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| 1 | Viral-Human Chimeric Transcript Predisposes Risk to Liver Cancer Development and Progression显示文摘 | Chi-Chiu Lau Tingting Sun Arthur K.K. Ching Mian He Jing-Woei Li Alissa M. Wong Ngai Na Co Anthony W.H. Chan Pik-Shan Li Raymond W.M. Lung Joanna H.M. Tong Paul B.S. Lai Henry L.Y. Chan Ka-Fai To Ting-Fung Chan Nathalie Wong | 2014 | Cancer Cell2014，，3： | 2 |
| 2 | Cervical priming with oral misoprostol in pre-labor rupture of membranes at term显示文摘 | Ngai SW TO WK Lao T | 1996 | Obstet Ggnecol1996，87，6： | 1 |
| 3 | Microgel particles at the fluid-fluid interfaces显示文摘 | Li Zifu Ngai To | 2013 | Nanoscale2013，5，4： | 1 |
| 4 | Microgel particles at the fluid-fluid interfaces显示文摘 | Li Zifu Ngai To | 2013 | Nanoscale2013，5，4： | 1 |
| 5 | Cervical priming with oral misoprostol in pre-labor rupture of membranes at terrm显示文摘 | Ngai SW To WK Lao T | 1996 | Obstet Gynecol1996，87，： | 1 |
| 6 | Hollow magnetic Janus microspheres templated from double Pickering emul- sions显示文摘 | Ning Yin Wang Chaoyang Ngai To | 2012 | RSC Advances2012，2，13： | 1 |
| 7 | Cervical priming with oral misoprostol in pre-labor rupture of membranes at term 显示文摘 | Ngai SW To WK Lao T | 1996 | Obstet Gynecol1996，87，6： | 1 |
| 8 | Cervical priming with oral misoprostol in pre-labor rupture of membranes at term显示文摘 | TO WK Lao T | 1996 | Obstet Ggnecol1996，87，6： | 1 |
| 9 | Reaction-controlled microgel-lipase co-stabilized compartmentalized emulsion for recyclable biodiesel production显示文摘Pickering emulsions have been widely used for biphasic catalysis in the past decade.However,it remains a great challenge to achieve simple product collection and enzyme recovery.Poly(N-isopropylacrylamide)(PNIPAM)-based microgels can endow Pickering emulsions with stimuli-responsiveness,while most microgelstabilized emulsions are oil-in-water(O/W)type and not ideal for interfacial catalysis.Besides,altering temperature or pH value for demulsification is time-and energy-consuming and may cause irreversible deactivation of enzymes.In this work,inverse water-in-oil(W/O)Pickering emulsions were formed using hexanoic acidswollen microgels as the sole emulsifiers.When lipase was added in the water phase,stable oil-in-water-in-oil(O/W/O)Pickering double emulsions could be formed through one-step emulsification,owing to the synergistic effect of the hydrophobic microgels and hydrophilic lipase at the interface.Compared with other biphasic systems,such double emulsion systems represent a desirable platform for highly efficient biodiesel production because of the ultra-high interfacial areas and fast mass transport between two phases.More importantly,the switchable transition between hydrophobicity/hydrophilicity of microgels is controlled by the catalytic reaction.Therefore,double emulsions demulsify spontaneously when substrates are used up without the need for energy input or loss of enzymatic activity,enabling the facile collection of products and demonstrating the excellent recyclability of the biphasic catalysis system. | Xin Guan Zhili Wan To Ngai | 2023 | Aggregate2023，4，3： | 0 |
| 10 | Inside-out assembly of viral antigens for the enhanced vaccination显示文摘Current attempts in vaccine delivery systems concentrate on replicating the natural dissemination of live pathogens,but neglect that pathogens evolve to evade the immune system rather than to provoke it.In the case of enveloped RNA viruses,it is the natural dissemination of nucleocapsid protein(NP,core antigen)and surface antigen that delays NP exposure to immune surveillance.Here,we report a multi-layered aluminum hydroxide-stabilized emulsion(MASE)to dictate the delivery sequence of the antigens.In this manner,the receptor-binding domain(RBD,surface antigen)of the spike protein was trapped inside the nanocavity,while NP was absorbed on the outside of the droplets,enabling the burst release of NP before RBD.Compared with the natural packaging strategy,the inside-out strategy induced potent type I interferon-mediated innate immune responses and triggered an immune-potentiated environment in advance,which subsequently boosted CD40+DC activations and the engagement of the lymph nodes.In both H1N1 influenza and SARS-CoV-2 vaccines,rMASE significantly increased antigen-specific antibody secretion,memory T cell engagement,and Th1-biased immune response,which diminished viral loads after lethal challenge.By simply reversing the delivery sequence of the surface antigen and core antigen,the inside-out strategy may offer major implications for enhanced vaccinations against the enveloped RNA virus. | Fengqiang Cao Sha Peng Yaling An Kun Xu Tianyi Zheng Lianpan Dai Kenji Ogino To Ngai Yufei Xia Guanghui Ma | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 11 | Dielectric Investigations on How Mg Salt Is Dispersed in and Released from Polylactic Acid显示文摘Composite biomaterials made of biodegradable polylactic acid(PLA) and bioactive magnesium(Mg) salt are developed for orthopaedic implants or metal implant coatings. The releasing of Mg salt into the biological environment benefits the bone growth, while with the releasing of Mg salt and degradation of PLA there forms a porous scaffold for tissue engineering. The size and morphology of the salt and voids are adjustable with such preparation conditions as salt content, pH of casting solution, and the solidification rate, so that we can control the salt releasing and degradation rate of PLA. Dielectric spectroscopy is used to investigate the dispersive structures of Mg salt and voids in the polymer matrix and to monitor the in situ releasing of Mg salts in the simulated body fluid(SBF). The current study provides us with an orthopedic biomaterial with controllable multi-phase structures, and a tool to investigate the in vivo behaviors of biomaterials. | Yu-jie Cao 朱丹 To Ngai Ling Qin Chi Wu Jian Shen | 2014 | Chinese Journal of Polymer Science2014，32，4： | 0 |
| 12 | DIRECT MEASUREMENT OF WEAK DEPLETION FORCE BETWEEN TWO SURFACES显示文摘在胶体的粒子和聚合物分子的混合物,如果聚合物分子的尺寸比 interparticle 分离大,粒子可以经历吸引人的弄空力量。这是因为如果他们在粒子之间留下来,单个聚合物分子比他们逃离内部粒子的空间的经历更少的 conformational 熵,它导致渗透的压力不平衡在内并且在差距外面并且导致 interparticle 吸引力。自从 1980 年代,这弄空力量是几研究的题目,但是当它要求 k B T 并且在以外的顺序的精力变化的察觉,这力量的直接测量仍然是试验性地挑战性的。我们在场这里,我们使用全部的内部思考显微镜学(TIRM ) 直接测量在一个免费动人的粒子和一座公寓之间的相互作用的结果在由小水溶性的器官的分子或聚合表面活化剂组成的答案出现。我们的结果显示那稳定的 nanobubbles (ca。150 nm ) 存在在上述水的答案免费。更重要地,如此的 nanobubbles 的存在导致在球形的粒子和扁平的表面之间的一个吸引力。用 TIRM,我们能直接与一个范围测量如此的弱相互作用直到 100 nm。而且,我们证明由作为一个弄空的代理人采用 thermo 敏感的 microgel 粒子,我们对份量上措施有能力并且 reversibly 作为解决方案 pH 的功能控制 k B T 规模弄空吸引力。 | Xiang-jun Gong Xiao-chen Xing Xiao-ling Wei To Ngai | 2011 | Chinese Journal of Polymer Science2011，29，1： | 0 |
| 13 | Pickering emulsions stabilized by biocompatible particles:A review of preparation,bioapplication,and perspective显示文摘The phenomenon of adsorption of solid particles at fluid interfaces to stabilize emulsions or foams have been known for more than a century.Today,particle-stabilized emulsions,often referred to as Pickering emulsions,are receiving growing attention as they are encountered in oil recovery and have long been used in personal care products and food industry.Over the past 10 years the focus of the Pickering emulsion has also increasingly shifted to biomedical applications with thanks to novel syntheses of a wide range of biocompatible particle stabilizers.Here,a brief overview of the development of biocompatible particles is given for Pickering emulsion stabilization,including alginate,poly(lactic-co-gIycolic acid)(PLGA),and protein-based particles.The materials prepared by templating from emulsion stabilized with biocompatible particles include colloidal capsules and hierarchically porous materials.It is hoped that the understanding gained from the recent intense activity in the field will enable more researchers to modify existing materials and design new formulations,which would be beneficial for exploring more biological applications. | Tong Zhang Fuguo Liu Jie Wu To Ngai | 2022 | Particuology2022，20，5： | 0 |
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