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| 1 | Risk prediction platform for pancreatic fistula after pancreatoduodenectomy using artificial intelligence显示文摘BACKGROUND Despite advancements in operative technique and improvements in postoperative managements,postoperative pancreatic fistula(POPF)is a life-threatening complication following pancreatoduodenectomy(PD).There are some reports to predict POPF preoperatively or intraoperatively,but the accuracy of those is questionable.Artificial intelligence(AI)technology is being actively used in the medical field,but few studies have reported applying it to outcomes after PD.AIM To develop a risk prediction platform for POPF using an AI model.METHODS Medical records were reviewed from 1769 patients at Samsung Medical Center who underwent PD from 2007 to 2016.A total of 38 variables were inserted into AI-driven algorithms.The algorithms tested to make the risk prediction platform were random forest(RF)and a neural network(NN)with or without recursive feature elimination(RFE).The median imputation method was used for missing values.The area under the curve(AUC)was calculated to examine the discriminative power of algorithm for POPF prediction.RESULTS The number of POPFs was 221(12.5%)according to the International Study Group of Pancreatic Fistula definition 2016.After median imputation,AUCs using 38 variables were 0.68±0.02 with RF and 0.71±0.02 with NN.The maximal AUC using NN with RFE was 0.74.Sixteen risk factors for POPF were identified by AI algorithm:Pancreatic duct diameter,body mass index,preoperative serum albumin,lipase level,amount of intraoperative fluid infusion,age,platelet count,extrapancreatic location of tumor,combined venous resection,co-existing pancreatitis,neoadjuvant radiotherapy,American Society of Anesthesiologists’score,sex,soft texture of the pancreas,underlying heart disease,and preoperative endoscopic biliary decompression.We developed a web-based POPF prediction platform,and this application is freely available at http://gffzz52cab37b8d4e4d2ch5cpxc0kf90q969uc.ffgz.tsg.suse.edu.cn This study is the first to predict POPF with multiple risk factors using AI.This platform is reliable(AUC 0.74),so it could be used to select patients who need especially intense therapy and to preoperatively establish an effective treatment strategy. | In Woong Han Kyeongwon Cho Youngju Ryu Sang Hyun Shin Jin Seok Heo Dong Wook Choi Myung Jin Chung Oh Chul Kwon Baek Hwan Cho | 2020 | World Journal of Gastroenterology2020，26，30： | 12 |
| 2 | Evaluation of esophageal function in patients with esophageal motor abnormalities using multichannel intraluminal impedance esophageal manometry显示文摘AIM: To evaluate the functional aspect of esophageal motility in healthy subjects and in patients who were referred for esophageal function testing using multichannel intraluminal impedance-esophageal manometry (MII-EM), and to assess the clinical utility of MII-EM. METHODS: From September 2003 to January 2004, we performed the MII-EM on healthy volunteers and all the patients who were referred for esophageal function testing. Each patient received 10 liquid and 10 viscous swallows. We analyzed the results, the impedance and the manometric findings. Some of the subjects had additional ambulatory 24-h pH study performed to diagnose gastroesophageal reflux disease (GERD). RESULTS: Among 89 studied subjects, the MII-EM findings showed normal esophageal motility in 50 (56.17%), ineffective esophageal motility (IEM) in 17 (19.10%), nutcracker esophagus in 7 (7.86%), achalasia in 4 (4.49%), and scleroderma esophagus in 11 (12.35%) cases. The completeness and the speed of bolus transit were in the order of nutcracker esophagus, normal manometry and IEM. Some of the swallows showing normal manometry and IEM had incomplete transit. In the achalasia and scleroderma esophagus, almost all the swallows had incomplete transit. The body amplitudes were higher for the swallows with complete transit than for the swallows with incomplete transit. There was not a significant difference in the manometric and impedance findings between the subjects with and without GERD. CONCLUSION: MII-EM is a useful tool in assessing theesophageal function in the patients having esophageal motility abnormality. The primary factors influencing the bolus transit are the amplitude of the esophageal body and normal peristalsis. | Yu Kyung Cho Myung-Gyu Choi Jae Myung Park Jung Hwan Oh Chang Nyol Paik Joon Wook Lee In Seok Lee Sang Woo Kim In-Sik Chung | 2006 | World Journal of Gastroenterology2006，12，39： | 8 |
| 3 | Distant skeletal muscle metastasis from intrahepatic cholangiocarcinoma presenting as Budd-Chiari syndrome显示文摘Intrahepatic cholangiocarcinoma is a malignant neoplasm arising from the biliary epithelium, which frequently invades adjacent organs or metastasizes to other visceral organs such as the lungs, bones, adrenals, and brain. However, distant skeletal muscle metastasis of cholangiocarcinoma has never been described before to the best of our knowledge and, furthermore, Budd-Chiari syndrome secondary to intrahepatic cholangiocarcinoma is also extremely rare. Here we present the first case overall of distant muscle metastasis from intrahepatic cholangiocarcinoma presenting as Budd-Chiari syndrome. A 44-year-old man admitted to the hospital with complaints of abdominal distension, edema of both legs, back pain and anorexia of 30 d' duration. Computed tomography and ultrasonography-guided percutaneous muscle biopsy established intrahepatic cholangiocarcinoma with disseminated thrombosis from inferior vena cava to bilateral iliac and femoral veins, and multiple skeletal muscle metastases in bilateral buttock and erector spinal muscle. | Oh Sung Kwon Dae Won Jun Sang Heum Kim Mee Yeon Chung Nam In Kim Moon Hee Song Han Hyo Lee Seung Hwan Kim Yoon Ju Jo Young Sook Park Jong Eun Joo | 2007 | World Journal of Gastroenterology2007，13，22： | 2 |
| 4 | Successful Treatment of Kounis Syndrome Type I Presenting as Cardiac Arrest with ST Elevation显示文摘To the Editor:Kounis syndrome describes a group of symptoms that manifest as unstable vasospastic or nonvasospastic angina or as acute myocardial infarction.It is triggered by the release of inflammatory mediators after an allergic reaction.[1,2] A 74-year-old man with urinary incontinence was treated with a radical cystectomy using the Mainz pouch procedure and ureteroscopic lithotripsy.He underwent the third infusion of contrast agent (iopromide) for evaluation ofpleural effusion in the right lower field of the lung.Two infusions of APCT with Iomeron(R) (Iomeprol) contrast medium had previously been administered to this patient. | Kie Young Oh Yong Nam In Chi Hwan Kwack Jung Soo Park Jin Hong Min Min Gyu Kang Sun Moon Kim | 2016 | Chinese Medical Journal2016，，5： | 1 |
| 5 | The Effect of Mosapride on Esophageal Motility and Bolus Transit in Asymptomatic Volunteers显示文摘 | Yu Kyung Cho Myung-Gyu Choi Hae Won Han Jae Myung Park Jung Hwan Oh Jeong Jo Jeong Young Seok Cho In Seok Lee Sang Woo Kim Kyu Yong Choi In-Sik Chung | 2006 | Journal of Clinical Gastroenterology2006，，4： | 1 |
| 6 | A source voltage-clamped resonant link inverter for a PMSM using a predictive current control technique显示文摘 | Oh In Hwan Seok Jung Young Youn Myung Joong | 1999 | IEEE Transactions on Power Elcetrocics1999，14，6： | 1 |
| 7 | Multiple synchronous early gastric cancers: High-risk group and proper management显示文摘 | In Seob Lee Young Soo Park Kab Choong Kim Tae Hwan Kim Hee Sung Kim Kee Don Choi Gin Hyug Lee Jeong Hwan Yook Sung Tae Oh Byung Sik Kim | 2012 | Surgical Oncology2012，，4： | 1 |
| 8 | Informative SSR markers for commercial variety discrimina- tion in watermelon ( Citrullus lanatus ) 显示文摘 | YongSham Kwon You - Hwan Oh Seung - In Yi | 2010 | Genes &genomics2010，32，2： | 1 |
| 9 | Fabrication characteristics of conductive materials for the flow rate and nozzle moving speed显示文摘 | Oh Sung Taek Lee In Hwan Cho Hae Yong | 2013 | Journal of Industrial Science and Technology Institute2013，27，1： | 1 |
| 10 | Realistic Long-term Prediction of Prestress Forces in PSC Box Girder Bridges显示文摘 | Byung Hwan Oh In Hwan Yang | 2001 | Journal of Bridge Engineering2001，6，9： | 1 |
| 11 | Appropriate gastrectomy resection margins for early gastric carcinoma显示文摘 | Beom Su Kim Seong Tae Oh Jeong Hwan Yook Hee Sung Kim In Seob Lee Byung Sik Kim | 2014 | J Surg Oncol2014，，3： | 1 |
| 12 | Investigation of various ionomer-coated carbon supports for direct methanol fuel cell applications显示文摘 | Aulice M Scibioh Oh In Hwan Lim Tae Hoon | 2008 | Applied Catalysis B: Environmental2008，77，34： | 1 |
| 13 | LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer显示文摘Prostate cancer(PCa)is the most commonly diagnosed genital cancer in men worldwide.Around 80%of the patients who developed advanced PCa suffered from bone metastasis,with a sharp drop in the survival rate.Despite great efforts,the detailed mechanisms underlying castration-resistant PCa(CRPC)remain unclear.Sirtuin 5(SIRT5),an NAD+-dependent desuccinylase,is hypothesized to be a key regulator of various cancers.However,compared to other SIRTs,the role of SIRT5 in cancer has not been extensively studied.Here,we revealed significantly decreased SIRT5 levels in aggressive PCa cells relative to the PCa stages.The correlation between the decrease in the SIRT5 level and the patient’s reduced survival rate was also confirmed.Using quantitative global succinylome analysis,we characterized a significant increase in the succinylation at lysine 118(K118su)of lactate dehydrogenase A(LDHA),which plays a role in increasing LDH activity.As a substrate of SIRT5,LDHA-K118su significantly increased the migration and invasion of PCa cells and LDH activity in PCa patients.This study reveals the reduction of SIRT5 protein expression and LDHA-K118su as a novel mechanism involved in PCa progression,which could serve as a new target to prevent CPRC progression for PCa treatment. | Oh Kwang Kwon In Hyuk Bang So Young Choi Ju Mi Jeon Ann-Yae Na Yan Gao Sam Seok Cho Sung Hwan Ki Youngshik Choe Jun Nyung Lee Yun-Sok Ha Eun Ju Bae Tae Gyun Kwon Byung-Hyun Park Sangkyu Lee | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 0 |
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