinflammatory cytokines and expression of immune-related genes,including Nfkb1,Stat1,and Ifnrg1,in pancreatic islets were significantly reduced after treatment.Our study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut microbiota.The strategy employed would facilitate further standardization and widespread application of TCM in many diseases. | Xizhan Xu Zezheng Gao Fuquan Yang Yingying Yang Liang Chen Lin Han Na Zhao Jiayue Xu Xinmiao Wang Yue Ma Lian Shu Xiaoxi Hu Na Lyu Yuanlong Pan Baoli Zhu Linhua Zhao Xiaolin Tong Jun Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 29 |
| 2 | Two Novel Antifungal Saponins from Tibetan Herbal Medicine Clematis tangutica显示文摘Antifungal assay-guided isolation of the ethanol extract of the aerial parts of Clematis tangutica yielded two novel triterpene saponins. Their structures were determined to be 3-O-a-L-arabinopyranosyl hederagenin 28-O-a-L-rhamnopyranosyl ester (1) and 3-O-b-D- glucopyranosyl(14)-a-L-arabinopyranosyl hederagenin 28-O-a-L-rhamnopyranosyl ester (2) on the basis of spectral data and chemical reactions. | Zhi Zhi DU, Na ZHU, Yue Mao SHEN* Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 | 2003 | Chinese Chemical Letters2003，14，7： | 20 |
| 3 | Combining LPJ-GUESS and HASM to simulate the spatial distribution of forest vegetation carbon stock in China显示文摘它在因为他们在陆上的生态系统的碳股票拥有大率,精确地在地区性的规模估计森林碳股票和空间分发是很重要的。然而,在地区性的规模的森林碳存货的当前的评价主要取决于森林库存数据,并且整个过程消费太多劳动,钱和时间。并且同时,它在森林碳存储上有许多否定影响更新。以便弄明白这些问题,基于当模特儿的高精确性表面(HASM ) ,这份报纸建议一个森林植被碳存储模拟方法。这个新方法作为 HASM 的起始的值采用 LPJ 猜测模型的输出并且把库存数据用作 HASM 的样品点在中国模仿森林碳存储的分发。这研究也作为数据来源采用中国的第七森林资源统计产生样品点,并且它也作为模拟精确性测试工作。HASM 模拟证明中国的全部的森林碳存储是 9.2405 Pg,当计算价值基于森林资源统计是 7.8115 Pg 时。森林资源统计基于森林华盖闭合被拿,并且 HASM 的结果对真实森林碳存储更合适。模拟结果也显示西南的山区域和东北森林是在中国的重要森林碳水库,并且他们分别地说明 39.82% 国家和 20.46% 总数森林植被碳存货。与以前的价值(1975-1995 ) 相比,二个区域的碳存储确实清楚地增加,这表明。这研究的结果证明在在中国的最后十年的大规模重新造林达到一个重要的碳水池。 | ZHAO Mingwei YUE Tianxiang ZHAO Na SUN Xiaofang ZHANG Xingying | 2014 | Journal of Geographical Sciences2014，24，2： | 18 |
| 4 | Expression of p57^(kip2), Rb protein and PCNA and their relationships with clinicopathology in human pancreatic cancer显示文摘AIM: To investigate the effects of inhibiting factor of cellcycle regulation p57kip2, retinoblastinoma protein (Rb protein)and proliferating cell nuclear antigen (PCNA) in the genesisand progression of human pancreatic cancer.METHODS: The expression of p57kip2, Rb protein and PCNAin tumor tissues and adjacent tissues of 32 patients withpancreatic cancer was detected with SP immunohistochemicaltechnique.RESULTS: p57kip2 protein positive-expression rate in tumortissues of pancreatic cancer was 46.9 %, which was lowerthan that in adjacent pancreatic tissues (75.0 %) (x2=5.317,P<0.05), p57kip2 protein positive-expression correlatedsignificantly with tumor cell differentiation (well-differentiationversus moderate or low-differentiation, P<0.05) but did notcorrelate significantly with lymph node metastasis (lymph nodemetastasis versus non-lymph node metastasis, P>0.05); Rbgene protein positive-expression rate in tumor tissues was50.0 %, which was also lower than that in adjacent pancreatictissues (78.1%) (x2=5.497, P<0.05); PCNA positive-expression rate was 71.9 %, being higher than that inadjacent pancreatic tissues (43.8 %) (x2=5.189, P<0.05),PCNA positive-expression also correlated significantly withtumor cell differentiation and lymph node metastasis (well-differentiation versus moderate or low- differentiation, lymphnode metastasis versus non-lymph node metastasis, P<0.05).Rb protein positive-expression rate in the tumor tissues ofp57kip2 protein positive-expression group was 53.3 %; andRb protein positive-expression rate in the tumor tissues ofp57kip2 protein negative-expression group was 47.1%. Therewas no significant relationship between the two groups(r=0.16507, P>0.05).CONCLUSION: The decreased expression of p57kip2, Rbprotein or over-expression of PCNA protein might contributeto the genesis or progression of pancreatic cancer, p57kip2,Rb protein and PCNA may play an important role in genesisand progression of pancreatic cancer. | Hui Yue Yan-Li Na Xin-Li Feng Shu-Ren Ma Fu-Lin Song Bo Yang Department of Gastroenterology and Pathology, General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China | 2003 | World Journal of Gastroenterology2003，9，2： | 15 |
| 5 | Inulin Can Alleviate Metabolism Disorders in ob/ob Mice by Partially Restoring Leptinrelated Pathways Mediated by Gut Microbiota显示文摘Inulin has been used as a prebiotic to alleviate glucose and lipid metabolism disorders in mice and humans by modulating the gut microbiota. However, the mechanism underlying the alleviation of metabolic disorders by inulin through interactions between the gut microbiota and host cells is unclear. We use ob/ob mice as a model to study the effect of inulin on the cecal microbiota by16 S rRNA gene amplicon sequencing and its interaction with host cells by transcriptomics. The inulin-supplemented diet improved glucose and lipid metabolism disorder parameters in ob/ob mice,alleviating fat accumulation and glucose intolerance. The a diversity of gut microbial community of ob/ob mice was reduced after inulin treatment, while the b diversity tended to return to the level of wild type mice. Interestingly, Prevotellaceae UCG 001(family Prevotellaceae) was obviously enriched after inulin treatment. A comparative analysis of the gene expression profile showed that the cecal transcriptome was changed in leptin gene deficiency mice, whereas the inulin-supplemented diet partially reversed the changes in leptin gene-related signaling pathways, especially AMPK signaling pathway, where the levels of gene expression became comparable to those in wild type mice.Further analysis indicated that Prevotellaceae UCG 001 was positively correlated with the AMPK signaling pathway, which was negatively correlated with markers of glycolipid metabolism disorders. Our results suggest that the inulin-supplemented diet alleviates glucose and lipid metabolism disorders by partially restoring leptin related pathways mediated by gut microbiota. | Xiaofeng Song Liang Zhong Na Lyu Fei Liu Boxing Li Yanan Hao Yong Xue Jing Li Yuqing Feng Yue Ma Yongfei Hu Baoli Zhu | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 12 |
| 6 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 7 | A de novo Genome of a Chinese Radish Cultivar显示文摘Here, we report a high-quality draft genome of a Chinese radish(Raphanus sativus) cultivar. This draft contains 387.73 Mb of assembled scaffolds, 83.93% of the scaffolds were anchored onto nine pseudochromosomes and 95.09% of 43 240 protein-coding genes were functionally annotated. 184.75 Mb(47.65%) of repeat sequences was identified in the assembled genome. By comparative analyses of the radish genome against 10 other plant genomes, 2 275 genes in 780 gene families were found unique to R. sativus. This genome is a good reference for genomic study and of great value for genetic improvement of radish. | ZHANG Xiaohui YUE Zhen MEI Shiyong QIU Yang YANG Xinhua CHEN Xiaohua CHENG Feng WU Zhangyan SUN Yuyan JING Yi LIU Bo SHEN Di WANG Haiping CUI Na DUAN Yundan WU Jian WANG Jinglei GAN Caixia WANG Jun WANG Xiaowu LI Xixiang | 2015 | Horticultural Plant Journal2015，1，3： | 10 |
| 8 | Sensitivity studies of a high accuracy surface modeling method显示文摘The sensitivities of the initial value and the sampling information to the accuracy of a high accuracy surface modeling(HASM) are investigated and the implementations of this new modeling method are modified and enhanced. Based on the fundamental theorem of surface theory, HASM is developed to correct the error produced in geographical information system and ecological modeling process. However, the earlier version of HASM is theoretically incomplete and its initial value must be produced by other surface modeling methods, such as spline, which limit its promotion. In other words, we must use other interpolators to drive HASM. According to the fundamental theorem of surface theory, we modify HASM, namely HASM.MOD, by adding another important nonlinear equation to make it independent of other methods and, at the same time, have a complete and solid theory foundation. Two mathematic surfaces and monthly mean temperature of 1951–2010 are used to validate the effectiveness of the new method. Experiments show that the modified version of HASM is insensitive to the selection of initial value which is particular important for HASM. We analyze the sensitivities of sampling error and sampling ratio to the simulation accuracy of HASM.MOD. It is found that sampling information plays an important role in the simulation accuracy of HASM.MOD. Another feature of the modified version of HASM is that it is theoretically perfect as it considers the third equation of the surface theory which reflects the local warping of the surface. The modified HASM may be useful with a wide range of spatial interpolation as it would no longer rely on other interpolation methods. | ZHAO Na YUE TianXiang ZHAO MingWei DU ZhengPing FAN ZeMeng CHEN ChuanFa | 2014 | Science China Earth Sciences2014，57，10： | 9 |
| 9 | Chronic Intermittent Hypobaric Hypoxia Ameliorates Renal Vascular Hypertension Through Up-regulating NOS in Nucleus Tractus Solitarii显示文摘Chronic intermittent hypobaric hypoxia(CIHH)is known to have an anti-hypertensive effect, which might be related to modulation of the baroreflex in rats with renal vascular hypertension(RVH). In this study, RVH was induced by the 2-kidney-1-clip method(2 K1 C) in adult male Sprague-Dawley rats. The rats were then treated with hypobaric hypoxia simulating 5000 m altitude for 6 h/day for 28 days. The arterial blood pressure(ABP), heart rate(HR), and renal sympathetic nerve activity(RSNA) were measured before and after microinjection of L-arginine into the nucleus tractus solitarii(NTS) in anesthetized rats.Evoked excitatory postsynaptic currents(eEPSCs) and spontaneous EPSCs(sEPSCs) were recorded in anterogradely-labeled NTS neurons receiving baroreceptor afferents. We measured the protein expression of neuronal nitric oxide synthase(nNOS) and endothelial NOS(eNOS) in the NTS. The results showed that the ABP in RVH rats was significantly lower after CIHH treatment. The inhibition of ABP, HR, and RSNA induced by L-arginine was less in RVH rats than in sham rats, and greater in the CIHHtreated RVH rats than the untreated RVH rats. The eEPSC amplitude in NTS neurons receiving baroreceptor afferents was lower in the RVH rats than in the sham rats and recovered after CIHH. The protein expression of nNOS and e NOS in the NTS was lower in the RVH rats than in the sham rats and this decrease was reversed by CIHH. In short, CIHH treatment decreases ABP in RVH rats via upregulating NOS expression in the NTS. | Na Li Yue Guan Yan-Ming Tian Hui-Jie Ma Xiangjian Zhang Yi Zhang Sheng Wang | 2019 | Neuroscience Bulletin2019，35，1： | 9 |
| 10 | Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome显示文摘Obstructive sleep apnea syndrome(OSAS)is a common breathing disorder in sleep in which the airways narrow or collapse during sleep,causing obstructive sleep apnea.The prevalence of OSAS continues to rise worldwide,particularly in middle-aged and elderly individuals.The mechanism of upper airway collapse is incompletely understood but is associated with several factors,including obesity,craniofacial changes,altered muscle function in the upper airway,pharyngeal neuropathy,and fluid shifts to the neck.The main characteristics of OSAS are recurrent pauses in respiration,which lead to intermittent hypoxia(IH)and hypercapnia,accompanied by blood oxygen desaturation and arousal during sleep,which sharply increases the risk of several diseases.This paper first briefly describes the epidemiology,incidence,and pathophysiological mechanisms of OSAS.Next,the alterations in relevant signaling pathways induced by IH are systematically reviewed and discussed.For example,IH can induce gut microbiota(GM)dysbiosis,impair the intestinal barrier,and alter intestinal metabolites.These mechanisms ultimately lead to secondary oxidative stress,systemic inflammation,and sympathetic activation.We then summarize the effects of IH on disease pathogenesis,including cardiocerebrovascular disorders,neurological disorders,metabolic diseases,cancer,reproductive disorders,and COVID-19.Finally,different therapeutic strategies for OSAS caused by different causes are proposed.Multidisciplinary approaches and shared decision-making are necessary for the successful treatment of OSAS in the future,but more randomized controlled trials are needed for further evaluation to define what treatments are best for specific OSAS patients. | Renjun Lv Xueying Liu Yue Zhang Na Dong Xiao Wang Yao He Hongmei Yue Qingqing Yin | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 8 |
| 11 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 12 | Edge detection and mathematic fitting for corneal surface with Matlab software显示文摘AIM:To select the optimal edge detection methods to identify the corneal surface,and compare three fitting curve equations with Matlab software. METHODS:Fifteen subjects were recruited. The corneal images from optical coherence tomography(OCT)were imported into Matlab software. Five edge detection methods(Canny,Log,Prewitt,Roberts,Sobel)were used to identify the corneal surface. Then two manual identifying methods(ginput and getpts)were applied to identify the edge coordinates respectively. The differences among these methods were compared. Binomial curve(y=Ax^2+Bx+C),Polynomial curve [p(x)=p1x^n+p2x^(n-1)+....+pnx+pn+1] and Conic section(Ax^2+Bxy+Cy^2+Dx+Ey+F=0)were used for curve fitting the corneal surface respectively. The relative merits among three fitting curves were analyzed. Finally,the eccentricity(e)obtained by corneal topography and conic section were compared with paired t-test. RESULTS:Five edge detection algorithms all had continuous coordinates which indicated the edge of the corneal surface. The ordinates of manual identifying were close to the inside of the actual edges. Binomial curve was greatly affected by tilt angle. Polynomial curve was lack of geometrical properties and unstable. Conic section could calculate the tilted symmetry axis,eccentricity,circle center,etc. There were no significant differences between ‘e' values by corneal topography and conic section(t=0.9143,P=0.3760 >0.05).CONCLUSION:It is feasible to simulate the corneal surface with mathematical curve with Matlab software. Edge detection has better repeatability and higher efficiency. The manual identifying approach is an indispensable complement for detection. Polynomial and conic section are both the alternative methods for corneal curve fitting. Conic curve was the optimal choice based on the specific geometrical properties. | Yue Di Mei-Yan Li Tong Qiao Na Lu | 2017 | International Journal of Ophthalmology(English edition)2017，10，3： | 7 |
| 13 | Two new lignans from Dipteronia dyeriana显示文摘新 sesquilignan, 7 鈥 ? 8 鈥 ? didehydroherpetotriol (1 ) ,和新 lignan glycoside,(+)-isolariciresinol-9 鈥 ?O- 伪 -l-rhamnopyranosyl-(1 鈫 ? 6 )- 尾 -d-glucopyranoside (2 ) ,从 Dipteronia dyeriana 的分支被孤立。他们的结构被分光镜的方法和化学证据阐明。与 39 渭 m ol/L 的 IC50 价值对人的白血球过多症 K562 房间加重 1 项拥有的禁止的活动。 | Rong Guo Min Luo Chun Lin Long Ma Lin Li Zhi Qin Ouyang Yi Ping Zhou Yue Hu Wang Xing Yu Li Ya Na Shi | 2008 | Chinese Chemical Letters2008，19，10： | 7 |
| 14 | Hot deformation behavior and microstructural evolution of powder metallurgical TiAl alloy显示文摘The hot deformation behavior of powder metallurgical(PM) TiAl alloys was investigated on Gleeble-3500 thermomechanical simulator, at a temperature range of 1050–1200 °C with an interval of 50 °C and a strain rate range of 0.001–1.000 s^(-1). The results show that the flow stress of PM TiAl alloy is sensitive to deformation temperature and strain rate, the peak stress decreases with the increase in deformation temperature and decrease in strain rate, and dynamic recrystallization occurs during the hot compression. The deformation active energy was calculated and the flow stress model during high-temperature deformation was established based on the Arrhenius equations and Zener–Hollomon parameter. The deformed microstructure consists of refined homogeneous γ and ɑ_2/γ grains. | Na Liu Zhou Li Wen-Yong Xu Yue Wang Guo-Qing Zhang Hua Yuan | 2017 | Rare Metals2017，36，4： | 7 |
| 15 | In situ grown Fe_(3)O_(4)particle on stainless steel:A highly efficient electrocatalyst for nitrate reduction to ammonia显示文摘NH_(3)is an essential feedstock for fertilizer synthesis.Industry-scale NH_(3)synthesis mostly relies on the Haber-Bosch method,however,which suffers from massive CO_(2) emission and high energy consumption.Electrocatalytic NO_(3)-reduction is an attractive substitute to the Haber-Bosch method for synthesizing NH_(3)under mild conditions.As this reaction will produce a variety of products,it highly desires efficient and selective electrocatalyst for NH_(3)generation.Here,we report in situ grown Fe_(3)O_(4)particle on stainless steel(Fe_(3)O_(4)/SS)as a high-efficiency electrocatalyst for NO_(3)^(-)reduction to NH_(3).In 0.1 M NaOH with 0.1 M NaNO_(3),such Fe_(3)O_(4)/SS reaches a remarkable Faradaic efficiency of 91.5%and a high NH_(3)yield of 10,145μg·h^(-1)·cm^(-2)at-0.5 V vs.reversible hydrogen electrode(RHE).Furthermore,it owns robust structural and electrochemical stability.This work provides useful guidelines to expand the scope of metallic oxide electrocatalysts for NH_(3)synthesis.The catalytic mechanism is uncovered and discussed further by theoretical calculations. | Xiaoya Fan Lisi Xie Jie Liang Yuchun Ren Longcheng Zhang Luchao Yue Tingshuai Li Yonglan Luo Na Li Bo Tang Yang Liu Shuyan Gao Abdulmohsen Ali Alshehri Qian Liu Qingquan Kong Xuping Sun | 2022 | Nano Research2022，15，4： | 7 |
| 16 | Application of chemical vapor-deposited monolayer ReSe2 in the electrocatalytic hydrogen evolution reaction显示文摘 | Shaolong Jiang Zhepeng Zhang Na Zhang Yahuan Huan Yue Gong Mengxing Sun Jianping Shi Chunyu Xie Pengfei Yang Qiyi Fang He Li Lianming Tong Dan Xie Lin Gu Porun Liu Yanfeng Zhang | 2018 | Nano Research2018，11，4： | 6 |
| 17 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 18 | Molecular characterization of three Hsp90 from Pieris and expression patterns in response to cold and thermal stress in summer and winter diapause of Pieris melete显示文摘热吃惊蛋白质(Hsps ) 在昆虫被连接了到压力和冬季 diapause,但是他们是否是夏天 diapause 的部件,仍然是未知的。分别地,在这研究,从 Pieris melete 的 Hsp90 的互补 DNA, Pieris rapae 和 Pieris canidia,命名 PmHsp90, PrHsp90 和 PcHsp90 被克隆并且定序。推出的氨基酸顺序分别地与 82.6, 82.6 和 82.7 kDa 的一个通常认为的分子的团由 718 氨基酸残余组成了。氨基酸序列在 Hsp90 家庭和合拢活动区域的 bHLH 蛋白质五个保存签名主题包含了所有。响应夏天 diapause 和冬季 diapause 的 PmHsp90 的微分表示模式,与热 / 寒冷应力有关,被调查。冷应力在夏天和冬季 diapause 蛹,然而并非在 nondiapause 个人导致了 Hsp90 upregulation。热吃惊 upregulated PmHsp90 逐渐地随在夏天 diapause,和 PmHsp90 的温度的增加是很快在冬季 diapause 的 upregulated。在 39 点在 30 min 热以后震惊牥捡慥???????? ???? ???? 吗?? | Wu, Yue‐Kun Zou, Chao Fu, Dao‐Meng Zhang, Wan‐Na Xiao, Hai‐Jun | 2018 | Insect Science2018，25，2： | 5 |
| 19 | Preparation of Electrospun PVDF Nanofiber Composite Filter Medium and Its Application in Air Filtration显示文摘Nanofibrous media with both high particle interception efficiency and robust air permeability has broad technological applications in areas including individual protection, industrial security, and environmental governance. However, producing such filtration media has proven to be extremely challenging. Here we reported an approach to preparing and fabricating a polyvinylidene fluoride (PVDF) nanofiber composite filter medium composed of 2D PVDF nanofiber nets and a stable substrate via onestep electrospinning for effective air filtration. PVDF nanofibers are obtained by adjusting the electrospinning process. With the combined properties of ultrasmall diameter, high porosity, and a bonded scaffold, the resulting PVDF nanofiber composite filter medium exhibits a robust high filtration efficiency of 99.901%(equivalent to an F9 rating) for 0.4 mm particles and a long service life (a large dust holding capacity of 36 g/m^2) for ultrafine airborne particles based on the sieving principle and surface filtration behavior. The successful synthesis of PVDF nanofibers medium would not only make it a promising candidate for air filtration, but also provide new insights into the design and development of composite nanofiber structures for various applications. | Qi Du Na Wang Wen Liu XueFeng Chen Yue Xu Ying Wan | 2019 | Paper And Biomaterials2019，4，1： | 5 |
| 20 | Enhancement of tumor cell death by combining cisplatin with an oncolytic adenovirus carrying MDA-7/IL-24显示文摘 | Yu-mei WU Kang-jian ZHANG Xue-tian YUE Yi-qiang WANG Yi YANG Gong-chu LI Na LI Yi-gang WANG | 2009 | Acta Pharmacologica Sinica2009，30，4： | 5 |
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