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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | The willow genome and divergent evolution from poplar after the common genome duplication显示文摘 | Xiaogang Dai Quanjun Hu Qingle Cai Kai Feng Ning Ye Gerald A Tuskan Richard Milne Yingnan Chen Zhibing Wan Zefu Wang Wenchun Luo Kun Wang Dongshi Wan Mingxiu Wang Jun Wang Jianquan Liu Tongming Yin | 2014 | Cell Research2014，24，10： | 28 |
| 3 | Climate change regionalization in China(1961–2010)显示文摘Since climatic condition is the important foundation for human subsistence and development and the key factor in sustainable development of economy and society, climate change has been a global issue attracting great attentions of politicians, scientists, governments, and the public alike throughout the world. Existing climate regionalization in China aims to characterize the regional differences in climate based on years of the mean value of different climate indexes. However, with the accelerating climate change nowadays, existing climate regionalization cannot represent the regional difference of climate change, nor can it reflect the disasters and environmental risks incurred from climate changes. This paper utilizes the tendency value and fluctuation value of temperature and precipitation from 1961 to 2010 to identify the climate change quantitatively, and completes the climate change regionalization in China(1961–2010) with county administrative regionalization as the unit in combination with China's terrain feature. Level-I regionalization divides China's climate change(1961–2010) into five tendency zones based on the tendency of temperature and precipitation, which are respectively Northeast China-North China warm-dry trend zone, East China-Central China wet-warm trend zone, Southwest China-South China dry-warm trend zone, Southeast Tibet-Southwest China wet-warm trend zone, and Northwest China-Qinghai-Tibet Plateau warm-wet trend zone; level-II regionalization refers to fourteen fluctuation regions based on level-I regionalization according to the fluctuation of temperature and precipitation. | SHI PeiJun SUN Shao WANG Ming LI Ning WANG JingAi JIN YunYun GU XiaoTian YIN WeiXia | 2014 | Science China Earth Sciences2014，57，11： | 22 |
| 4 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 5 | miR-27b inhibits gastric cancer metastasis by targeting NR2F2显示文摘增加的注意在癌症过程集中于 miRNAs 的下面规定。原子受体亚科 2 (NR2F2,也作为 COUP-TFII 知道) 涉及癌症的许多类型的发展,但是它在胃的癌症的角色留下逃犯。在这个实验, oncomine 和 Kaplan-meier 数据库表明 NR2F2 在胃的癌症是起来调整的并且高 NR2F2 表示贡献了差的幸存。MicroRNA-27b 被指向并且由在人的胃的癌症纸巾和房间的 NR2F2 下面调整。miR-27b 的宫外的表示在 vitro 并且在 vivo 禁止了胃的癌症房间增长和肿瘤生长。试金建议 miR-27b 的 overexpression 能支持 MGC-803 房间移植和侵略并且延迟他们的转移到肝。另外, miR-27b 的下面规定在 vitro 提高了 GES-1 房间增长和转移。这些调查结果表明 miR-27b 为改进病人是在胃的癌症和 biomarker 的肿瘤 suppressor 幸存。 | Qingzhao Feng Xionglin Wu Fuchao Li Beibei Ning Xiaofeng Lu Yin Zhang Ying Pan Wenxian Guan | 2017 | Protein & Cell2017，8，2： | 16 |
| 6 | 中国道路交通死亡率:2006—2016年国家疾病监测数据分析显示文摘可持续发展目标(SDG)3.6旨在2020年将全球道路交通事故伤亡人数减半。本研究目的在于评价中国2006—2016年降低道路交通伤害死亡率的进展。采用国家死因监测系统数据,用标准误计算粗率和年龄标准化死亡率,采用断点回归分析评价和量化2006—2016年整体和亚组道路交通死亡率的趋势。 | Wang L Ning P Yin P 李若曈(编译) 胡国清(编译) | 2019 | 中华预防医学杂志2019，53，9： | 15 |
| 7 | Epidemiological Data of Work-Related Musculoskeletal Disorders—China,2018–2020显示文摘Summary What is already known about this topic?In recent decades,work-related musculoskeletal disorders(WMSDs)have become increasingly prominent and have become an important issue that is of universal concern and an urgent need to be solved in all countries of the world.What is added by this report?The top three industries or occupational groups with the highest standardized prevalence rate of WMSDs were flight attendants,medical staff,and vegetable greenhouses in that order.Women workers were 1.5 times more likely to suffer from WMSDs than men workers. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2021 | China CDC weekly2021，3，18： | 13 |
| 8 | A study on arsenic trioxide inducing in vitro apoptosis of gastric cancer cell lines显示文摘INTRODUCTION Cell apoptosis,which involves the biologic regulation of the numbers and vital activity of cells,is an important metaboloc process in both normal cells and tumor cells. | Qin Long Gu Ning Li Li Zheng Gang Zhu Hao Ran Yin Yan Zhen Lin | 2000 | World Journal of Gastroenterology2000，6，3： | 12 |
| 9 | Alfalfa-containing diets alter luminal microbiota structure and short chain fatty acid sensing in the caecal mucosa of pigs显示文摘Background: Pork produced by outdoor-reared pigs raised mostly on alfalfa pastures attracts increasing population of consumer from most of the world. In China, pigs were raised with alfalfa-containing diets to seek for good quality pork.However, the influence of dietary alfalfa involving high level of insoluble dietary fiber(IDF) on pig intestinal luminal microbiota composition remains unclear. The objective of this study was to investigate the effects of alfalfa on luminal microbiota and short chain fatty acids(SCFA) production, and gene expressions involved in SCFA sensing, transporting and absorbing in pig caecal mucosa.Results: Twenty-four growing pigs were randomly allotted to four diets containing 0%, 5%, 10% and 15% alfalfa meal for a 28-d experiment. Ingestion of alfalfa meal-contained diets significantly increased the ratio of body weight gain to feed consumption. Illumina MiS eq sequencing of the V3 region of the 16 S r RNA genes showed that alfalfa-containing diet significantly decreased the relative abundance of genera Turicibacter, Acidiphilium, Paracoccus, Propionibacterium,Corynebacterium, Pseudomonas, Acinetobacter, and Staphylococcus, and increased the relative abundance of genera Lachnospira, Marvinbryantia, and Desulfovibrio in the caecal digesta. Butyrate concentration was significantly increased in the hindgut by the supplementation of alfalfa meal in diets. The m RNA gene expressions of FFAR3, SMCT1, MCT1,PYY, and GCG were significantly increased in the caecal mucosa of pigs fed alfalfa meal.Conclusions: Our results suggested that alfalfa-containing diet has exerted significant impacts on caecal microbiota composition, butyrate concentration and significantly upregulated m RNA expression of host caecal mucosal genes involved in SCFA sensing and absorption as well as regulation of satiety. | Jiawei Wang Chunfu Qin Ting He Kai Qiu Wenjuan Sun Xin Zhang Ning Jiao Weiyun Zhu Jingdong Yin | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 12 |
| 10 | Vam3, a derivative of resveratrol, attenuates cigarette smoke-induced autophagy显示文摘瞄准: 估价 Vam3 (Amurensis H ) 的功效, resveratrol 的二聚的衍生物,在禁止香烟导致烟的 autophagy。 | Ji SHI Ning YIN Ling-ling XUAN Chun-suo YAO Ai-min MENG Qi HOU | 2012 | Acta Pharmacologica Sinica2012，33，7： | 12 |
| 11 | Puerarin ameliorated pressure overload-induced cardiac hypertrophy in ovariectomized rats through activation of the PPARα/PGC-1 pathway显示文摘Estrogen deficiency induces cardiac dysfunction and increases the risk of cardiovascular disease in postmenopausal women and in those who underwent bilateral oophorectomy.Previous evidence suggests that puerarin,a phytoestrogen,exerts beneficial effects on cardiac function in patients with cardiac hypertrophy.In this study,we investigated whether puerarin could prevent cardiac hypertrophy and remodeling in ovariectomized,aortic-banded rats.Female SD rats subjected to bilateral ovariectomy(OVX)plus abdominal aortic constriction(AAC).The rats were treated with puerarin(50 mg·kg^(−1)·d^(−1),ip)for 8 weeks.Then echocardiography was assessed,and the rats were sacrificed,their heart tissues were extracted and allocated for further experiments.We showed that puerarin administration significantly attenuated cardiac hypertrophy and remodeling in AAC-treated OVX rats,which could be attributed to activation of PPARα/PPARγcoactivator-1(PGC-1)pathway.Puerarin administration significantly increased the expression of estrogen-related receptorα,nuclear respiratory factor 1,and mitochondrial transcription factor A in hearts.Moreover,puerarin administration regulated the expression of metabolic genes in AAC-treated OVX rats.Hypertrophic changes could be induced in neonatal rat cardiomyocytes(NRCM)in vitro by treatment with angiotensin Ⅱ(Ang Ⅱ,1μM),which was attenuated by co-treatemnt with puerarin(100μM).We further showed that puerarin decreased Ang Ⅱ-induced accumulation of non-esterified fatty acids(NEFAs)and deletion of ATP,attenuated the Ang II-induced dissipation of the mitochondrial membrane potential,and improved the mitochondrial dysfunction in NRCM.Furthermore,addition of PPARαantagonist GW6471(10μM)partially abolished the anti-hypertrophic effects and metabolic effects of puerarin in NRCM.In conclusion,puerarin prevents cardiac hypertrophy in AAC-treated OVX rats through activation of PPARα/PGC-1 pathway and regulation of energy metabolism remodeling.This may provide a new approach to prevent the development of heart failure in postmenopausal women. | Ning Hou Yin Huang Shao-ai Cai Wen-chang Yuan Li-rong Li Xia-wen Liu Gan-jian Zhao Xiao-xia Qiu Ai-qun Li Chuan-fang Cheng Shi-ming Liu Xiao-hui Chen Dao-feng Cai Jing-xuan Xie Min-sheng Chen Cheng-feng Luo | 2021 | Acta Pharmacologica Sinica2021，42，1： | 11 |
| 12 | Investigation on Work-Related Musculoskeletal Disorders--China, 2018−2019显示文摘What is already known about this topic?Work-related musculoskeletal disorders(WMSDs)have a high prevalence and seriously harmful,which has attracted extensive attention in various countries in the world.Currently,the occurrence and rules of WMSDs in key industries are not known in China.What is added by this report?The prevalence of WMSDs is relatively high among professional populations in key industries in China,with the most commonly affected body parts concentrated in neck,shoulders,and low back and increasing with age and working years.What are the implications for public health practice?This study determined the prevalence and distribution characteristics of WMSDs in key industries in China and provided scientific evidence to recommend for inclusion of WMSDs in the new revision of the list of occupational diseases in China. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2020 | China CDC weekly2020，2，18： | 11 |
| 13 | Recent progress on the recycling technology of Li-ion batteries显示文摘Lithium-ion batteries(LIBs)have been widely applied in portable electronic devices and electric vehicles.With the booming of the respective markets,a huge quantity of spent LIBs that typically use either LiFePO_(4) or Li N_(x)Co_(y)Mn_(z)O_(2) cathode materials will be produced in the very near future,imposing significant pressure for the development of suitable disposal/recycling technologies,in terms of both environmental protection and resource reclaiming.In this review,we firstly do a comprehensive summary of the-state-of-art technologies to recycle Li N_(x)Co_(y)Mn_(z)O_(2) and LiFePO_(4)-based LIBs,in the aspects of pretreatment,hydrometallurgical recycling,and direct regeneration of the cathode materials.This closed-loop strategy for cycling cathode materials has been regarded as an ideal approach considering its economic benefit and environmental friendliness.Afterward,as for the exhausted anode materials,we focus on the utilization of exhausted anode materials to obtain other functional materials,such as graphene.Finally,the existing challenges in recycling the LiFePO_(4) and Li N_(x)Co_(y)Mn_(z)O_(2) cathodes and graphite anodes for industrial-scale application are discussed in detail;and the possible strategies for these issues are proposed.We expect this review can provide a roadmap towards better technologies for recycling LIBs,shed light on the future development of novel battery recycling technologies to promote the environmental benignity and economic viability of the battery industry and pave way for the large-scale application of LIBs in industrial fields in the near future. | Yuqing Wang Ning An Lei Wen Lei Wang Xiaotong Jiang Feng Hou Yuxin Yin Ji Liang | 2021 | Journal of Energy Chemistry2021，30，4： | 10 |
| 14 | New records of Jurassic petrified wood in Jianchang of western Liaoning,China and their palaeoclimate implications显示文摘Diverse and rich fossil wood records have been documented from the Mesozoic of Liaoning Province, NE China. The Tiaojishan Formation(mainly distributed in Beipiao, Chaoyang, Fuxin and Jianchang regions) is one of the most significant horizons for the Jurassic petrified wood in Liaoning Province. Previously, wood fossils of this formation were mainly reported in Beipiao and Chaoyang regions, whereas fossil wood record was merely known in Jianchang region. Here we describe new fossil wood specimens from the Tiaojishan Formation in Jianchang County, western Liaoning. Two fossil wood taxa, i.e., Protaxodioxylon jianchangense Tian et Wang sp. nov. and Xenoxylon peidense Zheng et Zhang were recognized on the basis of anatomical features. These fossil wood records add new data for understanding the fossil wood diversity, floral composition and palaeoclimate of the Tiaojishan Formation. The occurrence of Xenoxylon and Protaxodioxylon implies a cool temperate, wet and seasonal climate condition with interannual variations during the Middle to Late Jurassic transition in western Liaoning region. | TIAN Ning XIE AoWei WANG YongDong JIANG ZiKun LI LiQin YIN YaLei ZHU ZhiPeng WANG JiaJia | 2015 | Science China Earth Sciences2015，58，12： | 10 |
| 15 | Changes in the epidemiology of hepatitis A in three socio-economic regions of China,1990-2017显示文摘Background:Hepatitis A(HepA)vaccination and economic transitions can change the epidemiology of HepA.China's Gross Domestic Product(GDP)per capita was known to be inversely associated with the incidence of HepA,but a deeper understanding of the epidemiology of HepA in different socio-economic regions is lacking.We compare the changing epidemiology of HepA in three socioeconomic-geographic regions of China.Methods:We obtained data on all HepA cases reported through the National Notifiable Disease Reporting System and assessed trends and changes in age-specific incidence rates by age quartile and season.We categorized the country into three regions,the sequential years into five era,compared the incidence,quartile age;seasonal intensity and coverage of HepA of the three regions.Linear regression was peiformed to analyse trends in incidence of HepA and to analyse the association between coverage and incidence.Results:The annual mean incidences of HepA in the eastern,central,and western regions decreased from 63.52/100000,50.57/100000 and 46.39/100000 in 1990-1992 to 1.18/100000,1.05/100000 and 3.14/100000 in 2012-2017,respectively.Decreases in incidence were seen in all age groups in the three regions;the incidence was highest(9.3/100000)in the youngest age group(0-4 years)of the western region,while in the central region,the age group with the highest incidence changed from 0 to 9 years to adults>60 years old.In 2017,the median age of HepA cases was 43 years(Q-Q3:33-55),47 years(Q1-Q3:32-60)and 33 years(Q1-Q3:9-52)in the eastern,central,and western provinces,respectively.Seasonal peaks became smaller or were nearly elimination nationwide,but seasonality persisted in some provinces.After the Expanded Program on Immunization(EPI)included HepA vaccine into the routine schedule in 2007,HepA coverage increased to>80%in the three regions and was negatively association with the HepA incidence.Conclusion:The incidence of HepA decreased markedly between 1990 and 2017.A socioeconomic inequity in coverage of HepA vaccine was almost eliminated after HepA vaccine was introduced into China's EPI system,but inequity in incidence still existed in lower socio-economic developed region. | Xiao-Jin Sun Guo-Min Zhang Rong-Jun Zhou Hui Zheng Ning Miao Zun-Dong Yin Fu-Zhen Wang | 2019 | Infectious Diseases of Poverty2019，8，5： | 9 |
| 16 | Surplus dietary isoleucine intake enhanced monounsaturated fatty acid synthesis and fat accumulation in skeletal muscle of finishing pigs显示文摘Background: Isoleucine(Ile) has been implicated in the regulation of energy homeostasis and adipogenesis.However,the impact of surplus dietary Ile intake on muscle lipogenesis remains unknown.The present study aimed to investigate the impact of dietary supplementation of extra-Ile on lipogenesis,fatty acid profile and lipid accumulation in skeletal muscle in finishing pigs.Methods: Forty-eight barrows with initial body weight of 77.0 ± 0.1 kg were allotted to one of two groups and fed diets containing 0.39%,0.53% standardized ileal digestible(SID) Ile with six replicates per treatment and four pigs per replicate for 30 d.Results: Dietary Ile intake significantly improved the intramuscular fat(IMF) content and monounsaturated fatty acid(MUFA) concentration in the skeletal muscle(P < 0.05),and decreased the drip loss and shear force(P < 0.05) without influencing the growth performance of pigs(P > 0.05).Moreover,the phosphorylation of adenosine monophosphate activated protein kinase α(AMPKα) and acetyl coenzyme A carboxylase(ACC) proteins that monitor lipid metabolism were decreased in skeletal muscle of pigs offered extra-Ile diet(P < 0.05).The mRNA expression of adipose-specific genes adipocyte determination and differentiation factor 1(ADD1),fatty acid synthase(FAS),and stearoyl-CoA desaturase(SCD) were upregulated and the activity of SCD was increased as well(P < 0.05).Conclusions: Surplus dietary Ile intake could increase IMF accumulation and MUFA synthesis in skeletal muscle through depressing the phosphorylation of AMPKα-ACC and stimulating the expression and activity of SCD,and increasing the capability of lipogenesis in skeletal muscle. | Yanhong Luo Xin Zhang Zhengpeng Zhu Ning Jiao Kai Qiu Jingdong Yin | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 9 |
| 17 | Linear FM Signal Parameter Estimation Using STFT and FRFT显示文摘 | SHEN Liran YIN Qingbo LU Mingyu ZHANG Qi GUO Lili SHEN Tianen ZHAO Guoku NING Shushi | 2013 | Chinese Journal of Electronics2013，22，2： | 8 |
| 18 | A new effect of IL-4 on human γδ T cells: promoting regulatory Vδ1 T cells via IL-10 production and inhibiting function of Vδ2 T cells显示文摘 | Yujia Mao Shanshan Yin Jianmin Zhang Yu Hu Bo Huang Lianxian Cui Ning Kang Wei He | 2016 | Cellular & Molecular Immunology2016，13，2： | 8 |
| 19 | 表面深滚处理对AZ91镁合金组织及性能的影响(英文)显示文摘在室温下对固溶处理后的AZ91 镁合金块体材料进行表面深滚处理,以研究其对合金表面显微组织和力学性能的影响。分析被加工试样表层沿深度方向的显微硬度和显微组织。结果表明,表面影响层厚度达到2.0 mm,可分为3 个亚层:从最表面起约为400μm 厚的严重变形层,大约600μm 厚的中等变形层和厚度达1000μm 的小变形层。在变形层中除晶粒细化外,还观察到应变诱导析出的β相(Mg17Al12),尤其是在严重变形层和中等变形层内。研究认为,晶粒细化、应变硬化和沉淀强化的协同作用使AZ91 镁合金在表面深滚后的硬度显著提高。 | 罗贤 Qi-yang TAN Ning MO Yu YIN 杨延清 Wyman ZHUANG Ming-xing ZHANG | 2019 | Transactions of Nonferrous Metals Society of China2019，29，7： | 7 |
| 20 | Functional anatomical hepatectomy guided by indocyanine green fluorescence imaging in patients with localized cholestasis:Report of four cases显示文摘BACKGROUND Liver cancer is a malignant tumor with a high incidence.At present,the most effective treatment is laparoscopic hepatectomy(LH).Indocyanine green fluorescence imaging(ICG-FI)has become an important tool in LH,and the most common fluorescent types of tumors are total fluorescence,partial fluorescence,and rim fluorescence.CASE SUMMARY We presented four cases of LH guided by ICG-FI in which we also observed the fourth special fluorescent type.When the tumor or intrahepatic stone compresses the adjacent bile duct to cause local cholestasis,the liver segment or subsegment with obstructed bile drainage will show strong fluorescence.Complete removal of the lesion together with the fluorescent liver parenchyma may help reduce the risk of tumor or stone recurrence.CONCLUSION This type of partial fluorescence can indicate local biliary compression,and the resection method is related to bile drainage,which may be called functional anatomical hepatectomy and ensures radical resection of the lesion. | Hong-Wei Han Ning Shi Yi-Ping Zou Yuan-Peng Zhang Ye Lin Zi Yin Zhi-Xiang Jian Hao-Sheng Jin | 2021 | World Journal of Gastrointestinal Surgery2021，13，3： | 7 |
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