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| 1 | Branched-chain amino acid treatment before transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘AIM:To examine the significance of branched-chain amino acid (BCAA) treatment before transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).METHODS:This study included 99 patients who underwent TACE therapy for HCC at our hospital and were followed up without treatment for at least 6 mo between January 2004 and January 2010.They were divided into 2 groups:those receiving BCAA granules (n=40) or regular diet (n=59,control).Data obtained were retrospectively analyzed (prior to TACE,and 1 wk,1,3,and 6 mo after TACE) in terms of nutritional condition and clinical laboratory parameters (serum albumin level and Child-Pugh score),both of which are determinants of hepatic functional reserve.RESULTS:The BCAA group comprised 27 males and 13 females with a mean age of 69.9 ± 8.8 years.The patients of the BCAA group were classified as follows:Child-Pugh A/B/C in 22/15/3 patients,and Stage Ⅱ/Ⅲ /ⅣA HCC in 12/23/5 patients,respectively.The controlgroup comprised 32 males and 27 females with a mean age of 73.2 ± 10.1 years.In the control group,9 patients had chronic hepatitis,Child-Pugh A/B/C in 39/10/1 patients,and StageⅠ/Ⅱ/Ⅲ/ⅣA HCC in 1/11/35/12 patients,respectively.Overall,both serum albumin level and Child-Pugh score improved significantly in the BCAA group as compared with the control 3 and 6 mo after TACE (P < 0.05).Further analysis was performed by the following categorization:(1) child-Pugh classification;(2) liver cirrhosis subgroup with a serum albumin level > 3.5 g/dL;and (3) epirubicin dose.A similar trend indicating a significant improvement of all variables in the BCAA group was noted (P < 0.05).CONCLUSION:Treatment with BCAA granules in patients who have undergone TACE for HCC is considered useful to maintain their hepatic functional reserve. | Hiroki Nishikawa Yukio Osaki Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Shinichiro Henmi Azusa Sakamoto Tetsuro Ishikawa Sumio Saito Ryuichi Kita Toru Kimura | 2012 | World Journal of Gastroenterology2012，18，12： | 16 |
| 2 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 3 | Signal transducer and activator of transcription 3 regulation by novel binding partners显示文摘Signal transducers and activators of transcription(STATs) mediate essential signals for various biological processes,including immune responses,hematopoiesis,and neurogenesis. STAT3,for example,is involved in the pathogenesis of various human diseases,including cancers,autoimmune and inflammatory disorders. STAT3 activation is therefore tightly regulated at multiple levels to prevent these pathological conditions. A number of proteins have been reported to associate with STAT3 and regulate its activity. These STAT3-interacting proteins function to modulate STAT3-mediated signaling at various steps and mediate the crosstalk of STAT3 with other cellular signaling pathways. This article reviews the roles of novel STAT3 binding partners such as DAXX,zipperinteracting protein kinase,Krüppel-associated box-associated protein 1,Y14,PDZ and LIM domain 2 and signal transducing adaptor protein-2,in the regulation of STAT3-mediated signaling. | Tadashi Matsuda Ryuta Muromoto Yuichi Sekine Sumihito Togi Yuichi Kitai Shigeyuki Kon Kenji Oritani | 2015 | World Journal of Biological Chemistry2015，6，4： | 2 |
| 4 | Effects of sesquiterpenes and triterpenes from the Rhizome of Alisma orientale on nitric oxide production in lipopoly-saccharide-activated macrophages:absolute stereostructures of alismaketones-B 23-acetate and -C 23-acetate显示文摘 | Hisashi Matsuda Tadashi Kageura lwao Toguchida | 1999 | Bioorganic and Medicinal Chemistry Letters1999，9，： | 1 |
| 5 | Gene transfer of human prostacyclin synthase into the liver is effective for the treatment of pulmonary hypertension in rats显示文摘 | Hitoshi Suhara Yoshiki Sawa Norihide Fukushima Koji Kagisaki Chieko Yokoyama Tadashi Tanabe Shigeaki Ohtake Hikaru Matsuda | 2002 | The Journal of Thoracic and Cardiovascular Surgery2002，，5： | 1 |
| 6 | Cytotoxic human peripheral blood-derived γδT cells kill glioblastoma cell lines: implications for cell-based immunotherapy for patients with glioblastoma显示文摘 | Tsutomu Nakazawa Mitsutoshi Nakamura Young Soo Park Yasushi Motoyama Yasuo Hironaka Fumihiko Nishimura Ichiro Nakagawa Shuichi Yamada Ryosuke Matsuda Kentaro Tamura Tadashi Sugimoto Yasuhiro Takeshima Akiko Marutani Takahiro Tsujimura Noriko Ouji Yukiteru | 2014 | Journal of Neuro-Oncology2014，，1： | 1 |
| 7 | Human Agonistic Antibody to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor 2 Induces Cytotoxicity and Apoptosis in Prostate Cancer and Bladder Cancer Cells显示文摘 | Osamu Shimada Xiuxian Wu Xinghua Jin Mohammed Ahmed Abdel-Muneem Nouh Michele Fiscella Vivian Albert Tadashi Matsuda Yoshiyuki Kakehi | 2007 | Urology2007，，2： | 1 |
| 8 | The Effect of Long-term Supplementation With Branched-chain Amino Acid Granules in Patients With Hepatitis C Virus-related Hepatocellular Carcinoma After Radiofrequency Thermal Ablation显示文摘 | Hiroki Nishikawa Yukio Osaki Eriko Iguchi Yorimitsu Koshikawa Soichiro Ako Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Azusa Sakamoto Shinichiro Henmi Keiichi Hatamaru Tetsuro Ishikawa Sumio Saito Akihiro Nasu Ryuichi Kita Toru Kimura | 2013 | Journal of Clinical Gastroenterology2013，，4： | 1 |
| 9 | Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages显示文摘 | Hisashi Matsuda Tadashi Kageura Toshio Morikawa Iwao Toguchida Shoichi Harima Masayuki Yoshikawa | 2000 | Bioorganic & Medicinal Chemistry Letters2000，，4： | 1 |
| 10 | Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene显示文摘 | Hiroyuki Nishiyama Hiroaki Higashitsuji Hiromichi Yokoi Katsuhiko Itoh Shozo Danno Tadashi Matsuda Jun Fujita | 1997 | Gene1997，，1： | 1 |
| 11 | Laparoscopic varicocelectomy:a simple tech nique for clip ligation of the spermatic vessels显示文摘 | Tadashi Matsuda Yasuki Horii Shin Higashi | 1992 | J Urol1992，147，4： | 1 |
| 12 | Smaller Ports Result in Shorter Convalescence After Laparoscopic Varicocelectomy显示文摘 | Tadashi Matsuda Keiji Ogura Junji Uchida Ichiro Fujita Toshiro Terachi Osamu Yoshida | 1995 | The Journal of Urology1995，，： | 1 |
| 13 | Physical and functional interactions between Daxx and TSG101显示文摘 | Ryuta Muromoto Kenji Sugiyama Tetsuya Yamamoto Kenji Oritani Kazuya Shimoda Tadashi Matsuda | 2004 | Biochemical and Biophysical Research Communications2004，，3： | 1 |
| 14 | Molecular cloning and functional characterization of two kinds of betaine-aldehyde dehydrogenase in betaine-accumulating mangrove Avicennia marina (Forsk.) Vierh.显示文摘 | Takashi Hibino Yu-Ling Meng Yoshinobu Kawamitsu Naoko Uehara Nobuyuki Matsuda Yoshito Tanaka Hiroshi Ishikawa Shigeyuki Baba Tetsuko Takabe Keishiro Wada Tadashi Ishii Teruhiro Takabe | 2001 | Plant Molecular Biology2001，，3： | 1 |
| 15 | On the vertical structure in round jet显示文摘 | Matsuda Tadashi Sakakibara | 2005 | Physics of Fluids2005，17，02： | 1 |
| 16 | Recent advances in urologic laparoscopic surgeries: laparoendoscopic single‐site surgery, natural orifice transluminal endoscopic surgery, robotics and navigation显示文摘 | Tadashi Matsuda | 2013 | Asian J Endosc Surg2013，，： | 1 |
| 17 | Molecular cloning and functional characterization of two kinds of betaine-aldehyde dehydrogenase in betaine-accumulating mangrove Avicennia marina (Forsk.) Vierh.显示文摘 | Takashi Hibino Yu-Ling Meng Yoshinobu Kawamitsu Naoko Uehara Nobuyuki Matsuda Yoshito Tanaka Hiroshi Ishikawa Shigeyuki Baba Tetsuko Takabe Keishiro Wada Tadashi Ishii Teruhiro Takabe | 2001 | Plant Molecular Biology2001，，3： | 1 |
| 18 | Laparoscopic varicocelectomy: a simple tech nique for clip ligation of the spermatic vessels显示文摘 | Yasuki Horii Shin Higashi | 1992 | Urol1992，147，4： | 1 |
| 19 | The Effect of Long-term Supplementation With Branched-chain Amino Acid Granules in Patients With Hepatitis C Virus-related Hepatocellular Carcinoma After Radiofrequency Thermal Ablation显示文摘 | Hiroki Nishikawa Yukio Osaki Eriko Iguchi Yorimitsu Koshikawa Soichiro Ako Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Azusa Sakamoto Shinichiro Henmi Keiichi Hatamaru Tetsuro Ishikawa Sumio Saito Akihiro Nasu Ryuichi Kita Toru Kimura | 2013 | Journal of Clinical Gastroenterology2013，，4： | 1 |
| 20 | Prevalence of H elicobacter pylori Infection by Birth Year and Geographic Area in Japan显示文摘 | Junko Ueda Masahiko Gosho Yoshikatsu Inui Toru Matsuda Masatoshi Sakakibara Katsuhiro Mabe Shigemi Nakajima Tadashi Shimoyama Mitsugi Yasuda Takashi Kawai Kazunari Murakami Tomoari Kamada Motowo Mizuno Shogo Kikuchi Yingsong Lin Mototsugu Kato | 2014 | Helicobacter2014，，2： | 1 |
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