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| 1 | Study of the mechanisms of acupuncture and moxibustion treatmentfor ulcerative colitis ratsinview of the gene expression of cytokines显示文摘AIM To observe the effect of acupuncture and moxibustion on the expression of IL 1β and IL 6 mRNA in ulcerative colitis rats. METHODS The SD rat ulcerative colitis model was created by immunological method associated with local stimulation. Colonic mucosa was prepared from human fresh surgical colonic specimens, homogenized by adding appropriate amount of normal saline and centrifuged at 3000*!r/*!min . The supernatant was collected for measurement of protein conentration and then mixed with Freund adjuvant. This antigen fluid was first injected into the plantae of the model group rats, and then into their plantae, dorsa, inguina and abdominal cavities (no Freund adjuvant for the last injection) again on the 10th, 17th, 24th and 31st day. When a certain titer of serum anti colonic antibody was reached, 2% formalin and antigen fluid (no Freund adjuvant) were administered separately by enema. The ulcerative colitis rat model was thus set up. The animals were randomly divided into four groups: model control group (MC, n =8), electro acupuncture group (EA, n =8), herbs partition moxibustion group (HPM 8), normal control group (NC, n =8). HPM: Moxa cones made of refined mugwort floss were placed on the medicinal pad (medicinal pad dispensing: Radix Aconiti praeparata, cortex Cinnamomi, etc ) for Qihai (RN 6) and Tianshu (ST 25, bilateral) and ignited. Two moxa cones were used for each acupoint once a day and 14 times in all. EA: Tianshu (bilateral) and Qihai were stimulated by the intermittent pulse with 2Hz frequency, 4mA intensity for 20 minutes once a day and 14 times in all. After treatment, rats of all four groups were killed simultaneously. The spleen was separated and the distal colon was dissected. Total tissue RNA was isolated by the guanidinium thiocyanate phenol chloroform extraction method. RT PCR technique was used to study the expression of IL 1β and IL 6 mRNA. RESULTS IL 1β and IL 6 mRNAs were not detected in the spleen and colonic mucosa of the NC rats, whereas they were significantly expressed in that of the MC rats. IL 1β and IL 6 mRNAs were markedly lower in the EA and HPM rats than that in MC rats. There was no significant difference between the levels of IL 1β and IL 6 mRNAs in the EA and HPM rats. The expressions of IL 1β and IL 6 mRNAs were nearly the same in the spleen and colon of all groups. CONCLUSION Acupuncture and moxibustion greatly inhibited the expression of IL 1β and IL 6 mRNA in the experimental ulcerative colitis rats. | Wu HG Zhou LB Pan YY Huang C Chen HP Shi Z Hua XG | 1999 | World Journal of Gastroenterology1999，5，6： | 45 |
| 2 | CCAAT/enhancer- binding protein activates the CD14 promoter and mediates transforming growth factor beta signaling in monocyte development显示文摘 | Pan Z Hetherington C J Zhang D E | 1999 | J Biol Chem1999，274，23： | 2 |
| 3 | Luminescence effect of silver nanoparticle in water phase显示文摘 | JIANG Z L YUAN W E PAN H C | 2005 | Spectrochim Acta Part B2005，61，1112： | 1 |
| 4 | Effects of prolactin-releasing peptide on tuberoinfundibular dopaminergic neuronal activity andprolactin secretion in estrogen-treated female rats显示文摘 | Yuan Z F Yang S C Pan J T | 2002 | J Biomed Sci2002，9，： | 1 |
| 5 | Kinetics and mechanisms of intragranular ferrite nucleation on non-metallic inclusions in low carbon steels显示文摘 | PAN T YANG Z G ZHANG C | 2006 | Materials Science and Engineering A2006，8440，4： | 1 |
| 6 | Uncertainty Analysis of Creep and Shrinkage Effects in Long-span Continuous Rigid Frame of Sutong Bridge显示文摘 | PAN Z F FU C C JIANG Y | 2011 | Journal of Bridge Engi- neering ASCE2011，16，2： | 1 |
| 7 | The potential dual effects of anesthetic isoflurane on hypoxia-induced caspase-3 activation and increases in beta-site amyloid precursor protein-cleaving enzyme levels显示文摘 | Pan C Xu Z Dong Y | 2011 | Anesth Analg2011，113，1： | 1 |
| 8 | 2013, Antigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011显示文摘 | Qi x Cui L Jiao Y Pan Y Li X Zu R Huo X Wu B Tang F Song Y Zhou M Wang H Cardona C J Xing Z | 2013 | Archives of Virology2013，158，1： | 1 |
| 9 | Determining gastric cancer resectabilityby dynamic MDCT显示文摘 | Pan Z Zhang H Yan C | 2010 | Eur Radiol2010，20，3： | 1 |
| 10 | Numerical simulation of vortex-induced vibration of a circular cylinder at low massdamping using RANS code显示文摘 | PAN Z Y CUI W C MIAO Q M | 2007 | Journal of Fluids and Structures2007，，23： | 1 |
| 11 | MALT1 is required for EGFR- induced NF-kappaB activation and contributes to EGFR-driven lung cancer progression显示文摘 | Pan D Jiang C Ma Z | 2015 | Oncogene2015，35，7： | 1 |
| 12 | Large doppler compensation for mobile OFDM based underwater acoustic communication显示文摘 | Yin J W Wang C Pan Z R | 2013 | Information Technology Journal2013，12，7： | 1 |
| 13 | Numerical inves- tigation of partial blockage effect on film cooling effective- ness显示文摘 | PAN C X ZHANG J Z HUANG K N | 2014 | Mathematical Problems in Engineering2014，，6： | 1 |
| 14 | Indications for early aspirin use in acute ischemic stroke:A combined analysis of 40,000 randomized patients from the Chinese Acute Stroke Trial and the International Stoke trial显示文摘 | Chen Z M Sandercock P Pan H C | 2000 | Stroke2000，31，： | 1 |
| 15 | An epoxy resin copolymer with zero shrinkage显示文摘 | He P S Zhou Z Q Pan C Y | 1989 | J Mater Sci1989，，24： | 1 |
| 16 | Effect of tauline on human fetal neuron cells: Proliferation and differentiation 显示文摘 | CHEN X C PAN Z L LIU D S | 1998 | Adv Exp Meal Biol1998，442，： | 1 |
| 17 | Investigation of Struc- tural ,Optical and Electronic Properties in A1-Sn Co-Doped ZnO Thin Films显示文摘 | Pan Z C Tian X L Wu S K | 2013 | Applied Surface Science2013，265，： | 1 |
| 18 | Low-complexity it- erative frequency domain decision feedback equalization 显示文摘 | Zhang C Wang Z C Pan C Y | 2011 | IEEE Transactions Vehicular Technology2011，60，3： | 1 |
| 19 | 查看详情显示文摘 | Pan Z W Lai H L Au F C K | | 0，，： | 1 |
| 20 | A single ZnO nanofiber-based highly sensitive amperometric glucose biosensor 显示文摘 | Ahmad M Pan C F Luo Z X | 2010 | Journal of Physical Chemistry C2010，114，20： | 1 |
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