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| 1 | Glucagon-like peptide-1 attenuates cardiac hypertrophy via the AngII/AT1R/ACE2 and AMPK/mTOR/p70S6K pathways显示文摘Glucagon-like peptide-1(GLP-1),a novel type of glucose-lowering agent,has been reported to exert cardioprotective effects.However,the cardioprotective mechanism of GLP-1 on spontaneous hypertension-induced cardiac hypertrophy has not been fully elucidated.In this study,we revealed that liraglutide or alogliptin treatment ameliorated spontaneous hypertension-induced cardiac hypertrophy,as evidenced by decreased levels of cardiac hypertrophic markers(atrial natriuretic peptide,brain natriuretic peptide,andβ-myosin heavy chain),as well as systolic blood pressure,diastolic blood pressure,mean arterial pressure,and histological changes.Both drugs significantly reduced the levels of angiotensin II(AngII)and AngII type 1 receptor(AT1R)and upregulated the levels of AngII type 2 receptor(AT2R)and angiotensin-converting enzyme 2(ACE2),as indicated by a reduced AT1R/AT2R ratio.Simultaneously,treatment with liraglutide or alogliptin significantly increased GLP-1 receptor expression and adenosine monophosphate-activated protein kinase(AMPK)phosphorylation and downregulated the phosphorylation of mammalian target of rapamycin(mTOR),p70 ribosomal S6 protein kinase,and eukaryotic translation initiation factor 4E binding protein 1 in spontaneous hypertension rats.Furthermore,our data demonstrated that the AMPK inhibitor compound C or mTOR activator MHY1485 inhibited the anti-hypertrophic effect of GLP-1.In summary,our study suggests that liraglutide or alogliptin protects the heart against cardiac hypertrophy by regulating the expression of AngII/AT1R/ACE2 and activating the AMPK/mTOR pathway,and GLP-1 agonist can be used in the treatment of patients with cardiac hypertrophy. | Jing Wang Shaohua Fan Qianfeng Xiong Yu Niu Xin Zhang Junnan Qin Yawei Shi Lihui Zhang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 1 |
| 2 | Stannate conversion coatings on Mg-8Li alloy显示文摘 | Lihui Yang Milin Zhang Junqing Li Xiang Yu Zhongyi Niu | | 0，，1： | 1 |
| 3 | A new scattering similarity based metric for ship detection in polarimetric synthetic aperture radar image显示文摘A new paradigm for ship detection in polarimetric synthetic aperture radar(Pol-SAR)image is presented.We firstly utilize the scattering similarity parameters to investigate the differences of scattering mechanism between ships and sea clutter.Based on these differences,we propose a novel ship detection metric,denoted as the scattering similarity based metric(SSM),to conduct ship detection task.The distribution model of SSM metric is investigated and modeled by kernel density estimation(KDE).Based on the statistical distribution,an adaptive constant false alarm rate(CFAR)detection scheme is implemented.We compare the proposed SSM with two classic polarimetric metrics,i.e.,the polarimetric cross-entropy(PCE)and the reflection symmetry metric(RSM).The experimental results conducted on C-band RADARSAT-2 Pol-SAR data demonstrate the feasibility and advantage of the proposed SSM metric both in sea clutter modeling and in ship detection. | Haitao Lang Yunhong Tao Lihui Niu Hongji Shi | 2020 | Acta Oceanologica Sinica2020，39，5： | 1 |
| 4 | The antilipolytic action of bis(α-furancarboxylato)oxovanadium(IV) in adipocytes显示文摘 | Lihui Gao Yanfen Niu Weiping Liu Mingjin Xie Xu Liu Zhihe Chen Ling Li | 2007 | Clinica Chimica Acta2007，，1： | 1 |
| 5 | The lithium and sodium storage performances of phosphorus and its hierarchical structure显示文摘Recent preparation of black phosphorene and subsequent discovery of its excellent optical and electronic properties have attracted great attenti on,and ren ewed interest to phosphorus.Rece nt researches have indicated that phosphorus structures are promisi ng an odes for lithium-ion and sodium-ion batteries.A high theoretical capacity of 2,596 mAh·g^-1 was predicted for phosphorus according to the reaction of 3Li/Na+P→Li3P/Na3P.However,fast capacity degradation is accompanying with most phosphorus structures due to the low electronic conductivity and structural pulverization induced by large volume change in charging and discharging proceses.The electrochemical performances are significantly affected by the hierarchical structural design of phosphorus.A few reviews of phosphorus structures have been reported recent?However,no review about the electrochemical performances of phosphorus structures according to their hierarchical structures has been reported.First of all,phosphrus allotropes along with their structure and fundamental properties are briefly reviewed in this work.Secondly,the studies on lithiation/sodiation mechanism of red/black phosphorus are presented.Thirdly,a summary about the electrochemical performances of red/black phosphorus composites with different hierarchical structures is presented.Furthermore,the,development challenges and future perspectives of phosphorus structures as anodes for LIBs and SIBs are discussed. | Dan Zhao Lihui Zhang Chengcheng Fu Jinying Zhang Chunming Niu | 2019 | Nano Research2019，12，1： | 1 |
| 6 | An efficient synthesis of pyrimidoquinoline derivatives via three-component reaction in aqueous media显示文摘 | Shi Daqing Niu Lihui Yao Hao | 2009 | J Heterocycl Chem2009，46，2： | 1 |
| 7 | Overexpression of UDP-glucose pyrophosphorylase gene could increase cellulose content in Jute ( Corchorus capsularis L.)显示文摘 | Gaoyang Zhang Jianmin Qi Jiantang Xu Xiaoping Niu Yujia Zhang Aifen Tao Liwu Zhang Pingping Fang LiHui Lin | 2013 | Biochemical and Biophysical Research Communications . 2013 (3-4)2013，，3： | 1 |
| 8 | Clean synthesis of pyrido pyrimidines in aqueous media显示文摘 | Shi Daqing Niu Lihui Zhuang Qiya | 2005 | J Chem Res2005，，10： | 1 |
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