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| 1 | Paleogene-Neogene stratigraphic realm and sedimentary sequence of the Qinghai-Tibet Plateau and their response to uplift of the plateau显示文摘Based on the data of 1:250000 geological mapping completed by CGS and the previous literature of the Cenozoic strata, 98 remnant basins and 5 stratigraphic realms with 13 stratigraphic subrealms have been recognized on the Qinghai-Tibet Plateau and its adjacent area. Through the research of the types of remnant basins, tectonic setting, stratigraphic sequence and sedimentary characteristics, contact relationship between the strata, the formation time and evolution history of sediments, we divided the uplift process and sedimentary response of the Qinghai-Tibet Plateau into 3 stages and 8 sub-stages, namely, subduction-collision uplift stage (65-34 Ma) with three sub-stages, intercontinental convergence and compressive uplift stage (34-13 Ma) with three sub-stages, and intercontinental isostatic adjustment uplift stage (since 13 Ma) with two sub-stages. | ZHANG KeXin WANG GuoCan JI JunLiang LUO ManSheng KOU XiaoHu WANG YueMing XU YaDong CHEN FenNing CHEN RuiMing SONG BoWen ZHANG JianYu LIANG YinPing | 2010 | Science China Earth Sciences2010，53，9： | 49 |
| 2 | Spatio-temporal framework of tectonic uplift stages of the Tibetan Plateau in Cenozoic显示文摘Four intensive uplift periods, i.e., 60–35, 25–17 and 12–8 Ma (but 18–13 Ma in the Himalayas of the southern Tibet), and since about 5 Ma, can be determined on the Tibetan Plateau by synthetical analysis of low-temperature thermo-chronology data, sedimentary deposit records, and structural deformation records of different areas. The strong tectonic uplift periods in different areas on the Tibetan Plateau are penecontemporaneous, except for the Himalayan area of the southern Tibet, where a rapid uplift and exhumation period, controlled by the activity of the South Tibetan Detachment System faults, occurred during 18–13 Ma. These strong uplift and exhumation periods correspond well to intensive deformation activity periods, suggesting tectonically-controlled uplift and exhumation. The deposit records, such as the distribution of coarse clastic sediments, the distribution of tectonically-controlled basins, stratigraphic discontinuousness or unconformity, and fault-controlled geomorphologic evolution, also match well with the strong uplift and exhumation periods. Expanding processes of the plateau are also discussed. | WANG GuoCan CAO Kai ZHANG KeXin WANG An LIU Chao MENG YanNing XU YaDong | 2011 | Science China Earth Sciences2011，54，1： | 49 |
| 3 | Cenozoic sedimentary records and geochronological constraints of differential uplift of the Qinghai-Tibet Plateau显示文摘Geological mapping data (1:250000) in the Qinghai-Tibet Plateau and its adjacent regions reveal the sediment sequences, distribution and tectonic evolution of the 92 Tertiary remnant basins. Southern Tibet and the Yecheng area in Xinjiang, located at southern and northwestern margins of the Qinghai-Tibet Plateau, respectively, were parts of the Neo-Tethys remnant sea in the Paleogene. In southern Tibet, both the subabyssal and abyssal sequences occur at the Gyangze, Saga, Guoyala, and Sangmai areas. The deep-water facies successions outcrop in the west, whereas the shallow-water facies sequences in the east, indicating the east to the west retreat of the Neo-Tethys Ocean. The retreat of the Neo-Tethys Ocean in the east was contributed to the earlier tectonic uplift of the eastern Qinghai-Tibet Plateau. The uplift process of the Plateau from the Late Cretaceous to Pliocene is described as follows: During the Late Cretaceous, tectonic uplift of the Qinghai-Tibet Plateau occurred in the northeastern part and the configuration of the Qinghai-Tibet Plateau was characterized by rise in the northeast and depression in the west. In the Paleocene-Eocene interval, the Tengchong-Baingoin and Kuyake-Golmud areas experienced local tectonic uplifting, the West Kunlun uplift zone broadened easterly, the Qilian uplift zone broadened southerly, and the Songpan-Garzê uplift zone shrank easterly. The Oligocene configuration of the Qinghai-Tibet Plateau was characterized by mountain chains rising along its margins and sedimentary basins in the central part because of tectonic uplifts of the Gangdisê and the Himalaya blocks. Meanwhile, the Kunlun-Altyn-Qilian uplift zones have also broadened southerly and northerly. In contrast, the great uplift zones of the Gangdisê, the Himalaya, the Karakorum, and the Kunlun blocks characterize the paleogeographic contours of the Qinghai-Tibet Plateau during the Miocene-Pliocene. Additionally, the thermochronological data on tectonic uplift events in southern Tibet, West Kunlun Mountains, Altyn Tagh, eastern Tibet, and western Sichuan all suggest that the most intense deformation occurred at 13-8 Ma and since 5 Ma, respectively, corresponding to two great uplift periods in Neogene. As a result, turnover of paleogeographic configuration of the Qinghai-Tibet Plateau occurred during the Neogene, experiencing a change from high contours in the east in the pre-Oligocene to high contours in the west at the end-Pliocene. The uplift of the Qinghai-Tibet Plateau during the Cenozoic was episodic, and the uplifts of various blocks within the Plateau were spatially and chronologically different. | ZHANG KeXin WANG GuoCan CAO Kai LIU Chao XIANG ShuYuan HONG HanLie KOU XiaoHu XU YaDong CHEN FenNing MENG YanNing CHEN RuiMing | 2008 | Science China Earth Sciences2008，51，11： | 31 |
| 4 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 5 | Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0-10.0 ng/mL:Results from the Chinese Prostate Cancer Consortium显示文摘Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years. | Rui Chen Liping Xie Xiaobing Cai Yiran Huang Liqun Zhou Lulin Ma Xu Gao Chuanliang Xu Shancheng Ren Pengfei Shao Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Li Lu Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tie Zhou Fubo Wang Biming He Yinghao Sun | 2015 | Asian Journal of Urology2015，2，2： | 8 |
| 6 | Application of deep learning in ecological resource research:Theories, methods, and challenges显示文摘Ecological resources are an important material foundation for the survival,development,and self-realization of human beings.In-depth and comprehensive research and understanding of ecological resources are beneficial for the sustainable development of human society.Advances in observation technology have improved the ability to acquire long-term,cross-scale,massive,heterogeneous,and multi-source data.Ecological resource research is entering a new era driven by big data.Traditional statistical learning and machine learning algorithms have problems with saturation in dealing with big data.Deep learning is a method for automatically extracting complex high-dimensional nonlinear features,which is increasingly used for scientific and industrial data processing because of its ability to avoid saturation with big data.To promote the application of deep learning in the field of ecological resource research,here,we first introduce the relationship between deep learning theory and research on ecological resources,common tools,and datasets.Second,applications of deep learning in classification and recognition,detection and localization,semantic segmentation,instance segmentation,and graph neural network in typical spatial discrete data are presented through three cases:species classification,crop breeding,and vegetation mapping.Finally,challenges and opportunities for the application of deep learning in ecological resource research in the era of big data are summarized by considering the characteristics of ecological resource data and the development status of deep learning.It is anticipated that the cooperation and training of cross-disciplinary talents may promote the standardization and sharing of ecological resource data,improve the universality and interpretability of algorithms,and enrich applications with the development of hardware. | Qinghua GUO Shichao JIN Min LI Qiuli YANG Kexin XU Yuanzhen JU Jing ZHANG Jing XUAN Jin LIU Yanjun SU Qiang XU Yu LIU | 2020 | Science China Earth Sciences2020，63，10： | 7 |
| 7 | Genomic selection: A breakthrough technology in rice breeding显示文摘Rice(Oryza sativa)provides a staple food source for more than half the world population.However,the current pace of rice breeding in yield growth is insufficient to meet the food demand of the everincreasing global population.Genomic selection(GS)holds a great potential to accelerate breeding progress and is cost-effective via early selection before phenotypes are measured.Previous simulation and experimental studies have demonstrated the usefulness of GS in rice breeding.However,several affecting factors and limitations require careful consideration when performing GS.In this review,we summarize the major genetics and statistical factors affecting predictive performance as well as current progress in the application of GS to rice breeding.We also highlight effective strategies to increase the predictive ability of various models,including GS models incorporating functional markers,genotype by environment interactions,multiple traits,selection index,and multiple omic data.Finally,we envision that integrating GS with other advanced breeding technologies such as unmanned aerial vehicles and open-source breeding platforms will further improve the efficiency and reduce the cost of breeding. | Yang Xu Kexin Ma Yue Zhao Xin Wang Kai Zhou Guangning Yu Cheng Li Pengcheng Li Zefeng Yang Chenwu Xu Shizhong Xu | 2021 | The Crop Journal2021，9，3： | 7 |
| 8 | Arbuscular Mycorrhizal Symbiosis Requires a Phosphate Transceptor in the Gigaspora margarita Fungal Symbiont显示文摘陆上的脉管的植物的多数能够形成 mutualistic 协会与要求 biotrophic arbuscular mycorrhizal (AM ) 从门 Glomeromycota 的真菌。这 mutualistic 共生提供糖类给真菌,并且相互地改进植物磷酸盐举起。AM 真菌的 transporters 能通过菌丝的网络从土壤获得磷酸盐。不过, AM 真菌的磷酸盐 transporters 的精确函数,并且他们是否充当传感器或作为滋养的 transporters,在真菌的信号 transduction 仍然保持不清楚。这里,我们从为 AM 共生被要求的 Gigaspora margarita 报导高亲密关系的磷酸盐 transporter GigmPT。GigmPT 的导致主人的基因 silencing 妨碍 G 的发展。margarita 在 AM 期间共生。最重要地, GigmPT 在 G 作为磷酸盐 transceptor 工作。关于表明小径以及蛋白质的磷酸盐的激活的 margarita kinase A 发信号串联。用代用品半胱氨酸可接近性方法,我们识别了残余 A 146( 在 transmembrane 领域[TMD ] IV ) 并且瓦尔 357( 在 TMD VIII ) GigmPT,哪个为磷酸盐在生长期间在酵母发信号和运输是批评的感应。一起,我们的结果从 AM 真菌 G 提供重要卓见进磷酸盐 transceptor 的分子的功能。margarita。 | Xianan Xie Hui Lin Xiaowei Peng Congrui Xu Zhongfeng Sun Kexin Jiang Antian Huang Xiaohui Wu Nianwu Tang Alessandra Salvioli Paola Bonfante Bin Zhao | 2016 | Molecular Plant2016，9，12： | 6 |
| 9 | Sedimentary Evolution of the Qinghai-Tibet Plateau in Cenozoic and its Response to the Uplift of the Plateau显示文摘We have studied the evolution of the tectonic lithofacies paleogeography of Paleocene-Eocene, Oligocene, Miocene, and Pliocene of the Qinghai-Tibet Plateau by compiling data regarding the type, tectonic setting, and lithostratigraphic sequence of 98 remnant basins in the plateau area. Our results can be summarized as follows. (1) The Paleocene to Eocene is characterized by uplift and erosion in the Songpan-Garzê and Gangdisê belts, depression (lakes and pluvial plains) in eastern Tarim, Qaidam, Qiangtang, and Hoh Xil, and the Neo-Tethys Sea in the western and southern Qinghai-Tibet Plateau. (2) The Oligocene is characterized by uplift in the Gangdisê-Himalaya and Karakorum regions (marked by the absence of sedimentation), fluvial transport (originating eastward and flowing westward) in the Brahmaputra region (marked by the deposition of Dazhuka conglomerate), uplift and erosion in western Kunlun and Songpan-Garzê, and depression (lakes) in the Tarim, Qaidam, Qiangtang, and Hoh Xil. The Oligocene is further characterized by depressional littoral and neritic basins in southwestern Tarim, with marine facies deposition ceasing at the end of the Oligocene. (3) For the Miocene, a widespread regional unconformity (ca. 23 Ma) in and adjacent to the plateau indicates comprehensive uplift of the plateau. This period is characterized by depressions (lakes) in the Tarim, Qaidam, Xining-Nanzhou, Qiangtang, and Hoh Xil. Lacustrine facies deposition expanded to peak in and adjacent to the plateau ca. 18-13 Ma, and north-south fault basins formed in southern Tibet ca. 13-10 Ma. All of these features indicate that the plateau uplifted to its peak and began to collapse. (4) Uplift and erosion occurred during the Pliocene in most parts of the plateau, except in the Hoh Xil-Qiangtang, Tarim, and Qaidam. The continuous uplift and intensive taphrogeny in the plateau divided the original large basin into small basins, deposition of lacustrine facies decreased considerably, and boulderstone accumulated, indicating a response to the overall uplift of the plateau. Here, we discuss the evolution of tectonic lithofacies paleogeography in Cenozoic and its response to the tectonic uplift of the Qinghai-Tibet Plateau in relation to the above characteristics. We have recognized five major uplift events, which occurred during 58-53 Ma, 45-30 Ma, 25-20 Ma, 13-7 Ma, and since 5 Ma. The results presented here indicate that the paleogeomorphic configurations of the Qinghai-Tibet Plateau turned over during the late Miocene, with high elevations in the east during the pre-Miocene switching to high contours in the west at the end of Miocene. | ZHANG Kexin WANG Guocan XU Yadong LUO Mansheng JI Junliang XIAO Guoqiao WANG An SONG Bowen LIANG Yinpin JIANG Shangsong CAO Kai CHEN Fenning CHEN Ruiming YANG Yongfeng | 2013 | Acta Geologica Sinica(English Edition)2013，87，2： | 6 |
| 10 | Characteristics of microfauna and their relationships with the performance of an activated sludge plant in China显示文摘微动物志组织的出现和许多与在中国的 Baoding Lugang 污水处理工厂的物理化学、运作的参数相比。属于并且爬行纤毛虫类是纤毛虫类的主导的组。爬行纤毛虫类和留有遗嘱的阿米巴与自河 BOD5 (生物化学的氧需求) 显示出一个强壮的协会。因此,自从他们的数字减少了,当这个过程生产了差的优秀自河,这二个组是可能的是有用简历指示物。留有遗嘱的阿米巴也有重要负相关与自河 TN (总氮) , NH4+-N, SS (推迟的固体) 和 SVI (污泥容量的索引) ,它意味着这组纤毛虫类可以是活性污泥系统的好性能的指示物。食肉的纤毛虫类和 flagellates 与 SVI 有重要正相关,建议这二个组可以是污泥的坏解决条件的指示物。因为微动物志种类的鉴定困难、费时间,我们用微动物志建议功能的组评估活性污泥系统的性能。 | ZHOU Kexin XU Muqi LIU Biao CAO Hong | 2008 | Journal of Environmental Sciences2008，20，4： | 5 |
| 11 | ^(10)Be/~7Be implies the contribution of stratosphere-troposphere transport to the winter-spring surface O_3 variation observed on the Tibetan Plateau显示文摘10Be/7Be is a stratospheric sensitive tracer.In this paper,measurements of 10Be/7Be and surface O3 from October 2005 to May 2006 at Mt.Waliguan (hereafter WLG,100.898°E,39.287°N,3810 m,a.s.l.),China global atmospheric watch (GAW) observatory,are introduced and used to investigate the stratosphere-troposphere transport (STT) and its impact on surface O3 on the Tibetan Plateau.The results show that the magnitude of STT is weak in winter,followed by strengthening from the end of winter to the middle of spring (from mid February to mid April) with large increases in 10Be,7Be,10Be/7Be and surface O3.At the end of spring (from the end of April to mid May in this paper),the STT weakened,and the continuous increase of surface O3 at WLG is produced by tropospheric photochemistry reactions. | ZHENG XiangDong SHEN ChengDe WAN GuoJiang LIU KeXin TANG Jie XU XiaoBin | 2011 | Chinese Science Bulletin2011，56，1： | 5 |
| 12 | The Mid-Miocene Pollen Record of the Xunhua Basin, NE Tibetan Plateau: Implications for Global Climate Change显示文摘The northeastern Tibetan Plateau is located at the convergence of the Asian winter and summer monsoons and westerlies; thus, this area has witnessed historic climate changes.The Xunhua basin is an intermontane basin on the northeastern margin of the Tibetan Plateau.The basin contains more than 2000 m of Cenozoic fluvial–lacustrine sediments, recording a long history of climate and environmental changes.We collected the mid-Miocene sediments from the Xunhua basin and used palynological methods to discuss the relationship between aridification in the interior of Asia, global cooling, and uplift of the Tibetan Plateau.Based on the palynological analysis of the Xigou section, Xunhua basin, the palynological diagram is subdivided into three pollen zones and past vegetation and climate are reconstructed.Zone I, Ephedripites–Nitraridites–Chenopodipollis–Quercoidites(14.0–12.5 Ma), represents mixed shrub–steppe vegetation with a dry and cold climate.In zone II, Pinaceae–Betulaepollenites–Ephedripites–Chenopodipollis–Graminidites(12.5–8.0 Ma), the vegetation and climate conditions improved, even though the vegetation was still dominated by shrub–steppe taxa.Zone III, Ephedripites–Nitrariadites–Chenopodipollis(8.0–5.0 Ma), represents desert steppe vegetation with drier and colder climate.The palynological records suggest that shrub–steppe dominated the whole Xigou section and the content gradually increased, implying a protracted aridification process, although there was an obvious climate improvement during 12.5–8.0 Ma.The aridification in the Xunhua basin and surrounding mountains during 14.0–12.5 Ma was probably related to global cooling induced by the rapid expansion of the East Antarctic ice-sheets and the relatively higher evaporation rate.During the 12.5–8.0 Ma period, although topographic changes(uplift of Jishi Shan) decreased precipitation and strengthened aridification in the Xunhua basin on leeward slopes, the improved vegetation and climate conditions were probably controlled by the decrease in evaporation rates as a result of continuous cooling.From 8.0 to 5.0 Ma, the rapid development of the desert steppe can be attributed to global cooling and uplift of the Tibetan Plateau. | XU Zenglian ZHANG Jianyu JI Junliang ZHANG Kexin | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 3 |
| 13 | Improved edge lightweight YOLOv4 and its application in on-site power system work显示文摘A“cloud-edge-end”collaborative system architecture is adopted for real-time security management of power system on-site work,and mobile edge computing equipment utilizes lightweight intelligent recognition algorithms for on-site risk assessment and alert.Owing to its lightweight and fast speed,YOLOv4-Tiny is often deployed on edge computing equipment for real-time video stream detection;however,its accuracy is relatively low.This study proposes an improved YOLOv4-Tiny algorithm based on attention mechanism and optimized training methods,achieving higher accuracy without compromising the speed.Specifically,a convolution block attention module branch is added to the backbone network to enhance the feature extraction capability and an efficient channel attention mechanism is added in the neck network to improve feature utilization.Moreover,three optimized training methods:transfer learning,mosaic data augmentation,and label smoothing are used to improve the training effect of this improved algorithm.Finally,an edge computing equipment experimental platform equipped with an NVIDIA Jetson Xavier NX chip is established and the newly developed algorithm is tested on it.According to the results,the speed of the improved YOLOv4-Tiny algorithm in detecting on-site dress code compliance datasets is 17.25 FPS,and the mean average precision(mAP)is increased from 70.89%to 85.03%. | Kexin Li Liang Qin Qiang Li Feng Zhao Zhongping Xu Kaipei Liu | 2022 | Global Energy Interconnection2022，5，2： | 3 |
| 14 | Epigenetic regulation of prostate cancer: the theories and the clinical implications显示文摘Epigenetics is the main mechanism that controls transcription of specific genes with no changes in the underlying DNA sequences. Epigenetic alterations lead to abnormal gene expression patterns that contribute to carcinogenesis and persist throughout disease progression. Because of the reversible nature, epigenetic modifications emerge as promising anticancer drug targets. Several compounds have been developed to reverse the aberrant activities of enzymes involved in epigenetic regulation, and some of them show encouraging results in both preclinical and clinical studies. In this article, we comprehensively review the up-to-date roles of epigenetics in the development and progression of prostate cancer. We especially focus on three epigenetic mechanisms: DNA methylation, histone modifications, and noncoding RNAs. We elaborate on current models/theories that explain the necessity of these epigenetic programs in driving the malignant phenotypes of prostate cancer cells. In particular, we elucidate how certain epigenetic regulators crosstalk with critical biological pathways, such as androgen receptor (AR) signaling, and how the cooperation dynamically controls cancer-oriented transcriptional profiles. Restoration of a “normal” epigenetic landscape holds promise as a cure for prostate cancer, so we concluded by highlighting particular epigenetic modifications as diagnostic and prognostic biomarkers or new therapeutic targets for treatment of the disease. | Yiji Liao Kexin Xu | 2019 | Asian Journal of Andrology2019，21，3： | 3 |
| 15 | Review of minimally invasive continuous glucose monitoring technology & instruments显示文摘Continuous blood glucose monitoring is important for the diagnosis,treatment,and study of diabetes. many organizations have been working on this subject in recent two decades. Glucose concentration in interstitial fluid is closely related to the blood glucose levels. Minimally invasive continuous blood glucose monitoring technology based on the glucose detection in interstitial fluid develops rapidly and gets more and more attentions from the patients and the doctors,due to its instantaneous real-time display of glucose level,'24/7'coverage,and the ability to characterize glycemic variability. According to the different detection methods,most of the continuous glucose monitoring technology could be divided into two kinds: subcutaneous implantation method and transdermal extraction method. This paper review s the recent development of minimally invasive blood glucose monitoring technology and instruments. The mainly remained challenges and related research directions are presented as well. | YU Haixia LI Dachao XU Kexin | 2016 | Instrumentation2016，3，4： | 2 |
| 16 | METTL3-mediated m^(6)A RNA methylation regulates dorsal lingual epithelium homeostasis显示文摘The dorsal lingual epithelium,which is composed of taste buds and keratinocytes differentiated from K14^(+)basal cells,discriminates taste compounds and maintains the epithelial barrier.N6-methyladenosine(m^(6)A)is the most abundant mRNA modification in eukaryotic cells.How METTL3-mediated m^(6)A modification regulates K14^(+)basal cell fate during dorsal lingual epithelium formation and regeneration remains unclear.Here we show knockout of Mettl3 in K14^(+)cells reduced the taste buds and enhanced keratinocytes.Deletion of Mettl3 led to increased basal cell proliferation and decreased cell division in taste buds.Conditional Mettl3 knock-in mice showed little impact on taste buds or keratinization,but displayed increased proliferation of cells around taste buds in a protective manner during post-irradiation recovery.Mechanically,we revealed that the most frequent m^(6)A modifications were enriched in Hippo and Wnt signaling,and specific peaks were observed near the stop codons of Lats1 and FZD7.Our study elucidates that METTL3 is essential for taste bud formation and could promote the quantity recovery of taste bud after radiation. | Qiuchan Xiong Caojie Liu Xin Zheng Xinyi Zhou Kexin Lei Xiaohan Zhang Qian Wang Weimin Lin Ruizhan Tong Ruoshi Xu Quan Yuan | 2022 | International Journal of Oral Science2022，14，3： | 2 |
| 17 | Additive and additive × additive interaction make important contributions to spikelets per panicle in rice near isogenic (Oryza sativa L.) lines显示文摘Epistasis plays an important role in the genetic basis of rice yield traits. Taking interactions into account in breeding programs will help the development of high-yielding rice varieties. In this study, three sets of near isogenic lines (NILs) targeting three QTLs for spikelets per panicle (SPP), namely qSPP1, qSPP2 and qSPP7, which share the same Zhenshan 97 genetic background, were used to produce an F 2 population in which the three QTLs segregated simultaneously. The genotypes of the individual F 2 plants at the three QTLs were replaced with three markers that are closely linked to the corresponding QTLs. These QTLs were validated in the F 2 and F 3 popula- tions at the single marker level. qSPP7 exhibited major pleiotropic effects on SPP, plant height and heading date. Multifactor analysis of variance was performed for the F 2 population and its progeny. Additive × additive interaction between qSPP2 and qSPP7 had significant effects on SPP in both the F 2 population and its progeny. Both additive and additive × additive interactions could explain about 73% of the total SPP phenotypic variance. The SPP performance of 27 three-locus combinations was ranked and favorable combinations were rec- ommended for rice breeding in different ecosystems. | Qin He Kexin Zhang Caiguo Xu Yongzhong Xing | 2010 | Journal of Genetics and Genomics2010，37，12： | 2 |
| 18 | From Micropores to Ultra-micropores inside Hard Carbon: Toward Enhanced Capacity in Room-/ Low-Temperature Sodium-Ion Storage显示文摘Pore structure of hard carbon has a fundamental influence on the electrochemical properties in sodium-ion batteries(SIBs).Ultra-micropores(<0.5 nm)of hard carbon can function as ionic sieves to reduce the diffusion of slovated Na+but allow the entrance of naked Na^(+) into the pores,which can reduce the interficial contact between the electrolyte and the inner pores without sacrificing the fast diffusion kinetics.Herein,a molten diffusion-carbonization method is proposed to transform the micropores(>1 nm)inside carbon into ultra-micropores(<0.5 nm).Consequently,the designed carbon anode displays an enhanced capacity of 346 mAh g^(−1) at 30 mA g^(−1) with a high ICE value of~80.6%and most of the capacity(~90%)is below 1 V.Moreover,the high-loading electrode(~19 mg cm^(−2))exhibits a good temperature endurance with a high areal capacity of 6.14 mAh cm^(−2) at 25℃ and 5.32 mAh cm^(−2) at −20℃.Based on the in situ X-ray diffraction and ex situ solid-state nuclear magnetic resonance results,the designed ultra-micropores provide the extra Na+storage sites,which mainly contributes to the enhanced capacity.This proposed strategy shows a good potential for the development of high-performance SIBs. | Jinlin Yang Xiaowei Wang Wenrui Dai Xu Lian Xinhang Cui Weichao Zhang Kexin Zhang Ming Lin Ruqiang Zou Kian Ping Loh Quan-Hong Yang Wei Chen | 2021 | Nano-Micro Letters2021，13，6： | 2 |
| 19 | Insights into skeletal stem cells显示文摘The tissue-resident skeletal stem cells(SSCs),which are self-renewal and multipotent,continuously provide cells(including chondrocytes,bone cells,marrow adipocytes,and stromal cells)for the development and homeostasis of the skeletal system.In recent decade,utilizing fluorescence-activated cell sorting,lineage tracing,and single-cell sequencing,studies have identified various types of SSCs,plotted the lineage commitment trajectory,and partially revealed their properties under physiological and pathological conditions.In this review,we retrospect to SSCs identification and functional studies.We discuss the principles and approaches to identify bona fide SSCs,highlighting pioneering findings that plot the lineage atlas of SSCs.The roles of SSCs and progenitors in long bone,craniofacial tissues,and periosteum are systematically discussed.We further focus on disputes and challenges in SSC research. | Qiwen Li Ruoshi Xu Kexin Lei Quan Yuan | 2022 | Bone Research2022，10，4： | 2 |
| 20 | Novel SFS-NDT in the field of defect detection显示文摘 | Song Limei Qu Xinghua Xu Kexin | 2005 | International NDT&E2005，38，5： | 1 |
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