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| 1 | Hepatitis C Virus Infection Downregulates the Ligands of the Activating Receptor NKG2D显示文摘Natural killer (NK) cells are a major component of the host innate immune defense against various pathogens. Several viruses, including hepatitis C virus (HCV), have developed strategies to evade the NK-cell response. In our study, we found HCV infection could trigger DNA damage response by both ataxia telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) pathways. Recent reports had revealed that NKG2D ligands (NK cell-activating ligands) were upregulated when a major DNA damage checkpoint pathway was activated. However, here we found that DNA damage response was activated but NKG2D ligands were downregulated upon HCV infection. Further studies showed that the protease NS3/4A of HCV which had been shown relation with immune invasion contributed to the reduced expression of NKG2D ligands. These findings provide a novel insight into the mechanisms evolved by HCV to escape from the NK cell response. | Chaoyang Wen Xiang He Hongfang Ma Ningbo Hou Congwen Wei Ting Song Yanhong Zhang Liping Sun Qingjun Ma Hui Zhong | 2008 | Cellular & Molecular Immunology2008，5，6： | 6 |
| 2 | A thermodynamic potential for barium zirconate titanate solid solutions显示文摘Barium zirconate titanate[Ba(ZrxTi_(1−x))O_(3)]solid solutions are promising lead-free ferroelectric materials that have received substantial interest.Thermodynamic analysis based on phenomenological Landau–Devonshire theory is a powerful method for theoretical investigation of ferroelectric materials,but cannot be applied to Ba(ZrxTi1−x)O3 because there is no thermodynamic potential.In this paper,a thermodynamic potential for Ba(ZrxTi_(1−x))O_(3)(0≤x≤0.3)solid solutions is constructed,and then a thermodynamic analysis carried out.The results accurately reproduce known phase structures and their transition temperatures,with good agreement with experimentally measured polarization,dielectric,and piezoelectric constants.It is found that Ba(ZrxTi_(1−x))O_(3) solid solutions at room temperature have three phase boundaries,including a tetragonal–orthorhombic phase boundary at x=0.013,an orthorhombic–rhombohedral phase boundary at x=0.0798,and a rhombohedral–paraelectric phase boundary at x=0.2135.The results also indicate that the chemical composition-induced ferroelectric–paraelectric phase boundary has superior electromechanical properties,suggesting a new way to enhance electromechanical coupling in Ba(ZrxTi_(1−x))O_(3) solid solutions. | Jinlin Peng Dongliang Shan Yunya Liu Kai Pan Chihou Lei Ningbo He Zhenyu Zhang Qiong Yang | 2018 | npj Computational Materials2018，，1： | 3 |
| 3 | Effects of Thermal and Hydric Conditions on Egg Incubation and Hatchling Phenotypes in Two Phrynocephalus Lizards显示文摘Flexible-shelled eggs of the lizards Phrynocephalus przewalskii and P. versicolor were incubated under different thermal and hydric conditions to elicit the effects of incubation environment on hatching success, embryonic development and duration as well as hatchling phenotypes. Embryogenesis of the two species was not sensitive to changes in the hydric environment except P. przewalskii incubated in 30°C group. Temperature significantly altered the duration of embryogenesis, with cooler temperatures leading to a longer incubation period. Hatching success was greater at 26 and 30°C than at 34°C. The hatchlings incubated at 26 and 30°C had longer snout-vent length, larger body mass, and better locomotor performance than those incubated at 34°C. Compared to P. przewalskii, P. versicolor had a shorter incubation period and yielded smaller hatchlings, which then had a higher survival rate in cooler and drier habitats. We conclude that an incubation temperature of 30°C would produce the best balance among developmental rate, hatching success, and post-hatching performance. We speculate that the upper temperature limit for incubation of P. versicolor eggs may be slightly higher than 34°C. | Xiaolong TANG Feng YUE Ming MA Ningbo WANG Jianzheng HE Qiang CHEN | 2012 | Asian Herpetological Research2012，3，3： | 3 |
| 4 | An atlas of CNV maps in cattle, goat and sheep显示文摘Copy number variation(CNV)is the most prevalent type of genetic structural variation that has been recognized as an important source of phenotypic variation in humans,animals and plants.However,the mechanisms underlying the evolution of CNVs and their function in natural or artificial selection remain unknown.Here,we generated CNV region(CNVR)datasets which were diverged or shared among cattle,goat,and sheep,including 886 individuals from 171 diverse populations.Using 9 environmental factors for genome-wide association study(GWAS),we identified a series of candidate CNVRs,including genes relating to immunity,tick resistance,multi-drug resistance,and muscle development.The number of CNVRs shared between species is significantly higher than expected(P<0.00001),and these CNVRs may be more persist than the single nucleotide polymorphisms(SNPs)shared between species.We also identified genomic regions under long-term balancing selection and uncovered the potential diversity of the selected CNVRs close to the important functional genes.This study provides the evidence that balancing selection might be more common in mammals than previously considered,and might play an important role in the daily activities of these ruminant species. | Yongzhen Huang Yunjia Li Xihong Wang Jiantao Yu Yudong Cai Zhuqing Zheng Ran Li Shunjin Zhang Ningbo Chen Hojjat Asadollahpour Nanaei Quratulain Hanif Qiuming Chen Weiwei Fu Chao Li Xiukai Cao Guangxian Zhou Shudong Liu Sangang He Wenrong Li Yulin Chen Hong Chen Chuzhao Lei Mingjun Liu Yu Jiang | 2021 | Science China(Life Sciences)2021，64，10： | 2 |
| 5 | Turbulent Wind Field Simulation of Wind Turbines With Rotational Effects显示文摘为准确得到风轮旋转效应对风力发电机组湍流风速脉动分量的影响,推导了旋转Fourier自谱和互谱。分析了风轮旋转效应通过相干函数和相位延迟体现的物理本质,提出了引入相位延迟参数的旋转Fourier自谱和互谱。以旋转Fourier自谱和互谱的模构建旋转谱矩阵,对其进行Cholesky分解,将相位延迟引入谱表现方法中实现风力发电机组湍流风场的模拟。最后,结合某1.5Mw三叶片变桨距风电机组进行纵向脉动风速时程的数值模拟,并对计算功率谱与目标谱进行了校核,证明该文算法可以更为准确地模拟作用在风轮旋转叶片上的脉动风速时程。 | HE Wei TIAN De DENG Ying WANG Ningbo | 2013 | 中国电机工程学报2013，33，11： | 1 |
| 6 | Structural and Sedimentary Characteristics of Hydrocarbon-Rich Sags in Lacustrine Sub-Basin of Half Graben Type, Pearl River Mouth Basin, South China Sea显示文摘Pearl River Mouth Basin undergoes complex tectonic evolution processes and forms lacustrine,transitional and marine sediments.Drilling shows that there exist large petroleum reserves in the hydrocarbon-rich sags of Pearl River Mouth Basin,South China Sea.To reduce the risk,the exploration,structural and sedimentary characteristics of the hydrocarbon-rich sags should be identified and described.Drilling,seismic,and microfossil data are integrated to interpret the structural and sedimentary evolution of the hydrocarbon-rich sags in Pearl River Mouth Basin.By analyzing the tectonic and sedimentary evolutionary characteristics,three conclusions may be drawn:1、The present regional tectonic characteristics of the PRMB are formed by mutual interactions of the Eurasian Plate,Pacific Plate,Philippine Plate and Indian Plate.During the Paleocene to early Eocene and late Eocene and early Oligocene,the PRMB is at the rifting stage.During the late Oligocene,the PRMB was at the rifting-depression transitional stage.After the Oligocene,the PRMB is at the depression stage.2、Tectonic conditions control the sedimentation process in the hydrocarbon-rich sags.During the lacustrine sedimentation stage,synsedimentary faults and intense faulting control the sedimentation.During the transitional sedimentation stage,weak fault activity influences the deposition process in the hydrocarbon-rich sags.During the marine sedimentation stage,weak fault activity and depression activity control the deposition process in the hydrocarbon-rich sags.3、Tectonic evolution affects the deposition process.The lacustrine,transitional and marine sedimentation corresponds to different tectonic conditions.The lacustrine sedimentation is formed under fault activity during the rifting stage.The transitional sedimentation is formed under weak fault activity during the late rifting stage.The marine sedimentation is formed under weak fault activity and depression activity during the rifting-depression and depression stages.4、The half graben is beneficial for the formation of lacustrine source rocks,which is responsible for the hydrocarbon-rich sag.Therefore the half graben mode contributes to the hydrocarbon-rich sags. | Lei He Xiaolong Wang Ningbo Cai Jie Qu Xiong Zhu Daomao Lin | 2019 | Open Journal of Yangtze Oil and Gas2019，4，3： | 1 |
| 7 | A real-time dual watermarking algorithm of H.264/AVC video stream for Video-on-Demand service显示文摘 | Yingliang He Gaobo Yang Ningbo Zhu | 2011 | AEUE - International Journal of Electronics and Communications2011，，4： | 1 |
| 8 | Preparation and characteristic research of anhydrous magnesium chloride with dehydrated ammonium carnallite显示文摘 | Zhou Ningbo Chen Baizhen He Xinkuai | 2006 | Journl of Central South University of Technology2006，13，4： | 1 |
| 9 | Electron-ion collider in China显示文摘Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as nuclei.As a future high energy nuclear physics project,an Electron-ion collider in China(EicC)has been proposed.It will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron ring.The proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3)×1033 cm^(−2)·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the EicC.The main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark contents.In addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the EicC.In order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge technologies.This document is the result of collective contributions and valuable inputs from experts across the globe.The EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United States.The success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China. | Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui Lingyun Dai Weitian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie Liang Zuotang Liang Chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao Liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou | 2021 | Frontiers of physics2021，16，6： | 1 |
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