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| 1 | Erlotinib usage after prior treatment with gefitinib in advanced non-small cell lung cancer: A clinical perspective and review of published literature显示文摘Erlotinib and gefitinib are among the most widely researched, used and available molecularly targeted therapies for treatment of advanced non-small cell lung cancer(NSCLC). They are both tyrosine kinase inhibitors(TKIs) of the epidermal growth factor receptor(EGFR). In the past decade, there have been reports on clinical benefit from use of erlotinib after gefitinib failure in NSCLC patients. A review of published literature on this focussed topic is provided herein. Pooled analysis of published literature shows that majority of patients were female(60.6%), non-smokers(64.5%), had adenocarcinoma histology(88.3%) and were of East Asian ethnicity(92.3%). Presence of sensitizing EGFR mutation was detected in 48.4% of subjects. Disease control rates with prior gefitinib therapy and with subsequent erlotinib treatment were 79.4% and 45.4% respectively. Based upon our review, the most important predictive factor for clinical benefit from erlotinib identified was previous response to gefitinib. The exact explanations for the potential benefit from erlotinib use in this patient population is still not known and further studies are required to determine the role of molecular mechanismsespecially those related to resistance to initial EGFR TKI therapy. | Navneet Singh Aditya Jindal Digambar Behera | 2014 | World Journal of Clinical Oncology2014，5，5： | 5 |
| 2 | 采用延性损伤模型和数值方法预测Ni-Cr基合金在温成形条件下的断裂极限显示文摘为了确定IN625合金的安全成形和断裂极限,在300和673 K下分别进行拉伸成形和深拉延成形实验。将实验获得的基于应力的断裂成形极限图(FFLD)转变为基于应力的σ-FFLD和有效塑性应变(EPS)跟三轴度(η)的关系曲线,以消除断裂极限对应变的过度依赖。为了预测断裂极限,校准7种不同的损伤模型。结果显示,Oh模型对断裂轨迹的预测能力最好,绝对误差最小。虽然实验得到的断裂极限仅用于数值分析,但没有一个损伤模型预测整个应力三轴度范围(0.33<η<0.66)的断裂应变。在不同的温度和润滑条件下深拉延成形圆柱杯,深拉延工艺窗口有助于确定起皱、安全和断裂区域。在润滑条件下,673 K时达到最大的拉延比2。利用Hill 1948各向异性屈服函数对拉伸成形和深拉延成形过程的数值预测结果均在可接受的误差范围内。 | Ayush MORCHHALE Anand BADRISH Nitin KOTKUNDE Swadesh Kumar SINGH Navneet KHANNA Ambuj SAXENA Chetan NIKHARE | 2021 | Transactions of Nonferrous Metals Society of China2021，31，8： | 3 |
| 3 | Interconversion of two commonly used performance tools: An analysis of 5844 paired assessments in 1501 lung cancer patients显示文摘AIM To establish the Karnofsky performance status(KPS) categories which would facilitate the interconversion of the KPS scale to the Eastern Cooperative Oncology Group(ECOG) performance status(PS) scale.METHODS This was a retrospective analysis of all patients attending the lung cancer clinic at a tertiary care center over a 5-year period(September 2009 to August 2014). All patients were assessed with both KPS and ECOG PS scales at each visit. Correlation between KPS and ECOG PS was assessed using Spearman's correlation coefficient. KPS categories equivalent to ECOG PS scores were compared using hit rate and weighted kappa(κw).RESULTS A total of 1501 patients were assessed over the study period, providing 5844 paired KPS and ECOG PS assessments. The study cohort had a mean(standard deviation; SD) age of 58.4(10.8) years, with the majority being current or ex-smokers(76.9%) and males(82.3%). Non-small cell lung cancer was the most common histological type(n = 1196, 79.7%) with the majority having advanced(stage ⅢB/Ⅳ) disease(83.4%). Mean baseline KPS and ECOG PS scores were 77.6(SD = 14.4) and 1.5(SD = 1) respectively. The most frequent KPS score was 80(29%), and the most frequent ECOG PS score was 1(43%). The overall correlation between KPS and ECOG PS was good(Spearman r =-0.84, P < 0.0001) but ranged from-0.727 to-0.972 between visits. KPS categories derived from our cohort [10-40(ECOG 4), 50-60(ECOG 3), 70(ECOG 2), 80-90(ECOG 1), 100(ECOG 0)] performed better [hit rate 78.1%, κw = 0.749(0.736-0.762) P < 0.0001] than those suggested in the past literature.CONCLUSION The current study provides the largest set of paired KPS-ECOG assessments to date. We suggest that the KPS categories 10-40, 50-60, 70, 80-90, and 100 are equivalent to ECOG PS categories of 4, 3, 2, 1, and 0 respectively. | Kuruswamy Thurai Prasad Harpreet Kaur Valliappan Muthu Ashutosh Nath Aggarwal Digambar Behera Navneet Singh | 2018 | World Journal of Clinical Oncology2018，9，7： | 2 |
| 4 | Noradrenaline vs. terlipressin in the treatment of hepatorenal syndrome: A randomized study显示文摘 | Virendra Singh Souvik Ghosh Baljinder Singh Pradeep Kumar Navneet Sharma Ashish Bhalla A.K. Sharma N.S. Choudhary Yogesh Chawla C.K. Nain | 2012 | Journal of Hepatology2012，，6： | 2 |
| 5 | Midodrine in patients with cirrhosis and refractory or recurrent ascites: A randomized pilot study显示文摘 | Virendra Singh Sahdeb P. Dhungana Baljinder Singh Rajesh Vijayverghia Chander K. Nain Navneet Sharma Ashish Bhalla Pramod K. Gupta | 2011 | Journal of Hepatology2011，，2： | 1 |
| 6 | Extrapulmonary small cell carcinoma of lymph node: Pooled analysis of all reported cases显示文摘AIM: To study clinical outcomes and management of lymph nodes extrapulmonary small cell carcinoma(LNEPSCC). METHODS: Herein, we perform a systematic search of published literature in the PubMed and EMBASE databases for studies describing LNEPSCC. For uniformity of reporting, LNEPSCC was staged as limited if it involved either single lymph node station or if surgery with curative intent had been undertaken. The disease was staged extensive if it involved two or more lymph node regions.RESULTS: The systematic literature review yielded eight descriptions(n = 14) involving cervical, submandibular and inguinal lymph nodes. Eleven(64.7%) patients had limited disease(LD) and six(35.3%) had extensive disease(ED) at presentation. Chemotherapy(n = 6, 35.3%) or surgery(n = 4, 23.5%) were the most common form of treatment given to these patients. Complete response was achieved in 12(70.6%) of the patients. Median(interquartile range) progression free survival and overall survival was 15(7-42) mo and 22(12.75-42) mo respectively. Of the three illustrative cases, two patients each had ED at presentation and achieved complete remission with platinum based combination chemotherapy.CONCLUSION: LNEPSCC is a rare disease with less than 15 reported cases in world literature. Surgical resection with curative intent is feasible in those with LD while platinum based combination chemoradiation is associated with favorable outcomes in patients with ED. Prognosis of LNEPSCC is better than that of small cell lung cancer in general. | Inderpaul Singh Sehgal Harpreet Kaur Sahajal Dhooria Amanjit Bal Nalini Gupta Digambar Behera Navneet Singh | 2016 | World Journal of Clinical Oncology2016，7，3： | 1 |
| 7 | Noradrenaline vs terlipressin in the treatment of type 2 hepatorenal syndrome: a randomized pilot study显示文摘 | Saubhik Ghosh Narendra S. Choudhary Arun K. Sharma Baljinder Singh Pradeep Kumar Ritesh Agarwal Navneet Sharma Ashish Bhalla Yogesh K. Chawla Virendra Singh | 2013 | Liver Int2013，，8： | 1 |
| 8 | Productivity and nutrient uptake of newly released wheat varieties at different sowing times under poplar plantation in north-western India显示文摘 | R. I. S. Gill Baljit Singh Navneet Kaur | 2009 | Agroforestry Systems2009，，： | 1 |
| 9 | Purification and characterization of alkaline cellulose produced by a novel isolate, Bacillus sphaericusJS1 显示文摘 | Jagtar Singh Navneet Batra Ranbir Chander Sobti | 2004 | Journal of Industrial Microbiology and Biotechnology2004，31，2： | 1 |
| 10 | Quality - of - life assessment in trials of lung cancer显示文摘 | Navneet Singh Ritesh Agarwal Ashutosh N Aggarwal | 2007 | Lancet2007，370，9591： | 1 |
| 11 | microRNAs : role in leukemia and their computational perspective显示文摘 | Ankur Omer Poonam Singh Navneet Kumar Yadav Rama Kant Singh | 2015 | WIREs RNA2015，，： | 1 |
| 12 | Clear-water scour depth below underwater pipelines显示文摘 | Subhasish Dey Navneet P Singh | 2007 | Research2007，2，1： | 1 |
| 13 | Clinical out- comes in non-small-cell lung cancer in relation to expression of pre- dictive and prognostic biomarkers显示文摘 | Navneet Singh Amanjit Bal Ashutosh N Aggarwal | 2010 | Future Oncology2010，6，5： | 1 |
| 14 | Optimization of CMOS Repeater Driven Interconnect RC Line Using Genetic Algorithm显示文摘In this work, optimization of complementary metal oxide semiconductor(CMOS) repeater driven interconnect resistive-capacitive(RC) line is carried out using genetic algorithm(GA). This work is aimed at powerdelay-product(PDP) minimization of RC interconnect at 180 nm technology node. The algorithm simultaneously optimizes the values of supply voltage, number of repeaters and repeater width for delay and PDP minimization.The accuracy of results obtained is verified by simulations from Cadence virtuoso tool. For delay minimization,comparison of GA results with previous results of the literature shows an improvement of 44.4% in the value of the optimal number of repeaters required. This improvement is obtained by increasing the repeater size, which also increases power dissipation, so a tradeoff has also been achieved in terms of PDP minimization. The comparison of PDP results obtained in this work, with the results at 70, 100, and 130 nm technologies from literature shows improvement in optimal number of repeaters required. The results of algorithm and simulations are in good agreement and demonstrate the validity of proposed algorithm. | KAUR Jasmeet GILL Sandeep Singh KAUR Navneet | 2017 | Journal of Shanghai Jiaotong university(Science)2017，22，2： | 0 |
| 15 | Extracellular Vesicles and Their Significance in COVID-19显示文摘Over the last few years,there is huge scientific attention towards the research related to Extracellular Vesicles(EVs),because of their unique property of inter cellular communications and effective biological significance in diagnosis and therapy[1].Extracellular Vesicles are lipid bilayer membrane bound biological entity,which contains different bioactive compounds(cargoes)such as microRNAs(miRNAs),mRNAs,proteins,and lipids.Based on their origin and size,EVs have been categorized into three different types(a)Exosomes(40 nm-150 nm)are smallest EVs,which are synthesized by endocytic pathways in the cells and secreted in extracellular space through exocytosis process,(b)Microvesicles are secreted from direct budding off plasma membranes and their size varying from 50 nm to 1000 nm and,(c)Apoptotic bodies are formed during apoptotic cell death process and respectively larger in size>1000 nm[1-3].EVs have been identified using different markers,that includes tetraspanins proteins(CD9,CD63,CD81,and CD83),endosomal sorting complexes required for transport(TSG101,Alix),heat shock proteins(Hsp60,Hsp70,Hsp90),and Rab proteins(RAB27a/b)[1]. | Sanjay Kumar Soumi Sadhu Himanshu Narayan Singh Navneet Kumar Dubey Nikhil Kumar Prashant Kumar Tiwari Rajan Malhotra Himani Sharma | 2022 | Advances in Human Physiology Research2022，4，1： | 0 |
| 16 | Responding to fire in an intensive care unit: Management and lessons learned显示文摘Healthcare institutions are vulnerable to disruptionfrom events such as earthquakes, fires, and floods, andthe damage incurred can endanger the lives of patientsin the hospital.[1] In this type of scenario hospital staffhave primary responsibility for the hospitalized patients'safety, since patients are neither fit to respond to sucha disaster, nor do they know how to respond.[2,3] Thesituation becomes more difficult and challenging if thedisaster occurs in critical care areas such as intensivecare units (ICUs) and operating rooms. | Navneet Dhaliwal Ranjitpal Singh Bhogal Ashok Kumar Anil Kumar Gupta | 2018 | World Journal of Emergency Medicine2018，9，2： | 0 |
| 17 | Coagulopathy reversal in intracerebral haemorrhage显示文摘As intracerebral hemorrahge becomes more frequent as a result of an aging population with greater comorbidities,rapid identification and reversal of precipitators becomes increasingly paramount.The aformentioned population will ever more likely be on some form of anticoagulant therapy.Understanding the mechanisms of these agents and means by which to reverse them early on is critical in managing the acute intracerebral hemorrhage. | Alexander Jacob Sweidan Navneet Kaur Singh Joseph Luke Conovaloff Matthew Bower Leonid I Groysman Mohammad Shafie Wengui Yu | 2020 | Stroke & Vascular Neurology2020，5，1： | 0 |
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