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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Review of anticancer mechanisms of isoquercitin显示文摘This review was based on a literature search of PubM ed and Scielo databases using the keywords 'quercetin,rutin,isoquercitrin,isoquercitin(IQ),quercetin-3-glucoside,bioavailability,flavonols and favonoids,and cancer' and combinations of all the words.We collected relevant scientific publications from 1990 to 2015 about the absorption,bioavailability,chemoprevention activity,and treatment effects as well as the underlying anticancer mechanisms of isoquercitin.Flavonoids are a group of polyphenolic compounds widely distributed throughout the plant kingdom.The subclass of flavonols receives special attention owing to their health benefits.The main components of this class are quercetin,rutin,and IQ,which is a flavonoid and although mostly found as a glycoside,is an aglycone(lacks a glycoside side chain).This compound presents similar therapeutic profiles to quercetin but with superior bioavailability,resulting in increased efficacy compared to the aglycone form.IQ has therapeutic applications owing to its wide range of pharmacological effects including antioxidant,antiproliferative,anti-inflammatory,anti-hypertensive,and anti-diabetic.The protective effects of IQ in cancer may be due to actions on lipid peroxidation.In addition,the antitumor effect of IQ and its underlying mechanism are related to interactions with Wnt signaling pathway,mixed-lineage protein kinase 3,mitogen-activated protein kinase,apoptotic pathways,as well proinflammatory protein signaling.This review contributed to clarifying the mechanisms of absorption,metabolism,and actions of IQ and isoquercitrin in cancer. | Guilherme di Camillo Orfali Ana Carolina Duarte Vivien Bonadio Natalia Peres Martinez Maria Elisa Melo Branco de Araújo Fernanda Bruschi Marinho Priviero Patricia Oliveira Carvalho Denise Gon?alves Priolli | 2016 | World Journal of Clinical Oncology2016，7，2： | 4 |
| 3 | Identification of patients at-risk for Lynch syndrome in a hospital-based colorectal surgery clinic显示文摘AIM:To determine the prevalence of a family history suggestive of Lynch syndrome (LS) among patients with colorectal cancer (CRC) followed in a coloproctology outpatient clinic in Southern Brazil.METHODS:A consecutive sample of patients with CRC were interviewed regarding personal and family histories of cancer.Clinical data and pathology features of the tumor were obtained from chart review.RESULTS:Of the 212 CRC patients recruited,61 (29%) reported a family history of CRC,45 (21.2%) were diagnosed under age 50 years and 11 (5.2%) had more than one primary CRC.Family histories consistent with Amsterdam and revised Bethesda criteria for LS were identified in 22 (10.4%) and 100 (47.2%) patients,respectively.Twenty percent of the colorectal tumors had features of the high microsatellite instability phenotype,which was associated with younger age at CRC diagnosis and with Bethesda criteria (P < 0.001).Only 5.3% of the patients above age 50 years had been previously submitted for CRC screening and only 4% of patients with suspected LS were referred for genetic risk assessment.CONCLUSION:A significant proportion of patients with CRC were at high risk for LS.Education and training of health care professionals are essential to ensure proper management. | Patrícia Koehler-Santos Patricia Izetti Jamile Abud Carlos Eduardo Pitroski Silvia Liliana Cossio Suzi Alves Camey Cláudio Tarta Daniel C Damin Paulo Carvalho Contu Mario Antonello Rosito Patricia Ashton-Prolla Joāo Carlos Prolla | 2011 | World Journal of Gastroenterology2011，17，6： | 2 |
| 4 | Prognosti c Value of I-ligh-Sensitivity C-Reactive Protein in Heart Failure: A Sy- stematic Review显示文摘 | SJosé Paulo Axaú jo Patricia Lourcnco Ana Azcvedo | 2009 | Journal of Cardiac Failure2009，15，3： | 1 |
| 5 | Development of new ethanol genetic Echerichia coli strains for fermentation of lignocellulosic biomass 显示文摘 | Dien B S Nichols N N Patricia JO'B | 2000 | Applied Biochemistry and Bioteehnology2000，84，： | 1 |
| 6 | 子宫颈癌筛查中传统子宫颈涂片、单层细胞学及人乳头状瘤病毒DNA检测的横断面研究显示文摘目的 比较子宫颈癌筛查中传统子宫颈涂片、单层细胞学,以及人乳头状瘤病毒检测的敏感性、特异性和观察者间的可信性。 设计 对同时进行了此3项检查并有参考标准(阴道镜和组织学)者进行横断面研究。 研究单位 法国的公立大学和私人诊所,本研究完全独立于病例提供者。 研究对象 因先前检出的细胞学异常而进行阴道镜检查的828名妇女和参加常规涂片检查的1757名妇女。 主要结果判定指标 临床读片和最优化解释(为取得一致所进行的双盲读片)。根据诊断异常的不同阈值计算出敏感性、特异性和加权κ值。 结果 根据Bethesda系统,传统子宫颈涂片检查得到的结果更为满意(91%比87%),比单层细胞学更可靠(加权κ值0.70比0.57),其敏感性和特异性更高。这些结果适用于临床读片和最优化解释,区分高级别和低级别病变,以及有低和高异常发生率的人群。人乳头状瘤病毒检测与单层细胞学检查同时进行,不论是系统性的还是只对于意义不明的非典型细胞,并不比传统涂片检查优越。 结论 在子宫颈癌筛选中,单层细胞学检查不如传统子宫颈涂片检查可靠,且更容易出现假阳性和假阴性结果。 | Jol Coste Batrix Cochand-Priollet Patricia de Cremoux Catherine Le Gals Isabelle Cartier Vincent Molini Sylvain Labb Marie-Cecile Vacher-Lavenu Philippe Vielh 徐艳峰 | 2003 | 英国医学杂志中文版2003，6，4： | 1 |
| 7 | Standard vs. radical pancreaticoduodenectomy for periampullary adenocarcinoma: A prospective, randomized trial evaluating quality of life in pancreaticoduodenectomy survivors显示文摘 | Tom C. Nguyen M.D. Taylor A. Sohn M.D. John L. Cameron M.D. Keith D. Lillemoe M.D. Kurtis A. Campbell M.D. Jo Ann Coleman R.N. Patricia K. Sauter R.N. Ross A. Abrams M.D. Ralph H. Hruban M.D. Charles J. Yeo M.D | 2003 | Journal of Gastrointestinal Surgery2003，，1： | 1 |
| 8 | Adolescent Stressors, Coping Strategies, and Psychological Health Studied in the Family Context显示文摘 | Brenda Jo Lohman Patricia A. Jarvis | 2000 | Journal of Youth and Adolescence2000，，1： | 1 |
| 9 | nor -Lignans from the leaves of Styrax ferrugineus (Styracaceae) with antibacterial and antifungal activity显示文摘 | Patricia Mendon?a Pauletti Angela Regina Araújo Maria Claudia Marx Young Astréa M Giesbrecht Vanderlan da Silva Bolzani | 2000 | Phytochemistry2000，，6： | 1 |
| 10 | New amino acids derived from L-pyroglutamic acid:Synthesis of trans-4-benzyl-cis-5-phenyl-L-proline,L-α-(2-benzyl-3-phenylpropyl)-glycine and L-α-(3-phenylpropyl)-glycine显示文摘 | Jo V B Wim V D N Patricia V | 1998 | Tetrahedron1998，54，： | 1 |
| 11 | Development of new ethanolgenic Echerichia coli strains for fermentation of lignocellulosic biomass 显示文摘 | DIEN BS NICHOLS NN PATRICIA JO'B | 2000 | Applied Biochemistry and Biotechnology2000，84，： | 1 |
| 12 | Classification and genetics of dystonia显示文摘 | Patricia M Carvalho A Laurie JO | 2002 | Lancet Neurology2002，1，： | 1 |
| 13 | Hepatoprotective effects of Spirulina maxima in patients with non-alcoholicfatty liver disease: a case series显示文摘 | Aldo FH Patricia V TD Marco A JO | 2010 | Journal of Medical Case Reports2010，4，： | 1 |
| 14 | Twin Study Indicates Loss of Interaction Between Microbiota and Mucosa of Patients With Ulcerative Colitis显示文摘 | Patricia Lepage Robert H?sler Martina E. Spehlmann Ateequr Rehman Aida Zvirbliene Alexander Begun Stephan Ott Limas Kupcinskas Jo?l Doré Andreas Raedler Stefan Schreiber | 2011 | Gastroenterology2011，，1： | 1 |
| 15 | Effect of angiotensin II with follicle cells and insulin-like growth factor-I or insulin on bovine oocyte maturation and embryo development显示文摘 | Jer?nimo Rubert Stefanello Marcos Henrique Barreta Patricia Marafon Porciuncula Jo?o Nelson Arruda Jo?o Francisco Oliveira Marcos Antonio Oliveira Paulo Bayard Gon?alves | 2006 | Theriogenology2006，，9： | 1 |
| 16 | Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study显示文摘 | Silvia de Sanjose Wim GV Quint Laia Alemany Daan T Geraets Jo Ellen Klaustermeier Belen Lloveras Sara Tous Ana Felix Luis Eduardo Bravo Hai-Rim Shin Carlos S Vallejos Patricia Alonso de Ruiz Marcus Aurelho Lima Nuria Guimera Omar Clavero Maria Alejo Anton | 2010 | Lancet Oncology2010，，11： | 1 |
| 17 | Women and the rural idyll显示文摘 | Jo Little Patricia Austin | 1996 | Journal of Rural Studies1996，，2： | 1 |
| 18 | Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior显示文摘 | Simone Becho Campos Débora Marques Miranda Bruno Rezende Souza Patricia Araújo Pereira Fernando Silva Neves Maria Aparecida Camargos Bicalho Paulo Henrique Casadei Melillo Juliana Tramontina Flávio Kapczinski Marco Aurélio Romano-Silva Humberto Correa | 2009 | Journal of Psychiatric Research2009，，5： | 1 |
| 19 | Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study显示文摘 | Silvia de Sanjose Wim GV Quint Laia Alemany Daan T Geraets Jo Ellen Klaustermeier Belen Lloveras Sara Tous Ana Felix Luis Eduardo Bravo Hai-Rim Shin Carlos S Vallejos Patricia Alonso de Ruiz Marcus Aurelho Lima Nuria Guimera Omar Clavero Maria Alejo Anton | 2010 | Lancet Oncology2010，，11： | 1 |
| 20 | The effect of exercise training on elderly persons with cognitive impairment and dementia:A meta-analysis显示文摘 | Patricia H Beatriz CA Kenneth JO | 2004 | Arch Phys Med Rehabil2004，85，2： | 1 |
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