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| 1 | Treatment of sepsis: What is the antibiotic choice in bacteremia due to carbapenem resistant Enterobacteriaceae?显示文摘Sepsis is one of the major challenges of today. Although gram-positive bacteria related infections are more prevalent in hospital setting, the highest mortality rate is associated with gram-negative microorganisms especially Enterobacteriaceae. Enterobacteriaceae, including Escherichia coli, Klebsiella spp., Proteus spp., Enterobacter spp. and Serratia spp. Resistance to β-lactams in Enterobacteriaceae is primarily attributed to the production of B-lactamase enzymes with subsequent antibiotic hydrolysis and to a lesser extent by alteration of efflux pump or porins expression. Carbapenem resistant Enterobacteriaceae(CRE) and Acinetobacter baumannii are the most notorious pathogens due to the high incidence of morbidity and mortality especially in the immunocompromised patients in the intensive care unit. The most appropriate antimicrobial therapy to treat CRE is still controversial. Combination therapy is preferred over monotherapy due to its broad-spectrum coverage of micro-organisms, due to its synergetic effect and to prevent development of further resistance. Current suggested therapies for CRE resistance as well as promising antibiotics that are currently under investigation for winning the war against the emerging CRE resistance are reviewed and discussed. | Fatema Alhashem Nicolette Leonie Tiren-Verbeet Emine Alp Mehmet Doganay | 2017 | World Journal of Clinical Cases2017，5，8： | 6 |
| 2 | 国外电子采购的发展及启示显示文摘不论在美国还是在荷兰,我们的调查研究发现,电子采购其实还处在婴儿期,只有在较大的工业公司才可以找到其实际应用。这和最近大肆渲染的电子采购应用前景形成了一个鲜明对比。根据我们的调查研究,我们对为什么电子采购的商业应用率很低给出5种解释。结论是电子采购将会改变采购现状,但速度远比一些研究机构预期得慢。从这5种原因中,实践者还可以学到在投资不同的电子采购解决方案之前要考虑哪些问题。 | Arjanvan Weele Nicolette Lakemond 金怡 陈璐 | 2008 | 浙江工商大学学报2008，，4： | 5 |
| 3 | Fatigue in children and adolescents with inflammatory bowel disease显示文摘AIM To identify factors other than active disease and anemia that contribute to fatigue in pediatric inflammatory bowel disease(IBD).METHODS We performed an electronic search in Medline and EMBASE from their inception to May 2017 using the search term 'fatigue' or the related keywords 'physical impairment' and 'inflammatory bowel disease' with the filter 'child'(age 0-18 years). Cross-sectional and case-control studies were included. We restricted our search to studies published in English. We used the PRISMA checklist and flow diagram. Duplicate articles were manually deleted in End Note. To identify further relevant studies, we checked the reference lists of the selected articles.RESULTS We identified 149 papers, of which 19 were retrieved for full text review. Eleven studies were subsequently excluded because fatigue was not evaluated as an outcome measure. Eight papers focused on the desired topic and were discussed in the final analysis. A lack of uniformity of outcome measures made the pooling of data impossible. In all but one study, questionnaires were used to evaluate fatigue. In the remaining study, an accelerometer was used to measure daily activities, sleeping time and their relationships with fatigue in a more quantifiable manner. Adolescents with IBD are significantly more fatigued than healthy controls. In addition to active disease, increased anxiety or depression and disturbed family relationships were frequently reported predictors of fatigue. Quantitative measurement of physical activity in patients with Crohn's disease showed a reduction in the number of steps per day, and patients with ulcerative colitis had a shorter duration of physical activity during the day.CONCLUSION Fatigue in pediatric IBD is related to a combination of biological, functional and behavioral factors, which should all be taken into account when managing fatigue. | Els Van de Vijver Ann Van Gils Laura Beckers Yannick Van Driessche Nicolette Dorien Moes Patrick Ferry van Rheenen | 2019 | World Journal of Gastroenterology2019，25，5： | 2 |
| 4 | Changing modes of governance in activation policies in France and The Netherlands: common path or countermodel?显示文摘 | Nicolette van Gestel Jean-Michel Herbillon | 2007 | International Journal of Sociology and Social Policy2007，，7： | 1 |
| 5 | Facilitation of antibody forming responses to viral vaccine antigens in young cats by recombinant baculovirus-expressed feline IFN-γ显示文摘 | VIRGIL E J NICOLETTE C HANNEKE I | 2002 | Vaccine2002，20，1314： | 1 |
| 6 | Breast Microcalcifications: Multivariate Analysis of Radiologicand Clinical Factors for Carcinoma显示文摘 | Eric Fondrinier Gérard Lorimier Véronique Guerin-Boblet Andrée-Fran?oise Bertrand Claude Mayras Nicolette Dauver | 2002 | World Journal of Surgery2002，，3： | 1 |
| 7 | Crisis management, tourism and sustainability: The role of indicators 显示文摘 | Nicolette de Sausmarez | 2007 | Journal of Sustainable Tourism2007，15，6： | 1 |
| 8 | Spirometry for patients in hospital and one month after admission with an acute exacerbation of COPD显示文摘 | Timothy Kenealy Nicolette Sheridan Robinson Adair Rea | 2011 | 2011 (defa)2011，，： | 1 |
| 9 | Left ventricular fibrosis in renovascular hypertensive rats:effect of lasartan and spironolactone显示文摘 | Nicolett A Heuges D Hinglais N | 1995 | Hypertension1995，26，1： | 1 |
| 10 | Adipose Derived Stem Cells and Smooth Muscle Cells: Implications for Regenerative Medicine显示文摘 | Jennifer Anne Villiers Nicolette Houreld Heidi Abrahamse | 2009 | Stem Cell Reviews and Reports2009，，3： | 1 |
| 11 | Coupling of large fire phe- nomenon with object geometry and object thermal re- sponse显示文摘 | Gritzo L A Nicolette V F | 1997 | Journal of Fire Sciences1997，15，： | 1 |
| 12 | Fusions between green fluorescent protein and β-glucuronidase as sensitive and vital bifunctional reporters in plants显示文摘 | Nicolette E.M. Quaedvlieg Helmi R.M. Schlaman Pieter C. Admiraal Susan E. Wijting Jens Stougaard Herman P. Spaink | 1998 | Plant Molecular Biology1998，，4： | 1 |
| 13 | Amniocentesis or chorionic villus sampling in multiple gestations? Experience with 500 cases显示文摘 | Cardivan den Berg Armando P. G.Braat DianeVan Opstal Dicky J. J.Halley Wim J.Kleijer Nicolette S.den Hollander HelenBrandenburg LeenPijpers Frans J.Los | 1999 | Prenat Diagn1999，，3： | 1 |
| 14 | International Pig-a gene mutation assay trial:evaluation of transferability across 14 laboratories显示文摘 | Dertinger SD Phonethepswath S Weller P Nicolette J Murray J Sonders P | 2011 | Environ Mol Mutagen2011，52，9： | 1 |
| 15 | Development of a real time PCR assay for detection of allergenic trace amounts of peanut ( Arachis hypogaea ) in processed foods显示文摘 | Inés María López-Calleja Silvia de la Cruz Nicolette Pegels Isabel González Teresa García Rosario Martín | 2013 | Food Control2013，，2： | 1 |
| 16 | Developing Integrated Solutions: The Importance of Relationships within the Network显示文摘 | Charlotta Windahl Nicolette Lakemond | 2006 | Industrial Marketing Management2006，35，7： | 1 |
| 17 | CAV3 gene mutation analysis in patients with idiopathic hyper‐CK‐emia显示文摘 | Jaap C.Reijneveld Ieke B.Ginjaar Wendy S.Frankhuizen Nicolette C.Notermans | 2006 | Muscle Nerve2006，，5： | 1 |
| 18 | Split hand-food malformation,tetralogy of fallot,mental retardation and a 1 Mb 19p deletion-evidence for further hctcrogeneity显示文摘 | Emmelien Aten Nicolette den Hollander Claudia Ruivenkamp | 2009 | Am J Me Genet A2009，149，5： | 1 |
| 19 | High content flow cytometric micronucleus scoring method is applicable to attachment cell hnes显示文摘 | Bryce SM Shi J Nicolette J | 2010 | Environ Mol Mutagen2010，51，3： | 1 |
| 20 | Transcriptional and mutational analysis of the Helicobacter pylori urease promoter显示文摘 | Beverly J. Davies Nicolette de Vries Sjoerd G. Rijpkema Arnoud H.M. van Vliet Charles W. Penn | 2002 | FEMS Microbiology Letters2002，，1： | 1 |
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