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| 1 | Seismic damage zone and width-throw scaling along the strike-slip faults in the Ordovician carbonates in the Tarim Basin显示文摘Understanding the scaling relation of damage zone width with displacement of faults is important for predicting subsurface faulting mechanisms and fluid flow processes. The understanding of this scaling relationship is influenced by the accuracy of the methods and types of data utilized to investigate faults. In this study, seismic reflection data are used to investigate the throw and damage zone width of five strike-slip faults a ecting Ordovician carbonates of the Tarim intracraton basin,NW China. The results indicate that fault slips with a throw less than 200 m had formed wide damage zones up to 3000 m in width. Also, damage zone width is found to have both a positive correlation and a power-law relation with throw of two orders of magnitude, with a ratio of these values varying in a range of 2–15. The relationship between throw and damage zone width is not a simple power-law and changes its slope from small to larger size faults. The results indicate that throw scales well with damage zone width for the studied faults, and hence these can be used to predict fault geometries in the Tarim Basin. The study of the wide carbonate damage zones presented here provides new insights into scaling of large-size faults, which involve multiple faulting stages. | De-Bo Ma Guang-Hui Wu Nicola Scarselli Xin-Sheng Luo Jian-Fa Han Zhi-Yong Chen | 2019 | Petroleum Science2019，16，4： | 7 |
| 2 | Innate and adaptive immune responses toward nanomedicines显示文摘Since the commercialization of the frst liposomes used for drug delivery,Doxil/Caelyx® and Myocet®,tremendous progress has been made in understanding interactions between nanomedicines and biological systems.Fundamental work at the interface of engineering and medicine has allowed nanomedicines to deliver therapeutic small molecules and nucleic acids more effciently.While nanomedicines are used in oncology for immunotherapy or to deliver combinations of cytotoxics,the clinical successes of gene silencing approaches like patisiran lipid complexes(Onpattro®)have paved the way for a variety of therapies beyond cancer.In parallel,the global severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has highlighted the potential of mR NA vaccines to develop immunization strategies at unprecedented speed.To rationally design therapeutic and vaccines,chemists,materials scientists,and drug delivery experts need to better understand how nanotechnologies interact with the immune system.This review presents a comprehensive overview of the innate and adaptative immune systems and emphasizes the intricate mechanisms through which nanomedicines interact with these biological functions. | Iara Maíra de Oliveira Viana Sabrina Roussel Joan Defrêne Eliana Martins Lima Frédéric Barabé Nicolas Bertrand | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 5 |
| 3 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 4 | Components of complex interventions for healthcare: A narrative synthesis of qualitative studies显示文摘Objective:Qualitative research on therapeutic components is necessary to evaluate the efficacy of complex interventions in healthcare.As few qualitative syntheses have been conducted,this study aimed to derive a new conceptual framework for understanding the components of complex interventions and provide evidence for the implementation and evaluation of complex healthcare interventions.Methods:A systematic search of seven databases was conducted to identify qualitative studies that explored components of complex healthcare interventions.Meta-ethnography was used to analyze the data and thematic analysis was used to build the conceptual framework.Results:Of the 35 included studies,most complex interventions were non-pharmacological,with cancer accounting for 22%,mental health for 14%,and stroke for 8%.Half of the studies were conducted in the United Kingdom.Three main categories emerged:what should healthcare workers do?what qualifications should they have?and what should patients do?Five main themes were identified:psychological,biological,cognitive and behavioral,environmental,and social support.Conclusion:This analysis provides a reference for designing components of complex interventions in further studies. | Sisi Ma He Yu Ning Liang Sijia Zhu Xun Li Nicola Robinson Jianping Liu | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，2： | 2 |
| 5 | WAHLENBERGIOSIDE, A PHENYLPROPANOID GLUCOSIDE FROM WAHLENBERGIA MARGINATA 显示文摘 | WEI GUANG MA REN XIANG TAN NICOLA FUZZATI JEAN -LUC WOLFENDER | 1997 | Phytochemistry1997，45，2： | 1 |
| 6 | MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions显示文摘 | du Rieu Ma?l Chalret Torrisani Jér?me Selves Janick Al Saati Talal Souque Anny Dufresne Marlène Tsongalis Gregory J Suriawinata Arief A Carrére Nicolas Buscail Louis Cordelier Pierre | 2010 | Clinical Chemistry2010，，： | 1 |
| 7 | Photorealistic modeling of tissue reflectance properties显示文摘 | Elhelw MA Nicolaou M Chung A | 2006 | Comput Aided Surg2006，11，6： | 1 |
| 8 | miR-122,a mammalian liver-specific microRNA,is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1显示文摘 | Chang J Nicolas E Marks D Sander C Lerro A Buendia MA | 2004 | RNA Biol2004，1，2： | 1 |
| 9 | Evaluation of 13 selected medicinal plants from Burkina Faso for their antiplasmodial properties显示文摘 | Olivia Jansen L. Angenot M. Tits J.P. Nicolas P. De Mol J.-B. Nikiéma M. Frédérich | 2010 | Journal of Ethnopharmacology2010，，1： | 1 |
| 10 | Once-daily inhaled fluticasone furoate and vilanterol versus vilanterol only for prevention of exacerbations of COPD: two replicate double-blind, parallel-group, randomised controlled trials显示文摘 | Mark T Dransfield Jean Bourbeau Paul W Jones Nicola A Hanania Donald A Mahler J?rgen Vestbo Andrew Wachtel Fernando J Martinez Frank Barnhart Lisa Sanford Sally Lettis Courtney Crim Peter MA Calverley | 2013 | The Lancet Respiratory Medicine2013，，3： | 1 |
| 11 | Registration of 3D trans-esophageal echocardiography to X-ray fluoroscopy using image-based probe tracking显示文摘 | Gang Gao Graeme Penney Yingliang Ma Nicolas Gogin Pascal Cathier Aruna Arujuna Geraint Morton Dennis Caulfield Jaswinder Gill C. Aldo Rinaldi Jane Hancock Simon Redwood Martyn Thomas Reza Razavi Geert Gijsbers Kawal Rhode | 2011 | Medical Image Analysis2011，，1： | 1 |
| 12 | miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1 显示文摘 | Chang J Nicolas E Marks D Sander C Lerro A Buendia MA | 2004 | RNA Biol2004，1，2： | 1 |
| 13 | Xanthine oxi- dase inhibition attenuates skeletal muscle signaling fol- lowing acute exercise but does not impair mitochondrial adaptations to endurance training 显示文摘 | Wadley GD Nicolas MA Hiam DS | 2013 | Am J Physiol En- docrinol Metab2013，304，8： | 1 |
| 14 | Improving Phase Unwrapping Techniques by the use of Local Frequency Estimates显示文摘 | Trouve E Nicolas J M Matre H | 1998 | IEEE Transactions on Geoscience and Remote Sensing1998，4，6： | 1 |
| 15 | miR-122, a mammalian liver-specific microRNA, is processed from her mRNA and may downregulate the high affinity cationic amino acid transporter CAT-l 显示文摘 | Chang J Nicolas E Marks D Sander C Lerro A Buendia MA Xu C Mason WS Moloshok T Bort R Zaret KS Taylor JM | 2004 | RNA Bioi2004，1，2： | 1 |
| 16 | Msx1 is required for dorsal diencephalon patterning显示文摘 | Bach A Lallemand Y Nicola MA | 2003 | Development2003，130，17： | 1 |
| 17 | Accuracy of helical computed tomography and fluorode- oxyglucose positron emission tomography for identifying lymph node mediastinal metastases in potentially reseetable non-small- cell lung cancer显示文摘 | Pozo-Rodriguez F Martin de Nicolas J L Sanchez-Nistal MA | 2005 | J Clin Oncol2005，23，： | 1 |
| 18 | Catalytic Asymmetric C?N Bond Formation: Phosphine‐Catalyzed Intra‐ and Intermolecular γ‐Addition of Nitrogen Nucleophiles to Allenoates and Alkynoates显示文摘 | Rylan J. Lundgren Ashraf Wilsily Nicolas Marion Cong Ma Ying Kit Chung Gregory C. Fu | 2013 | Angew Chem Int Ed2013，，9： | 1 |
| 19 | A comparison of crop data measured by two commercial sensors for variable-rate nitrogen application显示文摘 | Nicolas Tremblay Zhijie Wang Bao-Luo Ma Carl Belec Philippe Vigneault | 2009 | Precision Agriculture2009，，2： | 1 |
| 20 | Lipoxins stmmlate prostacyclin generation by human endothelial cells 显示文摘 | Brezinski ME Gimbrone MA Jr Nicolaou KC | 1989 | FEBS Lett1989，245，16： | 1 |
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