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| 1 | Site-Dependent Osseointegration of Biodegradable High-Purity Magnesium for Orthopedic Implants in Femoral Shaft and Femoral Condyle of New Zealand Rabbits显示文摘Magnesium(Mg) has been widely accepted as osteoconductive biomaterial, but osseointegration of Mg device at different implantation sites is still unclear. In the present study, high-purity magnesium(HP Mg)pins were implanted into femoral shaft and condyle of New Zealand rabbits concurrently. 2, 8, 12 and 16 weeks after surgery, rabbit femurs were harvested for micro-computed tomography(micro-CT) scanning and subsequent histological examinations. HP Mg pins were retrieved for scanning electron microscope and energy dispersive spectrum(SEM/EDS) analyses. HP Mg pins at both implantation sites performed stable corrosion with mineral deposition and bone incorporation on surface. However, difference in distribution of contact osteogenesis centers and biological properties of peri-implant bone tissues was detected between femoral shaft and femoral condyle. In femoral condyle, contact osteogenesis centers originated from both periosteum and cancellous bones and the whole HP Mg pin was encapsuled in trabecular bone at 16 weeks.Meanwhile, bone volume to total bone volume(BV/TV) and bone mineral density(BMD) of peri-implant bone tissues were above those of normal bone tissues. In femoral shaft, contact osteogenesis centers were only from periosteum and direct bone contact was confined in cortical bone, while BV/TV and BMD kept lower than normal. Furthermore, new formation of peri-implant bone tissues was more active in femoral condyle than in femoral shaft at 16 weeks. Therefore, although HP Mg performed good biocompatibility and corrosion behavior in vivo, its bioadaption of osseointegration at different implantations sites should be taken into consideration. Bone metaphysic was suitable for Mg devices where peri-implant bone tissues regenerated rapidly and the biological properties were close to normal bone tissues. | Pengfei Cheng Changli Zhao Pei Han Jiahua Ni Shaoxiang Zhang Xiaonong Zhang Yimin Chai | 2016 | Journal of Materials Science & Technology2016，32，9： | 4 |
| 2 | PtNi-W/C with Atomically Dispersed Tungsten Sites Toward Boosted ORR in Proton Exchange Membrane Fuel Cell Devices显示文摘The performance of proton exchange membrane fuel cells is heavily dependent on the microstructure of electrode catalyst especially at low catalyst loadings.This work shows a hybrid electrocatalyst consisting of PtNi-W alloy nanocrystals loaded on carbon surface with atomically dispersed W sites by a two-step straightforward method.Single-atomic W can be found on the carbon surface,which can form protonic acid sites and establish an extended proton transport network at the catalyst surface.When implemented in membrane electrode assembly as cathode at ultra-low loading of 0.05 mgPt cm^(−2),the peak power density of the cell is enhanced by 64.4%compared to that with the commercial Pt/C catalyst.The theoretical calculation suggests that the single-atomic W possesses a favorable energetics toward the formation of*OOH whereby the intermediates can be efficiently converted and further reduced to water,revealing a interfacial cascade catalysis facilitated by the single-atomic W.This work highlights a novel functional hybrid electrocatalyst design from the atomic level that enables to solve the bottle-neck issues at device level. | Huawei Wang Jialong Gao Changli Chen Wei Zhao Zihou Zhang Dong Li Ying Chen Chenyue Wang Cheng Zhu Xiaoxing Ke Jiajing Pei Juncai Dong Qi Chen Haibo Jin Maorong Chai Yujing Li | 2023 | Nano-Micro Letters2023，15，9： | 3 |
| 3 | Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance显示文摘Objective: Lack of effective therapies remains a problem in the treatment of oral squamous cell carcinoma(OSCC), especially in patients with advanced tumors. OSCC development is driven by multiple aberrancies within the cell cycle pathway, including amplification of cyclin D1 and loss of p16. Hence, cell cycle inhibitors of the CDK4/6-cyclin D axis are appealing targets for OSCC treatment. Here, we determined the potency of palbociclib and identified genetic features that are associated with the response of palbociclib in OSCC.Methods: The effect of palbociclib was evaluated in a panel of well-characterized OSCC cell lines by cell proliferation assays and further confirmed by in vivo evaluation in xenograft models. PIK3CA-mutant isogenic cell lines were used to investigate the effect of PIK3CA mutation towards palbociclib response.Results: We demonstrated that 80% of OSCC cell lines are sensitive to palbociclib at sub-micromolar concentrations.Consistently, palbociclib was effective in controlling tumor growth in mice. We identified that palbociclib-resistant cells harbored mutations in PIK3CA. Using isogenic cell lines, we showed that PIK3CA mutant cells are less responsive to palbociclib as compared to wild-type cells with concurrent upregulation of CDK2 and cyclin E1 protein levels. We further demonstrated that the combination of a PI3 K/mTOR inhibitor(PF-04691502) and palbociclib completely controlled tumor growth in mice.Conclusions: This study demonstrated the potency of palbociclib in OSCC models and provides a rationale for the inclusion of PIK3CA testing in the clinical evaluation of CDK4/6 inhibitors and suggests combination approaches for further clinical studies. | Nur Syafinaz Zainal Bernard Kok Bang Lee Zheng Wei Wong Iuan Sheau Chin Pei San Yee Chai Phei Gan Kein Seong Mun Zainal Ariff Abdul Rahman J. Silvio Gutkind Vyomesh Patel Sok Ching Cheong | 2019 | Cancer Biology & Medicine2019，16，2： | 3 |
| 4 | Incidence of Macrosomia in Rural Areas—Henan Province,China,2013–2017显示文摘Introduction:Macrosomia has short-term and long-term adverse health effects and is thus an important public health concern.Recent decades have witnessed increasing incidence of macrosomia in many countries.Methods:The present study used a large population-based birth cohort study to depict incidence of macrosomia among live births in rural areas of Henan Province of China from 2013 to 2017.Results:Among the 1,262,916 births,82,353 were cases of macrosomia.The overall incidence of all types of macrosomia,of macrosomia with birth weight<4,500 g,and of macrosomia with birth weight≥4,500 g were 6.52%,5.30%,and 1.22%,respectively.From 2013 to 2017,the incidence of macrosomia decreased by 31.3%from 7.96%in 2013 to 5.47%in 2017(X^(2)_(trend)=946.96,P_(trend)<0.001).Male infants and infants≥42 gestational weeks had significantly higher incidence of macrosomia than that of female infants and infants<42 gestational weeks(P<0.001).Conclusion:Gestational weight control through nutrition management and physical activities during pregnancy are needed to reduce incidence of macrosomia. | Shiqi Lin Jian Chai Jiajia Li Xuejun Shang Lijun Pei Lifang Jiang Junxi Zhang Panpan Sun Wei Dong Yuhong Wang Dezhuan Zhou | 2021 | China CDC weekly2021，3，37： | 3 |
| 5 | Comparative Study about Degradation of High-purity Magnesium Screw in Intact Femoral Intracondyle and in Fixation of Femoral Intracondylar Fracture显示文摘Bone screws encounter complex mechanical environment in fracture fixation of weight-bearing bone.In the present study, high-purity magnesium(HP Mg) screws were applied in fixation of rabbit femoral intracondylar fracture with 3 mm gap. In the control group, HP Mg screws of the same design were implanted at corresponding position of contralateral leg. At 4, 8 and 16 weeks after surgery, retrieved femurs went through micro-computed tomography(micro-CT) scanning and hard tissue processing. Under mechanical stress involved in fracture fixation, bending of screw bolt was observed at the portion exposed to facture gap at 4 weeks. Then local corrosion at the same portion was detected 16 weeks after surgery,which indicated the accumulation effect of mechanical stress on Mg corrosion. HP Mg screws in the fracture group had no significant difference with the control group in screw volume, surface area, surfaceto-volume ratio(S/V). And peri-implant bone volume/tissues volume(BV/TV) and bone volume density(BMD) in the fracture group was comparable to that in the control group. Furthermore, histological analysis showed new formed bone tissues in fracture gap and fracture healing 16 weeks after surgery. Under mechanical stress, HP Mg screw suffered bolt bending and local corrosion at the portion exposed to fracture gap. But it had no influence on the integral corrosion behaviors, osseointegration of HP Mg screw and the fracture healing. Therefore, HP Mg screws possessed good potential in fracture fixation of weightbearing bones. | Pei Han Pengfei Cheng Changli Zhao Shaoxiang Zhang Runhua Zhou Xiaonong Zhang Yimin Chai | 2017 | Journal of Materials Science & Technology2017，33，3： | 2 |
| 6 | Joining of Al2O3p/Al composites by transient liquid phase (TLP) bonding and a novel process of active-transient liquid phase (A-TLP) bonding显示文摘 | ZHANG Gui-feng ZHANG Jian-xun PEI Yi LI Si-yu CHAI Dong-lang | 2008 | Materials Science Engineering A2008，488，： | 1 |
| 7 | Single-dose pharmacokinetics and safety of iptakalim hydrochloride in Chinese healthy volunteers显示文摘 | Cai Y Chai D Pei F | 2012 | J Pharm Pharmacol2012，64，3： | 1 |
| 8 | Joining of Al2O3p/Al composites by transient liquid phase(TLP) bonding and a novel process of active-transient liquid phase(A-TLP) bonding显示文摘 | ZHANG Gui-feng ZHANG Jian-xun PEI Yi LI Si-yu CHAI Dong-lang | 2008 | Materials Science and Engineering A2008，488，： | 1 |
| 9 | Factors associated with activities of daily living among the disabled elders with stroke显示文摘Objective:To determine the factors associated with activities of daily living(ADL)among the disabled elders post-stroke.Methods:A total of 158 patients were chosen from community health service stations in eighteen regions of Tianjin city by convenience sampling from March to November in 2013.The Barthel Index(BI)and the short-formmini-nutritional assessment(MNA-SF)were used to evaluate the ADL,the nutritional status respectively.Statistical analysis was performed using independent sample t-test,one-way ANOVA,Pearson correlation and multiple linear regression analysis.Barthel ADL index was the main outcome.Results:The mean score of ADL was 50.50±27.125.The multiple linear regression showed that the factors which had significant impact on ADL were stroke frequency,types of stroke,nutritional status,financial status,and age.Conclusions:Disabled elders with recurrent strokes,hemorrhagic stroke,dependent financial resources,older age,worse nutritional status and living with family had poorer strokerelated outcome.Healthcare providers can discover the high-risk groups of disability and implement individualized preventive interventions in accordance with the related factors. | Li Pei Xiao-Ying Zang Yan Wang Qian-Wen Chai Jun-Ying Wang Chun-Yan Sun Qing Zhang | 2016 | International Journal of Nursing Sciences2016，3，1： | 1 |
| 10 | Rapid xenograft tumor progression in beta-arrestinl transgenic mice due to enhanced tumor angiogenesis显示文摘 | Zou L Yang R Chai J Pei G | 2008 | FASEB J2008，22，： | 1 |
| 11 | Induction of fuzzy rules and membership functions from training examples 显示文摘 | Tzung - Pei Hong Chai - Ying Lee | 1996 | Fuzzy Sets and Systems1996，84，： | 1 |
| 12 | The Characteristics of vasa Gene from Japanese Sea Bass(Lateolabrax japonicas) and Its Response to the External Hormones显示文摘The RNA helicase Vasa is an important regulator of primordial germ cell development. Its function in mature fish, especially the hormone-related differences in maturing male fish has seldom been documented. In this study, a full length c DNA sequence of the vasa gene was cloned from Japanese sea bass, Lateolabrax japonicas, and it was named jsb-vasa. Homology analysis showed that jsb-vasa was closely related to its teleost homologs. The spatial distribution of jsb-vasa indicated that it was only highly expressed in testis, showing its germ cell-specific expression pattern. During the testicular development cycle, jsb-vasa was highly expressed during early period of spermatogenesis, and reduced when spermatogenesis advanced. In addition, the jsb-vasa gene expression was significantly inhibited at 6 h, 12 h and 24 h after injecting h CG(human chorionic gonadotropin) and Gn RHa(Gonadotropin-releasing hormone analogue), indicating that jsb-vasa gene may play an important role in spermatogenesis of Japanese sea bass, and be under the regulation of external sex hormones. | CHI Meili WEN Haishen NI Meng QIAN Kun ZHANG Pei CHAI Senhao | 2015 | Journal of Ocean University of China2015，14，4： | 1 |
| 13 | An efficient method and system for simultaneously measuring the performance of vast scintillating materials显示文摘A method and system for automatically and simultaneously measuring the light output of multiple scintillators,or each scintillating unit of an array,were developed.Using a large area flat panel PSPMT H8500,the light output and energy resolution were obtained automatically by comparing with reference scintillators or array using an Energy Table,Look-up Table and energy spectrum data.The aim of developing an efficient performance evaluation of scintillators was achieved.Using the method,a scintillator performance testing system was set up and six LYSO crystals and a 3×3 LYSO array were measured.The results showed that the light output and energy resolution were accurately measured automatically.The deviation of repeat measurements for the same sample was not more than 2%,and the nonlinear deviation of the system was not more than 3%.The system is suitable for measuring the performance of crystals,especially where the mass measurement of crystals and arrays is required. | CHEN Yan ZHANG Zhiming LI Daowu SHUAI Lei HUANG Xianchao TANG Haohui LI Ting ZHUANG Kai WANG yingjie LIU Yantao ZHANG Yiwen CHAI Pei LIU Shuangquan ZHU Meiling WANG Baoyi WEI Long | 2012 | Nuclear Science and Techniques2012，23，3： | 0 |
| 14 | Disruption of the autism-related gene Pak1 causes stereocilia disorganization,hair cell loss,and deafness in mice显示文摘Several clinical studies have reported that hearing loss is correlated with autism in children.However,little is known about the underlying mechanism between hearing loss and autism.p21-activated kinases(PAKs)are a family of serine/threonine kinases that can be activated by multiple signaling molecules,particularly the Rho family of small GTPases.Previous studies have shown that Pak1 mutations are associated with autism.In the present study,we take advantage of Pak1 knockout(Pak1a/a)mice to investigate the role of PAK1 in hearing function.We find that PAK1 is highly expressed in the postnatal mouse cochlea and that PAK1 deficiency leads to hair cell(HC)apoptosis and severe hearing loss.Further investigation indicates that PAK1 deficiency downregulates the phosphorylation of cofilin and ezrin-radixin-moesin and the expression of b II-spectrin,which further decreases the HC synapse density in the basal turn of cochlea and disorganized the HC stereocilia in all three turns of cochlea in Pak1à/àmice.Overall,our work demonstrates that the autism-related gene Pak1 plays a crucial role in hearing function.As the first candidate gene linking autism and hearing loss,Pak1 may serve as a potential target for the clinical diagnosis of autism-related hearing loss. | Cheng Cheng Yilin Hou Zhonghong Zhang Yanfei Wang Ling Lu Liyan Zhang Pei Jiang Song Gao Qiaojun Fang Chengwen Zhu Junyan Gao Xufeng Liu Wei Xie Zhengping Jia Zhigang Xu Xia Gao Renjie Chai | 2021 | Journal of Genetics and Genomics2021，48，4： | 0 |
| 15 | Comparative transcriptome analyses reveal that the MsNST1 gene affects lignin synthesis in alfalfa(Medicago sativa L.)显示文摘As the second most abundant natural polymer,accounting for approximately 30%of the organic carbon in the biosphere,lignin plays an essential role in plant development.However,a high lignin content affects the nutritional quality of alfalfa(Medicago sativa L.),the most widely cultivated perennial legume forage crop.Histological analysis indicated that G-lignin and S-lignin were present in the stem,leaf,and petiole of alfalfa,and the deposition of lignin increased gradually in descending internodes.Neutral detergent fiber(NDF),acid detergent fiber(ADF),and acid detergent lignin(ADL)contents continually increased from the top to the bottom of the stem,and ADL content showed a similar trend in leaves.Alfalfa leaves and stems from five different nodes(1,2,4,6,and 8)were used as materials to investigate molecular regulatory mechanisms in lignin synthesis by RNA sequencing.Respectively 8074 and 7752 differentially expressed genes(DEGs)were identified in leaves and stems,and 1694 DEGs were common to the two tissues.‘‘Phenylpropanoid biosynthesis”was the most enriched pathway in both leaves and stems,and 134 key regulatory genes in lignin synthesis were identified by a weighted gene co-expression network analysis.The NAC family transcription factor MsNST1 gene was highly expressed in old leaf and stem tissues.The deposition pattern of G-and S-lignin differed among M.truncatula wild-type,nst1 mutants,and overexpression lines,and the transcription levels of lignin synthesis genes such as HCT,F5H,and COMT in these three materials also differed.These results suggest that MsNST1 affects lignin synthesis in alfalfa.These findings provide a genetic basis and abundant gene resources for further study of the molecular mechanisms of lignin synthesis,laying a foundation for low-lignin alfalfa breeding research. | Qiang Zhou Pei Mao Dong Luo Xutian Chai Hao Deng Qiangen Fang Longfa Fang Zhibiao Nan Jiangqi Wen Zhipeng Liu | 2022 | The Crop Journal2022，10，4： | 0 |
| 16 | The overexpression of Rps14 in Lgr5+progenitor cells promotes hair cell regeneration in the postnatal mouse cochlea显示文摘Sensory hair cells(HCs)in the cochlea cannot regenerate spontaneously in adult mammals after being damaged by external or genetic factors.However,several genes and signaling pathways are reported to induce cochlear HC regeneration at the early neonatal stage.Rps14 encodes a ribosomal protein that is involved in the regulation of cell differentiation and proliferation in mammals.However,its roles in the cochlea have not been reported in vivo.Here,we specifically overexpressed Rps14 in Lgr5+progenitor cells in the newborn mouse cochlea and found that Rps14 conditional overexpression(cOE)mice had significantly increased the ectopic HCs,including inner and outer HCs.We further explored the source of these ectopic HCs and found no EdU+supporting cells observed in the Rps14 cOE mice.The lineage tracing results,on the other hand,revealed that Rps14 cOE mice had significantly more tdTomato+HCs in their cochleae than control mice.These results indicated that regenerated HCs by cOE of Rps14 are most likely derived from inducing the direct trans-differentiation of Lgr5+progenitor cells into HCs.Moreover,real-time qPCR results suggested that the transcription factor genes Atoh1 and Gfi1,which are important in regulating HC differentiation,were upregulated in the cochlear basilar membrane of Rps14 cOE mice.In summary,this study provides in vivo evidence that,in the postnatal mouse cochlea,Rps14 is a potential gene that can promote the spontaneous trans-differentiation of Lgr5+progenitor cells into HCs.This gene may one day be exploited as a therapeutic target for treating hearing loss. | Jingru Ai Pei Jiang Jingyuan Huang Hairong Xiao Yanqin Lin Mingchen Dai Yintao Wang Yuan Zhang Mengyao Tian Renjie Chai Shasha Zhang | 2023 | Engineered Regeneration2023，4，3： | 0 |
| 17 | CACA guidelines for holistic integrative management of glioma显示文摘Glioma of the brain is a kind of tumor originating from neuroglial cells.It is the most common primary intracranial tumor,accounting for~30%of all central nervous system tumors and 80% of malignant brain tumors.Glioma is characterized by high disability and recurrence rates.The disease seriously threatens the life of patients,afects their quality of life,and brings a heavy economic and psychological burden to patients,families,and society.With the progression of molecular genetic testing technology and the completion of various clinical trials,the classifcation scheme for glioma is increasingly well established.Diagnosis and treatment regimens,including traditional and new regimens,are becoming increasingly specialized and standardized.The purpose is to develop a clinical diagnosis and treatment guideline for glioma in the Chinese population suitable for Chinese doctors and the general population based on domestic and international glioma research progress.Thus,domestic practitioners in the feld can obtain current information and provide better service to patients with glioma,promoting the development of domestic clinical medicine and basic research on glioma. | Daiming Fan Tao Jiang Wenbin Ma Chuanlu Jiang Yongping You Ying Mao Xiaoguang Qiu Chunsheng Kang Gang Li Qing Mao Xuejun Yang Zhiyong Qin Zhixiong Liu Weimin Wang Xinting Wei Wenbin Li Yunhui Liu Rutong Yu Xinguang Yu Dezhi Kang Yonggao Mou Lei Wang Wei Zhang Zhaoshi Bao Ruichao Chai Baoshi Chen Xing Fan Shengyu Fang Guanzhang Li Lianwang Li Shouwei Li Xing Liu Yanwei Liu Xia Shan Liang Wang Yinyan Wang Yu Wang Zheng Wang Zhiliang Wang Chenxing Wu Wei Yan Pei Yang Gan You Chuanbao Zhang Zhong Zhang Zheng Zhao | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
| 18 | Appropriateness, endoscopic findings and contributive yield of pediatric gastrointestinal endoscopy显示文摘AIM:To determine the predictability of the North American Society for Pediatric Gastroenterology,Hepatology and Nutrition(NASPGHAN)and American Society for Gastrointestinal Endoscopy(ASGE)guideline with regard to appropriate endoscopic practice in children,positive endoscopic findings and contributive yield in clinical practice.METHODS:This was a descriptive,retrospective analysis,conducted at the Department of Paediatrics,University Malaya Medical Centre,Malaysia.All children who had esophagogastroduodenoscopy(EGD)and colonoscopy from January 2008 to June 2011 were included.An endoscopy was considered appropriate when its indication complied with the NASPGHAN and ASGE guideline.All endoscopic findings were classified as either positive(presence of any endoscopic or histologic abnormality)or negative(no or minor abnormality,normal histology);effecting a positive contributive(a change in therapeutic decisions or prognostic consequences)or non-contributive yield(no therapeutic or prognostic consequences).RESULTS:Overall,76%of the 345 procedures(231EGD alone,26 colonoscopy alone,44 combined EGD and colonoscopy)performed in 301 children(median age 7.0 years,range 3 months to 18 years)had a positive endoscopic finding.Based on the NASPGHAN and ASGE guideline,99.7%of the procedures performed were considered as appropriate.The only inappropriate procedure(0.3%)was in a child who had EGD for assessment of the healing of gastric ulcer following therapy in the absence of any symptoms.The overall positive contributive yield for a change in diagnosis and/or management was 44%.The presence of a positive endoscopic finding was more likely to effect a change in the therapeutic plan than an alteration of the initial diagnosis.A total of 20(5.8%)adverse events were noted,most were minor and none was fatal.CONCLUSION:The NASPGHAN and ASGE guideline is more likely to predict a positive endoscopic finding but is less sensitive to effect a change in the initial clinical diagnosis or the subsequent therapeutic plan. | Way Seah Lee Hafizah Zainuddin Christopher CM Boey Pei Fan Chai | 2013 | World Journal of Gastroenterology2013，19，47： | 0 |
| 19 | Development and evaluation of a double-plane detector system for multi-radionuclide imaging显示文摘Purpose To develop a multi-radionuclide imaging system with a flexible and compact structure that has a potential for breast and other applications,and to evaluate its performances under both positron emission tomography and single photon emission imaging conditions.Methods The plane detector was composed of 5×6 blocks with an effective detection area of 168.6 mm×202.4 mm.Each block consisted of a 16×16 LYSO array.The pixel size is 1.9 mm×1.9 mm×15 mm.An 8×8 silicon photomultiplier(SiPM)array with SensL’s C-30035 sensors was coupled to the LYSO array,separated by a 1.5-mm-thick glass.To minimize the influence of temperature on the detector,the active part of the front-end electronics was kept away from SiPMs.Self-designed data acquisition system and reconstruction software were utilized to evaluate the performances of the whole system.Results All the blocks had excellent pixels identification.An average energy resolution of 11.39%for 511 keV and 21.37%for 140 keV was obtained.In the PET mode,the best spatial resolution was better than 2 mm and the system sensitivity reached up to 11.05%at 60 mm distance.In the single photon emission imaging mode,a spatial resolution better than 3 mm was obtained.Conclusion The results indicated that the system has a good overall performance and can be used in breast imaging and other general PET applications.It also has the potential to be used for single photon emission imaging.In pursuit of a better spatial resolution of cross-plane,PSF and DOI technology will be developed in the next work.For specific applications,further improvement of the detector system such as performance evaluation with phantoms will be carried out. | Zhen‑Rui Lu Xian‑Chao Huang Zhi‑Ming Zhang Ying‑Jie Wang Da‑Quan Cao Wei Zhou Xiao‑Yue Gu Xiao‑li Sun Pei Chai Hao‑Hui Tang Dao‑Wu Li Lin Li Chuang‑Xin Ma Long Wei | 2019 | Radiation Detection Technology and Methods2019，3，3： | 0 |
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