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| 1 | Laparoscopic and endoscopic co-operative surgery for nonampullary duodenal tumors显示文摘AIM To assess the safety and feasibility of laparoscopic and endoscopic co-operative surgery(LECS) for early nonampullary duodenal tumors.METHODS Twelve patients with a non-ampullary duodenal tumor underwent LECS at our hospital. One patient had two mucosal lesions in the duodenum. The indication for this procedure was the presence of duodenal tumors with a low risk for lymph node metastasis. In particular, the tumors included small(less than 10 mm) submucosal tumors(SMT) and epithelial mucosal tumors, such as mucosal cancers or large mucosal adenomas with malignant suspicion. The LECS procedures, such as full-thickness dissection for SMT and laparoscopic reinforcement after endoscopic submucosal dissection(ESD) for epithelial tumors, were performed for the 13 early duodenal lesions in 12 patients. Here we present the short-term outcomes and evaluate the safety and feasibility of this new technique.RESULTS Two SMT-like lesions and eleven superficial epithelial tumor-like lesions were observed. Seven and Six lesions were located in the second and third parts of the duodenum, respectively. All lesions were successfully resected en bloc. The defect in the duodenal wall was manually sutured after resection of the duodenal SMT. For epithelial duodenal tumors, the ulcer bed was laparoscopically reinforced via manual suturing after ESD. Intraoperative perforation occurred in two out of eleven epithelial tumor-like lesions during ESD; however, they were successfully laparoscopically repaired. The median operative time and intraoperative estimated blood loss were 322 min and 0 mL, respectively. Histological examination of the tumors revealed one adenoma with moderate atypia, ten adenocarcinomas, and two neuroendocrine tumors. No severe postoperative complications(Clavien-Dindo classification grade Ⅲ or higher) were reported in this series, but minor leakage secondary to pancreatic fistula occurred in one patient.CONCLUSION LECS can be a safe and minimally invasive treatment option for non-ampullary early duodenal tumors. | Daisuke Ichikawa Shuhei Komatsu Osamu Dohi Yuji Naito Toshiyuki Kosuga Kazuhiro Kamada Kazuma Okamoto Yoshito Itoh Eigo Otsuji | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 2 | Histological evaluation for chemotherapeutic responses of metastatic lymph nodes in gastric cancer显示文摘AIM: To investigate the effect of preoperative chemotherapy(pre-CTx) for metastatic lymph nodes(MLNs) of gastric cancer(GC). METHODS: A retrospective cohort of patients with advanced GC, who underwent pre-CTx followed by gastrectomy, was reviewed. The histological tumor regression grade(TRG), which considered the percentage of residual cancer in the visible tumor bed, was applied to primary tumors and individual MLNs: G1a(complete response), G1b(< 10%), G2(10%-50%) and G3(> 50%). The clinical response to pre-CTx was retrospectively evaluated using only MLNs information, and we compared the histological and clinical evaluations of MLNs.RESULTS: Twenty-eight patients were enrolled. A total of 438 MLNs were retrieved, and 22(5%), 48(11%), 63(14%) and 305(70%) LNs were assigned as G1 a, G1 b, G2 and G3, respectively. Stratification of the residual MLNs based on the TRGs was as follows: 28 G1 b MLNs(9%), 48 G2 MLNs(15%), and 253 G3 MLNs(76%) in the D1 region; 20(23%), 15(17%), and 52(60%) in the D2 region, respectively. However, no significant correlation was found between TRGs in MLNs and clinical response in the subgroup for which evaluation of clinical response was available.CONCLUSION: Pre-CTx does not provide any outstanding histological benefit for MLNs, and an appropriate D2 lymphadenectomy should routinely be performed to offer the chance of curative resection. | Osamu Kinoshita Daisuke Ichikawa Yusuke Ichijo Shuhei Komatsu Kazuma Okamoto Mitsuo Kishimoto Akio Yanagisawa Eigo Otsuji | 2015 | World Journal of Gastroenterology2015，21，48： | 2 |
| 3 | CASE REPORT: Autoimmune Pancreatitis Detected as a Mass in the Head of the Pancreas Without Hypergammaglobulinemia, Which Relapsed After Surgery: Case Report and Review of the Literature显示文摘 | Takao Taniguchi Hikaru Tanio Shuji Seko Osamu Nishida Fumihiko Inoue Motozumi Okamoto Shunnichi Ishigami Hisato Kobayashi | 2003 | Digestive Diseases and Sciences2003，，8： | 1 |
| 4 | Antitumor Activity of Lenvatinib (E7080): An Angiogenesis Inhibitor That Targets Multiple Receptor Tyrosine Kinases in Preclinical Human Thyroid Cancer Models显示文摘 | Osamu Tohyama Junji Matsui Kotaro Kodama Naoko Hata-Sugi Takayuki Kimura Kiyoshi Okamoto Yukinori Minoshima Masao Iwata Yasuhiro Funahashi Giovanni Tallini | 2014 | Journal of Thyroid Research2014，，： | 1 |
| 5 | Laparoscopic transhiatal approach for resection of an adenocarcinoma in long-segment Barrett's esophagus显示文摘Barrett's esophagus(BE) is a precursor of esophageal adenocarcinoma and is associated with gastroesophageal reflux disease, which is often preceded by a hiatal hernia. We describe a case of esophageal adenocarcinoma arising in long-segment BE(LSBE) associated with a hiatal hernia that was successfully treated with a laparoscopic transhiatal approach(LTHA) without thoracotomy. The patient was a 42-year-old male who had previously undergone laryngectomy and tracheal separation to avoid repeated aspiration pneumonitis. An ulcerative lesion was found in a hiatal hernia by endoscopy and superficial esophageal cancer was also detected in the lower thoracic esophagus. The histopathological diagnosis of biopsy samples from both lesions was adenocarcinoma. There were difficulties with the thoracic approach because the patient had severe kyphosis and muscular contractures from cerebral palsy. Therefore, we performed subtotal esophagectomy by LTHA without thoracotomy. Using hand-assisted laparoscopic surgery, the esophageal hiatus was divided and carbon dioxide was introduced into the mediastinum. A hernial sac was identified on the cranial side of the right crus of the diaphragm and carefully separated from the surrounding tissues. Abruption of the thoracic esophagus was performed up to the level of thearch of the azygos vein via LTHA. A cervical incision was made in the left side of the permanent tracheal stoma, the cervical esophagus was divided, and gastric tube reconstruction was performed via a posterior mediastinal route. The operative time was 175 min, and there was 61 m L of intra-operative bleeding. A histopathological examination revealed superficial adenocarcinoma in LSBE. Our surgical procedure provided a good surgical view and can be safely applied to patients with a hiatal hernia and kyphosis. | Atsushi Shiozaki Hitoshi Fujiwara Hirotaka Konishi Osamu Kinoshita Toshiyuki Kosuga Ryo Morimura Yasutoshi Murayama Shuhei Komatsu Yoshiaki Kuriu Hisashi Ikoma Masayoshi Nakanishi Daisuke Ichikawa Kazuma Okamoto Chouhei Sakakura Eigo Otsuji | 2015 | World Journal of Gastroenterology2015，21，29： | 1 |
| 6 | Evaluation of needle-knife precut papillotomy after unsuccessful biliary cannulation, especially with regard to postoperative anatomic factors显示文摘 | Hirotoshi Fukatsu Hirofumi Kawamoto Hironari Kato Ken Hirao Naoko Kurihara Takashi Nakanishi Osamu Mizuno Yuko Okamoto Tsuneyoshi Ogawa Etsuji Ishida Hiroyuki Okada Kohsaku Sakaguchi | 2008 | Surgical Endoscopy2008，，3： | 1 |
| 7 | Nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L显示文摘 | Falgueyret J P Oballa R M Osamu Okamoto | 2001 | Journal of Medicinal Chemistry2001，44，1： | 1 |
| 8 | Transcorneal electrical stimulation increases chorioretinal blood flow in normal human subjects显示文摘 | Takuji Kurimoto Takata Masashi Ryosuke Kashimoto Yuichi Tagami Hidehiro Oku Shinichirou Oono Osamu Mimura Tsunehiko Ikeda Norio Okamoto | 2010 | Clinical Ophthalmology . 2010 (defa)2010，，： | 1 |
| 9 | Evaluation of needle-knife precut papillotomy after unsuccessful biliary cannulation, especially with regard to postoperative anatomic factors显示文摘 | Hirotoshi Fukatsu Hirofumi Kawamoto Hironari Kato Ken Hirao Naoko Kurihara Takashi Nakanishi Osamu Mizuno Yuko Okamoto Tsuneyoshi Ogawa Etsuji Ishida Hiroyuki Okada Kohsaku Sakaguchi | 2008 | Surgical Endoscopy2008，，3： | 1 |
| 10 | The immunohistochemical evaluation of PSP/reg-protein in normal and diseased human pancreatic tissues显示文摘 | Yoshitake Satomura Norio Sawabu Hideki Ohta Hiroyuki Watanabe Osamu Yamakawa Yoshiharu Motoo Takashi Okai Daishu Toya Hiroshi Makino Hiroshi Okamoto | 1993 | International Journal of Pancreatology1993，，1： | 1 |
| 11 | Development of Ethernet Terminal Adapter 显示文摘 | HARADA KEIJI OKAMOTO OSAMU FUNATSU GENTARO | 2002 | NTT Review2002，14，4： | 1 |
| 12 | Synthetic α-Mannosyl Ceramide as a Potent Stimulant for an NKT Cell Repertoire Bearing the Invariant Vα19-Jα26 TCR α Chain显示文摘 | Naoki Okamoto Osamu Kanie Yi-Ying Huang Rei Fujii Hiroko Watanabe Michio Shimamura | 2005 | Chemistry & Biology2005，，6： | 1 |
| 13 | 为 basaloid 的 EMRC 的一个盒子颈的食管的有鳞的癌显示文摘 Basaloid squamous carcinoma (BSC) of the esophagus is a rare esophageal tumor. A 79-year-old man with a history of proximal gastrectomy for gastric adenocarcinoma in 2000 was followed-up by esophagogastroduodenoscopy (EGD) annually. In June 2010, EGD revealed a new protruding lesion in the cervical esophagus. The small lesion was approximately 5 mm in size. A biopsy specimen showed poorly differentiated squamous cell carcinoma. We performed endoscopic mucosal resection using a cap-fi tted endoscope (EMRC). The histological diagnosis of the endoscopically resected specimen was BSC and the invasion depth was limited to the muscularis mucosae. Horizontal and vertical margins were negative. We report the case of superfi cial BSC in the cervical esophagus successfully resected by EMRC. | Munetaka Nakamura Jun Nishikawa Shigeyuki Suenaga Takeshi Okamoto Fumiki Okamoto Osamu Miura Isao Sakaida | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，8： | 1 |
| 14 | Functional peptide of dermatopontin produces fibrinogen fibrils and modifies its biological activity显示文摘 | Weimin Wu Osamu Okamoto Aiko Kato Noritaka Matsuo Jun Kumai Motoyoshi Nomizu Sakuhei Fujiwara | 2014 | Journal of Dermatological Science2014，，： | 1 |
| 15 | Role of inducible nitric oxide synthase and cyclooxygenase - 2 in endotoxin - induced cerebral hyperemia显示文摘 | Okamoto H Osamu Ito Roman R J | 1998 | Stroke1998，29，6： | 1 |
| 16 | Response of poro-elastoplastic beds to standing waves显示文摘 | Hideo Sekiguchi Katsutoshi Kita Osamu Okamoto | 1995 | Soils and Foundations1995，35，3： | 1 |
| 17 | Marker-assisted breeding of a lymphocystis disease-resistant Japanese flounder ( Paralichthys olivaceus )显示文摘 | Kanako Fuji Osamu Hasegawa Kazumitsu Honda Kiyohiro Kumasaka Takashi Sakamoto Nobuaki Okamoto | 2007 | Aquaculture2007，，1： | 1 |
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