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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | An apparently new transmissible disease of cattle显示文摘 | OLAFSON P MAC C A FOX F H | 1946 | Cornell Vet1946，36，： | 1 |
| 3 | Significance and applications of phenolic compounds in the production and quality of milk and dairy products:a review显示文摘 | O' Connell J E Fox P F | 2001 | Int Dairy J2001，，11： | 1 |
| 4 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 5 | Influence of starters on chemical, biochemical,and sensory changes in Turkish White-Brined Cheese during ripening显示文摘 | Hayalogu A A Guven M Fox P F | 2005 | Journal of Dairy Science2005，，10： | 1 |
| 6 | Purification and characterization of Paecilomyces lilacinus dextranase显示文摘 | Lee J M Fox P F | 1985 | Enzyme and Microbial Technology1985，7，11： | 1 |
| 7 | Dairy chemistry and biochemistry 显示文摘 | FOX P F MCSWEENEY P L H | 1998 | Blackie Academic Professi-onal1998，，： | 1 |
| 8 | Heat-induced changes in the calcium sensitivity of caseins显示文摘 | J E O'connell P F Fox | 1999 | International Dairy Journal1999，9，12： | 1 |
| 9 | Influence of transglutaminase treatment on some physico-chemical properties of milk 显示文摘 | O' Sullivan M M Kelly A L Fox P F | 2002 | Dairy Research2002，69，： | 1 |
| 10 | Soluble nitrogen in cheddar cheese:comparison of extraction procedures显示文摘 | Kuchroo C N Fox P F | 1982 | Milchwissenschaft1982，37，6： | 1 |
| 11 | Effect of extracts of oak (Quercus petraea),oak leaves,aloe vera (Curacao aloe),coconut shall and wine on the colloidal stability of milk and concentrated milk显示文摘 | O' Connell J E Fox P F | 1999 | J Food Chem1999，66，： | 1 |
| 12 | Soluble nitrogen in cheese:comparison of extraction procedures显示文摘 | KUCHROO C N FOX P F | 1982 | Milchwissenschaft1982，，37： | 1 |
| 13 | Effects of phenolic compounds on the heat stability of milk and concentrated milk显示文摘 | O' Connell J E Fox P F | 1999 | J Dairy Res1999，66，： | 1 |
| 14 | Accelerated Ripening of Cheddar Cheese at Elevated Temperatures显示文摘 | FORKERTSMA B FOX P F MCSWEENEY P L H | 1999 | Dairy Journal1999，6，： | 1 |
| 15 | Anaerobic treatment applications and fundamentals: substrate specificity during phase separation 显示文摘 | Fox P Pohland F G | 1994 | Water Environment Research1994，66，5： | 1 |
| 16 | Assessment of proteolysis in cheese by reaction with trinityrobenzene sulphonic acid显示文摘 | RAHILLY J FOX P F | 1983 | Irish J Food Sci and Technol1983，7，： | 1 |
| 17 | Proteolysis during cheese manufacture and ripening显示文摘 | Fox P F | 1989 | Journal of Dairy Science1989，72，6： | 1 |
| 18 | Structural magnetic resonance imaging in the practical assessment of dementia:beyond exclusion显示文摘 | Scheltens P Fox N Barkhof F | | 0，，01： | 1 |
| 19 | Chemical methods for the characterization of proteolysis in cheese during ripening显示文摘 | MCSWEENEY P L H FOX P F | 1997 | Le Lait1997，77，1： | 1 |
| 20 | Proteolysis in Turkish White-brined cheese made with defined strains of Lactococcus显示文摘 | HAYALOGLU A A GUVEN M FOX P F | 2004 | International Dairy Journal2004，14，7： | 1 |
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