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| 1 | Effect of age on aortic atherosclerosis显示文摘Objective To examine the association of atherosclerosis burden in the survivors of an asymptomatic elderly cohort study and its relationship to other coronary risk factors (specifically, age) by evaluating aortic atherosclerotic wall burden by magnetic resonance imaging (MRI). Methods A total of 312 participants in an ongoing observational cohort study underwent cardiac and descending thoracic aorta imaging by MRI. Maximum wall thickness was measured and the mean wall thickness calculated.Wall/outer wall ratio was used as a normalized wall index (NWI) adjusted for artery size difference among participants. Percent wall volume (PWV) was calculated as NWI ×100.Results In this asymptomatic cohort (mean age: 76 years), the mean (SD) aortic wall area andwall thicknesswere 222 ±45 mm2 and 2.7 ±0.4 mm, respectively. Maximum wall thickness was 3.4 ±0.6 mm, and PWV was 32% ±4%. Women appeared to have smaller wall area,but after correcting for their smaller artery size, had significantly higher PWV than men (P = 0.03). Older age was associatedwith larger wall area (P = 0.04 for trend) with similar PWVs. However, there were no statistically significant associations between standard risk factors,Framingham global risk, or metabolic syndrome status, therapy for cholesterol or hypertension, coronary or aortic calcium score, and the aortic wall burden. Aortic calcificationwas associated with coronary calcification. Conclusions Asymptomatic elderly in this cohort had a greater descending thoracic aortic wall volume that correlated with age, andwomen had a significantly increased PWV compared to men. In these survivors, the atherosclerotic aortic wall burden was not significantly associated with traditional risk factors or with coronary or aortic calcium scores or coronary calcium progression. Results suggest that age, or as yet unidentified risk factor(s), may be responsible for the increase in atherosclerosis. | Michael A. Chen Miwa Kawakubo Patrick M. Colletti Dongxiang Xu Laurie LaBree Dustin Robert Detrano Stanley P Azen Nathan D. Wong Xue-Qiao Zhao | 2013 | Journal of Geriatric Cardiology2013，10，2： | 6 |
| 2 | Is Pulse Pressure Useful in Predicting Risk for Coronary Heart Disease? The Framingham Heart Study显示文摘 | Stanley S. Franklin Shehzad A. Khan Nathan D. Wong Martin G. Larson Daniel Levy | 1999 | Circulation1999，，4： | 3 |
| 3 | Basic Science显示文摘 | Nathan D. Wong Stanley S. Franklin | 2014 | Journal of the American Society of Hypertension2014，，10： | 1 |
| 4 | The Association of Framingham and Reynolds Risk Scores With Incidence and Progression of Coronary Artery Calcification in MESA (Multi-Ethnic Study of Atherosclerosis)显示文摘 | Andrew P. DeFilippis Michael J. Blaha Chiadi E. Ndumele Matthew J. Budoff Donald M. Lloyd-Jones Robyn L. McClelland Susan G. Lakoski Mary Cushman Nathan D. Wong Roger S. Blumenthal Joao Lima Khurram Nasir | 2011 | Journal of the American College of Cardiology2011，，20： | 1 |
| 5 | Impact of the Metabolic Syndrome on Mortality From Coronary Heart Disease, Cardiovascular Disease, and All Causes in United States Adults显示文摘 | Shaista Malik Nathan D. Wong Stanley S. Franklin Tripthi V. Kamath Gilbert J. L’Italien Jose R. Pio G Rhys Williams | 2004 | Circulation2004，，10： | 1 |
| 6 | Weight change modulates epicardial fat burden: A 4-year serial study with non-contrast computed tomography显示文摘 | Ryo Nakazato Ronak Rajani Victor Y. Cheng Haim Shmilovich Rine Nakanishi Yuka Otaki Heidi Gransar Piotr J. Slomka Sean W. Hayes Louise E.J. Thomson John D. Friedman Nathan D. Wong Leslee J. Shaw Matthew Budoff Alan Rozanski Daniel S. Berman Damini Dey | 2011 | Atherosclerosis2011，，1： | 1 |
| 7 | Threshold for the Upper Normal Limit of Indexed Epicardial Fat Volume: Derivation in a Healthy Population and Validation in an Outcome-Based Study显示文摘 | Haim Shmilovich Damini Dey Victor Y. Cheng Ronak Rajani Ryo Nakazato Yuka Otaki Rine Nakanishi Piotr J. Slomka Louise E.J. Thomson Sean W. Hayes John D. Friedman Heidi Gransar Nathan D. Wong Leslee J. Shaw Matthew Budoff Alan Rozanski Daniel S. Berman | 2011 | The American Journal of Cardiology2011，，11： | 1 |
| 8 | Does the Relation of Blood Pressure to Coronary Heart Disease Risk Change With Aging?: The Framingham Heart Study显示文摘 | Stanley S. Franklin Martin G. Larson Shehzad A. Khan Nathan D. Wong Eric P. Leip William B. Kannel Daniel Levy | 2001 | Circulation: Journal of the American Heart Association2001，，9： | 1 |
| 9 | Single Versus Combined Blood Pressure Components and Risk for Cardiovascular Disease: The Framingham Heart Study显示文摘 | Stanley S. Franklin Victor A. Lopez Nathan D. Wong Gary F. Mitchell Martin G. Larson Ramachandran S. Vasan Daniel Levy | 2009 | Circulation2009，，2： | 1 |
| 10 | Predominance of Isolated Systolic Hypertension Among Middle-Aged and Elderly US Hypertensives: Analysis Based on National Health and Nutrition Examination Survey (NHANES) III显示文摘 | Stanley S. Franklin Milagros J. Jacobs Nathan D. Wong Gilbert J. L’Italien Pablo Lapuerta | 2001 | Hypertension: Journal of the American Heart Association2001，，3： | 1 |
| 11 | Is Pulse Pressure Useful in Predicting Risk for Coronary Heart Disease? The Framingham Heart Study显示文摘 | Stanley S. Franklin Shehzad A. Khan Nathan D. Wong Martin G. Larson Daniel Levy | 1999 | Circulation1999，，4： | 1 |
| 12 | Hemodynamic Patterns of Age-Related Changes in Blood Pressure: The Framingham Heart Study显示文摘 | Stanley S. Franklin William Gustin Nathan D. Wong Martin G. Larson Michael A. Weber William B. Kannel Daniel Levy | 1997 | Circulation1997，，1： | 1 |
| 13 | Computed Tomographic Angiography Characteristics of Atherosclerotic Plaques Subsequently Resulting in Acute Coronary Syndrome显示文摘 | Sadako Motoyama Masayoshi Sarai Hiroto Harigaya Hirofumi Anno Kaori Inoue Tomonori Hara Hiroyuki Naruse Junichi Ishii Hitoshi Hishida Nathan D. Wong Renu Virmani Takeshi Kondo Yukio Ozaki Jagat Narula | 2009 | Journal of the American College of Cardiology2009，，1： | 1 |
| 14 | Serial Coronary CT Angiography–Verified Changes in Plaque Characteristics as an End Point显示文摘 | Kaori Inoue Sadako Motoyama Masayoshi Sarai Takahisa Sato Hiroto Harigaya Tomonori Hara Yoshihiro Sanda Hirofumi Anno Takeshi Kondo Nathan D. Wong Jagat Narula Yukio Ozaki | 2010 | JACC: Cardiovascular Imaging2010，，： | 1 |
| 15 | Comparative Value of Coronary Artery Calcium and Multiple Blood Biomarkers for Prognostication of Cardiovascular Events显示文摘 | Jamal S. Rana Heidi Gransar Nathan D. Wong Leslee Shaw Michael Pencina Khurram Nasir Alan Rozanski Sean W. Hayes Louise E. Thomson John D. Friedman James K. Min Daniel S. Berman | 2012 | The American Journal of Cardiology2012，，10： | 1 |
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